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Search Results for " hdac-4 "

Targets Recommended: HDAC

26

抑制剂 & 化合物

1

TargetMol 试剂盒

33

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Form	Specificity Of Inhibition
C0048	Deacetylase Inhibitor Cocktail (100× in 70% DMSO) 去乙酰化酶抑制剂 Cocktail（100× in 70% DMSO）	Solution (100× in 70% DMSO)	Class I/II/III <em>HDAC</em>

TargetMol 试剂盒

去乙酰化酶抑制剂 Cocktail（100× in 70% DMSO）

Cat.No: C0048

Cat. No.	Product Name	Target	Signaling Pathways
T11542	HDAC-IN-4	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.
T21551	2-hexyl-4-Pentynoic Acid	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	2-Hexyl-4-pentynoic acid 是一种丙戊酸 (VPA) 衍生物，可以抑制HDAC(IC50=13 µM) 和诱导HSP70。它可引起培养神经元的组蛋白高度乙酰化，防止谷氨酸诱导的兴奋性毒性，具有强大的神经保护作用。
T6392	AR42 OSU-HDAC42,AR-42,(S)-(+)-N-羟基-4-(3-甲基-2-苯基丁酰氨基)苯甲酰胺,AR 42,HDAC-42	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AR42 (OSU-HDAC42) 是一种 HDAC 抑制剂(IC50: 30 nM)。
T5886	4-Phenylbutyric acid 苯丁酸,4-苯基丁酸,Benzenebutyric acid	Virus Protease; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	4-Phenylbutyric acid (Benzenebutyric acid) 是一种组蛋白去乙酰化酶和内质网应激抑制剂，可研究癌症和感染等疾病。
T6481	Droxinostat NS 41080,4-(4-氯-2-甲基苯氧基)-N-羟基丁酰胺	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Droxinostat (NS 41080) 是HDAC3、HDAC6和HDAC8抑制剂，IC50分别为16.9、2.47和1.46 μM。
T1535	Sodium 4-phenylbutyrate 苯丁酸钠,Sodium Phenylbutyrate,Buphenyl,4-苯基丁酸钠盐,TriButyrate	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Sodium 4-phenylbutyrate (TriButyrate) 是一种组蛋白去乙酰化酶和内质网应激抑制剂，可研究癌症和感染等疾病。
T6325	PCI-34051 N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺,PCI 34051	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	PCI-34051 是一种有效的选择性的HDAC8抑制剂，IC50为 10 nM。
T5045	GSK4112 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452	Autophagy	Autophagy
	GSK4112 (SR6452) 是一种 Rev-erbα 激动剂，EC50 为 0.4 μM。它也是一种用于核血红素受体 Rev-erbα 的细胞生物学的小分子化学探针。
T64261	HDAC/HSP90-IN-4	Others	Others
	HDAC/HSP90-IN-4 能够明显抑制 HDAC 和 HSP90 的活性，化合物20（HDACIC50= 194 nM; HSP90αIC50= 153 nM）和化合物26（(HDACIC50= 360 nM; HSP90αIC50= 77 nM) 具有较强的 HDAC 和 HSP90α抑制效果。这两种化合物都能诱导 HSP90表达并下调 HSP90客户蛋白，而 HSP90客户蛋白在调节癌细胞的生存和侵袭中发挥着重要作用。
T14947	CHDI-390576	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CHDI-390576 是一种具有中枢神经系统渗透性、选择性和高效性的二苯甲酰异羟肟酸 IIa 类组蛋白脱乙酰酶(HDAC) 抑制剂，抑制 IIa 类 HDAC 4、HDAC 5、HDAC 7、HDAC 9 ，可用于研究癌症。
T1857	TMP269	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TMP269 是一种有效的特异性 IIa 类 HDAC 抑制剂，分别抑制 HDAC 4/HDAC 5/HDAC 7/HDAC 9，IC50值分别为 157 nM，97 nM，43 nM 和 23 nM。
T10883L	CRA-026440 hydrochloride CRA-026440 hydrochloride（847460-34-8 Free base）	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CRA-026440 hydrochloride 是有效的、广谱的 HDAC 抑制剂。CRA-026440 hydrochloride 作用于 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 和 HDAC10， Ki 值分别为 4 nM，14 nM，11 nM，15 nM，7 nM 和 20 nM。CRA-026440 hydrochloride 具有抗血管生成和抗肿瘤活性。
T6006	Romidepsin FR 901228,FK 228,Depsipeptide,罗米地辛,NSC 630176	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Romidepsin (FR 901228) 是一种 HDAC 抑制剂，抑制 HDAC1/2/4/6 (IC50=36/47/510/1400 nM)。Romidepsin 具有抗肿瘤活性，可以用于治疗外周 T 细胞淋巴瘤和皮肤 T 细胞淋巴瘤。
T6055	Quisinostat 奎诺司他,JNJ-26481585	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat (JNJ-26481585) 是一种高效的，具有口服活性的 pan-HDAC 抑制剂，对 HDAC1、HDAC2、HDAC4、HDAC10、HDAC11 作用的 IC50值范围为 0.11-0.64 nM。它在成神经细胞瘤中能诱导自噬，具有广泛的抗肿瘤活性。
T6865	Quisinostat dihydrochloride Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。
T3206	NKL 22 Histone Deacetylase Inhibitor IV,PAOA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	NKL 22 (Histone Deacetylase Inhibitor IV) 是一种有效的选择性组蛋白脱乙酰基酶(HDAC) 抑制剂，对 HDAC2/4/5/7/8 具有选择性，抑制HDAC1和HDAC3的IC50值分别为 199 和 69 nM。它可改善亨廷顿氏病转基因小鼠的疾病表型和转录异常。
T2383	Panobinostat 帕比司他,NVP-LBH589,LBH589	Apoptosis; HIV Protease; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Panobinostat (NVP-LBH589) 是一种广谱的 HDAC 抑制剂 (IC50=5 nM)，具有口服活性和非选择性。Panobinostat 具有抗肿瘤活性，可以诱导细胞凋亡和自噬。
T61583	CDK/HDAC-IN-1	Others	Others
	CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively.
T21749	4-iodo-SAHA	Others	Others
	4-Iodo-SAHA (1k) 是一种具有口服活性的I 类和II 类histone deacetylase (HDAC)抑制剂，对 Skbr3、 HT29、 U937、 JA16 和 HL60细胞的EC50值分别为1.1、0.95、0.12、0.24、0.85和1.3 μM。4-Iodo-SAHA (1k) 可用于癌症的研究。
T36105	coumarin-SAHA coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA	Others	Others
	Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm
T78708	JAK/HDAC-IN-2	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK/HDAC-IN-2 是一款高效的 JAK/HDAC 双靶点抑制剂，能在纳摩尔浓度范围内有效抑制 HDAC3/6 与 JAK1/2。此化合物不仅促进细胞凋亡，还能抑制组蛋白去乙酰化和 STAT3 磷酸化，对血液肿瘤和实体肿瘤细胞展现出了显著的抗增殖效果。
T83947	HDAC4 CHDI Degrader 11	Others	Others
	HDAC4 CHDI Degrader 11是一种高效且选择性的HDAC4降解剂（PROTAC），其在Jurkat E6-1细胞和Jurkat细胞中的DC50值分别为4 nM和6 nM。该化合物由类IIa HDAC抑制剂三氟甲基噁二唑通过连接体与Von Hippel-Lindau (VHL) 蛋白的配体连接而成。在亨廷顿病小鼠细胞模型中，HDAC4 CHDI Degrader 11能强效地降解HDAC4（DC50= 1nM）。在神经母细胞瘤细胞系中，可与P-糖蛋白抑制剂Elacridar联用以实现更有效的降解。
T60511	Theophylline sodium glycinate	Others	Others
	Theophylline (1,3-Dimethylxanthine) sodium glycinate 是一种有效的磷酸二酯酶 (PDE) 抑制剂，可抑制 PDE3 活性以松弛气道平滑肌。Theophylline sodium glycinate 可用于研究哮喘和慢性阻塞性肺疾病 (COPD) 。Theophylline sodium glycinate 也是一种腺苷受体拮抗剂和组蛋白脱乙酰酶 (HDAC) 激活剂。 Theophylline sodium glycinate 通过增加 IL-10 和抑制 NF-κB 的核输入而具有抗炎活性。Theophyllin sodium glycinate 可诱导细胞凋亡。
T36102	4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline	Others	Others
	4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer compounds.1,2,3It is also a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib , with antiproliferative activity.4,5
T36629	Givinostat	Others	Others
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...
T36103	TW9 TW9	Others	Others
	TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μM) and for HDAC1 over HDAC2 (IC50= 2.5 μM). TW9 (50 nM) induces apoptosis in, and inhibits proliferation of, MIA PaCa-2 pancreatic cancer cells. It induces cell cycle arrest at the G1phase in HPAC pancreatic cancer cells when used at a concentration of 2 μM. TW9 acts synergistica...

化合物

Cat.No: T11542

Target: HDAC

2-hexyl-4-Pentynoic Acid

Cat.No: T21551

Target: HDAC

Cat.No: T6392

Synonym: OSU-HDAC42,AR-42,(S)-(+)-N-羟基-4-(3-甲基-2-苯基丁酰氨基)苯甲酰胺,AR 42,HDAC-42

Target: HDAC

4-Phenylbutyric acid

Cat.No: T5886

Synonym: 苯丁酸,4-苯基丁酸,Benzenebutyric acid

Target: Virus Protease, HDAC

Cat.No: T6481

Synonym: NS 41080,4-(4-氯-2-甲基苯氧基)-N-羟基丁酰胺

Target: Apoptosis, HDAC

Sodium 4-phenylbutyrate

Cat.No: T1535

Synonym: 苯丁酸钠,Sodium Phenylbutyrate,Buphenyl,4-苯基丁酸钠盐,TriButyrate

Target: Apoptosis, HDAC, Autophagy

Cat.No: T6325

Synonym: N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺,PCI 34051

Target: Apoptosis, HDAC

Cat.No: T5045

Synonym: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452

Target: Autophagy

HDAC/HSP90-IN-4

Cat.No: T64261

Target: Others

Cat.No: T14947

Target: HDAC

Cat.No: T1857

Target: HDAC

CRA-026440 hydrochloride

Cat.No: T10883L

Synonym: CRA-026440 hydrochloride（847460-34-8 Free base）

Target: HDAC

Cat.No: T6006

Synonym: FR 901228,FK 228,Depsipeptide,罗米地辛,NSC 630176

Target: Apoptosis, HDAC

Cat.No: T6055

Synonym: 奎诺司他,JNJ-26481585

Target: Apoptosis, HDAC, Autophagy

Quisinostat dihydrochloride

Cat.No: T6865

Synonym: Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl

Target: Apoptosis, HDAC, Autophagy

Cat.No: T3206

Synonym: Histone Deacetylase Inhibitor IV,PAOA

Target: HDAC

Cat.No: T2383

Synonym: 帕比司他,NVP-LBH589,LBH589

Target: Apoptosis, HIV Protease, HDAC, Autophagy

CDK/HDAC-IN-1

Cat.No: T61583

Target: Others

Cat.No: T21749

Target: Others

Cat.No: T36105

Synonym: coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA

Target: Others

JAK/HDAC-IN-2

Cat.No: T78708

Target: JAK

HDAC4 CHDI Degrader 11

Cat.No: T83947

Target: Others

Theophylline sodium glycinate

Cat.No: T60511

Target: Others

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cat.No: T36102

Target: Others

Cat.No: T36629

Target: Others

Cat.No: T36103

Synonym: TW9

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03431	HDAC4 Protein, Human, Recombinant (aa 612-1084) histone deacetylase 4,HA6116,HDAC-4	Human	Baculovirus Insect Cells
	HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Th...
TMPY-00749	FGF-2 Protein, Human, Recombinant fibroblast growth factor 2 (basic),FGF-2,FGFB,HBGF-2,BFGF	Human	E. coli
	FGF-2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.5 kDa and the accession number is P09038-4.
TMPJ-00864	VEGF165 Protein, Human, Recombinant Vascular Endothelial Growth Factor Isoform 165,血管内皮生长因子,VEGF...	Human	HEK293 Cells
	Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul...
TMPK-00823	VEGF165 Protein, Human, Recombinant (His & Avi) 血管内皮生长因子,RP1-261G23.1,MVCD1,MGC70609,VEGFA,VEGFMGC70609,VPF,...	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
TMPY-03056	LSD1 Protein, Human, Recombinant (His & GST) BHC110,LSD1,KDM1,AOF2,lysine (K)-specific demethylase 1A	Human	Baculovirus Insect Cells
	LSD1 belongs to the flavin monoamine oxidase family. It contains 1 SWIRM domain and is a component of an RCOR/GFI/LSD1/HDAC complex. LSD1 interacts directly with GFI1 and GFI1B. LSD1 specifically removes histone H3K4me2 to H3K4me1 or H3K4me0 through a FAD-dependent oxidative reaction. When forming a complex with an androgen receptor (and possibly other nuclear hormone receptors), LSD1 changes its substrates to H3K9me2. Thus LSD1 is considered to act as a coactivator or a corepressor. It may play...
TMPY-04911	VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated vascular endothelial growth factor A,血管内皮生长因子	Human,Cynomolgus	HEK293 Cells
	VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.1 kDa and the accession number is P15692-4.
TMPY-02893	NT5C3A/NT5C3 Protein, Human, Recombinant P5N1,P5N-1,hUMP1,NT5C3,cN-III,PSN1,UMPH1,UMPH,POMP,5'-nucleo...	Human	E. coli
	NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but...
TMPK-00424	CD45 Protein, Human, Recombinant (His & Avi), Biotinylated LCA,LY5,EC 3.1.3.48,CD45,L-CA,T200,CD4...	Human	HEK293 Cells
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi...
TMPK-00822	VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled RP1-261G23.1,VEGFA,MGC70609,VEGF,VEGFMGC70609,VPF,VAS,MVCD1,...	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
TMPY-05598	Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated SIGLEC2,SIGLEC-2,CD22 molecule	Human	HEK293 Cells
	Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 103.7 kDa and the accession number is P20273-4.
TMPY-04471	APEG1 Protein, Human, Recombinant (His) SPEG complex locus,BPEG,SPEGalpha,SPEGβ,APEG-1,SPEGbeta,APEG...	Human	E. coli
	Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein that belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG / APEG-1 contains two fibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform 1 of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 of SPEG is predominantly expre...
TMPJ-01333	TEM8/ANTXR1 Protein, Human, Recombinant (His) ATR,ANTXR1,TEM8,Tumor Endothelial Marker 8,Anthrax Toxin Rec...	Human	HEK293 Cells
	Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothelial cells. ANTXR1 plays a role in cell attachment and migration. ANTXR1 interacts with extracellular matrix proteins and the actin cytoskeleton, it mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It ...
TMPK-00423	CD45 Protein, Human, Recombinant (His & Avi) CD45R,LY5,EC 3.1.3.48,B220,CD45,T...	Human	HEK293 Cells
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi...
TMPY-04754	CASK Protein, Human, Recombinant CMG,LIN2,MRXSNA,CAMGUK,calcium/calmodulin-dependent serine p...	Human	Baculovirus Insect Cells
	CASK Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 102.1 kDa and the accession number is O14936-4.
TMPY-00225	CLEC9A Protein, Mouse, Recombinant (hFc) C-type lectin domain family 9, member A,9830005G06Rik,DNGR-1	Mouse	HEK293 Cells
	CLEC9A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.1 kDa and the accession number is Q8BRU4-4.
TMPY-01117	MRAP Protein, Human, Recombinant (hFc) FALP,FGD2,melanocortin 2 receptor accessory protein,GCCD2,B2...	Human	HEK293 Cells
	MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain, has a unique structure, an antiparallel homodimer. MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. MRAP is highly expressed in the adrenal gland and is essential for adrenocorticotropin hormone (ACTH) rece...
TMPJ-00782	Amyloid Precursor Protein, Human, Recombinant (hFc) Amyloid Precursor,Amyloid Precursor Protein 695,APP695	Human	HEK293 Cells
	Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Of the three major splice isoforms of APP (APP695, APP751, and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective process...
TMPJ-00233	CD200R1/CRTR2 Protein, Human, Recombinant (His) Cell Surface Glycoprotein CD200 Receptor 1,OX2R,MOX2R,CD200 ...	Human	HEK293 Cells
	Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytopla...
TMPY-01823	PTK9 Protein, Human, Recombinant MGC41876,twinfilin actin binding protein 1,A6,MGC23...	Human	E. coli
	PTK9 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 29 kDa and the accession number is Q12792-4.
TMPY-01033	IL-32 Protein, Human, Recombinant (isoform alpha, His) IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform...	Human	HEK293 Cells
	IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,...
TMPY-00119	FLT1 Protein, Human, Recombinant (hFc) VEGFR1,VEGFR-1,fms-related tyrosine kinase 1,FLT-1,FLT	Human	HEK293 Cells
	FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is P17948-4.
TMPK-00702	ANTXR2 Protein, Human, Recombinant (His) cI-35,Antxr2,JHS,CMG-2,CMG2,JHF,HFS,ISH	Human	HEK293 Cells
	The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2),ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultured in vitro. ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds.
TMPY-04565	SRPK3 Protein, Human, Recombinant (His & GST) MSSK1,MGC102944,STK23,MSSK-1,SRSF protein ...	Human	Baculovirus Insect Cells
	Serine / threonine-protein kinase SRPK3, also known as Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, SR-protein-specific kinase 3, Serine / threonine-protein kinase 23, MSSK-1, SRPK3 and MSSK1, is a member of the protein kinase superfamily and CMGC Ser / Thr protein kinase family. SRPK3 is a protein kinase belonging to serine/arginine protein kinases (SRPK) family, which phosphorylates serine / arginine repeat-containing proteins, and is controlled by a muscle-...
TMPY-04563	CASK Protein, Human, Recombinant (His & GST) calcium/calmodulin-dependent serine protein kinase (MAGUK fa...	Human	Baculovirus Insect Cells
	CASK Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 130 kDa and the accession number is O14936-4.
TMPY-01822	PTK9 Protein, Human, Recombinant (His & GST) PTK9,MGC41876,A6,MGC23788,twinfilin actin binding p...	Human	E. coli
	PTK9 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 57 kDa and the accession number is Q12792-4.
TMPY-01933	CHI3L2 Protein, Human, Recombinant (His) YKL-39,CHIL2,chitinase 3 like 2,YKL39	Human	HEK293 Cells
	Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in b...
TMPY-00380	ANTXR2 Protein, Human, Recombinant (hFc) HFS,JHF,anthrax toxin receptor 2,ISH,CMG-2,CMG2	Human	HEK293 Cells
	ANTXR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.4 kDa and the accession number is P58335-4.
TMPY-00711	CD45 Protein, Human, Recombinant (hFc) GP180,L-CA,LY5,T200,protein tyrosine phosphatase, receptor t...	Human	HEK293 Cells
	CD45 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.1 kDa and the accession number is P08575-4.
TMPJ-00410	CD45R0 Protein, Human, Recombinant (His) CD45 antigen,L-CA,protein tyrosine phosphatase, rec...	Human	HEK293 Cells
	CD45R0 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 80-120 KDa and the accession number is P08575-4.
TMPJ-01256	Caspase-10 Protein, Human, Recombinant (His) CASP10,FAS-Associated Death Domain Protein Interleukin-1B-Co...	Human	E. coli
	Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca...
TMPJ-01188	CORO6 Protein, Human, Recombinant (His) Coronin-6,Clipin-E,CORO6	Human	E. coli
	Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is promin...
TMPK-01362	SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated MYD1,SIRP α V4,PTPNS1,BIT,SHPS1,SIRP alpha,SHPS-1,S...	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...
TMPK-01356	SIRP alpha V4 Protein, Human, Recombinant (His & Avi) BIT,SIRP α V4,MFR,SHPS1,SIRPA,SIRP α,P84,M...	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-Hi...

重组蛋白

HDAC4 Protein, Human, Recombinant (aa 612-1084)

Cat.No: TMPY-03431

Species: Human

Expression System: Baculovirus Insect Cells

FGF-2 Protein, Human, Recombinant

Cat.No: TMPY-00749

Species: Human

Expression System: E. coli

VEGF165 Protein, Human, Recombinant

Cat.No: TMPJ-00864

Species: Human

Expression System: HEK293 Cells

VEGF165 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00823

Species: Human

Expression System: HEK293 Cells

LSD1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03056

Species: Human

Expression System: Baculovirus Insect Cells

VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-04911

Species: Human,Cynomolgus

Expression System: HEK293 Cells

NT5C3A/NT5C3 Protein, Human, Recombinant

Cat.No: TMPY-02893

Species: Human

Expression System: E. coli

CD45 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00424

Species: Human

Expression System: HEK293 Cells

VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled

Cat.No: TMPK-00822

Species: Human

Expression System: HEK293 Cells

Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-05598

Species: Human

Expression System: HEK293 Cells

APEG1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04471

Species: Human

Expression System: E. coli

TEM8/ANTXR1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01333

Species: Human

Expression System: HEK293 Cells

CD45 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00423

Species: Human

Expression System: HEK293 Cells

CASK Protein, Human, Recombinant

Cat.No: TMPY-04754

Species: Human

Expression System: Baculovirus Insect Cells

CLEC9A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-00225

Species: Mouse

Expression System: HEK293 Cells

MRAP Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01117

Species: Human

Expression System: HEK293 Cells

Amyloid Precursor Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00782

Species: Human

Expression System: HEK293 Cells

CD200R1/CRTR2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00233

Species: Human

Expression System: HEK293 Cells

PTK9 Protein, Human, Recombinant

Cat.No: TMPY-01823

Species: Human

Expression System: E. coli

IL-32 Protein, Human, Recombinant (isoform alpha, His)

Cat.No: TMPY-01033

Species: Human

Expression System: HEK293 Cells

FLT1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00119

Species: Human

Expression System: HEK293 Cells

ANTXR2 Protein, Human, Recombinant (His)

Cat.No: TMPK-00702

Species: Human

Expression System: HEK293 Cells

SRPK3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04565

Species: Human

Expression System: Baculovirus Insect Cells

CASK Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04563

Species: Human

Expression System: Baculovirus Insect Cells

PTK9 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01822

Species: Human

Expression System: E. coli

CHI3L2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01933

Species: Human

Expression System: HEK293 Cells

ANTXR2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00380

Species: Human

Expression System: HEK293 Cells

CD45 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00711

Species: Human

Expression System: HEK293 Cells

CD45R0 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00410

Species: Human

Expression System: HEK293 Cells

Caspase-10 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01256

Species: Human

Expression System: E. coli

CORO6 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01188

Species: Human

Expression System: E. coli

SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01362

Species: Human

Expression System: HEK293 Cells

SIRP alpha V4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01356

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0260	HDAC-IN-4-d4
	HDAC-IN-4-d4 是 HDAC-IN-4 的氘代化合物。

同位素标记化合物

Cat.No: TMIH-0260

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