108
21
1
1
2
Cat. No. | Product Name | ||
---|---|---|---|
L1100 | 蛋白酶抑制剂库 | 343 compounds | |
343 种已知的小分子蛋白酶抑制剂的特有集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39729 |
HIV Protease Substrate 1
|
||
HIV Protease Substrate 1 is a fluorogenic compound that offers insights into the enzymatic activity of HIV protease, making it a valuable tool for studying this aspect. | |||
T1883 |
Des(benzylpyridyl) Atazanavi
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Des(benzylpyridyl) Atazanavi 是 Atazanavir 的 N-脱烷基代谢物 (M1),一种 HIV 蛋白酶抑制剂。 | |||
T7779 |
Nelfinavir
AG1341,甲磺酸萘非那韦 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Nelfinavir (AG1341) 是一种口服活性的 HIV-1 蛋白酶抑制剂,用于抑制 HIV 感染,是一种广谱抗癌剂。 | |||
T7903 |
Saquinavir
Ro 31-8959,沙奎那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂,可研究逆转录病毒。它也是 SARS-CoV 3CLpro 抑制剂,IC50为 1.36 μM。 | |||
T1623 |
Lopinavir
ABT-378,洛匹那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Lopinavir (ABT-378) 是一种选择性肽模拟 HIV-1 蛋白酶的高效抑制剂。它通过阻止 HIV-1 的成熟而起作用,从而阻断其感染性。它也是 SARS-CoV 3CLpro 的抑制剂。 | |||
T9854 |
HIV-1 inhibitor-6
3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo- |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) 是一种有效的HIV-1 pre-mRNA 选择性剪接抑制剂,可以阻断HIV 复制。 | |||
T2324 |
Darunavir
地瑞那韦,达芦那韦,TMC114 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Darunavir (TMC114) 是一种 HIV 蛋白酶抑制剂,用于治疗艾滋病和 HIV 感染。 由于单独使用时会出现抗病毒药物耐药性,因此与其他抗 HIV 药物联合使用。 | |||
T6001 |
Nelfinavir Mesylate
Viracept,Nelfin,AG1343,AG 1343 Mesylate,甲磺酸奈非那韦 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Nelfinavir Mesylate (Viracept) 是一种口服活性的 HIV-1蛋白酶抑制剂,用于抑制 HIV 感染,是一种广谱抗癌剂。 | |||
T76511 |
HIV Protease Substrate IV
|
||
HIV ProteaseSubstrate IV 是 HIV 蛋白酶的底物。HIV ProteaseSubstrate IV 可用于检测 HIV(人类免疫缺陷病毒)-1 蛋白酶的活性。 | |||
T6388 |
Amprenavir
141W94,安普那韦,Prozei,KVX-478,VX-478,安瑞那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Amprenavir (KVX-478) 是一种 HIV 蛋白酶抑制剂,Ki 为0.6 nM。它也是 SARS-CoV 3CLpro 抑制剂,IC50为 1.09 μM。 | |||
T74939 |
HIV protease-IN-1
|
Others | Others |
HIVprotease-IN-1 (compound 1·succinate) 是一种有效的HIV 蛋白酶 (HIV protease) 非肽抑制剂,可用于艾滋病的研究。 | |||
T76502 |
HIV-1, HIV-2 Protease Substrate
|
||
HIV-1,HIV-2Protease Substrate 是HIV-1,HIV-2蛋白酶的底物。HIV-1和HIV-2蛋白酶底物结合残基有 4 个保守取代残基。 | |||
T76485 |
HIV Protease Substrate I
|
||
HIV ProteaseSubstrate I 是HIV-1蛋白酶的显色底物。HIV ProteaseSubstrate I 具有HIV 蛋白酶的裂解位点。 | |||
T3335 |
Darunavir Ethanolate
地瑞那韦乙醇盐,UIC 94017,Darunavir Ethanolate,TMC114,达芦那韦乙醇 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Darunavir Ethanolate (UIC 94017) 是一种HIV 蛋白酶抑制剂,可以用于 HIV/AIDS 的相关研究。对野生型 HIV-1 蛋白酶的Ki 值为1 nM。 | |||
T1525 |
Ritonavir
RTV,利托那韦,Abbott 84538,A 84538,ABT 538 |
Apoptosis; SARS-CoV; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Ritonavir (ABT 538) 是一种 HIV 蛋白酶抑制剂,可研究 HIV 感染和 AIDS 。它也是 SARS-CoV 3CLpro 的抑制剂,IC50为 1.61 μM。 | |||
T76074 |
HIV Protease Substrate 1 TFA
|
||
HIV ProteaseSubstrate 1 TFA 是一种外源性 HIV 蛋白酶底物,可用于研究 HIV 蛋白酶的酶活性。 | |||
T79493 |
HIV-1 protease-IN-10
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
HIV-1protease-IN-10(化合物2)显示出对HIV-1潜伏期的逆转活性,IC50值为0.22 μM。该化合物通过与PKCδC1b结构域结合展现活性,IC50值为0.69 μM。此外,HIV-1protease-IN-10对于酯酶介导的水解表现出稳定性。 | |||
T79537 |
HIV-1 protease-IN-12
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1protease-IN-12 (compound 35b)为HIV-1蛋白酶抑制剂,具有0.51 nM的IC50值,同时对HIV耐药变体也具有抑制作用。 | |||
T3695 |
Pepstatin
抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C |
Amino Acids and Derivatives; Proteasome; HIV Protease; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination |
Pepstatin (Pepsin Inhibitor S 735A) 是由放线菌类产生的特异性天冬氨酸蛋白酶抑制剂,可抑制 HIV 蛋白酶的活性。 | |||
T63733 |
HIV-1 protease-IN-6
|
Others | Others |
HIV-1 protease-IN-6 (compound 17d) 是 HIV-1 蛋白酶 (HIV-1 protease) 的有效抑制剂 (IC50: 21 pM, Ki: 4.7 pM)。HIV-1 protease-IN-6 对 DRV (darunavir) 耐药病毒突变体具有显著的抗病毒效果 (antiviral activity),抑制强度甚至超过对野生型病毒。 | |||
T78950 |
HIV-1 protease-IN-8
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1protease-IN-8(compound 34b)是一款高效的HIV-1蛋白酶抑制剂,其IC50为0.32 nM。该化合物对野生型HIV-1(HIV-1NL4-3)及耐药变体(HIV-1MDR)的IC50分别为0.29 μM与1.90 μM,表明其对这两种型别均展现出显著的抗病毒效果。 | |||
T74488 |
HIV-1 protease-IN-4
|
Others | Others |
HIV-1protease-IN-4 (Compound II-22) 是一种有效的HIV-1蛋白酶抑制剂。HIV-1protease-IN-4 是阿扎那韦的前体。HIV-1蛋白酶-IN-4 作为前体,与口服母体活性分子相比,将母体 1 输送到大鼠血浆中的 AUC 高 5 倍,C24 高 67 倍[1]。 | |||
T79536 |
HIV-1 protease-IN-11
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1protease-IN-11 (compound 34a) 为一抗HIV-1蛋白酶抑制剂,其IC50值为0.41 nM,并对抗耐药变异表现出显著活性。 | |||
T74942 | HIV-1 protease-IN-7 | HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1protease-IN-7(化合物 16)作为一种HIV-1蛋白酶抑制剂,具有良好的口服活性,表现出优异的抑制效能(IC50=3.52 nM,EC50=37 nM)。 | |||
T79295 |
HIV-1 protease-IN-9
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1protease-IN-9 (compound 5b)为HIV-1蛋白酶抑制剂,具有0.028 nM的Ki值和66.8 nM的IC50,表现出显著的抗病毒活性。 | |||
T64112 |
HIV-1 protease-IN-5
|
Others | Others |
HIV-1 protease-IN-5 是一种 HIV-1 protease 抑制剂 (IC50: 1.64 nM)。HIV-1 protease-IN-5 对野生型和 DRV 耐药型 HIV-1 表现出明显的作用。 | |||
T63453 |
HIV-1 protease-IN-1
|
Others | Others |
HIV-1 protease-IN-1 是 HIV-1 蛋白酶的有效抑制剂 (IC50: 90 pM)。HIV-1 protease-IN-1 对 B-HIV 具有抗病毒活性 (EC50: 89 nM)。HIV-1 protease-IN-1 能够作用于 C-HIV 毒株 ZM246 (EC50: 13.59 nM) 以及 C-HIV 株 Indie (EC50: 8.23 nM)。 | |||
T63949 |
HIV-1 protease-IN-2
|
Others | Others |
HIV-1 protease-IN-2 是 HIV-1 protease 的有效抑制剂 (IC50: 2.53 nM)。HIV-1 protease-IN-2 对 DRV (达芦那韦)敏感或耐药性 HIV-1 突变体均表现出抗病毒效果。 | |||
T0100L |
Atazanavir
Zrivada,Reyataz,Latazanavir,阿扎那韦,BMS-232632 |
P450; SARS-CoV; HIV Protease; P-gp | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Atazanavir (BMS-232632) 是一种高选择性的HIV-1蛋白酶抑制剂,可研究艾滋病毒感染。它也是SARS-CoV 3CLpro 的抑制剂,IC50为 3.49 μM。它是CYP3A4的底物和抑制剂,也是P-糖蛋白的抑制剂和诱导剂。 | |||
T5863 |
Indinavir sulfate
L735524 sulfate,MK-639 sulfate,硫酸茚地那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Indinavir sulfate (L735524 sulfate) 是一种 HIV 蛋白酶抑制剂。它抑制 HIV-1 蛋白酶,IC50 值为 0.41 nM,Ki 值为 0.24 nM。它也是SARS-CoV 3CLpro 抑制剂,IC50为 1.71 μM。 | |||
T0100 |
Atazanavir sulfate
阿扎那韦硫酸盐,BMS-232632,BMS-232632 sulfate,硫酸阿扎那韦 |
P450; SARS-CoV; HIV Protease; P-gp | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Atazanavir sulfate (BMS-232632 sulfate) 是一种氮杂肽和 HIV 蛋白酶抑制剂,与其他抗 HIV 药物联合用于治疗 HIV 感染和艾滋病。它也是SARS-CoV 3CLpro 抑制剂,IC50为 3.49 μM。 | |||
T0825 |
Ebselen
SPI-1005,PZ-51,依布硒,CCG-39161 |
Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。 | |||
T8156 |
Saquinavir mesylate
沙奎拉韦,沙奎那韦甲磺酸盐,Ro 31-8959/003 |
HIV Protease; Autophagy | Autophagy; Microbiology/Virology; Proteases/Proteasome |
Saquinavir mesylate (Ro 31-8959/003) 是一种 HIV 蛋白酶抑制剂,可研究逆转录病毒。 | |||
T1776L |
Plerixafor octahydrochloride
盐酸普乐沙福,JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl |
Virus Protease; HIV Protease; CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Plerixafor octahydrochloride (JM3100 octahydrochloride) 是一种选择性的CXCR4拮抗剂,IC50为 44 nM。Plerixafor 是一种具有造血干细胞动员活性的双环霉素。 | |||
T4578 |
Tipranavir
PNU-140690 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Tipranavir 是一种蛋白酶抑制剂,对1种以上蛋白酶抑制剂耐药的HIV-1具有抑制作用 。Tipranavir 可有效抑制 HIV-1 蛋白酶 酶活性和二聚化,对抗多种蛋白酶抑制剂(PI)的HIV-1分离株具有有效的活性(IC50 为 66-410 nM)。Tipranavir 对SARS-CoV-2 3CLpro 活性有抑制作用。 | |||
T77347 |
2-Amino-6-bromopyridine
|
Others | Others |
2-Amino-6-bromopyridine 对HIV-68蛋白酶具有抑制作用。 | |||
T8238 |
Fosamprenavir Calcium Salt
福沙那伟钙,Diallyl Trisulfide,GW433908G |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fosamprenavir Calcium Salt (GW433908G) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药,具有改善的溶解性和抗HIV 感染作用。 | |||
T24362 |
L 756423
L756423,MK-944a,MK944a,L-756,423,L-756423,MK 944a |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
L 756423 (L756423) 是一种新型有效且具有选择性和竞争性的HIV蛋白酶抑制剂,对 HIV-1 PR 的 Ki 值为0.049 nM。L 756423 能阻止HIV(IIIb)感染的 MT25 淋巴细胞在0.50-0.1nM处的扩散,可用于研究获得性免疫缺陷综合征(AIDS)。 | |||
T15683 | L-689502 | HIV Protease | Microbiology/Virology; Proteases/Proteasome |
L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM). | |||
T39345 |
Lopinavir Metabolite M-1
|
Others | Others |
Lopinavir Metabolite M-1, an active metabolite derived from Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM. Additionally, in vitro studies have revealed notable antiviral properties associated with Lopinavir Metabolite M-1. | |||
T26552 |
Acetylpepstatin
Ac-Val-Val-Sta-Ala-Sta-OH,Acetyl-pepstatin |
||
Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease. | |||
T26446 |
A 77003
A-77003,Abbott 77003,A77003 |
Others | Others |
A 77003 is a HIV-1 protease inhibitor. A77003 impairs HIV-1 protease-mediated Gag processing. | |||
T24536 |
NIT
|
Others | Others |
NIT is an HIV-1 protease inhibitor. | |||
T24331 |
L 682679
L-682679,L-682,679,L682,679,L 682,679,L682679 |
Others | Others |
L 682679 is an inhibitor of HIV protease. | |||
T28292 |
Palinavir
BILA 2011 BS |
Others | Others |
Palinavir is an antiviral, it inhibits HIV-1 protease. | |||
T21039 |
PL 100
MK-8122,PL-100,PPL-100,PPL 100,MX-100 |
Others | Others |
PL 100 could inhibit HIV-1 protease. | |||
T28442 |
PPL-100
PL 461,PL461,PL-461,PPL100 |
Others | Others |
PPL-100, a HIV protease inhibitor, is used potentially for the treatment of HIV infection. | |||
T24266 |
KNI-1657
|
Others | Others |
KNI-1657 is a potent and selective HIV-1 protease inhibitor (Anti-HIV-1 pNL4-3, EC50: 3 nM). KNI-1657 is a highly potent HIV-1 Protease Inhibitor against Lopinavir. | |||
T26445 |
A 76889
A76889,A-76889 |
Others | Others |
A 76889 is an inhibitor of HIV-1 protease. | |||
T69423 |
GRL-98065
|
Others | Others |
GRL-98065 is an HIV protease inhibitor. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5783 |
Rosamultin
野蔷薇苷,罗莎白素 |
Antioxidant; HIV Protease | Microbiology/Virology; oxidation-reduction; Proteases/Proteasome |
Rosamultin 是从Potentilla anserina L 分离的 19 α-羟基型三萜。它抑制 HIV-1 蛋白酶,具有抗氧化、抗炎和镇痛作用。 | |||
TN1059 |
Ganoderic acid B
|
IL Receptor; HIV Protease; JAK; STAT | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells |
Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂,抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。 | |||
T4S1383 |
Escin IA
Aescin IA,Escin IA;Aescin IA,Escin IA |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Escin IA (Escin IA;Aescin IA);Aescin IA 是从马蹄中七叶树分离出的一种三萜皂苷,抑制HIV-1蛋白酶,IC50值为 35 μM。它具有抗 TNBC 转移活性,其作用机制涉及通过下调 LOXL2 表达抑制上皮-间质转化过程。 | |||
T4S1387 |
Isoescin IA
七叶皂苷C,异七叶皂苷 IA |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Isoescin IA 是一种从七叶树种子中分离出来的三萜皂苷。它具有抗HIV-1蛋白酶活性。 | |||
T5429 |
Theaflavin 3,3'-digallate
茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG |
Virus Protease; Antioxidant; HIV Protease; HSV | Microbiology/Virology; oxidation-reduction; Proteases/Proteasome |
Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂,IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制,可抑制 gp41 和 NS2B-3 蛋白酶的活性,并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚,有抗肿瘤作用。 | |||
T2S0223 |
Isosinensetin
异橙黄酮,6-Demethoxynobiletin |
Antioxidant; HIV Protease; Antibacterial; P-gp | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; oxidation-reduction; Proteases/Proteasome |
Isosinensetin (6-Demethoxynobiletin) 是从青皮中提取的一种甲氧基黄酮,具有抗氧化和抑制 HIV-1 蛋白酶的活性。 | |||
T3323 |
Ursonic Acid
CCRIS 7123,NSC4060,熊果酮酸,Prunol,3-Ketoursolic acid,Malol,TOS-BB-0966 |
Apoptosis; HIV Protease; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Ursonic Acid (TOS-BB-0966) 是一种天然三萜酸,属于熊果烷三萜类,其结构基于五环熊果烷骨架。 它具有作为 HIV-1 蛋白酶抑制剂的潜力。 | |||
TQ0217 |
Gomisin G
戈米辛G,戈米辛 G |
P450; HIV Protease | Metabolism; Microbiology/Virology; Proteases/Proteasome |
Gomisin G 是一种有抗HIV 活性的天然产物。 | |||
TN5675 |
Ganomycin I
|
||
Ganomycin I inhibits the activity of HIV-1 protease. | |||
TN7388 |
Ganoderic acid GS-2
|
Others | Others |
Ganoderic acid GS-2 inhibits the activity of the human immunodeficiency virus-1 (HIV-1) protease. | |||
T5S0983 |
Absinthin
Absinthiin,Absynthin,洋艾素 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Absinthin (Absynthin) 是结构独特的三萜类化合物,是艾草苦味高的原因。它是苦味受体hTAS2R46的激动剂,它利用 hTAS2R46 介导的受体特异性机制抑制组胺诱导的细胞内 Ca2+升高。 | |||
TN4347 |
Jacoumaric acid
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor. | |||
TN4705 |
Oleoside
|
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Oleoside 可从油橄榄和Zizyphus lotus L.树枝中提取,可能用于抑制HIV-1蛋白酶。 | |||
T75705 |
Pepstatin Trifluoroacetate
|
Others | Others |
Pepstatin (Pepstatin A) Trifluoroacetate 是一种由放线菌产生的特异性天冬氨酸蛋白酶(aspartic proteases)抑制剂,口服活性强。该化合物能有效抑制hemoglobin-pepsin、hemoglobin-proctase、casein-pepsin、casein-proctase、casein-acid protease和hemoglobin-acid protease的活性,其IC50值分别为4.5 nM、6.2 nM、150 nM、290 nM、520 nM和260 nM。此外,对HIV protease也有抑制作用。 | |||
TN4109 |
Ganolucidic acid A
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM. | |||
T10928 |
Cytochalasin A
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhy | |||
T75562 |
Ganoderic acid GS-1
|
Others | Others |
Ganoderic acid GS-1 是一种高度氧化的羊毛甾烷型三萜类化合物,具有抗 HIV-1蛋白酶活性,IC50为 58 μM。 | |||
T79953 |
Acetyl-binankadsurin A
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Acetyl-binankadsurin A(化合物5)是从南五味子(Kadsura longipedunculata)中提取的一种木脂素。该化合物对HIV-1蛋白酶表现出较低的抑制活性,其半抑制浓度(IC50)超过100 μg/mL。 | |||
TMA1012 |
Ganoderiol F
|
Androgen Receptor; HIV Protease; Autophagy | Autophagy; Endocrinology/Hormones; Microbiology/Virology; Proteases/Proteasome |
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced HO-1 expression, activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 and suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production. | |||
TN1660 |
Ganoderic acid C1
灵芝酸 C1,灵芝酸C1 |
IL Receptor; TNF; NF-κB; MAPK; COX; HIV Protease; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome |
Ganoderic acid C1 是分离自 G. lucidum 中的天然产物,能够抑制小鼠巨噬细胞TNF-α 的生成。 | |||
TN1670 |
Ganodermanondiol
灵芝酮二醇 |
HIV Protease; Nrf2; AMPK | Chromatin/Epigenetic; Immunology/Inflammation; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01711 |
Serpin B2 Protein, Human, Recombinant (GST)
PAI,serpin peptidase inhibitor, clade B (ovalbumin), member ... |
Human | Baculovirus Insect Cells |
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner.SerpinB2, also known as Plasminogen activator inhibitor 2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor and PAI2, is a cytoplasm protein that belongs to the serpin fa... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27097 |
CTP518
CTP 518,Deuterated Atazanivir-D3-1,CTP-518 |
||
CTP518, a deuterated Atazanivir derivative, is a HIV protease inhibitor. | |||
TMID-0082 |
Lopinavir-d8
|
||
Lopinavir-d8 是 Lopinavir 的氘代化合物。Lopinavir 的 CAS 号为 192725-17-0。Lopinavir 是一种选择性肽模拟 HIV-1 蛋白酶的高效抑制剂。它通过阻止 HIV-1 的成熟而起作用,从而阻断其感染性。它也是SARS-CoV 3CLpro的抑制剂。 |