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Search Results for " growth hormone–inhibiting hormone "

Targets Recommended: Others

抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1035L	Cyclic somatostatin Acetate Somatostatin (sheep), monoacetate (salt),Cyclic somatostatin Acetate(38916-34-6 free base),Somatostatin-14,SRIF-14,monoacetate (salt)	Others	Others
	Cyclic somatostatin Acetate(38916-34-6(free base)) (Somatostatin-14) 是一种环状十四肽，可调节许多内分泌和神经系统功能。
T1167	Cyproterone acetate Androcur,醋酸环丙氯地孕酮,Cyproterone 17-O-acetate,醋酸环丙孕酮	Androgen Receptor	Endocrinology/Hormones
	Cyproterone acetate (Cyproterone 17-O-acetate) 是能够抗雄激素(IC50=7.1 nM) 和孕激素合成的类固醇。它与 progesteron 和糖皮质激素受体有亲和力。
TP1302	Somatostatin
	Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and
T75157L	Cimdelirsen sodium	Others	Others
	Cimdelirsen (sodium) 为针对肝脏的反义寡核苷酸，通过减少生长激素受体(GHr)合成，抑制生长激素(GH)的过度分泌效应，进而降低肢端肥大症患者体内循环胰岛素样生长因子-1 (IGF-1)水平。
T40324	2,4-D sodium salt 2,4-Dichlorophenoxyaceticacidsodiumsalt,2,4-D sodium salt,Sodium 2,4-dichlorophenoxyacetate	Others	Others
	2,4-D sodium salt (Sodium 2,4-dichlorophenoxyacetate) is a selective systemic herbicide that effectively controls broad-leaved weeds. Acting as a plant hormone, it induces uncontrolled growth in meristematic tissues. By inhibiting DNA and protein synthesis, 2,4-D sodium salt hinders regular plant growth and development.
T73702	Mecasermin
	Mecasermin（Human IGF-I; FK 780），一种重组人胰岛素样生长因子I（IGF-I），主要用于研究因生长激素（GH）受体缺陷或GH抑制抗体导致的GH不敏感性而引起的生长障碍。
T84719	Veldoreotide TFA PTR-3173 TFA,DG3173 TFA	Others	Others
	Veldoreotide (DG3173) TFA，一种生长抑素类似物，能够结合并激活SSTR 2/4/5。其在腺瘤中抑制生长激素分泌的效果相较于Octreotide更为显著。此外，Veldoreotide亦展现出作为镇痛剂的潜力。
T85183	Degarelix acetate FE 200486	Others	Others
	Degarelix is a synthetic gonadotropin-releasing hormone receptor (GNRHR) antagonist (IC50= 3 nM in HEK293 cells expressing the human receptor), effective in inhibiting the growth of various prostate cell lines (WPMY-1, WPE1-NA22, BPH-1, and LNCaP) by activating caspase and inducing apoptosis after 72 hours of exposure to 10 μM. In vivo studies demonstrate that degarelix (2 mg/kg) significantly reduces plasma testosterone levels in rats to castrate levels for up to 49 days following administratio...

化合物

Cyclic somatostatin Acetate

Cat.No: TP1035L

Synonym: Somatostatin (sheep), monoacetate (salt),Cyclic somatostatin Acetate(38916-34-6 free base),Somatostatin-14,SRIF-14,monoacetate (salt)

Target: Others

Cyproterone acetate

Cat.No: T1167

Synonym: Androcur,醋酸环丙氯地孕酮,Cyproterone 17-O-acetate,醋酸环丙孕酮

Target: Androgen Receptor

Synonym: 2,4-Dichlorophenoxyaceticacidsodiumsalt,2,4-D sodium salt,Sodium 2,4-dichlorophenoxyacetate

Synonym: PTR-3173 TFA,DG3173 TFA

Target: Others

Degarelix acetate

Cat.No: T85183

Synonym: FE 200486

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5088	3-Indoleacetic acid sodium Indole-3-Acetic Acid sodium salt,Sodium 2-(1H-indol-3-yl)acetate,IAA sodium salt,吲哚乙酸钠,Heteroauxin sodium salt	Others; Endogenous Metabolite	Metabolism; Others
	3-Indoleacetic acid sodium (Heteroauxin sodium salt) 是一种天然存在的植物生长素类激素。能刺激细胞伸长和分裂，促进植物生长发育。然而，高浓度时，它表现出生长抑制作用，包括生长和阻止茎和根的生长。后一种效应形成了合成生长素被开发为农业除草剂和生物调节剂的基础。

天然产物

3-Indoleacetic acid sodium

Cat.No: T5088

Synonym: Indole-3-Acetic Acid sodium salt,Sodium 2-(1H-indol-3-yl)acetate,IAA sodium salt,吲哚乙酸钠,Heteroauxin sodium salt

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00186	GHRH Protein, Human, Recombinant (hFc) GRF,INN,growth hormone releasing ...	Human	HEK293 Cells
	The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in infertility. Growth hormone releasing hormone (GHRH) has recently been shown to increase the level of gamma-aminobutyric acid (GABA) and activate GABA receptors (GABARs) in the cerebral cortex. GABA is an inhibitory neurotransmitter that can inhibit seizures. GHRH may pl...
TMPJ-01076	FKBP4 Protein, Human, Recombinant (His) FKBP4,HSP-binding immunophilin,immunophilin FKBP52,FK506-bin...	Human	E. coli
	FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.