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Search Results for " guanylate cyclase "

Targets Recommended: Guanylate cyclase Others

46

抑制剂 & 化合物

17

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T38770	Guanylate cyclase-IN-1	Others	Others
	Guanylate cyclase-IN-1 (Example 46) is a specific inhibitor of guanylate cyclase, employed in research related to cardiovascular diseases.
T9080	Plecanatide	Guanylate cyclase	GPCR/G Protein
	Plecanatide 是尿鸟苷蛋白的类似物，是一种可口服的鸟苷酸环化酶-C (GC-C) 受体激动剂。在 T84 细胞实验中，它激活 GC-C 受体以刺激 cGMP 合成的EC50值为 190 nM。在小鼠结肠炎模型中，它具有抗炎活性。
T11852	Linaclotide	Guanylate cyclase	GPCR/G Protein
	Linaclotide 是一种有效的选择性鸟苷酸环化酶 C 激动剂，可用于治疗便秘型肠易激综合征 (IBS-C) 和慢性便秘的研究。
T16808	Runcaciguat	Others; Guanylate cyclase	GPCR/G Protein; Others
	Runcaciguat 是一种可溶性鸟苷酸环化酶刺激剂。 Runcaciguat 与特异性部分腺苷 A1 受体激动剂相结合，可用于心血管和肾脏疾病的研究。
T21607	Ataciguat HMR-1766	Others; Guanylate cyclase	GPCR/G Protein; Others
	Ataciguat (HMR-1766) 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 激活剂，具有血管舒张作用。它能够激活 sGC 的铁血红素铁氧化还原形式，刺激 cGMP 的产生。
T19777	ODQ	Apoptosis; Others; Guanylate cyclase	Apoptosis; GPCR/G Protein; Others
	ODQ 是一种选择性可溶性的鸟苷酰环化酶抑制剂，可增强顺铂促人间皮瘤细胞凋亡的作用。
T16344	NS-2028	Others; Guanylate cyclase	GPCR/G Protein; Others
	NS-2028 是一种高度选择性的可溶性鸟苷酸环化酶抑制剂。它抑制 3-吗啉代-sydnonimine 在人培养的脐静脉内皮细胞中形成环状 GMP，IC50为30mM。它抑制小鼠小脑匀浆和神经元 NO 合酶中的可溶性鸟苷酸环化酶活性，IC50分别为 17 和 20 mM。它可降低血管内皮生长因子诱导的血管生成和通透性。
T6775	BAY 41-2272	Guanylate cyclase	GPCR/G Protein
	BAY 41-2272 是一种直接且不依赖一氧化氮的可溶性鸟苷酸环化酶刺激剂。
T16383	Olinciguat IW-1701	Guanylate cyclase	GPCR/G Protein
	Olinciguat (IW-1701) 是一种口服鸟苷酸环化酶 (sGC) 刺激剂，在纯化的大鼠和人类酶测定以及全细胞测定中对 sGC 具有浓度依赖性刺激作用。
T1984	Cinaciguat BAY 58-2667	Guanylate cyclase	GPCR/G Protein
	Cinaciguat (BAY 58-2667) 是一种不依赖于一氧化氮的鸟苷酸环化酶化剂，Kd 值为3.2 nM，可用于急性失代偿性心力衰竭的研究。
T17226	Vericiguat 维利西呱,BAY1021189	Guanylate cyclase	GPCR/G Protein
	Vericiguat (BAY1021189) 是一种有效的口服鸟苷酸环化酶刺激剂。
T16569	Praliciguat IW-1973	Others; Guanylate cyclase	GPCR/G Protein; Others
	Praliciguat (IW-1973) 是一种有效且具有口服活性的可溶性鸟苷酸环化酶 (sGC) 刺激剂，还增强 NO 信号传导，可作为血管扩张剂。在 HEK-293 细胞中，它能够刺激 sGC，EC50值为 197 nM。
T6968	Riociguat 利奥西呱,BAY 632521	Guanylate cyclase	GPCR/G Protein
	Riociguat (BAY 632521) 是一种鸟苷酸环化酶的刺激剂，可导致血管平滑肌松弛，用于治疗严重的肺动脉高压。
T4381	Lificiguat 利非西呱,YC-1	Others; Guanylate cyclase; HIF	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Others
	Lificiguat (YC-1) 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶激活剂和低氧诱导因子 1α 的抑制剂。
T21712	BAY 41-8543	Others; Guanylate cyclase	GPCR/G Protein; Others
	BAY 41-8543 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 刺激剂，具有抗血小板作用。它在大鼠的肺和全身血管床中具有血管舒张活性，有用于心血管疾病的研究潜力。
T12670	(Rac)-MGV354 MGV354,外消旋MGV354	Others	Others
	(Rac)-MGV354 (MGV354) 是 MGV354 的外消旋体，MGV354 是可溶性鸟苷酸环化酶活化剂，在 GTM-3E 和 CHO 细胞中 EC50分别为 5 nM 和小于 0.5 nM。
T7201	Nelociguat N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯,BAY60-4552	Guanylate cyclase	GPCR/G Protein
	Nelociguat (BAY60-4552) 是一种一氧化氮敏感的可溶性鸟苷酸环化酶刺激剂。
T6888	Methylene Blue 亚甲蓝,methylthioninium chloride,CI-52015,Tetramethylthionine chloride,亚甲兰,Basic Blue 9	Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase	Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Methylene Blue (Tetramethylthionine chloride) 是鸟苷酸环化酶，是单胺氧化酶 A 和 NO 合酶抑制剂。它有抗伤害感受、抗疟疾、抗抑郁和抗焦虑作用，可研究高铁血红蛋白血症、神经退行性疾病和异环磷酰胺引起的脑病。它是血管加压剂，用作色素内窥镜检查中的染料。
T0006	Methylene Blue trihydrate 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue	Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase	Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Methylene Blue trihydrate (Basic blue 9) 是鸟苷酸环化酶，单胺氧化酶 A 和 NO 合酶抑制剂。它是血管加压药，在医疗中通常用作染料。它具有抗伤害感受，抗疟疾，抗抑郁和抗焦虑作用，可用于高铁血红蛋白血症，神经退行性疾病和异环磷酰胺引起的脑病的研究。
T76769	Indusatumab	Guanylate cyclase	GPCR/G Protein
	Indusatumab (5F9 Monoclonal antibody) 是一种 anti-human GUCY2C (Guanylate cyclase 2C) 单克隆抗体，可用于合成抗体-药物偶联物。
T21576	LY83583 6-Anilino-5,8-quinolinedione,6-anilinoquinoline-5,8-dione	Guanylate cyclase	GPCR/G Protein
	LY83583 是一种可溶性鸟苷酸环化酶竞争性抑制剂，IC50 为 2 µM。
T34648	Sinitrodil ITF296,ITF-296,ITF 296	Guanylate cyclase	GPCR/G Protein
	Sinitrodil (ITF-296) 是一种鸟苷酸环化酶兴奋剂，可用于治疗心肌缺血和心绞痛。
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T0096	Vardenafil 伐地那非,Vivanza,Levitra,Vardenafil hydrochloride	PDE	Metabolism
	Vardenafil (Vivanza) 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂，IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解，从而提高 cGMP 水平。它对 PDE1 (180 nM)，PDE6 (11 nM)，PDE2，PDE3，PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。
TP1219	Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate ANP (1-28), human, porcineANP(1-28)
	Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate 是颗粒鸟苷酸环化酶的刺激剂，已被发现通过增加环鸟苷单磷酸的合成来保护分离的心肌细胞免受复氧诱导的高收缩。Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate 也有助于在反复运动期间刺激脂解，并在运动期间控制脂解。
T39723	Mosliciguat	Others	Others
	Mosliciguat is a guanylate cyclase activator.
T10562	(4-Acetamidocyclohexyl) nitrate BM121307	Others	Others
	(4-Acetamidocyclohexyl) nitrate (BM121307) is an activator of guanylate cyclase.
T38482	MM 419447
	MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research.
T12501	Plecanatide acetate	Others	Others
	Plecanatide acetate is a agonist of guanylate cyclase-C (GC-C) receptor( EC50 of 190 nM in T84 cells), and shows anti-inflammatory activity in models of murine colitis.
T39673	Zagociguat	Others	Others
	Zagociguat is a soluble guanylate cyclase stimulator that enhances nitric oxide (NO) signaling, resulting in increased production of cyclic guanosine monophosphate. This compound shows promise for investigating non-central nervous system (CNS) disorders.
T76389	Prepro-ANF (56-92), human
	Prepro-ANF (56-92), human，是一种人类心房利钠因子的前体，同时也作为鸟苷酸环化酶的激活剂，有助于提升肾膜和肾单位微粒鸟苷酸环化酶的活性。
T11852L	Linaclotide acetate MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775	Others	Others
	Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.
T22197	CFM 1571 hydrochloride	Others	Others
	CFM 1571 hydrochloride is a chemical compound that acts as a stimulator of the nitric oxide receptor known as soluble guanylate cyclase (sGC). It demonstrates an EC50 value of 5.49 μM and an IC50 value of 2.84 μM. Soluble guanylate cyclase is an important signal-transduction enzyme that is activated by nitric oxide. The compound CFM 1571 hydrochloride shows potential for use in cardiovascular and other disease research [1] [2].
T37960	Guanylin(human) TFA
	Guanylin (human) TFA is a 15-amino acid peptide that serves as an endogenous activator of intestinal guanylate cyclase. This compound is primarily located in the gastrointestinal tract, where it regulates electrolyte and water transport in the intestinal and renal epithelia through a mechanism dependent on cyclic GMP. [1][2]
T80150	Guanylin (mouse, rat)	Guanylate cyclase	GPCR/G Protein
	Guanylin (mouse, rat) 是一种由15个氨基酸组成的多肽，并作为肠道鸟苷酸环化酶的激活剂。它可用于腹泻研究。
T10536	BI 703704	Others	Others
	BI 703704 是一种有效的可溶性鸟苷酸环化酶(sGC)激活剂，可抑制 ZSF1 大鼠的糖尿病肾病的进展。
T12888	MGV354	Others	Others
	MGV354 是一种可溶性鸟苷酸环化酶 (sGC) 激活剂，在 CHO 和 GTM-3E 细胞中 EC50值分别为 <0.5 nM 和 5 nM。
T62471	SGC agonist 1	Others	Others
	SGC agonist 1 是一种有效的可溶性鸟苷酸环化酶 (SGC) 激动剂。SGC agonist 1 能够提高溶解度并具有高细胞通透性。SGC agonist 1 具有潜力进行心血管疾病的研究。
T76274	Dolcanatide
	Dolcanatide为一种对GC-C(鸟苷酸环化酶-C)具有口服活性的激动剂，展现出通便、抗痛及抗炎效果，适用于炎症性肠病研究。
T81407	Prepro-Atrial Natriuretic Factor (26-55) (human)
	Prepro-Atrial Natriuretic Factor (26-55) (human) 为促进肾皮质与髓质循环GMP水平上升的多肽，同时也增强肾腺苷酸环化酶的活性。
T9901A-023	Indusatumab vedotin TAK-264,MLN0264	Others	Others
	Indusatumab vedotin (MLN-0264; AKT-264) 为一种以人类抗鸟苷酸环化酶 C (guanylate cyclase, GCC) 抗体与Monomethylauristatin微管破坏剂偶联的抗体-药物偶联物(ADC)。该化合物针对胰腺癌细胞系显示出抗增殖能力，可导致细胞周期在G2/M期停滞并促进细胞凋亡(apoptosis)。
T38482L	MM 419447 acetate(1092457-78-7 Free base)
	MM 419447 acetate(1092457-78-7 Free base) 是一种鸟苷酸环化酶-C激动剂，是利那洛肽的代谢物。 MM 419447 acetate 在肠易激综合征便秘 (IBS-C) 研究领域显示出前景。
T62909	SGC agonist 2	Others	Others
	SGC agonist 2 是一种有效的可溶性鸟苷酸环化酶 (SGC) 激动剂。其中可溶性鸟苷酸环化酶是 NO-sGC-cGMP 信号通路中的关键信号转导酶。SGC agonist 2 具有潜力进行心血管疾病 (心力衰竭、心绞痛、肺动脉高压、心肌梗塞) 和纤维化疾病 (肾纤维化、系统性硬化症) 的研究。
T80890	Uroguanylin-15 (Rat)
	Uroguanylin-15 (Rat) 是一种具备调节肾脏钠排泄功能的生物活性肽，尤其在摄入过量氯化钠时发挥作用。它与尿鸟苷蛋白及鸟苷蛋白相关，这两种肽能够激活肠道及肾脏中的鸟苷酸环化酶信号传导分子。尽管从尿液和十二指肠可分离出尿鸟苷素，大鼠结肠的提取物中却未观察到其存在。
T75339	Methylene blue hydrate	Others	Others
	亚甲蓝（Basic Blue 9）水合物，作为鸟苷酸环化酶（sGC）、单胺氧化酶A（MAO-A）及NO合酶（NOS）的抑制剂，常用于医疗作为血管加压剂及染料。该化合物通过影响一氧化氮合成酶/鸟苷酸环化酶信号通路，能够减少脉冲前抑制，同时作为一种氧化还原循环化合物，具有穿透血脑屏障的能力，并作为Tau蛋白聚集的抑制剂，有助于缓解脑水肿、减轻小胶质细胞活化和神经炎症。
T75137	BAY-747	Others	Others
	BAY-747 (BAY 1165747) 为一种通过口服生效且具有脑渗透性的sGC刺激剂。它能可逆地逆转L-NAME所诱导的记忆障碍并在大鼠中增强认知功能。BAY-747还可在有意识状态下降低正常血压及自发性高血压大鼠(SHR)的血压。此外，BAY-747在mdx/mTRG2小鼠模型中改善了与Duchenne肌营养不良症(DMD)相关的骨骼肌功能。

化合物

Guanylate cyclase-IN-1

Cat.No: T38770

Target: Others

Cat.No: T9080

Target: Guanylate cyclase

Cat.No: T11852

Target: Guanylate cyclase

Cat.No: T16808

Target: Others, Guanylate cyclase

Cat.No: T21607

Synonym: HMR-1766

Target: Others, Guanylate cyclase

Cat.No: T19777

Target: Apoptosis, Others, Guanylate cyclase

Cat.No: T16344

Target: Others, Guanylate cyclase

Cat.No: T6775

Target: Guanylate cyclase

Cat.No: T16383

Synonym: IW-1701

Target: Guanylate cyclase

Cat.No: T1984

Synonym: BAY 58-2667

Target: Guanylate cyclase

Cat.No: T17226

Synonym: 维利西呱,BAY1021189

Target: Guanylate cyclase

Cat.No: T16569

Synonym: IW-1973

Target: Others, Guanylate cyclase

Cat.No: T6968

Synonym: 利奥西呱,BAY 632521

Target: Guanylate cyclase

Cat.No: T4381

Synonym: 利非西呱,YC-1

Target: Others, Guanylate cyclase, HIF

Cat.No: T21712

Target: Others, Guanylate cyclase

Cat.No: T12670

Synonym: MGV354,外消旋MGV354

Target: Others

Cat.No: T7201

Synonym: N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯,BAY60-4552

Target: Guanylate cyclase

Cat.No: T6888

Synonym: 亚甲蓝,methylthioninium chloride,CI-52015,Tetramethylthionine chloride,亚甲兰,Basic Blue 9

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Methylene Blue trihydrate

Cat.No: T0006

Synonym: 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Cat.No: T76769

Target: Guanylate cyclase

Cat.No: T21576

Synonym: 6-Anilino-5,8-quinolinedione,6-anilinoquinoline-5,8-dione

Target: Guanylate cyclase

Cat.No: T34648

Synonym: ITF296,ITF-296,ITF 296

Target: Guanylate cyclase

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

Cat.No: T0096

Synonym: 伐地那非,Vivanza,Levitra,Vardenafil hydrochloride

Target: PDE

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate

Cat.No: TP1219

Synonym: ANP (1-28), human, porcineANP(1-28)

Cat.No: T39723

Target: Others

(4-Acetamidocyclohexyl) nitrate

Cat.No: T10562

Synonym: BM121307

Target: Others

Cat.No: T38482

Plecanatide acetate

Cat.No: T12501

Target: Others

Cat.No: T39673

Target: Others

Prepro-ANF (56-92), human

Cat.No: T76389

Linaclotide acetate

Cat.No: T11852L

Synonym: MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775

Target: Others

CFM 1571 hydrochloride

Cat.No: T22197

Target: Others

Guanylin(human) TFA

Cat.No: T37960

Guanylin (mouse, rat)

Cat.No: T80150

Target: Guanylate cyclase

Cat.No: T10536

Target: Others

Cat.No: T12888

Target: Others

Cat.No: T62471

Target: Others

Cat.No: T76274

Prepro-Atrial Natriuretic Factor (26-55) (human)

Cat.No: T81407

Indusatumab vedotin

Cat.No: T9901A-023

Synonym: TAK-264,MLN0264

Target: Others

MM 419447 acetate(1092457-78-7 Free base)

Cat.No: T38482L

Cat.No: T62909

Target: Others

Uroguanylin-15 (Rat)

Cat.No: T80890

Methylene blue hydrate

Cat.No: T75339

Target: Others

Cat.No: T75137

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01424	GUCA2B Protein, Human, Recombinant (His) Guanylate cyclase activator 2B,GUCA2B	Human	HEK293 Cells
	Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. GUCA2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 13.5 kDa and the accession number is Q16661.
TMPH-03310	GUCY2C Protein, Rat, Recombinant (His & Myc) Guanylyl cyclase C,Gucy2c,Heat-stable enterotoxin r...	Rat	HEK293 Cells
	Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin. GUCY2C Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 51.4 kDa and the accession number is P23897.
TMPY-06353	GUCA2B Protein, Mouse, Recombinant (His) Ugn,AV066530,Gcap2,guanylate cyclase activ...	Mouse	HEK293 Cells
	GUCA2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.55 kDa and the accession number is Q3UWA6-1.
TMPH-01425	GUCY1A2 Protein, Human, Recombinant (His) Guanylate cyclase soluble subunit alpha-2,...	Human	E. coli
	GUCY1A2 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPJ-00910	GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated Intestinal guanylate cyclase,STAR,STA rece...	Human	HEK293 Cells
	GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 65-110 KDa and the accession number is P25092.
TMPJ-00911	GUCY2C Protein, Human, Recombinant (hFc) GUC2C,STAR,hSTAR,GC-C,STA receptor,GUCY2C,Guanylyl cycla...	Human	HEK293 Cells
	GUCY2C Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P25092.
TMPY-03463	GCAP1 Protein, Human, Recombinant (His & GST) guanylate cyclase activator 1A (retina),CO...	Human	Baculovirus Insect Cells
	GCAP1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 50.7 kDa and the accession number is P43080.
TMPY-03554	GCAP1 Protein, Human, Recombinant GCAP,dJ139D8.6,GUCA,GCAP1,COD3,C6orf131,GUCA1,CORD14,gua...	Human	Baculovirus Insect Cells
	GCAP1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 23.1 kDa and the accession number is P43080.
TMPH-00984	NPR2 Protein, Human, Recombinant (His) Atrial natriuretic peptide receptor 2,Atrial natriuretic pep...	Human	E. coli
	NPR2 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-00982	NPR1 Protein, Human, Recombinant (E. coli, His) Guanylate cyclase A,Atrial natriuretic pep...	Human	E. coli
	NPR1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli.
TMPH-00983	NPR1 Protein, Human, Recombinant (His) Guanylate cyclase A,Atrial natriuretic pep...	Human	P. pastoris (Yeast)
	NPR1 Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-00633	Heat-stable enterotoxin A2 Protein, E. coli, Recombinant (His & Myc & SUMO) sta2,Heat-stable enterotoxin A2	E. coli	E. coli
	Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
TMPH-00635	Heat-stable enterotoxin ST-IA/ST-P Protein, E. coli, Recombinant (GST) STh,sta1,Heat-stable enterotoxin ST-IA/ST-P,STp	E. coli	E. coli
	Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
TMPH-03715	Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO) Y-STB,ystB,Heat-stable enterotoxin B	Yersinia enterocolitica	E. coli
	Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Could play an important role in pathogenesis.
TMPH-00634	Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant Heat-stable enterotoxin ST-2	E. coli	E. coli
	Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 2.0 kDa and the accession number is P01560.
TMPH-03250	NPR3 Protein, Rat, Recombinant (His & SUMO) Npr3,Atrial natriuretic peptide receptor 3,Atrial natriureti...	Rat	E. coli
	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system wi...
TMPH-00985	NPR3 Protein, Human, Recombinant (His) Atrial natriuretic peptide receptor type C,Atrial natriureti...	Human	E. coli
	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-...

重组蛋白

GUCA2B Protein, Human, Recombinant (His)

Cat.No: TMPH-01424

Species: Human

Expression System: HEK293 Cells

GUCY2C Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03310

Species: Rat

Expression System: HEK293 Cells

GUCA2B Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06353

Species: Mouse

Expression System: HEK293 Cells

GUCY1A2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01425

Species: Human

Expression System: E. coli

GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00910

Species: Human

Expression System: HEK293 Cells

GUCY2C Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00911

Species: Human

Expression System: HEK293 Cells

GCAP1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03463

Species: Human

Expression System: Baculovirus Insect Cells

GCAP1 Protein, Human, Recombinant

Cat.No: TMPY-03554

Species: Human

Expression System: Baculovirus Insect Cells

NPR2 Protein, Human, Recombinant (His)

Cat.No: TMPH-00984

Species: Human

Expression System: E. coli

NPR1 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-00982

Species: Human

Expression System: E. coli

NPR1 Protein, Human, Recombinant (His)

Cat.No: TMPH-00983

Species: Human

Expression System: P. pastoris (Yeast)

Heat-stable enterotoxin A2 Protein, E. coli, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00633

Species: E. coli

Expression System: E. coli

Heat-stable enterotoxin ST-IA/ST-P Protein, E. coli, Recombinant (GST)

Cat.No: TMPH-00635

Species: E. coli

Expression System: E. coli

Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO)

Cat.No: TMPH-03715

Species: Yersinia enterocolitica

Expression System: E. coli

Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant

Cat.No: TMPH-00634

Species: E. coli

Expression System: E. coli

NPR3 Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03250

Species: Rat

Expression System: E. coli

NPR3 Protein, Human, Recombinant (His)

Cat.No: TMPH-00985

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0595	Vericiguat-d3
	Vericiguat-d3 是 Vericiguat 的氘代化合物。Vericiguat 的 CAS 号为 1350653-20-1。Vericiguat 是一种有效的口服鸟苷酸环化酶刺激剂。
TMIH-0497	Riociguat-13C-d6
	Riociguat-13C-d6 是 Riociguat 的 13C 和氘代化合物。Riociguat 的 CAS 号为 625115-55-1。Riociguat 是一种鸟苷酸环化酶的刺激剂，可导致血管平滑肌松弛，用于治疗严重的肺动脉高压。
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...
TMIJ-0114	Vardenafil-d5
	Vardenafil-d5 是 Vardenafil 的氘代化合物。Vardenafil 的 CAS 号为 224785-90-4。Vardenafil 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂，IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解，从而提高 cGMP 水平。它对 PDE1 (180 nM)，PDE6 (11 nM)，PDE2，PDE3，PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。

同位素标记化合物

Cat.No: TMIH-0595

Riociguat-13C-d6

Cat.No: TMIH-0497

Cat.No: T71402

Cat.No: TMIJ-0114

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