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Search Results for " hbx "
Targets Recommended: Others

5

抑制剂 & 化合物

1

天然产物

3

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T71837 HBX

Others Others
HBX is a deubiquitinase inhibitor. It inhibits HAdV type 5 (species C, HAdV-C5) replication and oncogenic transformation through inhibition of the cellular pro-viral factor ubiquitin-specific protease 7 (USP7). HBX also significantly inhibits virus genome replication and progeny release of all adenovirus types tested, with the exception of types 12 and 31, from tested species.
T21527 HBX 41108

HBX-41108,7-氯-9-氧代-9H-茚并[1,2-B]吡嗪-2,3-二甲腈

DUB; p53 Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
HBX 41108 (HBX-41108) 是一种泛素特异性蛋白酶 7 的非竞争性抑制剂,IC50为 424 nM。它诱导 p53 依赖的凋亡,抑制 USP7 介导的 p53 去泛素化以稳定 p53 并抑制癌细胞生长。
T15464 HBX 19818

DUB Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
HBX 19818 是一种特异性泛素特异性蛋白酶 7 (USP7) 抑制剂,IC50值为 28.1 μM。
T24129 HBX28258

HBX 28258,HBX-28258

Others Others
HBX28258 is a recombinant human USP7 protein inhibitor. In human colon cancer and embryonic kidney cell, it acts by binding the active site through a covalent mechanism and selectively inactivating USP7 protein.
T11669 IR415

HBV Microbiology/Virology
IR415 选择性地与 HBx 相互作用 (Kd=2 nM) 并阻断 HBV 介导的 RNAi 抑制,逆转 HBx 蛋白对 Dicer 核糖核酸内切酶活性的抑制作用。IR415 具有抗 HBV 的活性。

化合物

HBX
Cat.No: T71837
Synonym:
Target: Others
HBX 41108
Cat.No: T21527
Synonym: HBX-41108,7-氯-9-氧代-9H-茚并[1,2-B]吡嗪-2,3-二甲腈
Target: DUB, p53
HBX 19818
Cat.No: T15464
Synonym:
Target: DUB
HBX28258
Cat.No: T24129
Synonym: HBX 28258,HBX-28258
Target: Others
IR415
Cat.No: T11669
Synonym:
Target: HBV
Cat. No. Product Name Target Signaling Pathways
TN6458 Acetylshikonin

Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.

天然产物

Acetylshikonin
Cat.No: TN6458
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPH-00806 HBV-D (isolate Germany/1-91/1991) Protein X (His & SUMO)

HBx,X,Peptide X,Protein X,pX

HBV-D E. coli
HBV-D (isolate Germany/1-91/1991) Protein X (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.7 kDa and the accession number is O93195.
TMPH-00807 HBV-D subtype ayw (isolate France/Tiollais/1979) Protein X (His & SUMO)

Protein X,HBx,X,Peptide X,pX

HBV-D E. coli
HBV-D subtype ayw (isolate France/Tiollais/1979) Protein X (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.6 kDa and the accession number is P03165.
TMPH-00808 HBV-D subtype ayw (isolate Japan/JYW796/1988) Protein X (His)

Peptide X,Protein X,HBx,pX,X

HBV-D E. coli
HBV-D subtype ayw (isolate Japan/JYW796/1988) Protein X (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 22.6 kDa and the accession number is Q9QMI3.

重组蛋白

HBV-D (isolate Germany/1-91/1991) Protein X (His & SUMO)
Cat.No: TMPH-00806
Species: HBV-D
Expression System: E. coli
HBV-D subtype ayw (isolate France/Tiollais/1979) Protein X (His & SUMO)
Cat.No: TMPH-00807
Species: HBV-D
Expression System: E. coli
HBV-D subtype ayw (isolate Japan/JYW796/1988) Protein X (His)
Cat.No: TMPH-00808
Species: HBV-D
Expression System: E. coli
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