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Search Results for " gonadotropin releasing hormone receptor "

Targets Recommended: Others

33

抑制剂 & 化合物

4

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1288	Fertirelin	Others	Others
	Fertirelin 是 GnRH 和 LH-RH 的类似物，可用于研究牛滤泡囊肿。它是促性腺激素释放激素激动剂。
T1494	Alarelin Acetate 阿拉瑞林,Alarelin	GNRH Receptor	GPCR/G Protein
	Alarelin Acetate 是一种合成的GnRH 激动剂。
T27837	Linzagolix	GNRH Receptor	GPCR/G Protein
	Linzagolix 是一种口服有活性的非多肽GnRH 拮抗剂。可用于研究子宫肌瘤、子宫腺肌症、子宫内膜异位症。
T5520	Cetrorelix Acetate 醋酸西曲瑞克,Cetrorelix	GNRH Receptor	GPCR/G Protein
	Cetrorelix Acetate 是一种GnRH 受体的强效拮抗剂(IC50:1.21 nM)。
T4102	Goserelin acetate 醋酸戈舍瑞林,Fertilan,ICI-118630 acetate,Zoladex	Apoptosis; GNRH Receptor	Apoptosis; GPCR/G Protein
	Goserelin acetate (Fertilan) 是一种促性腺激素释放激素 (GnRH/LHRH) 十肽类似物，能作为GnRH 激动剂。它可研究乳腺癌、上皮性卵巢癌和前列腺癌。
T11174	(R)-Elagolix 恶拉戈利,NBI-56418	GNRH Receptor	GPCR/G Protein
	(R)-Elagolix (NBI-56418) 是口服具有活性的、选择性高的非肽类促性腺激素释放激素受体短期有效拮抗剂 (KD = 54 pM)。
T5031	Elagolix sodium NBI-56418 sodium,恶拉戈利钠	GNRH Receptor	GPCR/G Protein
	Elagolix sodium (NBI-56418 sodium) 是人GnRH 受体拮抗剂，其IC50=0.25 nM，Ki=3.7 nM。
T10217L	Abarelix R3827,阿巴瑞克,PPI 149	GNRH Receptor	GPCR/G Protein
	Abarelix (PPI 149) 是一种促性腺激素释放激素 (GnRH) 拮抗剂，用于前列腺癌研究。
T3630	Relugolix RVT-601,瑞卢戈利,TAK-385	GNRH Receptor	GPCR/G Protein
	Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T5520L	Cetrorelix diacetate NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate	GNRH Receptor	GPCR/G Protein
	Cetrorelix diacetate (NS-75A) 是GnRH 受体的强效拮抗剂(IC50:1.21 nM)。
TP2337	Ganirelix Acetate	GNRH Receptor	GPCR/G Protein
	Ganirelix Acetate 是一种促性腺激素释放激素 (GnRH) 受体拮抗剂。
T17301	Opigolix ASP-1707	GNRH Receptor	GPCR/G Protein
	Opigolix (ASP-1707)是一种可口服促性腺激素释放激素 (GnRH) 受体拮抗剂，可用于研究子宫内膜异位症相关疼痛、风湿性关节炎和子宫肌瘤。
T10988L	Degarelix acetate(214766-78-6 free base)	GNRH Receptor	GPCR/G Protein
	Degarelix acetate(214766-78-6 free base) 是促性腺激素释放激素受体 (GnRHR) 的竞争性可逆拮抗剂。
TP1307	Buserelin Acetate (57982-77-1 free base) 布舍瑞林,Buserelin Acetate	GNRH Receptor	GPCR/G Protein
	Buserelin Acetate (57982-77-1 free base) (Buserelin Acetate) 是促性腺激素释放激素受体 (GnRHR) 的激动剂。
TP1896L1	Kisspeptin 234 acetate(1145998-81-7 free base)	GPR; Kisspeptin	Endocrinology/Hormones; GPCR/G Protein
	Kisspeptin 234 acetate(1145998-81-7 free base) 是Kisspeptin 受体 (KISS1, GPR54) 拮抗剂；是Kisspeptin-10 类似物。它抑制 Kisspeptin-10 对磷酸肌醇 (IP) (IC50 = 7 nM) 的刺激和促性腺激素释放激素 (GnRH) 的释放。
T23412	T 98475	Others	Others
	gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist,orally active
T10988	Degarelix	GNRH Receptor	GPCR/G Protein
	Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.
T10475	BAY-784	Others	Others
	BAY-784 is a gonadotropin-releasing hormone receptor (GnRH-R) antagonist (IC50s: 21 and 24 nM for human and rat GnRH-R).
T76351	[D-Ala6]-LH-RH	Others	Others
	[D-Ala6]-LH-RH，一种黄体激素释放激素(LHRH)模拟物，充当GnRH受体的激动剂。
T76350	[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH
	[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH 是一种黄体激素释放激素 (LHRH) 类似物，可作为 GnRH 受体拮抗剂。
TP1936	RFRP-3(human) RFRP 3 (human)
	Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
T28795	SKI2496 SKI 2496,SKI-2496	Others	Others
	SKI2496 is a potent and orally bioavailableantagonist of Gonadotropin-Releasing Hormone Receptor (hGnRHR IC50 = 0.46 nM; max. LH inh. inh. (%, h)= 84%, 12h; LH inh. (24h) = 76%.). SKI2496 exhibits more selective antagonistic activity toward the human GnRH
T70309	Dicetrorelix pamoate	Others	Others
	Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein...
T84706	DCOIT Kathon 930	Others	Others
	DCOIT是一种典型的异噻唑啉酮，能激活促性腺激素释放激素受体(GnRHR)在大脑中引发卵泡刺激素和黄体生成素的合成。此外，DCOIT干扰了G蛋白偶联受体、MAPK和Ca2+信号传递途径。
T85273	Gonadorelin acetate	Others	Others
	Gonadorelin, a gonadotropin-releasing hormone receptor (GNRHR; Ki= 13 nM in CHO cells expressing the human receptor) agonist and tropic hormone, effectively stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from rat anterior pituitary cultures at 0.1 μg doses. Additionally, it triggers LH release from bovine anterior pituitary cultures at a 1 μM concentration. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (ED50= 610.3 ng/kg). ...
T76436	[MePhe7]-Neurokinin B
	[MePhe7]-Neurokinin B为NK-3受体(NK3R)激动剂，具有3 nM的IC50值。通过激活神经激肽3受体，[MePhe7]-Neurokinin B能够调节脉冲促性腺激素释放激素(GnRH)的分泌，成为调控该过程的潜在调节剂。
T68701	Abarelix acetate	Others	Others
	Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseli...
T72990	BAY 1214784	Others	Others
	BAY 1214784是一种针对人促性腺激素释放激素受体(hGnRH-R)的高效、选择性口服活性拮抗剂，属于螺二氢吲哚衍生物化合物。该化合物能显著降低血浆促黄体激素水平，最高可达49%，同时显示出较低的药代动力学变异性和良好的耐受性，表现出研究子宫肌瘤的潜力。
T70775	Zoptarelin doxorubicin
	Zoptarelin doxorubicin, also known as AEZS-108, is an LHRH agonist. Zoptarelin doxorubicin is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates in...
T85183	Degarelix acetate FE 200486	Others	Others
	Degarelix is a synthetic gonadotropin-releasing hormone receptor (GNRHR) antagonist (IC50= 3 nM in HEK293 cells expressing the human receptor), effective in inhibiting the growth of various prostate cell lines (WPMY-1, WPE1-NA22, BPH-1, and LNCaP) by activating caspase and inducing apoptosis after 72 hours of exposure to 10 μM. In vivo studies demonstrate that degarelix (2 mg/kg) significantly reduces plasma testosterone levels in rats to castrate levels for up to 49 days following administratio...
T76047	TAK-683 TFA
	TAK-683 TFA是一种高效的全KISS1R激动剂(IC50=170 pM)，拥有较好的代谢稳定性，是九肽metastin的类似物，对KISS1R有激动效应，其对人和大鼠EC50值分别为0.96 nM和1.6 nM。TAK-683 TFA能够降低下丘脑GnRH水平，进而减少血浆FSH、LH、睾酮的浓度，显示出对激素依赖性前列腺癌研究的可能性。
T35794	Kisspeptin-54 (human) (trifluoroacetate salt)
	Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-5...
T81485	Phoenixin-14 TFA PNX-14 TFA
	Phoenixin-14 (PNX-14) TFA 是具抗焦虑、心脏保护及神经保护效果的穿透大脑屏障神经肽。它通过上调GnRH受体mRNA调控垂体促性腺激素分泌，并促进胰岛素释放。此外，Phoenixin-14 TFA保护小鼠免受缺血/再灌注(IR)伤害，通过降低ROS、提高GSH减缓氧化应激。

化合物

Cat.No: TP1288

Target: Others

Alarelin Acetate

Cat.No: T1494

Synonym: 阿拉瑞林,Alarelin

Target: GNRH Receptor

Cat.No: T27837

Target: GNRH Receptor

Cetrorelix Acetate

Cat.No: T5520

Synonym: 醋酸西曲瑞克,Cetrorelix

Target: GNRH Receptor

Goserelin acetate

Cat.No: T4102

Synonym: 醋酸戈舍瑞林,Fertilan,ICI-118630 acetate,Zoladex

Target: Apoptosis, GNRH Receptor

Cat.No: T11174

Synonym: 恶拉戈利,NBI-56418

Target: GNRH Receptor

Elagolix sodium

Cat.No: T5031

Synonym: NBI-56418 sodium,恶拉戈利钠

Target: GNRH Receptor

Cat.No: T10217L

Synonym: R3827,阿巴瑞克,PPI 149

Target: GNRH Receptor

Cat.No: T3630

Synonym: RVT-601,瑞卢戈利,TAK-385

Target: GNRH Receptor

Cetrorelix diacetate

Cat.No: T5520L

Synonym: NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate

Target: GNRH Receptor

Ganirelix Acetate

Cat.No: TP2337

Target: GNRH Receptor

Cat.No: T17301

Synonym: ASP-1707

Target: GNRH Receptor

Degarelix acetate(214766-78-6 free base)

Cat.No: T10988L

Target: GNRH Receptor

Buserelin Acetate (57982-77-1 free base)

Cat.No: TP1307

Synonym: 布舍瑞林,Buserelin Acetate

Target: GNRH Receptor

Kisspeptin 234 acetate(1145998-81-7 free base)

Cat.No: TP1896L1

Target: GPR, Kisspeptin

Cat.No: T23412

Target: Others

Cat.No: T10988

Target: GNRH Receptor

Cat.No: T10475

Target: Others

Cat.No: T76351

Target: Others

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH

Cat.No: T76350

Cat.No: TP1936

Synonym: RFRP 3 (human)

Cat.No: T28795

Synonym: SKI 2496,SKI-2496

Target: Others

Dicetrorelix pamoate

Cat.No: T70309

Target: Others

Cat.No: T84706

Synonym: Kathon 930

Target: Others

Gonadorelin acetate

Cat.No: T85273

Target: Others

[MePhe7]-Neurokinin B

Cat.No: T76436

Abarelix acetate

Cat.No: T68701

Target: Others

Cat.No: T72990

Target: Others

Zoptarelin doxorubicin

Cat.No: T70775

Degarelix acetate

Cat.No: T85183

Synonym: FE 200486

Target: Others

Cat.No: T76047

Kisspeptin-54 (human) (trifluoroacetate salt)

Cat.No: T35794

Phoenixin-14 TFA

Cat.No: T81485

Synonym: PNX-14 TFA

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04307	GNRH2 Protein, Human, Recombinant (hFc) LH-RHII,gonadotropin releasing hormone...	Human	HEK293 Cells
	GNRH2 (Gonadotropin-Releasing Hormone 2) is a Protein Coding gene. This gene is a member of the gonadotropin-releasing hormone (GnRH) gene family. Proteins encoded by members of this gene family are proteolytically cleaved to form neuropeptides which, in part, regulate reproductive functions by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). 3 alternatively spliced human isoforms have been reported. The second mammalian...
TMPJ-00365	GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated AXLLG,Growth arrest-specific protein 6,AXL receptor...	Human	HEK293 Cells
	Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, plat...
TMPJ-00366	GAS6 Protein, Human, Recombinant (hFc) AXLLG,Gas6,GAS-6,AXLLGAXL stimulatory factor,growth arrest-s...	Human	HEK293 Cells
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ...
TMPY-04999	GAS6 Protein, Human, Recombinant (His)	Human	HEK293 cells
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ...

重组蛋白

GNRH2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04307

Species: Human

Expression System: HEK293 Cells

GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00365

Species: Human

Expression System: HEK293 Cells

GAS6 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00366

Species: Human

Expression System: HEK293 Cells

GAS6 Protein, Human, Recombinant (His)

Cat.No: TMPY-04999

Species: Human

Expression System: HEK293 cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0268	Relugolix-d6
	Relugolix-d6 是 Relugolix 的氘代化合物。Relugolix 的 CAS 号为 737789-87-6。Relugolix 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的IC50值分别为0.33 nM和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。

同位素标记化合物

Cat.No: TMIJ-0268

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