12
2
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7832 |
Ibrolipim
NO-1886 |
LPL Receptor | GPCR/G Protein |
Ibrolipim (NO-1886) 是口服具有活力的脂蛋白脂肪酶 (LPL) 激活剂。它能够降低血浆甘油三酸酯,增加高密度脂蛋白胆固醇水平,具有肾保护和降血脂的作用。 | |||
T14667 |
BLT-1
|
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
BLT-1 是一种氨基硫脲铜螯合剂,是一种选择性清除受体 B1 型 (SR-BI) 抑制剂,抑制高密度脂蛋白 (HDL) 和 SR-BI 介导的细胞之间的脂质转移。 | |||
T15821 |
LY518674
LY-674 |
PPAR | DNA Damage/DNA Repair; Metabolism |
LY518674 (LY-674) 是一种高效、选择性的 PPARα 激动剂,对人 PPARα 作用的 EC50 值为 42 nM。LY518674 能降低甘油三酸酯,增加 HDL-C,可用于研究动脉粥样硬化。 | |||
T1415 |
Gemfibrozil
吉非罗齐,CI-719,Jezil,Decrelip,Lopid |
P450; Adrenergic Receptor; PPAR | DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Gemfibrozil (CI-719) 是一种PPAR-α激活剂,可作为降脂药。它也是P450非选择性抑制剂,对 CYP2C9、2C19、2C8 和 1A2 的Ki 值分别为 5.8、24、69 和 82 μM。 | |||
T10771 |
CETP-IN-3
|
Others | Others |
CETP-IN-3 is an inhibitor of the plasma glycoprotein cholesterol ester transfer protein (CETP), elevating HDL-C through inhibition of CETP. | |||
T11386 |
Gemcabene calcium
PD-72953 calcium |
Others | Others |
Gemcabene calcium , a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) andexerting anti-inflammatory activity, lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP). | |||
T68504 |
Obicetrapib calcium
|
Others | Others |
Obicetrapib calcium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction. | |||
T68695 |
(R)-Bambuterol
|
Others | Others |
Bambuterol is a prodrug of β2-agonist commonly used for the treatment of asthma and chronic obstructive pulmonary disease (COPD) with the advantage of once daily dosing and favorable side effect profile. Administration of a single-dose of R-bambuterol resulted in dose-dependent reductions in the levels of plasma LDL-C, high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1) at Tmax. R-bambuterol can lower the plasma levels of LD... | |||
T36139 |
BMS-795311
|
Others | Others |
Potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable. Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID:265... | |||
T68505 |
Obicetrapib sodium
|
Others | Others |
Obicetrapib sodium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction. | |||
T68503 |
Obicetrapib potassium
|
Others | Others |
Obicetrapib potassium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction. | |||
T83757 |
RG33 TFA
|
||
RG33是一种33个氨基酸的合成肽,与apolipoprotein A1 (ApoA1)的C-末端域中两个Y类螺旋的209-219和220-241氨基酸相对应。它能溶解含有1,2-dimyristoyl-sn-glycero-3-PC (DMPC)的多层囊泡(MLVs),形成重组HDL。与脂质结合的RG33在J774巨噬细胞中诱导胆固醇外流。RG33 (12 mg/kg)可降低胰岛素抵抗性小鼠的血糖水平。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3427 |
Polydatin
Piceid,虎杖苷,Polydotin Peceid |
Apoptosis; Mitophagy; NF-κB; Autophagy | Apoptosis; Autophagy; NF-κB |
Polydatin (Piceid) 是从传统中药虎杖根中提取的一种天然产物,在多个实验模型中具有抗炎作用。它可抑制 G6PD,并诱导氧化和内质网应激。 | |||
T3771 |
Methyl protodioscin
山药,Smilax saponin B,NSC-698790 |
Apoptosis | Apoptosis |
Methyl protodioscin (Smilax saponin B) 是一种甾二糖苷,能诱导细胞周期阻滞,具有抗肿瘤活性。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00947 |
APOC2 Protein, Human, Recombinant (His & SUMO)
ApoC-II,APC2,Apolipoprotein C-II,... |
Human | E. coli |
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. APOC2 Protein, Human, Recomb... | |||
TMPY-00055 |
LCAT Protein, Human, Recombinant (His)
lecithin-cholesterol acyltransfer... |
Human | HEK293 Cells |
Lecithin: cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport. Lecithin cholesterol acyltransferase (LCAT) plays a pivotal role in HDL metabolism.LCAT is intimately involved in HDL maturation an... | |||
TMPJ-00286 |
ANGPTL3 Protein, Human, Recombinant (hFc)
ANGPTL3,ANGPT5,Angiopoietin-related protein 3,ANG-5,Angiopoi... |
Human | HEK293 Cells |
Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains,respectively. ANGPTL3 directly inhibits ... | |||
TMPK-01450 |
HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
KRAS1,MHC,K-RAS4B,KRAS,CFC2,K-RAS... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01456 |
HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein, Human, MHC (His & Avi)
KRAS2,NS,MHC,C-K-RAS,KRAS1,K-RAS2A,K-RAS2B... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01451 |
HLA-C 03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi)
NS3,K-RAS4A,K-Ras 2,NS,KRAS1,RASK2,MHC,KI-RAS,KRAS,... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |