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Search Results for " hdl "
Targets Recommended: Others

25

抑制剂 & 化合物

4

天然产物

25

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T24134 HDL376

SDZ-HDL376,SDZHDL376,HDL 376,SDZ HDL376,HDL-376

Others Others
HDL376 (SDZ HDL376) 是一种清道夫受体 BI 抑制剂。
T7832 Ibrolipim

NO-1886

LPL Receptor GPCR/G Protein
Ibrolipim (NO-1886) 是口服具有活力的脂蛋白脂肪酶 (LPL) 激活剂。它能够降低血浆甘油三酸酯,增加高密度脂蛋白胆固醇水平,具有肾保护和降血脂的作用。
T14667 BLT-1

Others; HCV Protease Microbiology/Virology; Others; Proteases/Proteasome
BLT-1 是一种氨基硫脲铜螯合剂,是一种选择性清除受体 B1 型 (SR-BI) 抑制剂,抑制高密度脂蛋白 (HDL) 和 SR-BI 介导的细胞之间的脂质转移。
T2499 Torcetrapib

CP-529414,托彻普

CETP Metabolism
是胆固醇酯转移蛋白 (CETP) 选择性抑制剂。根据人血浆的抑制曲线,Torcetrapib (CP-529414) 对CETP 的最有效浓度为 37 nM。
T6048 Dalcetrapib

JTT-705,达塞曲匹,RO4607381

CETP Metabolism
Dalcetrapib (RO4607381) 是rhCETP 抑制剂(IC50:0.2 μM),具有增加血浆中HDL 胆固醇含量的作用。
T1928 Anacetrapib

安塞曲匹,MK-0859

CETP Metabolism
Anacetrapib (MK-0859) 是 CETP 的抑制剂,能够抑制 rhCETP (IC50:7.9±2.5 nM) 和 C13S CETP 突变型 (IC50:11.8±1.9 nM) 的活性。
T15821 LY518674

LY-674

PPAR DNA Damage/DNA Repair; Metabolism
LY518674 (LY-674) 是一种高效、选择性的 PPARα 激动剂,对人 PPARα 作用的 EC50 值为 42 nM。LY518674 能降低甘油三酸酯,增加 HDL-C,可用于研究动脉粥样硬化。
T6262 Evacetrapib

LY2484595

CETP Metabolism
Evacetrapib (LY2484595) 是 CETP 的选择性抑制剂,在人血浆中,抑制人重组 CETP 蛋白 (IC50:5.5 nM) 和 CETP (IC50:36 nM) 活性。
T1415 Gemfibrozil

吉非罗齐,CI-719,Jezil,Decrelip,Lopid

P450; Adrenergic Receptor; PPAR DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
Gemfibrozil (CI-719) 是一种PPAR-α激活剂,可作为降脂药。它也是P450非选择性抑制剂,对 CYP2C9、2C19、2C8 和 1A2 的Ki 值分别为 5.8、24、69 和 82 μM。
T30917 CI 924

EINECS 279-174-7,CI-924,CI924

Others Others
CI 924 is a lipid-lowering drug. CI 924 increased anti-atherosclerotic HDL and decreased VLDL at 600 mg/day.
T10771 CETP-IN-3

Others Others
CETP-IN-3 is an inhibitor of the plasma glycoprotein cholesterol ester transfer protein (CETP), elevating HDL-C through inhibition of CETP.
T69408 GW590735 sodium

Others Others
GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.
T30588 Brl 26314

Brl-26314,Brl26314

Others Others
Brl 26314 can elevate HDL-cholesterol in rats.
T11386 Gemcabene calcium

PD-72953 calcium

Others Others
Gemcabene calcium , a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) andexerting anti-inflammatory activity, lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP).
T68504 Obicetrapib calcium

Others Others
Obicetrapib calcium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T36139 BMS-795311

Others Others
Potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable. Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID:265...
T68695 (R)-Bambuterol

Others Others
Bambuterol is a prodrug of β2-agonist commonly used for the treatment of asthma and chronic obstructive pulmonary disease (COPD) with the advantage of once daily dosing and favorable side effect profile. Administration of a single-dose of R-bambuterol resulted in dose-dependent reductions in the levels of plasma LDL-C, high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1) at Tmax. R-bambuterol can lower the plasma levels of LD...
T68505 Obicetrapib sodium

Others Others
Obicetrapib sodium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T68503 Obicetrapib potassium

Others Others
Obicetrapib potassium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T38908 MK-8262

Others Others
MK-8262, an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor (IC 50 = 53 nM, log D = 5.3), is a bistrifluoromethyl analogue that shows promise in research related to high-density lipoprotein (HDL) and low-density lipoprotein (LDL) with potential implications for coronary heart disease (CHD).
T83757 RG33 TFA

RG33是一种33个氨基酸的合成肽,与apolipoprotein A1 (ApoA1)的C-末端域中两个Y类螺旋的209-219和220-241氨基酸相对应。它能溶解含有1,2-dimyristoyl-sn-glycero-3-PC (DMPC)的多层囊泡(MLVs),形成重组HDL。与脂质结合的RG33在J774巨噬细胞中诱导胆固醇外流。RG33 (12 mg/kg)可降低胰岛素抵抗性小鼠的血糖水平。
T35813 CAY10592

Others Others
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARδ receptor agonists, though relatively obscure, have recently been reported to elevate high-density lipoprotein (HDL) cholesterol and lower plasma triglyceride (TG) levels in obese insulin resistant rhesus monkeys. CAY10592 is a full PPARδ agonist (EC50 = 30 nM) ...
T70660 Azalanstat HCl

Others Others
Azalanstat HCl is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat HCl has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered l...
T70661 Azalanstat mesylate

Others Others
Azalanstat mesylate is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat mesylate has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially...
T35632 Pinolenic Acid

Others Others
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.[1] Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the sa...

化合物

HDL376
Cat.No: T24134
Synonym: SDZ-HDL376,SDZHDL376,HDL 376,SDZ HDL376,HDL-376
Target: Others
Ibrolipim
Cat.No: T7832
Synonym: NO-1886
Target: LPL Receptor
BLT-1
Cat.No: T14667
Synonym:
Target: Others, HCV Protease
Torcetrapib
Cat.No: T2499
Synonym: CP-529414,托彻普
Target: CETP
Dalcetrapib
Cat.No: T6048
Synonym: JTT-705,达塞曲匹,RO4607381
Target: CETP
Anacetrapib
Cat.No: T1928
Synonym: 安塞曲匹,MK-0859
Target: CETP
LY518674
Cat.No: T15821
Synonym: LY-674
Target: PPAR
Evacetrapib
Cat.No: T6262
Synonym: LY2484595
Target: CETP
Gemfibrozil
Cat.No: T1415
Synonym: 吉非罗齐,CI-719,Jezil,Decrelip,Lopid
Target: P450, Adrenergic Receptor, PPAR
CI 924
Cat.No: T30917
Synonym: EINECS 279-174-7,CI-924,CI924
Target: Others
CETP-IN-3
Cat.No: T10771
Synonym:
Target: Others
GW590735 sodium
Cat.No: T69408
Synonym:
Target: Others
Brl 26314
Cat.No: T30588
Synonym: Brl-26314,Brl26314
Target: Others
Gemcabene calcium
Cat.No: T11386
Synonym: PD-72953 calcium
Target: Others
Obicetrapib calcium
Cat.No: T68504
Synonym:
Target: Others
BMS-795311
Cat.No: T36139
Synonym:
Target: Others
(R)-Bambuterol
Cat.No: T68695
Synonym:
Target: Others
Obicetrapib sodium
Cat.No: T68505
Synonym:
Target: Others
Obicetrapib potassium
Cat.No: T68503
Synonym:
Target: Others
MK-8262
Cat.No: T38908
Synonym:
Target: Others
RG33 TFA
Cat.No: T83757
Synonym:
Target:
CAY10592
Cat.No: T35813
Synonym:
Target: Others
Azalanstat HCl
Cat.No: T70660
Synonym:
Target: Others
Azalanstat mesylate
Cat.No: T70661
Synonym:
Target: Others
Pinolenic Acid
Cat.No: T35632
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T3771 Methyl protodioscin

山药,Smilax saponin B,NSC-698790

Apoptosis Apoptosis
Methyl protodioscin (Smilax saponin B) 是一种甾二糖苷,能诱导细胞周期阻滞,具有抗肿瘤活性。
T3427 Polydatin

Piceid,虎杖苷,Polydotin Peceid

Apoptosis; Mitophagy; NF-κB; Autophagy Apoptosis; Autophagy; NF-κB
Polydatin (Piceid) 是从传统中药虎杖根中提取的一种天然产物,在多个实验模型中具有抗炎作用。它可抑制 G6PD,并诱导氧化和内质网应激。
TN5057 Stachybotramide

LDL Metabolism
Stachybotramide preferentially stimulate the plasma cholesteryl ester transfer protein (CETP)-mediated transfer of cholesteryl esters (CE) from high density lipoprotein (HDL) to both very low density lipoprotein (VLDL) and low density lipoprotein (LDL).
TN3397 Alpinumisoflavone

ERK; LDL; NF-κB; MEK; MAPK; Antifection MAPK; Metabolism; Microbiology/Virology; NF-κB
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is endowed with estrogenic properties accounting, at least in part, for E. lysistemon effects. Alp

天然产物

Methyl protodioscin
Cat.No: T3771
Synonym: 山药,Smilax saponin B,NSC-698790
Target: Apoptosis
Polydatin
Cat.No: T3427
Synonym: Piceid,虎杖苷,Polydotin Peceid
Target: Apoptosis, Mitophagy, NF-κB, Autophagy
Stachybotramide
Cat.No: TN5057
Synonym:
Target: LDL
Alpinumisoflavone
Cat.No: TN3397
Synonym:
Target: ERK, LDL, NF-κB, MEK, MAPK, Antifection
Cat. No. Product Name Species Expression System
TMPY-02956 Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)

APOL1,apolipoprotein L1,APOL,FSGS4,APOL-I,APO-L

Human Baculovirus Insect Cells
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomer...
TMPH-00357 SAA1 Protein, Feline, Recombinant (His)

Serum amyloid A protein,SAA1

Feline P. pastoris (Yeast)
Major acute phase reactant. Apolipoprotein of the HDL complex. SAA1 Protein, Feline, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 12.1 kDa and the accession number is P19707.
TMPJ-00158 Apolipoprotein A-I/APOA1 Protein, Human, Recombinant

Apolipoprotein A-I,APOA1,Apo-AI,ApoA-I

Human E. coli
Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including T...
TMPY-00055 LCAT Protein, Human, Recombinant (His)

lecithin-cholesterol acyltransferase

Human HEK293 Cells
Lecithin: cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport. Lecithin cholesterol acyltransferase (LCAT) plays a pivotal role in HDL metabolism.LCAT is intimately involved in HDL maturation an...
TMPY-02947 SAA4 Protein, Human, Recombinant (GST)

SAA4,serum amyloid A4, constitutive,C-SAA,CSAA

Human E. coli
SAA4 is a member of the SAA family. SAA proteins are family of apolipoproteins of high density lipoprotein (HDL). They can be separated into two distinct groups. First group (SAA1, SAA2, and SAA3) consists of acute phase reactant whose expression level increase in the blood in a response to trauma, infection, inflammation, and neoplasia. These acute phase SAAs associates with HDL during inflammation and remodel the HDL particle by displacing Apo-A1. The second distinct group consists of SAA4 and...
TMPJ-00523 SAA2 Protein, Human, Recombinant (His)

SAA2,SAA,Serum Amyloid A2

Human E. coli
Serum amyloid A-2 protein (SAA2) belongs to the SAA family. It expressed by the liver and secreted in plasma. SAA2 functions as major acute phase reactant and could works as apolipoprotein of the HDL complex. Increased levels of A-SAA in serum are indicative of inflammatory disease. When highly expressed, SAA can displace ApoA1 as the major apolipoprotein in HDL complexes, weakening the function of HDL as a reverse (lipid clearing) cholesterol transporter. A highly charged region of SAA2 and SAA...
TMPH-02902 SAA3 Protein, Mouse, Recombinant (His)

Serum amyloid A-3 protein,Saa3

Mouse P. pastoris (Yeast)
Major acute phase reactant. Apolipoprotein of the HDL complex. SAA3 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 13.8 kDa and the accession number is P04918.
TMPH-03501 SAA1 Protein, Sheep, Recombinant (His)

SAA1,Serum amyloid A protein

Sheep E. coli
Major acute phase reactant. Apolipoprotein of the HDL complex. SAA1 Protein, Sheep, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.7 kDa and the accession number is P42819.
TMPH-00836 SAA1 Protein, Horse, Recombinant (His)

Serum amyloid A protein,SAA1

Horse E. coli
Major acute phase reactant. Apolipoprotein of the HDL complex. SAA1 Protein, Horse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 15.8 kDa and the accession number is P19857.
TMPH-00302 SAA1 Protein, Bovine, Recombinant (His)

Serum amyloid A protein,SAA1

Bovine E. coli
Major acute phase reactant. Apolipoprotein of the HDL complex. SAA1 Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.6 kDa and the accession number is P35541.
TMPJ-00757 Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (His)

Apolipoprotein A-II,Truncated apolipoprotein A-II,ProapoA-II...

Human HEK293 Cells
Apolipoprotein A-II(Apo-AII for short), also known as Apolipoprotein A2, is a secreted protein which belongs to the apolipoprotein A2 family. It exists as a disulfide-linked homodimer; and also can form a disulfide-linked heterodimer with APOD. APOA2 is the 2nd most abundant protein of the high density lipoprotein particles. This protein may stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Defects in APOA2 gene might cause apolipop...
TMPH-00358 SAA1 Protein, Feline, Recombinant (B2M & His)

Serum amyloid A protein,SAA1

Feline E. coli
Major acute phase reactant. Apolipoprotein of the HDL complex. SAA1 Protein, Feline, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 24.1 kDa and the accession number is P19707.
TMPH-00501 SAA1 Protein, Canine, Recombinant (GST & His)

SAA1,Serum amyloid A protein

Canine E. coli
Major acute phase reactant. Apolipoprotein of the HDL complex. SAA1 Protein, Canine, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 42.5 kDa and the accession number is P19708.
TMPH-02901 SAA3 Protein, Mouse, Recombinant (E. coli, His)

Serum amyloid A-3 protein,Saa3

Mouse E. coli
Major acute phase reactant. Apolipoprotein of the HDL complex. SAA3 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 15.8 kDa and the accession number is P04918.
TMPH-00947 APOC2 Protein, Human, Recombinant (His & SUMO)

ApoC-II,APC2,Apolipoprotein C-II,Apolipoprotein C2,APOC2,Apo...

Human E. coli
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. APOC2 Protein, Human, Recomb...
TMPJ-00286 ANGPTL3 Protein, Human, Recombinant (hFc)

ANGPTL3,ANGPT5,Angiopoietin-related protein 3,ANG-5,Angiopoi...

Human HEK293 Cells
Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains,respectively. ANGPTL3 directly inhibits ...
TMPH-02514 APOA4 Protein, Mouse, Recombinant (His)

Apolipoprotein A4,Apolipoprotein A-IV,ApoA-IV,Apo-AIV,Apoa4

Mouse P. pastoris (Yeast)
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
TMPH-02316 YJEFN3 Protein, Human, Recombinant

YjeF N-terminal domain-containing protein 3,YJEFN3,ApoA-I-bi...

Human E. coli
May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progeni...
TMPJ-00805 Apolipoprotein E/APOE Protein, Mouse, Recombinant (His)

Apo-E,APOE,Apolipoprotein E

Mouse HEK293 Cells
Apolipoprotein E (Apo-E), is a member of the apolipoprotein A1/A4/E family. ApoE is a major protein component of serum LDL, VLDL, HDL, and chylomicrons. APOE may function in mediating the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. APOE is usually secreted in plasma. Phosphorylation sites are present in the extracellular medium.
TMPJ-00756 Apolipoprotein E/APOE3 Protein, Human, Recombinant (His)

Apolipoprotein E,Apo-E,APOE,ApoE3

Human HEK293 Cells
ApoE, a glycoprotein, is a structural component of very low density lipoprotein (vLDL) synthesized by the liver and intestinally synthesized chylomicrons . ApoE is also a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport .ApoE mediates high affinity binding of chylomicrons and vLDL particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol rich particles in the plasma .Apo...
TMPJ-00601 Apolipoprotein C-II/APOC2 Protein, Human, Recombinant (His)

Apolipoprotein C2,Apolipoprotein C-II,APC2 and APOC2

Human E. coli
APOC2 activates the lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. APOC2 is component of the very low density lipoprotein (VLDL) fraction in plasma. It is also an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoprot...
TMPJ-00292 CD36 Protein, Human, Recombinant (hFc)

FATCHDS7,Glycoprotein IIIb,SCARB3,CD36,Fatty acid translocas...

Human HEK293 Cells
Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition rece...
TMPJ-00833 MPO Protein, Mouse, Recombinant (His)

MPO,Myeloperoxidase

Mouse HEK293 Cells
Myeloperoxidase (MPO) is a hemecontaining enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxidedependent conversion of chloride, bromide, and iodide to multiple reactive species. MPO activity results in protein nitrosylation and the formation of 3-chlorotyrosine and dityrosine crosslinks. Modification of ApoB100, as well as the lipid and cholesterol components of LDL and HDL, promotes the development of a...
TMPJ-00480 SAA1 Protein, Human, Recombinant (His)

SAA1,SAA,Serum Amyloid A-1 Protein

Human E. coli
Serum Amyloid A1 Protein (SAA1) is an acute phase apolipoprotein reactant that is produced predominantly by hepatocytes and is under the regulation of inflammatory cytokines. SAA is produced mainly in the liver and circulates in low levels in the blood. SAA may play a role in the immune system and facilitate the repair of injured tissues, it also acts as an antibacterial agent, and signals the migration of germ-fighting cells to sites of infection. SAA also functions as an apolipoprotein of the ...
TMPH-02690 PLA2G10 Protein, Mouse, Recombinant (His & Myc)

Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi...

Mouse E. coli
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li...

重组蛋白

Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02956
Species: Human
Expression System: Baculovirus Insect Cells
SAA1 Protein, Feline, Recombinant (His)
Cat.No: TMPH-00357
Species: Feline
Expression System: P. pastoris (Yeast)
Apolipoprotein A-I/APOA1 Protein, Human, Recombinant
Cat.No: TMPJ-00158
Species: Human
Expression System: E. coli
LCAT Protein, Human, Recombinant (His)
Cat.No: TMPY-00055
Species: Human
Expression System: HEK293 Cells
SAA4 Protein, Human, Recombinant (GST)
Cat.No: TMPY-02947
Species: Human
Expression System: E. coli
SAA2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00523
Species: Human
Expression System: E. coli
SAA3 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02902
Species: Mouse
Expression System: P. pastoris (Yeast)
SAA1 Protein, Sheep, Recombinant (His)
Cat.No: TMPH-03501
Species: Sheep
Expression System: E. coli
SAA1 Protein, Horse, Recombinant (His)
Cat.No: TMPH-00836
Species: Horse
Expression System: E. coli
SAA1 Protein, Bovine, Recombinant (His)
Cat.No: TMPH-00302
Species: Bovine
Expression System: E. coli
Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00757
Species: Human
Expression System: HEK293 Cells
SAA1 Protein, Feline, Recombinant (B2M & His)
Cat.No: TMPH-00358
Species: Feline
Expression System: E. coli
SAA1 Protein, Canine, Recombinant (GST & His)
Cat.No: TMPH-00501
Species: Canine
Expression System: E. coli
SAA3 Protein, Mouse, Recombinant (E. coli, His)
Cat.No: TMPH-02901
Species: Mouse
Expression System: E. coli
APOC2 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-00947
Species: Human
Expression System: E. coli
ANGPTL3 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00286
Species: Human
Expression System: HEK293 Cells
APOA4 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02514
Species: Mouse
Expression System: P. pastoris (Yeast)
YJEFN3 Protein, Human, Recombinant
Cat.No: TMPH-02316
Species: Human
Expression System: E. coli
Apolipoprotein E/APOE Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00805
Species: Mouse
Expression System: HEK293 Cells
Apolipoprotein E/APOE3 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00756
Species: Human
Expression System: HEK293 Cells
Apolipoprotein C-II/APOC2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00601
Species: Human
Expression System: E. coli
CD36 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00292
Species: Human
Expression System: HEK293 Cells
MPO Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00833
Species: Mouse
Expression System: HEK293 Cells
SAA1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00480
Species: Human
Expression System: E. coli
PLA2G10 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02690
Species: Mouse
Expression System: E. coli
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