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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37577 |
Glycogen Phosphorylase Inhibitor
|
Others | Others |
Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM). It blocks glucagon-induced hepatic glycogenolysis in vivo. Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells. | |||
T8493 |
Ingliforib
GPi 296,CP 368296 |
Phosphorylase | Metabolism |
Ingliforib (CP 368296) 是glycogen phosphorylase 抑制剂,能够抑制肝脏、肌肉和大脑的 glycogen phosphorylase ,其IC50值分别为 52,352 和 150 nM,具有心脏保护的作用。 | |||
T10421 |
AVE5688
|
Phosphorylase | Metabolism |
AVE5688 是糖原磷酸化酶 (glycogen phosphorylase (GP)) 抑制剂,抑制兔肌肉糖原磷酸化酶 rmGPb 和 rmGPa 的活性,IC50 值分别为 430 nM 和 915 nM,Kd 值分别为 170 nM 和 530 nM;AVE5688 可用于二型糖尿病的研究。 | |||
T22683 |
CP-316819
CP 316819,GPi 819 |
Others | Others |
CP-316819 (GPi 819) 是一种高效的糖原磷酸化酶 (GPase) 抑制剂,具有降血糖作用,抑制 huSMGPa 和 huLGPa,可在低血糖期间维持神经元活性,可用于研究高血糖。 | |||
T6455 |
CP-91149
|
Phosphorylase | Metabolism |
CP91149 是GP (糖原磷酸化酶)的抑制剂,能够促进糖原的重新合成,但不会造成糖原的过度积累。它对2型糖尿病具有潜在的研究价值。 | |||
T22803 | GPi 688 | Others | Others |
glycogen phosphorylase inhibitor | |||
T68524 |
AVE 9423
|
Others | Others |
AVE 9423 is an allosteric glycogen phosphorylase inhibitor. | |||
T31048 |
CP-320626
CP 320626 |
Others | Others |
CP-320626 is an effective inhibitor of glycogen phosphorylase A (LGPA) in the human liver and GPA in the human muscle. Can act synergistically with glucose. It is a possible target for the treatment of type 2 diabetes. | |||
T84381 |
1,4-dideoxy-1,4-imino-D-Arabinitol hydrochloride
DAB |
Others | Others |
1,4-Dideoxy-1,4-imino-D-arabinitol (DAB) functions as an inhibitor of glycogen phosphorylase, a crucial enzyme in glycogenolysis, demonstrating the ability to hinder this process in isolated liver cells (IC50= 1.0 µM) and cerebral cortex and cerebellum homogenates (IC50s = 463 and 383 nM, respectively). Employed extensively in different animal models, DAB inhibits glycogenolysis within the liver and brain. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN4584 |
Morolic acid
|
IL Receptor; COX; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro |