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Search Results for " her4 "

Targets Recommended: HER

17

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T5390	BMS-599626 Hydrochloride AC480 Hydrochloride	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BMS-599626 Hydrochloride (AC480 Hydrochloride) 是一种口服生物有效的HER1、HER2和HER4酪氨酸激酶抑制剂(IC50分别为22、32和190 nM)，具有潜在的抗肿瘤活性。BMS-599626 Hydrochloride 抑制人表皮生长因子受体HER1, HER2和HER4，从而抑制过表达这些受体的肿瘤细胞的增殖。
T11213	Epertinib hydrochloride S-22611 hydrochloride	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Epertinib hydrochloride (S-22611 hydrochloride) 是口服可逆的选择性EGFR、HER2和HER4抑制剂，IC50值分别为 1.48、7.15 和 2.49 nM，具有抗肿瘤活性。
T6719	Varlitinib ASLAN001,ARRY-334543	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Varlitinib (ASLAN001) 是有效，可逆的泛 EGFR 小分子抑制剂，对 HER1，HER2 和 HER4 的 IC50 值分别为7，2，4 nM。
T2303	(S)-Afatinib BIBW2992,阿法替尼	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	(S)-Afatinib (BIBW2992) 是一种不可逆的 EGFR 家族抑制剂，对 EGFRwt、EGFR (L858R)、EGFR (L858R/T790M)、HER2 和 HER4 的 IC50 分别为 0.5/0.4/10/14/1 nM。
T6039	TAK-285 TAK285,TAK 285	EGFR; MEK; HER; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors
	TAK-285 是一种新型 HER2 和 EGFR(HER1) 双重抑制剂，IC50 分别为 17 和 23 nM。它可穿过血脑屏障，有抗肿瘤活性，对 HER1/2 的选择性是 HER4 的 10 倍以上。
T5398	BMS 599626 2HCl (873837-23-1(HCl)) AC480 dihydrochloride	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) 是 HER1 和 HER2 的选择性抑制剂（IC50：20 nM 和 30 nM），对 HER4 的效力降低约 8 倍，对 Lck、VEGFR2、c-Kit、MET 等的效力降低 100 倍以上。
T8758	Poziotinib hydrochloride HM 781-36B hydrochloride,NOV120101 hydrochloride,波齐替尼盐酸盐	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Poziotinib hydrochloride 不可逆地抑制 EGFR（HER1 或 ErbB1），包括 EGFR 突变体、HER2 和 HER4，从而抑制过度表达这些受体的肿瘤细胞的增殖。它是一种口服生物可利用的、基于喹唑啉的泛表皮生长因子受体（EGFR 或 HER）抑制剂，具有潜在的抗肿瘤活性。
T5168	EGFR-IN-12 EGFR Inhibitor	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-12 (EGFR Inhibitor) 是一种 4,6-二取代的嘧啶，可诱导细胞凋亡，具有抗肿瘤活性。它是ATP 竞争性，不可逆且高度选择性的EGFR 抑制剂，IC50为 21 nM。它对EGFR 的选择性高于 HER4 和 55种其他激酶。它还抑制突变型EGFRL858R 和EGFRL861Q，IC50分别为 63 nM 和 4 nM。
T11213L	Epertinib S-22611	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor activity.
T2610L	BMS-599626 2HCL(714971-09-2 Free base) BMS 599626 dihydrochloride,BMS-599626 2HCL(714971-09-2 Free base),AC480 2HCl	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BMS-599626 2HCL (AC480 2HCl) 是BMS-599626 衍生物。BMS-599626 是一种可口服且具有选择性的 HER1 和 HER2 双重抑制剂， IC50 分别为 20 和 30 nM。BMS-599626 抑制肿瘤细胞增殖，并有可能增加肿瘤对放疗的反应。
T2630	Poziotinib HM781-36B,NOV120101	Apoptosis; EGFR; HER	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Poziotinib (NOV120101) 是一种不可逆的 HER1/2/4 抑制剂 (IC50s: 3/5/23 nM)。
T34760	SYR127063 SYR-127063,BDBM 92454,SYR 127063,BDBM-92454,BDBM92454	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	SYR127063 (BDBM-92454) 是一种有效的选择性 HER2 抑制剂，以反应构象与 HER2 结合。
T62047	pan-HER-IN-1	Others	Others
	pan-HER-IN-1 (Compound C5) 是不可逆的、口服有效的广谱HER 抑制剂。pan-HER-IN-1抑制EGFR、HER4、EGFRT790M/L858R 和HER2的活性，IC50分别为 0.38、1.6、2.2 和 3.5 nM。pan-HER-IN-1可以诱导细胞凋亡 (apoptosis)，显示出抗肿瘤活性。
T62621	pan-HER-IN-2	Others	Others
	pan-HER-IN-2 (Compound C6) 是一种口服具有活力的、可逆的广谱 HER 抑制剂，能够作用于 EGFR (IC50: 0.72 nM)、HER4 (IC50: 2.0 nM)、EGFRT790M (IC50: 8.2 nM) / L858R (IC50: 75.1 nM)。pan-HER-IN-2 可以诱导细胞凋亡 (apoptosis)，具有抗肿瘤作用。
T14677	BMS-690514	EGFR; VEGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BMS-690514是可口服的EGFR 和VEGFR 抑制剂，对于EGFR、HER2和HER4的IC50值分别为5、9 和 60 nM。
T2610	BMS-599626 AC480	EGFR; MEK; HER; Src	Angiogenesis; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors
	BMS-599626 (AC480) 是可口服的选择性 HER1和HER2抑制剂，IC50分别为 20 和 30 nM。它对 HER4 的 IC50值为 190 nM，可抑制肿瘤细胞增殖，有治疗肿瘤的潜力。
T7819	TAS0728	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	TAS0728 是一种 HER2 抑制剂，与HER2的 C805 位点共价结合，IC50值为 13 nM。它抑制 HER2、HER3 及其下游效应蛋白的磷酸化，具有抗肿瘤活性。

化合物

BMS-599626 Hydrochloride

Cat.No: T5390

Synonym: AC480 Hydrochloride

Target: HER

Epertinib hydrochloride

Cat.No: T11213

Synonym: S-22611 hydrochloride

Target: EGFR, HER

Cat.No: T6719

Synonym: ASLAN001,ARRY-334543

Target: HER

Cat.No: T2303

Synonym: BIBW2992,阿法替尼

Target: EGFR, HER

Cat.No: T6039

Synonym: TAK285,TAK 285

Target: EGFR, MEK, HER, Aurora Kinase

BMS 599626 2HCl (873837-23-1(HCl))

Cat.No: T5398

Synonym: AC480 dihydrochloride

Target: HER

Poziotinib hydrochloride

Cat.No: T8758

Synonym: HM 781-36B hydrochloride,NOV120101 hydrochloride,波齐替尼盐酸盐

Target: EGFR

Cat.No: T5168

Synonym: EGFR Inhibitor

Target: Apoptosis, EGFR

Cat.No: T11213L

Synonym: S-22611

Target: EGFR, HER

BMS-599626 2HCL(714971-09-2 Free base)

Cat.No: T2610L

Synonym: BMS 599626 dihydrochloride,BMS-599626 2HCL(714971-09-2 Free base),AC480 2HCl

Target: HER

Cat.No: T2630

Synonym: HM781-36B,NOV120101

Target: Apoptosis, EGFR, HER

Cat.No: T34760

Synonym: SYR-127063,BDBM 92454,SYR 127063,BDBM-92454,BDBM92454

Target: EGFR, HER

Cat.No: T62047

Target: Others

Cat.No: T62621

Target: Others

Cat.No: T14677

Target: EGFR, VEGFR, HER

Cat.No: T2610

Synonym: AC480

Target: EGFR, MEK, HER, Src

Cat.No: T7819

Target: EGFR, HER

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00448	HER4/ERBB4 Protein, Human, Recombinant (His & Avi) HER4,ALS19,4ICD,p180erbB4	Human	HEK293 Cells
	Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS. HER4/ERBB4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted mol...
TMPK-00449	HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated E4ICD,ALS19,ErbB4,4ICD,HER	Human	HEK293 Cells
	Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS. HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The...
TMPY-03021	ErbB4 Protein, Mouse, Recombinant (His) c-erbB-4,Her4,erb-b2 receptor tyr...	Mouse	HEK293 Cells
	ErbB4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.5 kDa and the accession number is Q99P91.
TMPY-02246	HB-EGF Protein, Human, Recombinant DTSF,DTR,HEGFL,heparin-binding EGF-like growth factor,DTS	Human	Baculovirus Insect Cells
	Heparin-binding EGF-like growth factor (HBEGF), a member of the EGF family of growth factors, exerts its biological activity through activation of the EGFR and other ErbB receptors. Soluble mature HBEGF is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells but not endothelial cells. HBEGF activates two EGF receptor subtypes, HER1 and HER4, and binds to cell surface HSPG. The transmembrane form of...

重组蛋白

HER4/ERBB4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00448

Species: Human

Expression System: HEK293 Cells

HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00449

Species: Human

Expression System: HEK293 Cells

ErbB4 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03021

Species: Mouse

Expression System: HEK293 Cells

HB-EGF Protein, Human, Recombinant

Cat.No: TMPY-02246

Species: Human

Expression System: Baculovirus Insect Cells

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