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Search Results for " hdac in 7 "

Targets Recommended: HDAC

10

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2025	HDAC-IN-7 HBI-8000,西达本胺杂质,CS055,Chidamide impurity	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-7 (HBI-8000) 是 Chidamide 的一种杂质。Chidamide 是一种可口服的 HDAC 酶 I 类 HDAC1/2/3 和 IIb 类 HDAC10 抑制剂。
T82227	HDAC1/CDK7-IN-1	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC1/CDK7-IN-1（compound 8e）是一款针对CDK7和HDAC1的双重抑制剂，其IC50值分别为893 nM 和248 nM 。该化合物能有效抑制MDA-MB-231、MCF-7、A549及HCT-116等多种癌细胞系的生长。此外，HDAC1/CDK7-IN-1在HCT-116细胞中诱发了细胞周期阻滞与凋亡（apoptosis）现象，并能够抑制其细胞迁移能力。
T14947	CHDI-390576	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CHDI-390576 是一种具有中枢神经系统渗透性、选择性和高效性的二苯甲酰异羟肟酸 IIa 类组蛋白脱乙酰酶(HDAC) 抑制剂，抑制 IIa 类 HDAC 4、HDAC 5、HDAC 7、HDAC 9 ，可用于研究癌症。
T6865	Quisinostat dihydrochloride Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。
T61510	PIM-1/HDAC-IN-1	Others	Others
	PIM-1/HDAC-IN-1 (compound 4d) is a potent inhibitor of PIM-1, with an IC 50 of 343.87 nM. It also exhibits strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC 50 values of 63.65 and 62.39 nM, respectively. Furthermore, PIM-1/HDAC-IN-1 demonstrates apoptosis-inducing potential in MCF-7 cell lines, specifically inducing pre-G1 apoptosis and causing cell cycle arrest at the G2/M phase [1].
T81974	KPZ560	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	KPZ560作为HDAC1和HDAC2的有效抑制剂，在IC50数值上分别达到12 nM 和68 nM 。此化合物能提升小鼠颗粒神经元树突的棘密度，同时也能抑制MCF乳腺癌细胞系的生长。
T74783	HDAC-IN-53	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-53是一种口服活性的选择性HDAC1-3抑制剂，其IC50分别为47 nM、125 nM和450 nM。该化合物不针对II类HDAC(HDAC4、5、6、7、9；IC50>10 μM)展现抑制作用。HDAC-IN-53能够诱导caspase依赖的细胞凋亡并在裸鼠中显著抑制人肿瘤异种移植物生长，同时抑制携带MC38结肠癌的免疫活性小鼠的肿瘤发展。
T79674	HDAC-IN-64	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-64 (Compound 13) 为HDAC抑制剂，对HDAC4/6的IC50值为24 nM及85 nM。其对前列腺癌（PCA）细胞表现出抗增殖与抗迁移效果，并能抑制LNCaP和RWPE-1细胞的生长，GI50值分别达到0.32 μM与1.1 μM。
T36110	L-Pyrohomoglutamic Acid	Others	Others
	L-Pyrohomoglutamic acid is an amino acid building block.1,2It has been used in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors. 1.Pomplun, S., Wang, Y., Kirschner, A., et al.Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)Angew. Chem. Int. Ed.54(1)345-348(2015) 2.Taddei, M., Cini, E., Giannotti, L., et al.Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors...
T79713	JMJD3/HDAC-IN-1	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	JMJD3/HDAC-IN-1 (compound A5b) 是靶向 JMJD3 和 HDAC1（IC50=16 nM）的双重抑制剂。它能够促进 H3K27 高甲基化和 H3K9 高乙酰化，并通过裂解 caspase-7 和 PARP 导致细胞凋亡。此外，JMJD3/HDAC-IN-1 对抑制癌细胞克隆形成、迁移和侵袭也表现出有效性。

化合物

Cat.No: T2025

Synonym: HBI-8000,西达本胺杂质,CS055,Chidamide impurity

Target: HDAC

HDAC1/CDK7-IN-1

Cat.No: T82227

Target: HDAC

Cat.No: T14947

Target: HDAC

Quisinostat dihydrochloride

Cat.No: T6865

Synonym: Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl

Target: Apoptosis, HDAC, Autophagy

PIM-1/HDAC-IN-1

Cat.No: T61510

Target: Others

Cat.No: T81974

Target: HDAC

Cat.No: T74783

Target: HDAC

Cat.No: T79674

Target: HDAC

L-Pyrohomoglutamic Acid

Cat.No: T36110

Target: Others

JMJD3/HDAC-IN-1

Cat.No: T79713

Target: HDAC

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01475	HDAC7 Protein, Human, Recombinant (His)	Human	E. coli
	N/A. HDAC7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26 kDa and the accession number is Q8WUI4 (BC064840).
TMPY-06036	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) FGFR-1,FLG,CD331,HH2,FLT2,KAL2,FGFBR,HBGFR,CEK,HRTFDS,fibrob...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7.
TMPK-00828	Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc) PEMT,Episialin,Mucin1,PUM,KL-6,MUC-1,Muc	Human	HEK293 Cells
	MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers.
TMPK-00392	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) CD331,FGFR-1,FLT-2,BFGFR,N-sam,FGFR1 β (IIIc),bFGF-R-1	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession numb...
TMPK-01371	IGFBP-7 Protein, Human, Recombinant (hFc) RAMSVPS,TAF,IGFBPRP1,AGM,IBP7,MAC25,IGFBP-7	Human	HEK293 Cells
	IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. IGFBP-7 Protein, Human, Recombinant (hFc) is expres...
TMPK-00394	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated FGFR1 β (IIIc),N-sam,FLT-2,BFGFR,bFGF-R-1,CD331,FGFR-1	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the ...
TMPY-06035	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) KAL2,OGD,N-SAM,CEK,FLT2,HH2,FLG,CD331,BFGFR,HBGFR,FLT-2,FGFB...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7.
TMPK-00395	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated FGF R1a,FGFR1 α,FGFR1 alpha,FGFR1 α (IIIc)	Human	HEK293 Cells
	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
TMPK-00393	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) FGFR1 α,FGFR1 alpha,FGF R1a,FGFR1 α (IIIc)	Human	HEK293 Cells
	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.

重组蛋白

HDAC7 Protein, Human, Recombinant (His)

Cat.No: TMPH-01475

Species: Human

Expression System: E. coli

FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)

Cat.No: TMPY-06036

Species: Human

Expression System: HEK293 Cells

Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00828

Species: Human

Expression System: HEK293 Cells

FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00392

Species: Human

Expression System: HEK293 Cells

IGFBP-7 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01371

Species: Human

Expression System: HEK293 Cells

FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00394

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)

Cat.No: TMPY-06035

Species: Human

Expression System: HEK293 Cells

FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00395

Species: Human

Expression System: HEK293 Cells

FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00393

Species: Human

Expression System: HEK293 Cells

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