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Search Results for " hcv "

Targets Recommended: HCV Protease HCV Protease

243

抑制剂 & 化合物

23

天然产物

14

重组蛋白

5

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9577	HCV-IN-31	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	HCV-IN-31 是一种HCV 抑制剂，EC50/EC95值为15.7 μM。
T11541	HCV-IN-30	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	HCV-IN-30 是 HCV NS5A 复制复合物的抑制剂（基因型 1a 和 1b 复制子的 IC50 = 901 和 102 nM）。
T11539	HCV-IN-29	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	HCV-IN-29 是一种丙型肝炎病毒抑制剂。
TQ0090	Nesbuvir HCV-796	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Nesbuvir 是一种选择性丙型肝炎病毒（HCV）非结构蛋白5B（NS5B）RNA 依赖性聚合酶抑制剂。Nesbuvir 对含1b HCV 复制子的肝癌细胞的 IC50为9nM。
T32050	HCV-371 HCV 371	Others	Others
	HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase γ and other unrelated viral polymerase
T27530	HCV-086 HCV086	Others	Others
	HCV-086, a RNA-directed RNA polymerase (NS5B) inhibitor, is used for the treatment of HCV infection.
T11540	HCV-IN-3	Others	Others
	HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor (IC50: 20 μM; Kd: 29 μM).
T11548	HCV-IN-7	Others	Others
	HCV-IN-7 is an orally active and potent pan-genotypic HCV NS5A inhibitor (IC50s: 3-47 pM). It shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake.
TP1468	HCV-IN-4
	HCV-IN-4, a potent and orally active inhibitor of HCV NS5A, demonstrates significant efficacy against genotypes GT1a, GT2b, GT3a, and the GT1a mutations Y93H and L31V. Its half-maximal effective concentrations (EC90s) are 3 pM, 0.3 nM, 0.01 nM, 0.5 nM, and 0.02 nM, respectively[1].
T11548L	HCV-IN-7 hydrochloride	Others	Others
	HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor (IC50s: 3-47 pM). It shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake.
T79626	HCV-IN-44	Others	Others
	HCV-IN-44（化合物28）为一种针对HCVNS5B蛋白的抑制剂，能够有效阻止丙型肝炎病毒（HCV）的复制。此化合物主要应用于HCV感染的相关研究。
T63407	HCV-IN-36	Others	Others
	HCV-IN-36 是口服具有活力的HCV 进入抑制剂，表现出良好的抗病毒作用 (EC50: 0.016 μM, CC50: 8.78 μM)。
T63566	HCV-IN-33	Others	Others
	HCV-IN-33 (Compound (S)-3i) 是 HCV 进入抑制剂。
T63567	HCV-IN-34	Others	Others
	HCV-IN-34 是口服具有活力的 HCV 进入抑制剂。HCV-IN-35 表现出良好的抗病毒效果 (EC50: 0.010 μM, CC50: 7.50 μM)。
T63406	HCV-IN-35	Others	Others
	HCV-IN-35 是 HCV 的有效抑制剂，表现出潜力进行感染性疾病的研究。
T64202	HCV-IN-40	Others	Others
	HCV-IN-39 (Compound 18a) 是一种有效的、口服具有活力的 hepatitis C virus (HCV) 核苷抑制剂，能够作用于 GT1a 复制子 (EC50: 0.259 μM)、GT1b 复制子 (EC50: 0.434 μM) 和 GT1b CES1 复制子 (EC50: 0.069 μM)。
T79625	HCV-IN-43	Others	Others
	HCV-IN-43（化合物2）为HCVNS5B蛋白抑制剂，有效抑制丙型肝炎病毒（HCV）复制，适用于HCV感染研究。
T63585	HCV-IN-37	Others	Others
	HCV-IN-37 是 HCV 的有效抑制剂。HCV-IN-37 以 15 mg/kg 的单剂量对大鼠口服给药后，能够在大鼠血浆中持久存在。活性衍生物 HCV-IN-37 的高效力主要是由对病毒进入阶段的抑制作用驱动。
T63396	HCV-IN-38	Others	Others
	HCV-IN-38 是选择性的、有效的、口服具有活力的丙型肝炎病毒 (HCV) 抑制剂，其EC50值为15 nM，SI 值为431。HCV-IN-38 具有良好的安全性及口服药代动力学，表现出较高的抗HCV 活性和较低的细胞毒性作用。
T74625	HCV-IN-41	Others	Others
	HCV-IN-41 (compound 4) 是一种高效的丙肝病毒 (HCV)抑制剂，对 HCV1b、2a、3a 和 4a 的 EC50分别为 0.006762 nM、5.183 nM、1.365 nM 和 142.2 nM。HCV-IN-41 能降低 HCVRNA 的复制。
T76518	HCV Peptide (131-140)
	HCVPeptide (131-140) 是一种肽。HCVPeptide (131-140) 可用于丙型肝炎病毒（HCV）的研究。
T3489	Dasabuvir ABT-333,达塞布韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Dasabuvir (ABT-333) 是丙型肝炎病毒非结构蛋白 5B 的非核苷抑制剂，是一种 RNA 依赖性 RNA 聚合酶，具有抗 HCV 的潜在活性。
T76520	HCV Peptide (257-266)
	HCVPeptide (257-266) 是一种肽。HCVPeptide (257-266) 可用于丙型肝炎病毒（HCV）的研究。
T76519	HCV Peptide (35-44)
	HCVPeptide (35-44)为HCV核心蛋白的35至44位段，具有HLA-A2限制性CTL表位功能。该肽段通过KIR2DL2/3直接抑制NK细胞活性，以及协同CD94:NKG2A受体抑制NK细胞活性。
T38237	2′-O-Methylcytidine	Nucleoside Antimetabolite/Analog; HCV Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	2'-O-Methylcytidine 是 2'-代核苷，可抑制 HCV 复制。它在体外抑制 NS5B 催化的 RNA 合成，其抑制方式是与底物核苷三磷酸竞争。
T5126	Glecaprevir ABT-493	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Glecaprevir (ABT-493) 是一种新型的 HCV NS3/4A 蛋白酶抑制剂，其 IC50值在 3.5 和 11.3 nM 之间。它也是 SARS-CoV 3CLpro 的抑制剂，IC50为 4.09 μM。
T76522	HCV Core Protein (59-68)
	HCVCore Protein (59-68) 是一种含有 HCV 核心蛋白 59-68 残基的肽。
T4197	HZ-1157 HZ1157,DHFR-inhibitor	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	HZ-1157 (DHFR-inhibitor) 是一种丙型肝炎病毒抑制剂，对 HCV NS3/4A 蛋白酶具有抑制活性。
T19862	Voxilaprevir 维昔普维,伏西瑞韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Voxilaprevir 是丙型肝炎病毒非结构蛋白 3/4A 蛋白酶的抑制剂，具有抗病毒活性。它抑制基因型 1b 和 3a 野生型 NS3 蛋白酶的 Ki 值分别为 0.038 nM 和 0.066 nM。
T76523	HCV Core Protein (107-114)
	HCVCore Protein (107-114) 是主要线性 HCV 核心区域中免疫原性极低的残基。HCVCore Protein (107-114) 被鉴定为 101-118 区域内的结合位点，其包含基因型 Ⅰ/Ⅱ 和基因型 Ⅲ/Ⅵ 之间不同的两个残基。HCVCore Protein (107-114) 可能是传播 HCV 血清型的潜在位点。
T1822	Clemizole 克立咪唑,吡咯咪唑	HCV Protease; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Clemizole 是一种 H1 组胺受体拮抗剂，可抑制 NS4B 的 RNA 结合和丙型肝炎病毒复制。它也是TRP5通道抑制剂。
T4547	Grazoprevir MK-5172	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Grazoprevir (MK-5172) 是一种丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂，具有跨基因型和耐药变体的广泛活性，对 gt1b、gt1a、gt2a、gt2b 和 gt3a 的Ki 分别为 0.01 nM、0.01 nM、0.08 nM、0.15 nM 和 0.90 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T17190	U18666A	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	U18666A 是一种细胞渗透性药物，是一种胆固醇合成和转运抑制剂，抑制埃博拉病毒，登革热病毒和人类丙型肝炎病毒的复制。
T5938	4-Phenoxybenzylamine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	4-Phenoxybenzylamine 通过稳定无活性构象来抑制NS3蛋白的功能，对 HCV NS3/4a 的 IC50 约为 500 μM。
T4474	Asunaprevir BMS-650032,阿那匹韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Asunaprevir (BMS-650032) 是一种有口服活性的 HCV NS3 蛋白酶抑制剂，IC50值为 0.2 nM-3.5 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T1822L	Clemizole hydrochloride 克立咪唑盐酸,盐酸克立咪唑	HCV Protease; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Clemizole hydrochloride 是一种 TRPC5通道的抑制剂。它还是一种 H1 组胺受体拮抗剂，抑制 HCV 复制。
T76514	HCV-1 e2 Protein (554-569)
	HCV-1 e2 Protein (554-569) 是一段重要的丙型肝炎病毒(HCV) e2 蛋白的抗原区域，具有一个推定的 N-糖基化位点，这个位点被认为之前影响了e2蛋白的免疫识别。
T76516	HCV-1 e2 Protein (484-499)
	HCV-1 e2 蛋白 (484-499) 是由 16 个氨基酸组成的肽。 HCV-1 e2 蛋白 (484-499) 来源于具有 HCV 抗体的个体血清中丙型肝炎病毒的包膜 2 蛋白。
T76521	HCV NS4A Protein (18-40) (JT strain)
	HCVNS4A Protein (18-40) (JT strain) 为HCVNS4A 肽，由第18至40个NS4A蛋白残基构成，能够增强NS3蛋白酶的催化效率。
T22394	Paritaprevir ABT450,ABT-450,帕利普韦,Veruprevir	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Paritaprevir (ABT450) 是一种非结构蛋白 3/4A 蛋白酶抑制剂，对 HCV 1a 和 HCV 1b 的 EC50 值分别为 1 和 0.21 nM。它也是SARS-CoV 3CLpro 的抑制剂，IC50为 1.31 μM。
T15573	Inarigivir soproxil SB9200	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Inarigivir soproxil (SB9200) 是一种先天免疫激动剂。它还显示出针对耐药丙型肝炎病毒 (HCV) 变体的有效抗病毒活性。在基因型 1 HCV 复制子系统细胞中， HCV 1a/1b 的 EC50 为 2.2 和 1.0 μM。
T4988	Boceprevir SCH 503034,EBP 520,波普瑞韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Boceprevir (SCH 503034) 是一种口服有效的选择性 HCV NS3 蛋白酶抑制剂。在酶试验中的 Ki 为 14 nM，在基于细胞的复制子试验中 EC90 为 350 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T25268L	Coblopasvir dihydrochloride Coblopasvir dihydrochloride(1312608-46-0 Free base)	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Coblopasvir dihydrochloride 是一种泛基因型非结构蛋白 5A(NS5A)抑制剂。本品可用于慢性丙型肝炎病毒感染的研究。
T16088	MK-0608	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	MK-0608 是一种可口服的体外 HCV 复制抑制剂。在亚基因组复制子测定中，EC50值为 0.3 μM，EC90值为 1.3 μM。
T80089	HCV-1 e2 Protein (554-569) (TFA)
	HCV-1 e2 Protein (554-569) TFA 为丙型肝炎病毒（HCV）e2 蛋白关键抗原区段，含一个假定 N-糖基化位点，该位点早先推测会影响 e2 蛋白的免疫识别。
T9567	Samatasvir ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Samatasvir (ATOLIHZIXHZSBA-BTSKBWHGSA-N) 是 NS5A HCV 复制抑制剂。它能够有效的选择复制子及感染性 HCV，在基因型 1至5 复制子中，EC50= 2~24 pM。
T6190	Telaprevir VX-950,LY-570310,Incivek,MP-424,特拉匹韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Telaprevir (Incivek) 是一种选择性可逆的HCV NS3-4A 蛋白酶抑制剂，作用于基因 1型 (H 株) NS3 蛋白酶结构域和 NS4A 辅因子肽，Ki 为 7 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T4544	Elbasvir MK-8742	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Elbasvir (MK-8742) 是丙型肝炎病毒的非结构蛋白 5A 抑制剂，可用于治疗慢性 HCV 感染。
T1565	Deferiprone 去铁酮,Deferidone,CP20	Others; HCV Protease; Ferroptosis; UGT	Apoptosis; Metabolism; Microbiology/Virology; Others; Proteases/Proteasome
	Deferiprone (Deferidone) 是口服活性铁螯合剂，可研究地中海贫血中的输血性铁过载。
T0013	Mecarbinate 优多降,Dimecarbine,Dimecarbin,美卡比酯	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Mecarbinate 是一种吲哚衍生物，具有抗 HCV 活性和免疫调节作用。

化合物

Cat.No: T9577

Target: HCV Protease

Cat.No: T11541

Target: Others, HCV Protease

Cat.No: T11539

Target: HCV Protease

Cat.No: TQ0090

Synonym: HCV-796

Target: HCV Protease

Cat.No: T32050

Synonym: HCV 371

Target: Others

Cat.No: T27530

Synonym: HCV086

Target: Others

Cat.No: T11540

Target: Others

Cat.No: T11548

Target: Others

Cat.No: TP1468

HCV-IN-7 hydrochloride

Cat.No: T11548L

Target: Others

Cat.No: T79626

Target: Others

Cat.No: T63407

Target: Others

Cat.No: T63566

Target: Others

Cat.No: T63567

Target: Others

Cat.No: T63406

Target: Others

Cat.No: T64202

Target: Others

Cat.No: T79625

Target: Others

Cat.No: T63585

Target: Others

Cat.No: T63396

Target: Others

Cat.No: T74625

Target: Others

HCV Peptide (131-140)

Cat.No: T76518

Cat.No: T3489

Synonym: ABT-333,达塞布韦

Target: HCV Protease

HCV Peptide (257-266)

Cat.No: T76520

HCV Peptide (35-44)

Cat.No: T76519

2′-O-Methylcytidine

Cat.No: T38237

Target: Nucleoside Antimetabolite/Analog, HCV Protease

Cat.No: T5126

Synonym: ABT-493

Target: HCV Protease, SARS-CoV

HCV Core Protein (59-68)

Cat.No: T76522

Cat.No: T4197

Synonym: HZ1157,DHFR-inhibitor

Target: HCV Protease

Cat.No: T19862

Synonym: 维昔普维,伏西瑞韦

Target: HCV Protease

HCV Core Protein (107-114)

Cat.No: T76523

Cat.No: T1822

Synonym: 克立咪唑,吡咯咪唑

Target: HCV Protease, Histamine Receptor

Cat.No: T4547

Synonym: MK-5172

Target: HCV Protease, SARS-CoV

Cat.No: T17190

Target: Others, HCV Protease

4-Phenoxybenzylamine

Cat.No: T5938

Target: HCV Protease

Cat.No: T4474

Synonym: BMS-650032,阿那匹韦

Target: HCV Protease, SARS-CoV

Clemizole hydrochloride

Cat.No: T1822L

Synonym: 克立咪唑盐酸,盐酸克立咪唑

Target: HCV Protease, Histamine Receptor

HCV-1 e2 Protein (554-569)

Cat.No: T76514

HCV-1 e2 Protein (484-499)

Cat.No: T76516

HCV NS4A Protein (18-40) (JT strain)

Cat.No: T76521

Cat.No: T22394

Synonym: ABT450,ABT-450,帕利普韦,Veruprevir

Target: HCV Protease

Inarigivir soproxil

Cat.No: T15573

Synonym: SB9200

Target: HCV Protease

Cat.No: T4988

Synonym: SCH 503034,EBP 520,波普瑞韦

Target: HCV Protease, SARS-CoV

Coblopasvir dihydrochloride

Cat.No: T25268L

Synonym: Coblopasvir dihydrochloride(1312608-46-0 Free base)

Target: HCV Protease

Cat.No: T16088

Target: HCV Protease

HCV-1 e2 Protein (554-569) (TFA)

Cat.No: T80089

Cat.No: T9567

Synonym: ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719

Target: HCV Protease

Cat.No: T6190

Synonym: VX-950,LY-570310,Incivek,MP-424,特拉匹韦

Target: HCV Protease, SARS-CoV

Cat.No: T4544

Synonym: MK-8742

Target: HCV Protease

Cat.No: T1565

Synonym: 去铁酮,Deferidone,CP20

Target: Others, HCV Protease, Ferroptosis, UGT

Cat.No: T0013

Synonym: 优多降,Dimecarbine,Dimecarbin,美卡比酯

Target: HCV Protease

Cat. No.	Product Name	Target	Signaling Pathways
T5S1598	Mulberroside C 桑皮苷 C,桑皮苷C	Antioxidant; HCV Protease	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Mulberroside C 是桑树中的主要生物活性成分之一，可抑制 HCV 复制，具有抗病毒活性。
T2770	Gentiopicroside Gentiopicrin,龙胆苦甙,龙胆苦苷	P450; HCV Protease	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Gentiopicroside (Gentiopicrin) 是天然环烯醚萜苷，具有抗炎和抗氧化活性。它抑制P450的活性，对 CYP2A6 的 IC50和 Ki 值分别为 61 µM 和 22.8 µM，
T3810	Saikosaponin B2 柴胡皂苷 B2,柴胡皂甙 B2	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Saikosaponin B2 是从柴胡根中分离得到的一种活性成分，可抑制 HCV 病毒感染的侵入，有抗癌作用。
TN2089	Platycodin D3 桔梗皂苷D3,桔梗皂苷 D3	HCV Protease; NF-κB	Microbiology/Virology; NF-κB; Proteases/Proteasome
	Platycodin D3 是桔梗中有抗HCV 活性的一种三萜皂苷类天然产物。
T3001	Honokiol 和厚朴酚,NSC 293100	ERK; HCV Protease; MEK; Akt; Autophagy	Autophagy; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Honokiol (NSC-293100) 是厚朴提取物的活性成分，靶向多种信号分子，具有抗氧化，抗炎，抗血管生成和抗癌活性。它可抑制 Akt 的激活并增强 ERK1/ERK2 的磷酸化。
T7607	PSI-6130 R 1656,2'-去氧-2'-氟-2'-C-甲基胞苷	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	PSI-6130 (R 1656) 是高效选择性 HCV NS5B 聚合酶抑制剂，抑制 HCV 复制，IC50值为 0.6 μM。
T3821	Deapioplatycodin D Deapi-platycodin D,去芹糖桔梗皂苷 D,去芹糖桔梗皂苷D,DesapioplatycodinD	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Deapioplatycodin D 是从桔梗中分离出的一种三萜皂苷，具有抗丙型肝炎病毒活性。
TN6732	Oenothein B	Apoptosis; HCV Protease; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Oenothein B 是一种聚（ADP-核糖）糖水解酶的特异性抑制剂。 Oenothein B 具有抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。
T0392	Artemisinin Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,青蒿素,Artemisinine	HCV Protease; Ferroptosis; Akt; Parasite	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Artemisinin (Qinghaosu) 是一种倍半萜烯内酯，是从青蒿植物的地上部分分离的一种抗疟疾药物。它有神经保护和抗癌作用。
T1188	Mizoribine Bredinin,NSC 289637,咪唑立宾,HE 69	HCV Protease; SARS-CoV; Tyrosinase	Microbiology/Virology; Proteases/Proteasome
	Mizoribine (NSC-289637) 是一种免疫抑制剂，抑制HCVRNA 复制，有抗 HCV 活性，IC50约为 100 μM。它抑制SARS-CoV 复制，对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50分别为 3.5 μg/mL 和 16 μg/mL。
T7203	Oglufanide 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH	VEGFR; HCV Protease; Endogenous Metabolite	Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂，可抑制血管内皮生长因子，可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。
TN1033	Sennidin A	HCV Protease; transporter; Akt; PI3K	Cytoskeletal Signaling; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Sennidin A 是从狭叶番泻分离得到的一种天然产物，能够抑制 HCV NS3 解旋酶，其 IC50值为0.8 μM。它诱导 Akt 和葡萄糖转运蛋白4的磷酸化，刺激葡萄糖掺入。
TN1034	Sennidin B	HCV Protease; transporter; Akt; PI3K	Cytoskeletal Signaling; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Sennidin B 是从Cassia angustifolia 分离得到的Sennidin A 异构体，它刺激葡萄糖掺入，诱导Akt 和葡萄糖转运蛋白4 的磷酸化。
TN7356	THCVA-A Δ1-Tetrahydrocannabivarinic A	Others	Others
	THCVA-A is a natural product and can be used as a standard reference.
T38375	Pseudane IX 2-nonyl-4-hydroxyquinoline,2-nonyl-1H-quinolin-4-one,2-nonyl-4(1h)-quinolone	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Pseudane IX (2-nonyl-1H-quinolin-4-one) 可减少丙型肝炎病毒 (HCV) 对 Huh 7.5 细胞的感染，IC50 为 1.4 μg/ml。
T16165	Myriocin ISP-I,Thermozymocidin	HCV Protease; Antifungal	Microbiology/Virology; Proteases/Proteasome
	Myriocin (Thermozymocidin) 是一种从 Myriococcum albomyces 中得到的代谢产物，是一种丝氨酸-棕榈酰转移酶 (SPT) 抑制剂,具有潜在的抗肿瘤抗癌和抗寄生虫活性，通过 PI3K/Akt/mTOR 通路调节巨噬细胞极化和功能来抑制肿瘤生长。Myriocin 抑制 HCV 感染，可用于研究神经病变和真菌感染。
T2774	Lycorine hydrochloride 石蒜碱,Licorine hydrochloride,Galanthidine hydrochloride,Narcissine hydrochloride,Lycorine chloride,Amarylline hydrochloride,盐酸石蒜碱	Virus Protease; HCV Protease; Antibacterial; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Lycorine hydrochloride (Narcissine hydrochloride) 是黑色素瘤血管生成抑制剂，是一种来自石蒜的主要活性成分，抑制 Hey1B 细胞的有丝分裂增殖，IC50值为 1.2 μM，具有抗肿瘤活性。
TN6508	Trachelogenin (-)-Trachelogenin	Virus Protease; c-Myc; HCV Protease; Wnt/beta-catenin	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	Trachelogenin ((-)-Trachelogenin) 分离自Combretum fruticosum，是一种 HCV 进入抑制剂具有抗增殖作用，其机制与影响β-Catenin 信号通路中的 β-Catenin、c-Myc 和 GSK3 等关键蛋白的磷酸化有关，且呈浓度依赖性。Trachelogenin具有抗病毒、抗炎和镇痛活性，在 HCVcc 和 HCVpp 模型中的 IC50 分别为 0.325 和 0.259 μg/mL。
TN1138	γ-Fagarine γ-崖椒碱,gamma-Fagarine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug/ml, respectively. It has sister chromatid exchanges (SCEs)-inducing activity
TN3809	Dehydrojuncusol	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is active against resistant HCV variants frequently found in patients with treatment failure.
TN5079	Sulochrin	HCV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparent cytotoxicity up to 50 uM. Sulochrin has an inhibitory activity to eosinophil degranulation.
TN4404	Ladanein	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins.Ladanein possesses free radicals DPPH and ABTS +.scavenging activity, it also displays moderate (20-40 microM) activities against K562, K562R (imatinib-resistant), and 697 human leukemia cell lines.
TN3438	Arborinine	HCV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC50 values being 6.4 ± 0.7 ug/ml. Arborinine shows antifeedant activity against Spodoptera frugiperda. Arborinin shows

天然产物

Cat.No: T5S1598

Synonym: 桑皮苷 C,桑皮苷C

Target: Antioxidant, HCV Protease

Gentiopicroside

Cat.No: T2770

Synonym: Gentiopicrin,龙胆苦甙,龙胆苦苷

Target: P450, HCV Protease

Saikosaponin B2

Cat.No: T3810

Synonym: 柴胡皂苷 B2,柴胡皂甙 B2

Target: Others, HCV Protease

Cat.No: TN2089

Synonym: 桔梗皂苷D3,桔梗皂苷 D3

Target: HCV Protease, NF-κB

Cat.No: T3001

Synonym: 和厚朴酚,NSC 293100

Target: ERK, HCV Protease, MEK, Akt, Autophagy

Cat.No: T7607

Synonym: R 1656,2'-去氧-2'-氟-2'-C-甲基胞苷

Target: HCV Protease

Deapioplatycodin D

Cat.No: T3821

Synonym: Deapi-platycodin D,去芹糖桔梗皂苷 D,去芹糖桔梗皂苷D,DesapioplatycodinD

Target: Others, HCV Protease

Cat.No: TN6732

Target: Apoptosis, HCV Protease, Antibacterial, Antifungal

Cat.No: T0392

Synonym: Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,青蒿素,Artemisinine

Target: HCV Protease, Ferroptosis, Akt, Parasite

Cat.No: T1188

Synonym: Bredinin,NSC 289637,咪唑立宾,HE 69

Target: HCV Protease, SARS-CoV, Tyrosinase

Cat.No: T7203

Synonym: 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH

Target: VEGFR, HCV Protease, Endogenous Metabolite

Cat.No: TN1033

Target: HCV Protease, transporter, Akt, PI3K

Cat.No: TN1034

Target: HCV Protease, transporter, Akt, PI3K

Cat.No: TN7356

Synonym: Δ1-Tetrahydrocannabivarinic A

Target: Others

Cat.No: T38375

Synonym: 2-nonyl-4-hydroxyquinoline,2-nonyl-1H-quinolin-4-one,2-nonyl-4(1h)-quinolone

Target: HCV Protease

Cat.No: T16165

Synonym: ISP-I,Thermozymocidin

Target: HCV Protease, Antifungal

Lycorine hydrochloride

Cat.No: T2774

Synonym: 石蒜碱,Licorine hydrochloride,Galanthidine hydrochloride,Narcissine hydrochloride,Lycorine chloride,Amarylline hydrochloride,盐酸石蒜碱

Target: Virus Protease, HCV Protease, Antibacterial, Autophagy

Cat.No: TN6508

Synonym: (-)-Trachelogenin

Target: Virus Protease, c-Myc, HCV Protease, Wnt/beta-catenin

Cat.No: TN1138

Synonym: γ-崖椒碱,gamma-Fagarine

Target: HCV Protease

Dehydrojuncusol

Cat.No: TN3809

Target: HCV Protease

Cat.No: TN5079

Target: HCV Protease, Antifection

Cat.No: TN4404

Target: HCV Protease

Cat.No: TN3438

Target: HCV Protease, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01564	Hepatitis C virus (HCV-1a) E2 Protein (His) HCV-1a E2	HCV	HEK293 Cells
	Hepatitis C virus (HCV-1a) E2 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32 kDa and the accession number is NP_751921.1.
TMPY-04135	Hepatitis C virus Envelope Glycoprotein E1/HCV-E1 (subtype 1b, strain HC-J4) Protein (His) HCV-E1	HCV	HEK293 Cells
	Hepatitis C virus Envelope Glycoprotein E1/HCV-E1 (subtype 1b, strain HC-J4) Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.7 kDa and the accession number is AAC15725.1.
TMPY-00296	Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His) HCV-1a E2	HCV	HEK293 Cells
	Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.2 kDa and the accession number is BAA03581.1.
TMPY-05166	Hepatitis C virus (HCV) (serotype 1b, isolate HC-J4) Envelope/E2 Protein (His) HCV-1a E2	HCV	HEK293 Cells
	Hepatitis C virus (HCV) (serotype 1b, isolate HC-J4) Envelope/E2 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.4 kDa and the accession number is AAC15723.1.
TMPY-00323	Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST) NS3	HCV	E. coli
	HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t...
TMPJ-01273	ACY3 Protein, Human, Recombinant (His) Acylase III,Aminoacylase-3,ACY3,Hepatitis C virus core-bindi...	Human	E. coli
	Aspartoacylase 3, also known as ACY3, N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), Acylase III, Aminoacylase-3, Aspartoacylase-2, Aspartoacylase-2, HCV core-binding protein 1 and ASPA2, is a member of the Aspartoacylase subfamily. ACY3 plays an important role in deacetylating mercapturic acids in kidney proximal tubules and acts on N-acetyl-aromatic amino acids.ACY3 is located in the cytoplasm of S2 and S3 proximal tubules and the apical domain of S1 proximal tubules. ACY3 ...
TMPY-02285	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS2 Protein NS2 Protein	H1N1	E. coli
	Non-structural protein 2 (NS2) plays a crucial role in the hepatitis C virus (HCV) assembly. NS2 was predicted to be composed of three transmembrane (TM) segments. Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage but also for infectious virus production.NS2 protein is essential for hepatitis C virus (HCV) replication. NS2 protein was expressed and purified. Aptamers against NS2 protein were raised and ant...
TMPH-01548	IFI6 Protein, Human, Recombinant (B2M & His) Interferon-induced protein 6-16,IFI6,Interferon alpha-induci...	Human	E. coli
	Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells.
TMPH-01104	Claudin-9 Protein-VLP, Human, Recombinant (His) CLDN9,Claudin-9	Human	HEK293 Cells
	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. Claudin-9 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 24.2 kDa and the accession number is O95484.
TMPH-00848	OASL Protein, Human, Recombinant (His) 59 kDa 2'-5'-oligoadenylate synthase-like protein,Thyroid re...	Human	E. coli
	Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. OASL Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 65.1 kDa and the accession number is Q15646.
TMPH-01248	ADAR Protein, Human, Recombinant (His & SUMO) ADAR1,IFI-4,136 kDa double-stranded RNA-binding protein,Inte...	Human	E. coli
	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences duri...
TMPH-00809	Hepatitis C Genome polyprotein (His) Genome polyprotein	HCV	E. coli
	Hepatitis C Genome polyprotein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 71.3 kDa and the accession number is S4UAW6.
TMPJ-01330	CD299 Protein, Human, Recombinant (His & Flag) DC-SIGNR,L-SIGN,CD299,CD209L,LSIGN,C-type lectin domain fami...	Human	HEK293 Cells
	CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysoso...
TMPY-02193	GOLPH2/GOLM1 Protein, Human, Recombinant (His) HEL46,PSEC0257,GOLPH2,bA379P1.3,C9orf155,GP73,golgi membrane...	Human	HEK293 Cells
	Golgi membrane protein 1, also known as Golgi membrane protein GP73, Golgi phosphoprotein 2, and GOLM1, is a protein that belongs to the GOLM1 / CASC4 family. GOLM1 is widely expressed. It is highly expressed in the colon, prostate, trachea, and stomach. It is expressed at a lower level in testis, muscle, lymphoid tissues, white blood cells, and spleen. It is predominantly expressed by cells of the epithelial lineage. GOLM1 is expressed at a low level in the normal liver. Expression significantl...

重组蛋白

Hepatitis C virus (HCV-1a) E2 Protein (His)

Cat.No: TMPY-01564

Species: HCV

Expression System: HEK293 Cells

Hepatitis C virus Envelope Glycoprotein E1/HCV-E1 (subtype 1b, strain HC-J4) Protein (His)

Cat.No: TMPY-04135

Species: HCV

Expression System: HEK293 Cells

Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His)

Cat.No: TMPY-00296

Species: HCV

Expression System: HEK293 Cells

Hepatitis C virus (HCV) (serotype 1b, isolate HC-J4) Envelope/E2 Protein (His)

Cat.No: TMPY-05166

Species: HCV

Expression System: HEK293 Cells

Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)

Cat.No: TMPY-00323

Species: HCV

Expression System: E. coli

ACY3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01273

Species: Human

Expression System: E. coli

Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS2 Protein

Cat.No: TMPY-02285

Species: H1N1

Expression System: E. coli

IFI6 Protein, Human, Recombinant (B2M & His)

Cat.No: TMPH-01548

Species: Human

Expression System: E. coli

Claudin-9 Protein-VLP, Human, Recombinant (His)

Cat.No: TMPH-01104

Species: Human

Expression System: HEK293 Cells

OASL Protein, Human, Recombinant (His)

Cat.No: TMPH-00848

Species: Human

Expression System: E. coli

ADAR Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01248

Species: Human

Expression System: E. coli

Hepatitis C Genome polyprotein (His)

Cat.No: TMPH-00809

Species: HCV

Expression System: E. coli

CD299 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-01330

Species: Human

Expression System: HEK293 Cells

GOLPH2/GOLM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02193

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T12955	Sofosbuvir D6 PSI-7977 D6,GS-7977 D6	Others	Others
	Sofosbuvir D6 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
T26871	BMT-052 BMT052
	BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).
T12571	PSI-6206 13C,d3 Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3	Others	Others
	PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is a potent and selective HCV NS5B polymerase inhibitor.
TMIH-0524	Sofosbuvir-13C-d3
	Sofosbuvir-13C-d3 是 Sofosbuvir 的 13C 和氘代化合物。Sofosbuvir 的 CAS 号为 1190307-88-0。Sofosbuvir 是一种丙型肝炎病毒聚合酶 NS5B 的尿苷单磷酸类似物抑制剂，用作治疗慢性丙型肝炎的抗病毒剂。
T38297	Ribavirin-13C5 Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...

同位素标记化合物

Cat.No: T12955

Synonym: PSI-7977 D6,GS-7977 D6

Target: Others

Cat.No: T26871

Synonym: BMT052

PSI-6206 13C,d3

Cat.No: T12571

Synonym: Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3

Target: Others

Sofosbuvir-13C-d3

Cat.No: TMIH-0524

Cat.No: T38297

Synonym: Ribavirin-13C5

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