40
80
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2099 |
ABT-737
|
Mitophagy; BCL; Autophagy | Apoptosis; Autophagy |
ABT737 是 BH3 模拟物,是Bcl-2、Bcl-xL 和Bcl-w 抑制剂,EC50分别为 30.3 nM、78.7 nM 和 197.8 nM。它诱导自噬,有研究急性髓系白血病的潜力。它还诱导 BCL-2/BAX 复合物的破坏和 BAK 依赖性。 | |||
T9975 |
GPR183
3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide |
Others | Others |
GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) 是一种趋化受体,在 B 细胞中具有成熟作用,其内源性配体是氧甾醇 7α,25-二羟基胆固醇 (7α,25-OHC)。 GPR183 可用于炎症性肠病 (IBD) 的研究。 | |||
T6019 |
Volasertib
BI 6727,伏拉塞替 |
Apoptosis; PLK | Apoptosis; Cell Cycle/Checkpoint |
Volasertib (BI 6727) 是一种具有口服活性的高效ATP 竞争性Polo 样激酶 1 抑制剂。它抑制 PLK2 和 PLK3,IC50分别为 5 和 56 nM。它是二氢蝶呤酮衍生物,有抗肿瘤活性,可诱导有丝分裂停滞和细胞凋亡。 | |||
T67899 |
Topoisomerase II inhibitor 13
|
Topoisomerase | DNA Damage/DNA Repair |
Topoisomerase II inhibitor 13抑制拓扑异构酶II (Topo II),对HL-60衍生的HL-60/MX2癌细胞具有较强的抗Topo II 毒性的抗增殖活性。 | |||
T14982 |
Clofilium tosylate
|
Potassium Channel | Membrane transporter/Ion channel |
Clofilium tosylate 是一种钾通道阻滞剂,可诱导人早幼粒细胞白血病细胞凋亡,具有抗心律失常作用。 | |||
T35976 |
6-Formylpterin
Pterin-6-aldehyde,6 Formylpterin |
Apoptosis; NOS; Xanthine Oxidase; Antibacterial | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology |
6-Formylpterin (Pterin-6-aldehyde) 是 Xanthine Oxidase 的抑制剂(Ki约为0.6 nM),对沙鼠的短暂性IRI具有强大的神经保护作用。6-Formylpterin 诱导 HL-60 细胞内ROS 生成以及细胞凋亡 (apoptosis)。6-Formylpterin 抑制iNOS的表达,可在细胞内产生过氧化氢并恢复人中性粒细胞杀菌活性受损。 | |||
T41231 |
GP 1a
|
Cannabinoid Receptor; PERK; Arrestin | Apoptosis; GPCR/G Protein |
GP 1a 是cannabinoid receptor 2(CB2)的强效激动剂(EC50=7.1),是在cAMP、GTPγS 和β-arrestin 招募试验中显示的。GP 1a 对CB2受体的选择性约为CB1受体的30倍,且在体外增加HL-60细胞的P-ERK1/2表达。GP 1a 对皮肤伤口愈合有益。GP 1a 可抑制炎症和纤维生成,同时促进上皮的重新形成。 | |||
T73588 |
8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY
|
||
8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY 是一种新型的 BODIPY 荧光染料,可用于治疗细胞毒性研究。 | |||
T34694 |
Spicamycin
|
Others | Others |
Spicamycin can be used as a potent inducer of differentiation of human myeloid leukemia cells (HL-60) and murine myeloid leukemia cells (M1). | |||
T41133 |
Ursonic acid methyl ester
|
Others | Others |
Ursonic acid methyl ester, an esterified derivative of Ursolic acid, exhibits growth inhibitory activity against four tumor cell lines: HL-60, BGC, Bel-7402, and Hela, and the ED50 values for inhibition are >100 μg/ml. | |||
T27766 |
Hymeglusin
L-659,699,L 659,699,F-244,1233A,L659,699 |
Antibiotic | Microbiology/Virology |
Hymeglusin 是一种选择性 3-羟基-3-甲基戊二酰辅酶 A (HMG-CoA) 合酶 1 抑制剂,也是一种抗生素,可降低 HL-60 和 KG-1 细胞中 BCL2 的表达水平,可用于研究白血病。 | |||
T36693 |
FD-211
|
Others | Others |
FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 μg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 μg/ml for all). |1. Nozawa, O., Okazaki, T., Sakai, N., et al. A novel bioactive δ lactone FD-211. Taxonomy, isolation and char... | |||
T78978 |
Antitrypanosomal agent 13
|
Parasite | Microbiology/Virology |
Antitrypanosomal agent 13 (compound 4b) 是一种高效的抗锥虫剂,具备显著的杀锥虫活性和细胞毒性。针对 T. brucei 和 HL-60,Antitrypanosomal agent 13 的 GI50 值分别为 0.18 μM 和 8.4 μM。 | |||
T82774 |
Caspase-3 activator 3
|
Caspase | Apoptosis; Proteases/Proteasome |
Caspase-3 activator 3 (compound 2h) 通过激活caspase 3诱导HL-60和K562细胞apoptosis,表现出抗白血病活性。其对HL-60细胞的IC50值为42.89 μM,对K562细胞的IC50值为33.61 μM。 | |||
T13643 |
Demethoxydeacetoxypseudolaric acid B analog
脱甲氧基脱乙酰土槿皮乙酸,去甲氧基去乙酰氧基土槿甲酸B类似物 |
Others | Others |
Demethoxydeacetoxypseudolaric acid B analog 是由 Pseudolaric acid B 半合成得到,能够有效抑制 HMEC-1、HL-60、A-549、MB-MDA-468、BEL-7402、HCT116、Hela 细胞,且 IC50值范围为 0.136-1.162 μM。 | |||
T36399 |
PAO-Nap
|
||
PAO-Nap is a chemically modified version of PAO, in which a naphthalimide fluorophore is attached to the compound using a linker called aminocaproic acid. This modified compound, PAO-Nap, exhibits a selective targeting of thioredoxin reductase, leading to the induction of apoptosis in HL-60 cells through oxidative stress mechanisms[1]. | |||
T36894 |
5-Bromouridine
|
Others | Others |
5-Bromouridine is a brominated analog of the nucleoside uridine .1It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine .25-Bromouridine decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM, respectively). It induces apoptosis and halts the cell cycle at the S phase in HL-60 cells. It is photoreactive, and UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of of RNA-protein interactions.... | |||
T69066 |
Forphenicine
|
Others | Others |
Forphenicine is a bacterial metabolite that has been found in S. fulvoviridis and an inhibitor of alkaline phosphatase (IC50 = 0.036 µg/ml for the chicken intestine enzyme). It inhibits the growth of HL-60 leukemia cells when used at a concentration of 10 µM. Forphenicine (50 and 500 µg/animal) increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE). | |||
T36418 |
O-Desmethyl-N-deschlorobenzoyl Indomethacin
|
Others | Others |
O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ... | |||
T78815 |
MOZ-IN-3
|
Histone Acetyltransferase | Chromatin/Epigenetic |
MOZ-IN-3 (Compound 6j) 是KAT6A (MOZ) 乙酰转移酶的抑制剂,IC50值为30 nM。该化合物在四种髓系白血病细胞系(HL-60、U937、SKNO-1、K562)上展现了抗肿瘤活性,并且显示出良好的代谢稳定性及药代动力学特性。 | |||
T61828 |
DNA-PK-IN-8
|
Others | Others |
DNA-PK-IN-8(化合物DK1)是一种高效、选择性且口服活性的DNA依赖蛋白激酶 (DNA-PK) 抑制剂,其IC50值为0.8 nM。与Doxorubicin联合应用时,该化合物能在多种癌细胞中展现出协同的抗增殖效应,并能显著地抑制HL-60肿瘤生长。 | |||
T82775 |
Caspase-3 activator 2
|
Caspase | Apoptosis; Proteases/Proteasome |
Caspase-3 activator 2 (Compound 2f) 是诱导细胞凋亡的caspase 3激活剂,适用于癌症研究。该化合物对 HL-60 细胞和 K562 细胞展示出细胞毒性,IC50 值分别为 33.52 μM 和 76.90 μM。 | |||
T36593 |
TEI-9648
|
Others | Others |
TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has cons... | |||
T84388 |
HA-14-1
|
Others | Others |
HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 µM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human acute myeloid leukemia (HL-60) cells, with a 50 µM concentration resulting in a 90% loss of cell viability. | |||
T19228 |
Calcitriol Impurities D
24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3 |
Antiviral | Immunology/Inflammation |
Calcitriol Impurities D (24-Homo Calcitriol) 是维生素的一种激素形式,可促进HL-60人早幼粒细胞白血病细胞分化为单核细胞。Calcitriol Impurities D 具有骨吸收活性,抑制人类免疫缺陷病毒在人体细胞中的复制。Calcitriol Impurities D 具有抗病毒活性们可以用于治疗艾滋病和病毒感染。 | |||
T77629 |
FD274
FD 274,FD-274 |
PI3K; mTOR | PI3K/Akt/mTOR signaling |
FD274 是一种高效的 PI3K/mTOR 双重抑制剂,对 PI3Kα/β/γ/δ 和 mTOR 具有抑制作用, IC50 分别为 0.65 nM、1.57 nM、0.65 nM、0.42 nM 和 2.03 nM。 FD274 在 AML 细胞系抗增殖实验中显示出显着的抗增殖活性。 FD274 在 HL-60 异种移植模型中表现出剂量依赖性的坑肿瘤生长活性。 FD274具有用于急性髓系白血病研究的潜力。 | |||
T76379 |
Myelopeptide-2
|
||
Myelopeptide-2 分离于猪骨髓细胞培养上清,能够恢复 HL-60 白血病细胞或麻疹病毒条件抑制下人 T 淋巴细胞的丝裂原反应活性、白细胞介素-2 (IL-2) 合成水平和白细胞介素-2受体 (IL-2R) 表达水平。Myelopeptide-2 参与免疫稳态调节,在抗肿瘤和抗病毒研究中具有广阔的应用前景。 | |||
T37068 |
NR-160
|
Others | Others |
NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells. | |||
T84479 |
F-Amidine TFA
|
Others | Others |
F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, wi... | |||
T36035 |
CAY10784
|
Others | Others |
CAY10784 is a STAT3 inhibitor (IC50= 0.74 μM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 μM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 μM for both). CAY10784 is also active againstH. pyloriandC. jejuni(MICs = 1.6 and 4.7 μM, respectively).2 1.Lü, Z., Li, X., Li, K., et al.Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway i... | |||
T69629 |
M‑89 MLL inhibitor
|
Others | Others |
M‑89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein−Protein Interaction (Kd = 1.4 nM; IC50 = 25nM). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4;11 and MOLM-13 leukemia cell lines carrying MLL fusion with IC50 values of 25 and 55 nM, respectively, and demonstrates >100-fold selectivity over the HL-60 leukemia cell line lacking MLL fusion. | |||
T83724 |
TPP-1 hydrochloride
Targeting PD-L1 Peptide |
||
TPP-1是一种针对程序化细胞死亡蛋白1(PD-1)及其配体PD-1配体(PD-L1)之间蛋白-蛋白相互作用的肽抑制剂。它在无细胞实验中结合到PD-L1(Kd = 94.67 nM)。TPP-1 (20 µM)能逆转PD-L1在抗CD3激活的人类CD4+ T细胞中所引起的干扰素γ(IFN-γ)水平的下降。在使用HL-60白血病细胞与抗CD3激活的人类CD4+ T细胞共培养并在植入前预处理时,以4 mg/kg的剂量给药,可减少小鼠异种移植模型中的肿瘤体积。 | |||
TP2193 |
Myelopeptide-2 (MP-2)
|
Others | Others |
Myelopeptide-2 (MP-2) with the sequence Leu-Val-Val-Tyr-Pro-Trp is originally isolated from the supernatant of porcine bone marrow cell culture and is able to restore the mitogen responsiveness of human T lymphocytes inhibited by conditioned medium from H | |||
T37056 |
D-erythro-MAPP
|
Others | Others |
D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 μM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 μM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner. | |||
T38377 |
ADTL-EI1712
ADTL-EI1712 |
Others | Others |
ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively).1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 μM. ADTL-EI1712 inhibits proliferation of HL-60 and MKN74, but not HeLa, cancer cells (IC50s = 1.26, 2.55, and >50 μM, respectively). It reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model when administered at a do... | |||
T35927 |
C2 L-threo Ceramide (d18:1/2:0)
C2 L-threo Ceramide (d18:1/2:0) |
Others | Others |
C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide . C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1... | |||
T4057 |
Hoechst 33258 trihydrochloride
Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258 |
Parasite | Microbiology/Virology |
Hoechst 33258 trihydrochloride (Bisbenzimide) 是一种能够用于 DNA 染色的荧光染料。 | |||
T35772 |
Emestrin
|
Others | Others |
Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 μg/ml, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestr... | |||
T35536 |
Tpl2 Kinase Inhibitor (hydrochloride)
|
Others | Others |
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by calcitriol in HL-60 and U937 leukemia cells when used at a concentration of 5 μM.2Tpl2 kinase inhibitor (5... | |||
T36199 |
AZD 1152 (hydrochloride)
|
Others | Others |
AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3AZD 1152 inhibits tumor xenograft growthin vivo.4,5 1.Mortlock, A.A., Foote, K.M., Heron, N.M., et al.Discovery, synthesis, and in vivo activity of a new class of p... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1121 |
Evocarpine
|
Apoptosis; cAMP; Anti-infection; Calcium Channel; Antibacterial | Apoptosis; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Evocarpine 是从 Evodiae fructus 分离得到的一种喹诺酮类生物碱,有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。 | |||
TN1684 |
Ginsenoside F5
人参皂苷 F5,人参皂苷F5 |
Apoptosis | Apoptosis |
Ginsenoside F5 是从人参中提取的一种天然产物,通过凋亡途径显着抑制 HL-60 细胞的生长。 | |||
TJS0328 |
Nordalbergin
6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One,6,7-二羟基-4苯基香豆素 |
Others | Others |
Nordalbergin 是一种香豆素,分离自Dalbergia sissoo的木皮中。 它能够显著性的诱导 HL-60 细胞的分化。 | |||
T1882 |
Meisoindigo
N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛 |
Apoptosis | Apoptosis |
Meisoindigo (Natura-α) 是 Indirubin 的衍生物,可以造成急性髓细胞性白血病细胞周期在 G0/G1 期停滞,并诱导凋亡,具有高抗肿瘤活性。 | |||
TQ0309 |
Glaucocalyxin B
蓝萼乙素 B,蓝萼乙素 |
Autophagy | Autophagy |
Glaucocalyxin B 是从碎米桠中分离出来的二萜类天然产物,可降低 HL-60 细胞的生长,IC50为 5.86 μM,具有抗癌和抗肿瘤活性。 | |||
TN7043 |
Neolancerin
|
Others | Others |
Neolancerin 是一种对 HL-60 细胞具有弱细胞毒作用的天然产物。 | |||
T1166 |
Ellipticine
玫瑰树碱,NSC 71795,Elliptisine |
Topoisomerase | DNA Damage/DNA Repair |
Ellipticine (Elliptisine) 是一种有效的抗肿瘤剂,抑制 DNA 拓扑异构酶 II 活性,对白血病、神经母细胞瘤和胶质母细胞瘤有部分活性。 | |||
T67922 |
Lepidiline C
|
Others | Others |
Lepidiline C 是一种 从十字花科Lepidium meenii Walpers 根中提取的新型的咪唑类生物碱 ,对HL-60细胞表现出细胞毒活性(IC50为:27.7 μM)。 | |||
T10390 |
Asperphenamate
|
Others; Antifungal | Microbiology/Virology; Others |
Asperphenamate 是 Aspergillus flatiipes 的真菌代谢产物。 T47D 细胞、MDA-MB-231 细胞和 HL-60 细胞的 IC50 分别为 92.3 μM、96.5 μM 和 97.9 μM。 Asperphenamate 具有抗癌作用。 | |||
T5S1000 |
Sophoraflavanone G
Kushenol F,槐黄烷酮 G,Vexibinol |
Apoptosis | Apoptosis |
Sophoraflavanone G (Kushenol F) 是从苦参中提取到的一种天然产物,通过抑制 MAPK 相关通路诱导 MDA-MB-231 和 HL-60 细胞凋亡,具有抗肿瘤和抗炎特性。 | |||
TJS0487 |
(-)-Syringaresinol
DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素 |
Others | Others |
(-)-Syringaresinol (DL-Syringaresinol) 来源于番荔枝 Annona Montana 的茎。 (-)-Syringaresinol 通过 G1 期阻滞和诱导细胞凋亡来抑制人早幼粒细胞 HL-60 细胞的增殖,并具有抗癌活性。 | |||
TN4375 |
Kamebanin
|
Antifection | Microbiology/Virology |
Kamebanin 是一种天然二萜类化合物,具有抗菌活性。它对 HeLa 和 HL-60 细胞显示出有效的细胞毒活性。 | |||
T25664 |
Lepidiline A
Macaline A |
Others | Others |
Lepidiline A (Macaline A) 是一种具有抗炎症活性的黄酮木质素。Lepidiline A 对HL-60细胞具有细胞毒活性,IC50值为 32.3 μM。它是从芸苔科植物Lepidium meyenii Walpers 的活性成分,可改善小鼠内源性性激素的平衡,提高果蝇的繁殖力。Lepidiline A 靶向HSD17B1基因的机制来增强酶的活性,提高性激素的生物转化效率,提高生殖能力。Lepidiline A 具有抗癌活性。 | |||
TN1369 |
Alloimperatorin
Prangenidin,别欧前胡素 |
Others | Others |
Alloimperatorin (Prangenidin) 是一种从Angelica dahurica 的提取得到的香豆素类化合物,具有抗肿瘤作用。 | |||
T5826 |
Eupalinolide A
|
HSP | Cytoskeletal Signaling; Metabolism |
Eupalinolide A 是分离于林泽兰中的一种天然产物,通过抑制 HSF1 与 HSP90 的相互作用,激活 HSF1,诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。 | |||
TN1215 |
(2S)-2'-Methoxykurarinone
2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone |
Akt; Antifection | Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling |
(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物,具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号,抑制破骨细胞形成和骨吸收。 | |||
T36528 |
Illudin M
|
Apoptosis; DNA Alkylator/Crosslinker | Apoptosis; DNA Damage/DNA Repair |
Illudin M是真菌O. illudens中的一种细胞毒性倍半萜,能使DNA烷基化。它对 HL-60 人类白血病细胞的细胞毒性为 6-100 nM。Illudin M 具有抗癌活性,是抗癌化合物的前药,可用于合成抗癌化合物。 | |||
T3864 |
Erianin
|
BCL; Antibacterial | Apoptosis; Microbiology/Virology |
Erianin 能抑制吲哚胺-2,3-双加氧酶诱导的肿瘤血管生成,可用作退烧药和止疼剂。 | |||
T3405 |
[6]-Gingerol
6-Gingerol,gingerol,(S)-(+)-[6]Gingerol,6-姜酚 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
[6]-Gingerol ((S)-(+)-[6]Gingerol) 是一种从生姜中分离的活性物质,具有抗癌,抗炎和抗氧化活性。 | |||
TN1258 |
3-Acetyl-beta-boswellic acid
3-O-Acetyl-beta-boswellic acid,3-乙酰基-BETA-乳香酸 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
3-Acetyl-beta-boswellic acid 是一种乳香酸,分离自乳香锯缘胶树脂。 | |||
T4601 |
9-Methoxycanthin-6-one
|
Others | Others |
9-Methoxycanthin-6-one 是存在于完整植株和不同外植体的愈伤组织中的 Canthin-6-one 生物碱,具有抗肿瘤作用。 | |||
T6S2238 |
Eupalinolide B
|
Others | Others |
Eupalinolide B 是一种胚芽倍半萜,分离自Eupatorium lindleyanum 中。它对BGC-823、A-549 和 HL-60 等肿瘤细胞具有细胞毒性。 | |||
T3S2325 |
Ardisiacrispin A
百两金素,Saxifragifolin B,LTS-4,Deglucocyclamin |
HSV | Microbiology/Virology |
Ardisiacrispin A (Deglucocyclamin) 是一种常见的三萜皂苷,来自于紫金牛属物种。 它与来自紫金牛属的 A. crenata 中的一些三萜皂苷具有相似的生物学特性,如对肿瘤细胞具有细胞毒活性、免疫调节和抗病毒活性。 | |||
TN4245 |
Icariside D2
|
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 uM, it induces apoptosis via alteration of expression of apoptosis-related proteins and decreased phosphorylation of AKT in HL-60 cells. | |||
TN5456 |
Isoerysenegalensein E
|
||
Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the cas | |||
TN5373 |
Ustusolate A
|
||
1. Ustusolate A shows weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 microM, respectively. | |||
TN5676 |
Musellarin B
|
||
Musellarin B is cytotoxic toward several of the human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). | |||
TN2318 |
Yadanziolide C
|
Others | Others |
Yadanziolide C induces differentiation with cultured HL-60 promyelocytic leukemia cells. | |||
TN4373 |
Kaempferol tetraacetate
|
Antifection | Microbiology/Virology |
Kaempferol tetraacetate is a potent antiplatelet agent. It exhibits significant cytotoxicity in vitro against three human cell lines HL-60, U937 and SK-MEL-1. | |||
T19960 |
Hinesol
(-)-Hinesol |
||
Hinesol is a unique sesquiterpenoid isolated from Atractylodes lancea rhizome. Hinesol has been found to induce apoptosis through the JNK signaling pathway in HL-60 cells. | |||
T72795 |
(S)-Erypoegin K
|
Others | Others |
(S)-Erypoegin K,一种显示对HL-60细胞具有有效抗增殖活性的抗癌剂,能诱导细胞凋亡(apoptosis)。 | |||
TN1572 |
Desacetylcinobufotalin
|
Others | Others |
Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines. | |||
T61955 |
Aspochalasin M
|
Others | Others |
Aspochalasin M 对 HL-60 细胞表现出适度的活性(IC50= 20.0 μM)。Aspochalasin M 在白血病疾病中具有研究的潜力。 | |||
TN5211 |
Ustusolate E
|
Others | Others |
Ustusolate E exhibits moderate cytotoxicity against A549 and HL-60 cells with the IC50 value of 9.0 microM. | |||
TN3250 |
7-Prenyljacareubin
|
Others | Others |
7-Prenyljacareubin shows moderate cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7, and SW480 cell lines. | |||
TN4087 | Furowanin A | Caspase | Apoptosis; Proteases/Proteasome |
Furowanin A shows significant cytotoxicity against HL-60 cells, it induces that Caspase-9 and caspase-3 inhibitors suppresses apoptosis. | |||
TN3371 |
Albatrelin G
|
Others | Others |
Albatrelin G shows weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro. | |||
TN2837 |
29-Nor-20-oxolupeol
|
Others | Others |
29-Nor-20-oxolupeol(3 beta-Hydroxy-30-norlupan-20-one) has growth inhibitory effects on HL-60 cells. | |||
TN2184 |
Schisanlactone E
五内脂 |
Others | Others |
Schisanlactone E may show moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL-60. | |||
TN3992 |
Erysubin A
|
Others | Others |
Erysubin A , wighteone, and lupalbigenin show promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM). | |||
TN3477 |
Baccatin VIII
|
Others | Others |
Baccatin VIII exhibits inhibitory effects on HL-60 and MCF-7, with IC50 values of 3.44 and 9.67 uM, respectively. | |||
T81529 |
Peganumine A
|
Others | Others |
Peganumine A,一种天然产物,源自Peganum harmala,具备对HL-60、MCF-7、PC-3、HepG2细胞线显示出细胞毒性作用,其IC50值依次为5.8、38.5、40.2、55.4 µM[1]< /sup>。 | |||
TN6054 |
Norglaucine hydrochloride
|
||
(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and non-tumor peripheral blood mononuc | |||
TN5210 |
Ustusolate C
|
Others | Others |
Ustusolate C and ustusolate E exhibit moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 microM, respectively. | |||
TN5212 |
Uvedalin
|
Others | Others |
Uvedalin shows cytotoxicity against HeLa, HL-60, and Murine B16-F10 melanoma cell lines. | |||
TN3561 |
Cabraleone
|
Others | Others |
The mixture of cabraleone and ocotillone shows cytotoxicity against HL-60 leukaemia cell line. | |||
TN4799 |
Piptocarphin F
|
Others | Others |
Piptocarphin F shows strong cytotoxic activities against mouse lymphoid tumor cell line P388. It also shows cytotoxic activity (IC50 3.87-12.5 umol/L) against the human leukemic cell line HL-60. | |||
TN3799 |
Dehydrocrebanine
|
Antifection | Microbiology/Virology |
Dehydrocrebanine has strong activity against promyelocytic leukemia cells (HL-60) with an IC50 of 2.14 ug/mL. It also shows potent antimalarial activity with an IC50 value of 70 ng/ml. | |||
T81937 |
Lewis a trisaccharide
Lewis a |
||
Lewis a trisaccharide 是精子聚糖结构和 HL-60 细胞表面聚糖结构的主要组分。 | |||
TN3838 |
Desmethylrocaglamide
|
Others | Others |
Desmethylrocaglamide is a novel inducer of cellular differentiation using HL-60 promyelocytic cells, it may be a drug for the prevention and therapy of cancer. It also has insecticidal activity. | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00502 |
PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
PDI5,HL-60,PAD,PADI5,Protein-arginine deim... |
Cynomolgus | E. coli |
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biot... | |||
TMPK-01238 |
PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
PDI5,Protein-arginine deiminase type-4,HL-60 |
Human | E. coli |
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinyla... | |||
TMPK-00501 |
PADI4 Protein, Cynomolgus, Recombinant (His)
Protein-arginine deiminase type-4,HL60 PAD... |
Cynomolgus | E. coli |
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. PADI4 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expres... | |||
TMPJ-00532 |
PADI4 Protein, Human, Recombinant (E. coli, His)
PDI5,PADI4,Protein-arginine Deiminase type IV,HL- |
Human | E. coli |
Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune fe... | |||
TMPY-03051 |
B3GNT2 Protein, Human, Recombinant (hFc)
B3GNT-2,B3GNT,UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosamin... |
Human | HEK293 Cells |
B3GNT2 belongs to the beta-1,3-N-acetylglucosaminyltransferase family. It is a type II transmembrane protein that prefers the substrate of lacto-N-neotetraose. Alternative splicing produced 2 isoforms of the human protein. B3GNT2 catalyzes the initiation and elongation of poly-N- acetyllactosamine chains. Enzymatic activities of some glycosyltransferases are markedly increased via complex formation with other transferases or cofactor proteins. B3GNT2 and beta3Gn-T8 can form a heterodimer in vitr... |