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Search Results for " hnscc "

Targets Recommended: RAAS MRP AChR

14

抑制剂 & 化合物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1484	Perindoprilat Perindoprilate,培哚普利	RAAS; MRP; AChR	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Perindoprilat (Perindoprilate) 是一种血管紧张素转换酶抑制剂。
T13176	TNO155 Batoprotafib	Phosphatase	Metabolism
	TNO155 是具有口服活性野生型SHP2的选择性变构抑制剂 (IC50= 0.011 µM)。它有研究 RTK 依赖性恶性肿瘤（尤其是晚期实体瘤）的潜力。
T4325	COTI-2 COTI 2,COTI2	Apoptosis; p53	Apoptosis
	COTI-2是一种具有口服活性的低毒性抗癌药物，是 p53 突变体激活剂。它通过激活突变型 p53 和抑制PI3K/AKT/mTOR 途径发挥作用，通过 p53 依赖和非依赖机制在 HNSCC 中具有抗肿瘤活性。它诱导多种人肿瘤细胞凋亡，可将突变型 p53 转化为野生型构象。
T76890	Petosemtamab MCLA 158	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Petosemtamab (MCLA 158) 是一种高效的抗 EGFR (Kd: 0.22 nM) 和抗 LGR5 (Kd: 0.86 nM) 单克隆抗体。Petosemtamab 促使 LGR5+ 癌细胞中的 EGFR 信号传导中断和受体分解。Petosemtamab 可用于头颈部鳞状细胞癌 (HNSCC)、转移性结直肠癌 (CRC) 等实体瘤的研究。
T76691	Monalizumab	IFNAR; Chk	Cell Cycle/Checkpoint; Immunology/Inflammation
	Monalizumab 是一种新型靶向自然杀伤细胞群 2A (NKG2A) 的免疫检查点抑制剂。Monalizumab 是一种人源化抗 NKG2A 的单克隆抗体，可促使 IFN-γ 产生，从而激活自然杀伤细胞功能。Monalizumab 具有抗肿瘤活性，可用于研究颈部鳞状细胞癌 (HNSCC)。
T10313	(Rac)-AMXT-1501 4HCl	Dopamine Receptor; Antibacterial	GPCR/G Protein; Microbiology/Virology; Neuroscience
	(Rac)-AMXT-1501 4HCl 是一种多胺转运抑制剂,抑制多胺转运与顺铂在 HNSCC 中协同作用。(Rac)-AMXT-1501 4HCl 具有潜在的抗菌活性，通过靶向鸟氨酸脱羧酶和多胺转运抑制神经母细胞瘤细胞增殖，抑制肺炎球菌的荚膜生物合成。
T16690	Pyrazofurin	Others	Others
	Pyrazofurin is a pyrimidine nucleoside analogue, inhibits cell proliferation and DNA synthesis in cells by inhibiting UMP synthase. Pyrazofurin is a sensitive orotate-phosphoribosyltransferase inhibitor (IC50s between 0.06-0.37 µM in the cell lines Hep-2,
T76918	Barecetamab
	Barecetamab (ISU-104) 是一种人源话抗 ErbB3单克隆抗体。Barecetamab 可用于复发/转移性 (R/M) 头颈部鳞状细胞癌 (HNSCC) 的研究。
T9133L	Caroverine P 201-1	Others	Others
	Caroverine is a potential chemotherapeutical agent in HNSCC cell lines.
T62790	JH-XIV-68-3	Others	Others
	JH-XIV-68-3 是一种选择性的 DYRK1A/B 大环抑制剂。JH-XIV-68-3 在生化和细胞测定中能够选择性作用于 DYRK1A 和近亲 DYRK1B。JH-XIV-68-3 在头颈部鳞状细胞癌 (HNSCC) 细胞系中具有抗肿瘤作用。
T72776	NR2F1 agonist 1	Others	Others
	NR2F1 agonist 1 是一种核受体 NR2F1激动剂，可特异性激活恶性细胞的休眠程序。NR2F1 agonist 1 上调 NR2F1 和调节休眠的下游靶基因。NR2F1 agonist 1 通过 NR2F1 激活在头颈部鳞状细胞癌 (HNSCC) 中诱导神经嵴样生长抑制。NR2F1 agonist 1 在小鼠原发肿瘤模型中抑制肿瘤生长。
T82188	HN-1
	HN-1为一种12-mer多肽，在头颈部鳞状细胞癌(HNSCC)细胞上展现特异性活性。作为肿瘤特异性肽，HN-1可渗透肿瘤组织，并在细胞膜上转移活性分子。
T63050	JH-XVII-10	Others	Others
	JH-XVII-10 是一种具有选择性的、口服具有活力的、有效的 DYRK1A (IC50: 3 nM) 和 DYRK1B (IC50: 5 nM) 抑制剂。JH-XVII-10 在颈部鳞状细胞癌 (HNSCC) 细胞系中表现出抗肿瘤效果。
T68663	GPI-15427	Others	Others
	GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment...

化合物

Cat.No: T1484

Synonym: Perindoprilate,培哚普利

Target: RAAS, MRP, AChR

Cat.No: T13176

Synonym: Batoprotafib

Target: Phosphatase

Cat.No: T4325

Synonym: COTI 2,COTI2

Target: Apoptosis, p53

Cat.No: T76890

Synonym: MCLA 158

Target: EGFR

Cat.No: T76691

Target: IFNAR, Chk

(Rac)-AMXT-1501 4HCl

Cat.No: T10313

Target: Dopamine Receptor, Antibacterial

Cat.No: T16690

Target: Others

Cat.No: T76918

Cat.No: T9133L

Synonym: P 201-1

Target: Others

Cat.No: T62790

Target: Others

NR2F1 agonist 1

Cat.No: T72776

Target: Others

Cat.No: T82188

Cat.No: T63050

Target: Others

Cat.No: T68663

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00782	PLAU/uPA Protein, Mouse, Recombinant (His & Avi) PLAU,UPA,BDPLT5,ATF,u-PA,QPD,Urokinase,URK	Mouse	HEK293 Cells
	Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC. PLAU/uPA Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.00 kDa and the accession number is P06869.
TMPK-00274	PLAU/uPA Protein (active form), Human, Recombinant (His & Avi), Biotinylated QPD,Urokinase,BDPLT5,UPA,ATF,URK,u-PA,PLAU	Human	HEK293 Cells
	Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC. PLAU/uPA Protein (active form), Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.3 kDa and the accession number is P0074...
TMPK-00539	PLAU/uPA Protein (active form), Cynomolgus, Recombinant (His) URK,ATF,UPA,u-PA,Urokinase,QPD,PLAU,BDPLT5	Cynomolgus	HEK293 Cells
	Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC. PLAU/uPA Protein (active form), Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 47.23 kDa and the accession number is A0A2K5WND1.
TMPK-00783	PLAU/uPA Protein, Mouse, Recombinant (His & Avi), Biotinylated ATF,URK,Urokinase,PLAU,u-PA,UPA,QPD,BDPLT5	Mouse	HEK293 Cells
	Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC. PLAU/uPA Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.00 kDa and the accession number is P06869.
TMPY-03748	BCL2L12 Protein, Human, Recombinant (GST) BCL2-like 12 (proline rich)	Human	E. coli
	BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. BCL2L12 is a recently identified gene belonging to the BCL2 family, members of which are implicated in hematologic malignancies, including chronic lymphocytic leukemia (CLL). BCL2L12 can be considered as a new independent prog...

重组蛋白

PLAU/uPA Protein, Mouse, Recombinant (His & Avi)

Cat.No: TMPK-00782

Species: Mouse

Expression System: HEK293 Cells

PLAU/uPA Protein (active form), Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00274

Species: Human

Expression System: HEK293 Cells

PLAU/uPA Protein (active form), Cynomolgus, Recombinant (His)

Cat.No: TMPK-00539

Species: Cynomolgus

Expression System: HEK293 Cells

PLAU/uPA Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00783

Species: Mouse

Expression System: HEK293 Cells

BCL2L12 Protein, Human, Recombinant (GST)

Cat.No: TMPY-03748

Species: Human

Expression System: E. coli

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