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Search Results for " hmgb1 "

Targets Recommended: Others

9

抑制剂 & 化合物

4

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T82189	HMGB1-IN-2	Others	Others
	HMGB1-IN-2 (compound 15) 是一种针对高度保守的核蛋白 HMGB1 的抑制剂，其在 RAW264.7 细胞中展现出 NO 抑制活性，IC50 为 20.2 μM。 HMGB1-IN-2 (30 μM) 能够减少 IL-1β、TNF-α、caspase-1 p20 的表达，并抑制 NF-κB p65 的磷酸化作用，显示出抗凋亡特性。在脓毒症急性肾损伤模型的小鼠中，HMGB1-IN-2（15 mg/kg；腹腔注射）可有效减轻肾脏伤害。此外，HMGB1-IN-2 对 Huh7 细胞和 A549 细胞的 IC50 分别为 77.0 μM 和 82.0 μM。
T78056	HMGB1-IN-1	Others	Others
	HMGB1-IN-1（化合物6）在RAW264.7细胞中具有显著的NO抑制活性，其IC50为15.9 ± 0.6 μM。该化合物能够抑制HMGB1/NF-κB/NLRP3信号通路，并且在肾损伤模型中展现出优异的抗炎及抗脓毒症效果。
T4074	GSK-872 GSK872,GSK'872,GSK2399872A	RIP kinase	Apoptosis; NF-κB
	GSK-872 (GSK2399872A) 是一种有效且特异性的 RIP3 激酶抑制剂，降低 RIPK3 介导的坏死和随后的 HMGB1 的细胞质易位和表达，可改善早期脑损伤中的脑水肿和神经功能缺损。它以高亲和力结合 RIP3 激酶结构域，IC50为1.8 nM，并抑制激酶活性，IC50为1.3 nM。
T24167	Inflachromene ICM	Others	Others
	Inflachromene(ICM) 是一种 HMGB1 和 HMGB 表达抑制剂，具有抗炎活性。Inflachromene 通过抑制 HMGB1 易位来减轻小鼠癫痫模型的癫痫发作严重程度，通过 HMGB1/2 调节的 TLR4-NF-κB 通路抑制内膜增生，通过调节 Beclin 1 活性来抑制自噬。Inflachromene 可用于研究癫痫。
T66703	Fmoc-D-Cha-OH	Apoptosis	Apoptosis
	Fmoc-D-Cha-OH（FDCO）是一种凋亡 DNase γ 抑制剂，抑制 HMGB1释放。
T9948	NecroX-7 LC-280126,LC28-0126,LC28 0126	NADPH-oxidase	Immunology/Inflammation
	NecroX-7 (LC-280126) 是一种有效的自由基清除剂和 HMGB1(高迁移率族蛋白 1) 抑制剂。NecroX-7 可以作为对乙酰氨基酚毒性的解毒剂。NecroX-7 通过抑制缺血/再灌注损伤中 HMGB1 的释放发挥保护作用。NecroX-7 抑制 HMGB1 诱导的 TNF 和 IL-6的释放，以及TLR-4和晚期糖基化终产物受体的表达，用于移植物抗宿主病 (GVHD) 研究。
T31411	DHA-37 DHA 37	Others	Others
	DHA-37 is an inducer of autophagic cell death through upregulation of HMGB1 in A549 cells.
T63473	Anti-inflammatory agent 18	Others	Others
	Anti-inflammatory agent 18 能够抑制NO 的活性 (IC50: 15.94 μM)，对 HMGB1 诱导的后期炎症反应具有抑制作用，能够用于研究后期炎症疾病，如冠状病毒病 (COVID-19)、败血症等。
T63660	Anti-inflammatory agent 19	Others	Others
	Anti-inflammatory agent 19 能够抑制 NO (IC50: 36.00 μM)。Anti-inflammatory agent 19 对 HMGB1 诱导的后期炎症反应表现出抑制作用。Anti-inflammatory agent 19 能够用于研究后期炎症疾病，如冠状病毒病 (COVID-19)、败血症等。

化合物

Cat.No: T82189

Target: Others

Cat.No: T78056

Target: Others

Cat.No: T4074

Synonym: GSK872,GSK'872,GSK2399872A

Target: RIP kinase

Cat.No: T24167

Synonym: ICM

Target: Others

Cat.No: T66703

Target: Apoptosis

Cat.No: T9948

Synonym: LC-280126,LC28-0126,LC28 0126

Target: NADPH-oxidase

Cat.No: T31411

Synonym: DHA 37

Target: Others

Anti-inflammatory agent 18

Cat.No: T63473

Target: Others

Anti-inflammatory agent 19

Cat.No: T63660

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN6774	Emodin 6-O-β-D-glucoside 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin	Others	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) 是一种从 Reynoutria japonica 中提取的活性化合物。它具有显著的抗炎和屏障保护活性，可用于研究动脉粥样硬化及糖尿病并发症。
T2741	Glycyrrhizic acid Glycyrrhizin,甘草酸	Virus Protease; Dehydrogenase; MAO	Metabolism; Microbiology/Virology; Neuroscience
	Glycyrrhizic acid (Glycyrrhizin) 是甘草里面的活性成分三萜皂苷，为 HMGB1的拮抗剂，有用于肿瘤、糖尿病等研究的潜力。
T6S0721	Orientin 荭草苷,Lutexin,Luteolin-8-glucoside	Others	Others
	Orientin (Luteolin-8-glucoside) 是天然存在的生物活性类黄酮，是一种有前景的神经保护剂，具有多种生物特性，如抗炎、抗肿瘤、抗氧化、保护心脏等。它有用于神经性疼痛研究潜力。
T5S1632	Barlerin 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01	VEGFR; TNF; NF-κB; Akt; Caspase	Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷，从中国西藏民间药用植物中分离得到，能够抑制NF-κB 活性。

天然产物

Emodin 6-O-β-D-glucoside

Cat.No: TN6774

Synonym: 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin

Target: Others

Glycyrrhizic acid

Cat.No: T2741

Synonym: Glycyrrhizin,甘草酸

Target: Virus Protease, Dehydrogenase, MAO

Cat.No: T6S0721

Synonym: 荭草苷,Lutexin,Luteolin-8-glucoside

Target: Others

Cat.No: T5S1632

Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02707	HMGB1 Protein, Mouse, Recombinant (His) High mobility group protein 1,Hmgb1	Mouse	E. coli
	HMGB1 Protein, Mouse, Recombinant (His) is expressed in E. coli.
TMPY-02590	HMGB1 Protein, Mouse, Recombinant (hFc) HMG-1,SBP-1,high mobility group box 1<...	Mouse	HEK293 Cells
	HMGB1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.3 kDa and the accession number is P63158.
TMPJ-00095	HMGB1 Protein, Human, Recombinant (Truncated) HMG1,HMG-1,High Mobility Group Protein B	Human	E. coli
	HMGB1 Protein, Human, Recombinant (Truncated) is expressed in E. coli expression system. The predicted molecular weight is 13 KDa and the accession number is P09429.
TMPH-03313	HMGB1 Protein, Rat, Recombinant (His) High mobility group protein 1,Amphoterin,High mobil...	Rat	E. coli
	HMGB1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P63159.
TMPK-00104	HMGB1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated HMG3,HMG-1,HMGB1,SBP-1,H...	Human	HEK293 Cells
	High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that promotes inflammation when released extracellularly after cellular activation, stress, damage or death. HMGB1 operates as one of the most intriguing molecules in inflammatory disorders via recently elucidated signal and molecular transport mechanisms. Treatments based on antagonists specifically targeting extracellular HMGB1 have generated encouraging results in a wide number of experimental models of infectious and sterile i...
TMPJ-00094	HMGB1 Protein, Human, Recombinant (N-teminal) HMG1,HMGB1,High Mobility Group Pr...	Human	E. coli
	HMGB1 Protein, Human, Recombinant (N-teminal) is expressed in E. coli expression system. The predicted molecular weight is 14 KDa and the accession number is P09429.
TMPY-01848	HMGB1 Protein, Human, Recombinant (aa 1-215, His) SBP-1,high mobility group box 1,HMG-1<...	Human	HEK293 Cells
	HMGB1 Protein, Human, Recombinant (aa 1-215, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A024RDR0.
TMPY-00822	HMGB1 Protein, Human, Recombinant (hFc) HMG1,SBP-1,high mobility group box 1	Human	HEK293 Cells
	HMGB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.5 kDa and the accession number is A0A024RDR0.
TMPY-03427	HMGB1 Protein, Human, Recombinant (aa 57-158, His) SBP-1,HMG3,high mobility group box 1,HMG	Human	E. coli
	HMGB1 Protein, Human, Recombinant (aa 57-158, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 13.6 kDa and the accession number is P09429.

重组蛋白

HMGB1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02707

Species: Mouse

Expression System: E. coli

HMGB1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02590

Species: Mouse

Expression System: HEK293 Cells

HMGB1 Protein, Human, Recombinant (Truncated)

Cat.No: TMPJ-00095

Species: Human

Expression System: E. coli

HMGB1 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03313

Species: Rat

Expression System: E. coli

HMGB1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00104

Species: Human

Expression System: HEK293 Cells

HMGB1 Protein, Human, Recombinant (N-teminal)

Cat.No: TMPJ-00094

Species: Human

Expression System: E. coli

HMGB1 Protein, Human, Recombinant (aa 1-215, His)

Cat.No: TMPY-01848

Species: Human

Expression System: HEK293 Cells

HMGB1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00822

Species: Human

Expression System: HEK293 Cells

HMGB1 Protein, Human, Recombinant (aa 57-158, His)

Cat.No: TMPY-03427

Species: Human

Expression System: E. coli

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