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Cat. No. | Product Name | ||
---|---|---|---|
L7100 | 抗肥胖化合物库 | 2247 compounds | |
2247 个抗肥胖化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T67898 |
α-Glucosidase-IN-22
|
Glucosidase | Metabolism |
α-Glucosidase-IN-22是一种α-葡萄糖苷酶选择性抑制剂(IC50=0.64 μM)。α-Glucosidase-IN-22有抗糖尿病的活性,在2型糖尿病(T2DM)研究中具有潜力。 | |||
T67728 |
α-Glucosidase-IN-23
|
Glucosidase | Metabolism |
α-Glucosidase-IN-23 是具有口服活性的 α-Glucosidase 抑制剂。α-Glucosidase-IN-23 通过抑制 a-glucosidase 降低血糖 (IC50= 4.48 μM)。α-Glucosidase-IN-23 可用于糖尿病的研究。 | |||
T41028 |
α-Glucosidase
α-D-Glucosidase,α-葡萄糖苷酶 |
Others | Others |
α-Glucosidase (α-D-Glucosidase) is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of the substrate. It plays a vital role in facilitating glucose absorption by the small intestine. Inhibiting α-Glucosidase effectively manages non-insulin-dependent diabetes mellitus (NIDDM). | |||
T60715 |
α-Glucosidase-IN-4
|
Glucosidase | Metabolism |
α-Glucosidase-IN-4 是一种有效的α- 葡萄糖苷酶 (α-glucosidase)抑制剂,具有降血压和降糖活性。 | |||
T76110 |
β-Glucosidase
|
Others | Others |
β-Glucosidase 是纤维素降解的限速酶。β-Glucosidase 是糖苷水解酶中的主要组份。β-Glucosidase 参与土壤中纤维素的降解,具有监测生物土壤质量的潜力。 | |||
T63574 |
α-Glucosidase-IN-12
|
Others | Others |
α-Glucosidase-IN-12 是 α- 葡萄糖苷酶 (α-glucosidase) 的有效抑制剂 (IC50: 10.20 μM)。 | |||
T60389 |
α-Glucosidase-IN-5
|
Others | Others |
α-Glucosidase-IN-5 (compound 8) 从 Polyalthia cinnamomea 的树枝提取物中分离出来,是一种有效的α-葡萄糖苷酶抑制剂,IC50为 57.9 μM。α-Glucosidase-IN-5 具有研究糖尿病的潜力[ 1]。 | |||
T78794 |
α-Glucosidase-IN-31
|
Glucosidase | Metabolism |
α-Glucosidase-IN-31(compound R1)是一种有效的口服α-Glucosidase抑制剂,具有10.1 μM的IC50值,能显著降低血糖并具抗糖尿病活性。 | |||
T78740 |
α-Glucosidase-IN-28
|
Glucosidase | Metabolism |
α-Glucosidase-IN-28(Compound 18)是一种有效的α-Glucosidase抑制剂,具有IC50为0.62 μM和Ki为3.93μM。该化合物通过与α-Glucosidase的OBS区域结合以及与周围氨基酸建立多重疏水作用力,展现抑制活性。它主要用于研究糖尿病及其相关疾病。 | |||
T79318 |
α-Glucosidase-IN-30
|
Glucosidase | Metabolism |
α-Glucosidase-IN-30 (compound 8c) 是竞争性的α-glucosidase抑制剂,口服活性强,Ki值为40.0 µM,IC50值为49.0 µM。该化合物对MCF-7和HDF细胞系无细胞毒性,适合用于2型糖尿病研究。 | |||
T62222 |
α-Glucosidase-IN-11
|
Others | Others |
α-Glucosidase-IN-11 是一种高渗透性的 α-葡萄糖苷酶 (α-glucosidase) 的竞争性抑制剂 (IC50: 0.56 μM)。α-Glucosidase-IN-11 能够结合 α-葡萄糖苷酶中 Trp 残基,对蛋白质的折叠具有调节作用,能够用于血糖水平的调节。 | |||
T61094 |
α-Glucosidase-IN-8
|
Others | Others |
α-Glucosidase-IN-8 (Compound 4k) is a potent, competitive inhibitor of α-glucosidase. It displays an impressive IC50 value of 0.18 μg/mL [1]. | |||
T61519 |
α-Glucosidase-IN-18
|
Others | Others |
α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM. This compound exhibits antidiabetic properties [1]. | |||
T61166 |
α-Glucosidase-IN-16
|
Others | Others |
α-Glucosidase-IN-16 is a highly effective and orally bioavailable inhibitor of α-glucosidase, displaying a remarkable IC50 value of 3.28 μM. This compound demonstrates the ability to significantly decrease blood glucose levels in diabetic rats induced by Streptozotocin. Notably, α-Glucosidase-IN-16 also exhibits noteworthy antidiabetic activity [1]. | |||
T61124 |
α-Glucosidase-IN-9
|
Others | Others |
α-Glucosidase-IN-9 (compound 7) is a highly potent α-glucosidase inhibitor with an IC50 of 55.6 μM, making it suitable for type II diabetes research [1]. | |||
T79700 |
α-Glucosidase-IN-32
|
Glucosidase | Metabolism |
α-Glucosidase-IN-32 (compound f26),是一种口服有效的α-glucosidase抑制剂,具有可逆、非竞争性特点,IC50值为3.07 μM。该化合物通过与α-glucosidase形成氢键和疏水相互作用,以改变其构象和二级结构,从而抑制酶活性。α-Glucosidase-IN-32 主要用于糖尿病研究。 | |||
T64230 |
α-Glucosidase-IN-3
|
Others | Others |
α-Glucosidase-IN-3 是一种针对 α-葡萄糖苷酶和 α-淀粉酶的齐墩果酸肟酯衍生物,对α-葡萄糖苷酶的 IC50 值为 0.35 μM。 | |||
T62972 |
α-Glucosidase-IN-17
|
Others | Others |
α-Glucosidase-IN-17 (Compound 12B) 是一种有效的、具有口服活性的α-glucosidase 抑制剂,IC50为 3.79 μM。α-Glucosidase-IN-17 具有抗糖尿病活性。 | |||
T80710 |
α-Glucosidase-IN-40
|
Glucosidase | Metabolism |
α-Glucosidase-IN-40 (compound 5)是一款非竞争性α-glucosidase抑制剂,其半抑制浓度(IC50)为24.62 μM。 | |||
T79237 |
α-Glucosidase-IN-27
|
Glucosidase | Metabolism |
α-Glucosidase-IN-27(化合物8l)是一种有效的α-glucosidase抑制剂,其IC50值为25.78 μM。该化合物有望用于研究2型糖尿病(D2M)。 | |||
T78731 |
α-Glucosidase-IN-26
|
Glucosidase | Metabolism |
α-Glucosidase-IN-26(化合物 7i)是一种有效的α-glucosidase抑制剂,其半抑制浓度(IC50)为4.63 µM,适用于2型糖尿病(T2DM)的研究。 | |||
T80708 |
α-Glucosidase-IN-42
|
Glucosidase | Metabolism |
α-Glucosidase-IN-42(Compound 26)是一种9-O-小檗红素羧酸衍生物,展现出明显的α-葡萄糖苷酶抑制活性,其IC50值约为1.61 μM。此化合物适用于抗糖尿病研究领域。 | |||
T63361 |
α-Glucosidase-IN-13
|
Others | Others |
α-Glucosidase-IN-13 是 α-glucosidase 抑制剂 (IC50: 5.69 μM)。 | |||
T62994 |
α-Glucosidase-IN-10
|
Others | Others |
α-Glucosidase-IN-10 (compound 13) 是一种 α-glucosidase 的有效抑制剂 (IC50: 92.7 μM)。α-Glucosidase-IN-10 能够用于研究 II 型糖尿病。 | |||
T61249 |
α-Glucosidase-IN-2
|
Others | Others |
α-Glucosidase-IN-2 (compound 5d) 是一种有效的α-Glucosidase 抑制剂,IC50of 9.48 μM。α-Glucosidase-IN-2 是一种抗糖尿病药物。 | |||
T80711 |
α-Glucosidase-IN-39
|
Glucosidase | Metabolism |
α-Glucosidase-IN-39 是一种针对α-glucosidase enzyme 的有效抑制剂,具有 869.06 ppm 的 IC50 值,适用于抗糖尿病研究。 | |||
T61331 |
α-Glucosidase-IN-20
|
Others | Others |
α-Glucosidase-IN-20 (Compound 3B) is a highly effective and orally active inhibitor of α-glucosidase. It exhibits potent anti-diabetic properties, as evidenced by its IC50 value of 3.01 μM [1]. | |||
T80709 |
α-Glucosidase-IN-41
|
Glucosidase | Metabolism |
α-Glucosidase-IN-41(compound 5o)是一种高效α-glucosidase抑制剂,能诱导α-Glu的二级结构发生变化,进而抑制酶的催化活性,适用于糖尿病的研究。 | |||
T79259 |
α-Glucosidase-IN-25
|
Glucosidase | Metabolism |
α-Glucosidase-IN-25 (Compound (R)-8k) 为具有IC50值为1.19 μM的α-葡萄糖苷酶竞争性抑制剂,适用于抗糖尿病研究。 | |||
T78881 |
α-Glucosidase-IN-36
|
Glucosidase | Metabolism |
α-Glucosidase-IN-36(compound 5g)作为一种α-glucosidase抑制剂,表现出有效的抑制活性,其IC50值为6.69 ± 0.18 μM,Ki值为1.65 μM,Kis值为4.54 μM。该化合物通过与α-glucosidase的活性位点结合及可能改变其二级结构来执行其抑制功能。α-Glucosidase-IN-36在2型糖尿病(T2DM)的研究中有应用潜力。 | |||
T78741 |
α-Glucosidase-IN-29
|
Glucosidase | Metabolism |
α-Glucosidase-IN-29 (compound 19) 作为α-葡萄糖苷酶抑制剂,具有IC50=1.21 μM和Ki=1.80 μM的特性,适用于糖尿病及相关疾病的研究。 | |||
T63562 |
α-Glucosidase-IN-14
|
Others | Others |
α-Glucosidase-IN-14 是 α- 葡萄糖苷酶 (α-glucosidase) 的有效抑制剂 (IC50: 5.22 μM)。 | |||
T62891 |
α-Glucosidase-IN-19
|
Others | Others |
α-Glucosidase-IN-19 (Compound 6B) 是一种口服具有活力的 α-glucosidase 抑制剂 (IC50: 3.63 μM),具有抗糖尿病作用。 | |||
T63310 |
α-Glucosidase-IN-6
|
Others | Others |
α-Glucosidase-IN-6 是 α-glucosidase 的竞争性抑制剂 (IC50: 5.69 μM),表现出抗糖尿病的研究潜力。 | |||
T61503 |
α-Glucosidase-IN-15
|
Others | Others |
α-Glucosidase-IN-15 (Compound 14B) exhibits potent inhibitory activity against α-glucosidase, with an IC50 value of 3.34 μM. It possesses antidiabetic properties [1]. | |||
T80712 |
α-Glucosidase-IN-38
|
Glucosidase | Metabolism |
α-Glucosidase-IN-38 (Compound 11j) is an effective α-glucosidase inhibitor with an IC50 of 12.44±0.38 μM, playing a significant role in diabetes mellitus (DM). | |||
T61761 |
α-Glucosidase-IN-21
|
Others | Others |
α-Glucosidase-IN-21 (Compound 2B) is a highly potent and orally bioavailable inhibitor of α-glucosidase. With an impressive IC50 value of 2.62 μM, this compound exhibits remarkable anti-diabetic properties [1]. | |||
T78864 |
α-Glucosidase-IN-33
|
Glucosidase | Metabolism |
α-Glucosidase-IN-33 (compound 7c) 是一种有效的α-葡萄糖苷酶抑制剂,IC50值为2.39 μM,主要用于2型糖尿病及高血糖研究。 | |||
T78865 |
α-Glucosidase-IN-34
|
Glucosidase | Metabolism |
α-Glucosidase-IN-34 (compound 7f) 作为一种有效的α-葡萄糖苷酶抑制剂,具有2.90 μM的IC50值,主要用于2型糖尿病和高血糖的研究。 | |||
TQ0300 |
Conduritol B epoxide
|
Glucosidase | Metabolism |
Conduritol B epoxide 是不可逆的,β-glucosidase 共价抑制剂。 | |||
T78878 |
α-Amylase/α-Glucosidase-IN-5
|
Glucosidase | Metabolism |
α-Amylase/α-Glucosidase-IN-5 (compound 4l) 是一种同时针对α-葡萄糖苷酶 (Glucosidase) 和α-淀粉酶 (Amylases) 的抑制剂,IC50 值分别为 5.96 μM 和 1.62 μM,显示出潜在的抗糖尿病活性。 | |||
T8989 |
NCGC 607
NCGC607 |
Others | Others |
NCGC 607 是一种葡萄糖脑苷酶的非抑制性分子伴侣。 | |||
T60255 |
α-Amylase/α-Glucosidase-IN-1
|
Others | Others |
α-Amylase/α-Glucosidase-IN-1 (compound 33) 是一种有效的α-淀粉酶/α-葡萄糖苷酶抑制剂,对α-淀粉酶和 α-葡萄糖苷酶的IC50值分别为 2.01、2.09 μM。动力学研究预测α-Amylase/α-Glucosidase-IN-1 具有抗高血糖的潜力。 | |||
T79402 |
α-Amylase/α-Glucosidase-IN-4
|
Glucosidase | Metabolism |
α-Amylase/α-Glucosidase-IN-4 (compound 5) 是一种针对 α-葡萄糖苷酶 (Glucosidase) 及 α-淀粉酶 (Amylases) 的双效抑制剂,分别展现出 0.15 μM 和 1.10 μM 的IC50s。该化合物展示了其潜在的抗糖尿病活性。 | |||
T80715 |
α-Amylase/α-Glucosidase-IN-6
|
Others | Others |
α-Amylase/α-Glucosidase-IN-6 (compound 5j) 是一种对α-amylase和α-glucosidase具有双重抑制作用的有效化合物,其IC50s分别为17.0 µM和40.1 µM。该化合物还表现出抗高血糖活性。 | |||
T79225 |
α-Amylase/α-Glucosidase-IN-3
|
Glucosidase | Metabolism |
α-Amylase/α-Glucosidase-IN-3 (Compound 17) 是一种具有针对α-Amylase和α-Glucosidase的双重抑制活性的化合物,其IC50分别为0.70 μM和1.10 μM。该化合物可应用于II型糖尿病的研究领域。 | |||
T61706 |
α-Amylase/α-Glucosidase-IN-2
|
Others | Others |
α-Amylase/α-Glucosidase-IN-2 (compound 5) exhibits strong inhibition activity towards both α-amylase and α-glucosidase enzymes, with IC 50 values of 13.02 μM and 13.09 μM, respectively. This compound shows promise for investigating diabetic complications [1]. | |||
T8986 |
ML198
|
Glucokinase | Metabolism |
ML198 是葡萄糖脑苷脂酶激活剂(EC50:0.4 μM)。它不会抑制该酶的作用,且能促进其易位至溶酶体,可用于研究戈谢病。 | |||
T4280 |
Gcase activator 1
LTI-291,LTI 291,LTI291 |
Glucosidase | Metabolism |
Gcase activator 1 (LTI-291) 是葡糖脑苷脂酶 (Gcase) 的激活剂。 | |||
T0920 |
Ambroxol
氨溴索,氨溴索碱,Ambroxolum,NA-872 |
P450; Autophagy | Autophagy; Metabolism |
Ambroxol (NA-872) 是前药溴己辛的活性代谢产物,是一种分泌溶解剂,具有强效祛痰作用,用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬,有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣,可增加葡糖脑苷脂酶的活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2144 |
Resveratroloside
|
P450; NO Synthase | Immunology/Inflammation; Metabolism |
Resveratroloside 是α-glucosidase 的竞争性抑制剂,可以对血糖水平进行调节,对心脏具有保护作用。 | |||
T13130 |
Terphenyllin
|
Glucosidase | Metabolism |
Terphenyllin 是一种天然对三联苯代谢物,分离自珊瑚源真菌念珠菌,能够显著抑制α-葡萄糖苷酶的活性。 | |||
T3S0860 |
Gitogenin
|
UGT | Metabolism |
Gitogenin 是一种从Tribulus longipetalus 整株中分离出来的天然类固醇,是一种 UDP-葡萄糖醛酸转移酶 1A4 (UGT1A4) 和 α-葡萄糖苷酶的选择性抑制剂,其IC50分别为 0.69 µM (使用三氟拉嗪为底物) 和 37.2 μM,对人类主要细胞色素 P450 亚型的活性无抑制作用。 | |||
TN6771 |
Malabaricone B
|
Others | Others |
Malabaricone B 是一种源自香料的酚类物质,它通过不依赖 p53 的途径诱导肺癌细胞中的线粒体损伤。 | |||
T7544 |
Fucoidan
岩藻多糖 |
Others | Others |
Fucoidan 是一种 α-淀粉酶和 α-葡萄糖苷酶的有效抑制剂,是一种生物特性多糖。 它具有抗凝血,抗肿瘤,抗氧化和抗脂肪特性。 | |||
T75612 |
α-Glucosidase-IN-24
|
Others | Others |
α-Glucosidase-IN-24 (Compound 13) 是一种α-Glucosidase 抑制剂,IC50为 451 μM,可以从Swertia kouitchensis 中分离得到。 | |||
T80713 |
α-Glucosidase-IN-37
|
||
α-Glucosidase-IN-37(Compound 11)展示出中等水平的抑制作用,能够抑制LPS诱导的NO产生,并在巨噬细胞中表现出23.7 μM的IC50值。该化合物对α-Glucosidase的抑制活性相对较弱。 | |||
TN1451 |
Brevifolincarboxylic acid
|
AhR; Aryl Hydrocarbon Receptor; Glucosidase | Immunology/Inflammation; Metabolism |
Brevifolincarboxylic acid 是从头状蓼中分离得到的一种天然产物,抑制芳烃受体(AhR)。它是一种 α-葡萄糖苷酶抑制剂,IC50 为 323.46 μM。 | |||
T8319 |
Butyl isobutyl phthalate
ButylIsobutylPhthalate,邻苯二甲酸-1-丁酯-2-异丁酯 |
Glucosidase | Metabolism |
Butyl isobutyl phthalate (ButylIsobutylPhthalate) 是一种非竞争性 α-葡萄糖苷酶抑制剂,IC50=38 μM,可以从海带的根状茎中分离得到。它具有降血糖作用,可用于糖尿病相关的研究。 | |||
TN1990 |
Norathyriol
芒果苷元 |
Akt; DNA/RNA Synthesis; AMPK; PPAR | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
Norathyriol 是来自芒果的芒果苷代谢物,具有抗氧化、抗癌、抗菌和抗炎活性。它以非竞争性方式抑制 α-葡萄糖苷酶,IC50为 3.12 μM。它还抑制PPARα、PPARβ和PPARγ,IC50分别为 92.8、102.4 和 153.5 µM。 | |||
T12142 |
N-Caffeoyl O-methyltyramine
|
Glucosidase | Metabolism |
N-Caffeoyl O-methyltyramine 是一种生物碱,分离自Cuscuta reflexa,能够较大程度抑制α-葡萄糖苷酶的活性(IC50:103.58 μM)。 | |||
T41044 |
Naringinase
|
Glucosidase | Metabolism |
Naringinase 是一种在自然界中广泛存在的水解酶复合物,具有 α-L-鼠李糖苷酶和 β-D-葡萄糖苷酶的活性,主要用于糖苷的水解。 | |||
T7028 |
Licochalcone C
LICOCHALCONEC,甘草查尔酮C |
Phosphatase; Antioxidant; Glucosidase | Metabolism; oxidation-reduction |
Licochalcone C (LICOCHALCONEC) 能够抑制 α-葡萄糖苷酶,其对 α-葡萄糖苷酶的 IC50 <100 nM,对蛋白酪氨酸磷酸酶 1B 的 IC50=92.43 μM 。 | |||
T8260 |
4',5-Dihydroxyflavone
|
Lipoxygenase; Glucosidase | Metabolism |
4',5-Dihydroxyflavone 是大豆 LOX-1,Ki=102.6 μM。它也是一种酵母 α-葡萄糖苷酶抑制剂,IC50=66 μM。 | |||
TN2030 |
P-Hydroxyphenethyl trans-ferulate
反式-阿魏酸对羟基苯乙酯 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
p-Hydroxyphenethyl trans-ferulate 具有抗高血糖 (酵母α-葡萄糖苷酶,IC5019.24 ± 1.73 µmol L-1),抗氧化,抗炎活性,也具有抗癌特性和血清素能特性。 | |||
T2956 |
Cedryl acetate
乙酸柏木酯,Cedrol acetate,Cedranyl acetate |
Antifungal | Microbiology/Virology |
Cedryl acetate (Cedranyl acetate) 是一种三环倍半萜烯,分离自草莓番石榴植物,能够表现出 α-葡萄糖苷酶的抑制活性。 | |||
T2S1158 |
4,5-Dicaffeoylquinic acid
3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C |
Others; HBV; Endogenous Metabolite | Metabolism; Microbiology/Virology; Others |
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种天然产物,有抗病毒、抗肝毒性活性。 | |||
T6723 |
Voglibose
AO 128,伏格列波糖,Glustat,Basen |
Glucosidase | Metabolism |
Voglibose (Glustat) 是一种 valiolamine 的衍生物,可抑制α-葡萄糖苷酶活性,可作用于高血糖症等。 | |||
T0247 |
Acarbose
阿卡波糖,BAY g 5421 |
Glucosidase | Metabolism |
Acarbose (BAY g 5421) 是一种具有口服具有活力 α-葡萄糖苷酶 (alpha-glucosidase) 抑制剂 (IC50=11 nM),是一种降糖药。它能提高磺脲类药物或胰岛素的降血糖作用。 | |||
T5S0788 |
Oroxin A
木蝴蝶苷A,Baicalein 7-O-glucoside |
PPAR | DNA Damage/DNA Repair; Metabolism |
Oroxin A (Baicalein 7-O-glucoside) 是从黄芩根中提取的一种天然产物,是PPARγ的部分激动剂,可激活 PPARγ 转录。它通过对接 PPARγ 的蛋白配体结合区域起到激活作用。它对 α-葡萄糖苷酶有抑制活性,具有抗氧化能力,可用于癌症研究。 | |||
TN1926 |
Methyl caffeate
Methyl caffeate acid,金银花,咖啡酸甲酯 |
Others; Antibacterial | Microbiology/Virology; Others |
Methyl caffeate (Methyl caffeate acid) acid 是一种抗微生物剂,有抗菌和抗分枝杆菌活性。它还抑制 α-葡萄糖苷酶,有氧化应激抑制活性,抗血小板活性,子宫颈癌的抗增殖活性以及肺和白细胞的抗癌活性。 | |||
TQ0308 |
Castanospermine
1,6,7,8-Tetrahydroxyoctahydroindolizine,栗精胺,亚胺糖栗树精胺,(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine |
Glucosidase | Metabolism |
Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) 能够抑制α- and β-glucosidases 的所有形式。 | |||
T8202 |
Kaempferol 3-O-gentiobioside
Kaempferol 3-gentiobioside,山柰酚 3-龙胆双糖苷 |
Glucosidase | Metabolism |
Kaempferol 3-O-gentiobioside 是一种黄酮类化合物,从C. alata 叶中分离得到,具有抗糖尿病特性。它有抗 α-glucosidase 活性,并具有对碳水化合物酶的抑制作用,其 IC50=50.0 µM。 | |||
T0314 |
Hexylresorcinol
己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol |
Apoptosis; Tyrosinase; Antibacterial; Parasite | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然产物,具有抗菌、驱虫、防腐和抗肿瘤活性。它是一种可逆、非竞争性的 α-葡萄糖苷酶抑制剂,有抗 DNA 氧化损伤的保护作用。它可诱导鳞癌细胞凋亡。 | |||
T6S1525 |
3,4-Dicaffeoylquinic acid
Isochlorogenic acid B,金银花,异绿原酸B |
Apoptosis; Antioxidant; Influenza Virus; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology; oxidation-reduction |
3,4-Dicaffeoylquinic acid (Isochlorogenic acid B) 是一种天然产物,具有α-葡萄糖苷酶抑制作用和凋亡介导的细胞毒性 。它还具有抗病毒、抗氧化、DNA 保护、神经保护和肝保护特性。 | |||
T3675 |
1-Deoxynojirimycin
Duvoglustat,Moranoline,1-脱氧野尻霉素,moranolin |
PI3K; Glucosidase | Metabolism; PI3K/Akt/mTOR signaling |
1-Deoxynojirimycin (Moranoline) 是一种口服具有活性的 α-葡萄糖苷酶抑制剂。它具有降血糖、减肥和抗病毒的活性。它抑制餐后血糖,预防糖尿病。 | |||
T3235 |
Rebaudioside A
Reb-A 97,瑞鲍迪甙 A,Reb A,Stevioside A3,莱苞迪甙 A,Glycoside A3 |
Endogenous Metabolite; Glucosidase | Metabolism |
Rebaudioside A (Reb A) 是一种甜菊醇糖苷,也是一种 α-glucosidase 抑制剂,IC50=35.01 ug/mL。 | |||
T21344 |
1-Deoxynojirimycin hydrochloride
Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin |
PI3K; Antibacterial; Antibiotic; Glucosidase | Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
1-Deoxynojirimycin hydrochloride (Moranoline) 是一种口服有效的 α-葡萄糖苷酶抑制剂,具有降血糖、减肥和抗病毒的作用,可抑制餐后血糖,预防糖尿病。 | |||
TN6784 |
ethyl rosmarinate
迷迭香酸乙酯 |
MMP; Tyrosinase; Glucosidase | Metabolism; Proteases/Proteasome |
ethyl rosmarinate 抑制酪氨酸酶、α-葡萄糖苷酶和基质金属蛋白酶-1 (MMP-1) 的活性。 | |||
TN2326 |
(Z)-Butylidenephthalide
(Z)-3-Butylidenephthalide |
Glucosidase | Metabolism |
(Z)-Butylidenephthalide ((Z)-3-Butylidenephthalide) 具有抗肿瘤和降血糖作用,能有效抑制胶质瘤的肿瘤生长,抑制 R-葡萄糖苷酶活性。 | |||
T3S2072 |
3-Butylidenephthalide
Butylidene phthalide,n-Butylidenephthalide,丁烯基苯酞,丁烯基苯酞;丁烯基酞内酯 |
Parasite; Glucosidase | Metabolism; Microbiology/Virology |
3-Butylidenephthalide (Butylidene phthalide) 是从 Ligusticum chuanxiongHort 鉴定出的一种邻苯二甲酸酐衍生物,有杀虫活性。 | |||
TQ0226 |
Jionoside B1
|
Glucosidase | Metabolism |
Jionoside B1 是从熟地黄(Gaertn.)的根中分离出来的,抑制 α-葡萄糖苷酶。 | |||
T6S2122 |
Ginkgolic Acid (C13:0)
6-Tridecylsalicylic acid,Ginkgolic acid (13:0),Ginkgoneolic Acid,银杏酸C13:0,Ginkgolic acid C13:0 |
Antibacterial; Glucosidase | Metabolism; Microbiology/Virology |
Ginkgolic Acid (C13:0) (6-Tridecylsalicylic acid) 是一种天然防龋药,有抑菌活性。 | |||
TL0009 |
coniferin
Coniferoside,松柏苷,Abietin |
Others; Antifungal | Microbiology/Virology; Others |
Coniferin (Abietin) 是一种松柏醇中的葡萄糖苷。它抑制真菌生长和黑化反应,具有 ATP 依赖性转运活性并具有抗氧化作用。 | |||
TN1488 |
Chrysin 6-C-glucoside 8-C-arabinoside
|
Others | Others |
Chrysin 6-C-glucoside 8-C-arabinoside 是α±-葡萄糖苷酶抑制剂,α±-葡萄糖苷酶抑制剂广泛用于2型糖尿病的治疗。 | |||
TN1487 |
Chrysin 6-C-arabinoside 8-C-glucoside
|
Others | Others |
Chrysin 6-C-arabinoside 8-C-glucoside 是α±-葡萄糖苷酶抑制剂,α±-葡萄糖苷酶抑制剂广泛用于2型糖尿病的治疗。 | |||
TN1705 |
Glycyrrhisoflavone
|
MAO; Tyrosinase; NO Synthase; Immunology/Inflammation related | Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome |
Glycyrrhisoflavone 是一种具有抗炎作用的酪氨酸酶抑制剂。 Glycyrrhisoflavone 抑制 α-葡萄糖苷酶和单胺氧化酶。 | |||
TN2302 |
Viscidulin III
Ganhuangenin |
Glucosidase | Metabolism |
Viscidulin III (Ganhuangenin) 存在于黄芩中,可作为α-葡萄糖苷酶抑制剂。 | |||
TN7134 |
Magnoloside B
|
Glucosidase | Metabolism |
Magnoloside B 是一种来自木兰果实的苯乙醇糖苷,是一种 α-glucosidase 抑制剂,对自由基诱导的氧化损伤的保护作用,可用于研究癌症。 | |||
T1529 |
Miglitol
BAY1099,米格列醇,BAY-m1099 |
Others | Others |
Miglitol (BAY1099) 是一种口服抗糖尿病化合物,能够抑制糖复合体分解为葡萄糖。 | |||
TN1928 |
Methyl rosmarinate
|
MMP; Anti-infection; Tyrosinase | Microbiology/Virology; Proteases/Proteasome |
Methyl rosmarinate 是一种非竞争性 tyrosinase 抑制剂,从 Rabdosia serra 中分离得到的,对蘑菇酪氨酸酶作用的 IC50值为 0.28 mM,也能抑制a-glucosidase。 | |||
T6S1371 |
Isovitexin
Homovitexin,Saponaretin,Apigenin-6-C-Glucoside,异牡荆黄素 |
NF-κB; JNK; Glucosidase | MAPK; Metabolism; NF-κB |
Isovitexin (Apigenin-6-C-Glucoside) 是从亚洲水稻种得到的一种黄酮,具有抗氧化和抗炎活性。它的作用与JNK1/2的抑制剂类似,抑制NF-κB 的活化。 | |||
T6S0535 |
Pinoresinol diglucoside
Pinoresinol Diglucopyranoside,松脂醇二葡萄糖苷 |
Glucosidase | Metabolism |
Pinoresinol diglucoside (Pinoresinol Diglucopyranoside) 是一种分离自杜仲和其他植物物种中的主要木脂素,具有多种药理活性。 | |||
TN2277 |
Torachrysone-8-O-b-D-glucoside
芦荟大黄素 8-葡萄糖甙,Torachrysone 8-O-glucoside |
Antifection | Microbiology/Virology |
Torachrysone-8-O-b-D-glucoside 可从 Polygonum multiflorum 分离得到。它对 DPCs(真皮乳头细胞)的增殖具有促进作用。 | |||
TN2130 |
Manghaslin
槲皮素-3-O-芸香糖-(1→2)-O-鼠李糖苷,Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside |
AChE; Glucosidase | Metabolism; Neuroscience |
Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) 是具有抗炎活性的黄酮苷,对 AChE 具有抑制活性,IC50=94.92 µM。 | |||
T3796 |
Betulinaldehyde
Betulinic aldehyde,Betulinal,Betunal,白桦脂醛 |
Apoptosis; Antibacterial | Apoptosis; Microbiology/Virology |
Betulinaldehyde (Betunal) 是五环三萜,有抗金黄色葡萄球菌等细菌和真菌作用。 | |||
T5690 |
7,4'-Di-O-methylapigenin
芹菜素二甲醚,4',7-DIMETHOXY-5-HYDROXYFLAVONE |
Amylase | Metabolism |
7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) 可能具有抗真菌c.zeyheri 的作用,是一种潜在的抗真菌药物。它还能抑制药物流出泵(IC50 = 51.64μg /毫升)。 | |||
TN4368 |
Kaempferol-3,7-di-O-β-glucoside
Kaempferol 3,7-di-O-glucoside |
Glucosidase; Amylase | Metabolism |
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) 是一种来自 Morettia philaena 的黄酮醇,对 α-淀粉酶 (α-amylase)、α-葡萄糖苷酶 (α-glucosidase) 和乙酰胆碱酯酶 (Acetylcholinesterase) 具有抑制作用。Kaempferol-3,7-di-O-β-glucoside 具有神经保护活性,可减缓分化神经元细胞 SH-SY5Y 免受 Amyloid β 肽诱导的损伤。Kaempferol-3,7-di-O-β-glucoside 可用于研究阿尔茨海默氏症类的神经系统疾病。 | |||
TN1956 |
Mulberrofuran G
|
Phosphatase; HBV; Glucosidase | Metabolism; Microbiology/Virology |
Mulberrofuran G分离自自 Morus alba L.,具有抗乙型肝炎病毒活性,可保护缺血损伤诱导的细胞死亡。Mulberrofuran G 是一种 PTP1B 和 α-葡萄糖苷酶的双重抑制剂,可用于研究阿尔茨海默症。 | |||
T6S1369 |
Vitexin
牡荆素,Apigenin-8-C-glucoside |
Antioxidant | oxidation-reduction |
Vitexin 是一种存在于多种药用植物(如榕树、螺旋藻)中的 c-糖基化的黄酮。 它具有广泛的药理作用,包括抗氧化,抗癌,抗炎,抗痛觉过敏和神经保护作用。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05099 |
GBA/glucocerebrosidase Protein, Human, Recombinant (His)
glucosidase, β, acid,GLUC,GCB,GBA1,glucosidase<... |
Human | HEK293 Cells |
Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD. | |||
TMPH-01635 |
MGAM Protein, Human, Recombinant (aa 87-954, His)
MGAM,Maltase-glucoamylase,Alpha-1,4-glucosidase |
Human | Baculovirus Insect Cells |
May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. MGAM Protein, Human, Recombinant (aa 87-954, His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 101.1 kDa and the accession number is O43451. | |||
TMPH-01636 |
MGAM Protein, Human, Recombinant (aa 960-1853, His)
Alpha-1,4-glucosidase,Maltase-glucoamylase,MGAM |
Human | Baculovirus Insect Cells |
May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. | |||
TMPY-01579 |
GBA3 Protein, Human, Recombinant (His)
glucosidase, beta, acid 3 (gene/pseudogene),GBA3,MG... |
Human | Baculovirus Insect Cells |
Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to theglycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in r... | |||
TMPH-02771 |
GBA Protein, Mouse, Recombinant (His & SUMO)
Lysosomal galactosylceramidase,Cholesteryl-beta-glucosid... |
Mouse | E. coli |
GBA Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-03484 |
Agn1 Protein, S. pombe, Recombinant (His & Myc)
Glucan endo-1,3-alpha-glucosidase agn1,Endo-1,3-alp... |
Fission yeast | E. coli |
Has a role in cell separation where it is required for the degradation of the cell wall material surrounding the septum (the septum edging) which must be hydrolyzed before full separation of the daughter cells can occur. Hydrolyzes 1,3-alpha-glucan predominantly into pentasaccharides. Agn1 Protein, S. pombe, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 51.8 kDa and the accession number is O13716. | |||
TMPH-02772 |
GBA Protein, Mouse, Recombinant (His)
Cholesteryl-beta-glucosidase,Lysosomal galactosylce... |
Mouse | P. pastoris (Yeast) |
GBA Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 57.5 kDa and the accession number is P17439. | |||
TMPH-01624 |
GBA Protein, Human, Recombinant
Lysosomal glycosylceramidase,Acid beta-glucosidase,... |
Human | E. coli |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... | |||
TMPH-01623 |
GBA Protein, Human, Recombinant (His & Myc & SUMO)
Lysosomal acid glucosylceramidase,GBA1,Lysosomal galactosylc... |
Human | E. coli |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... | |||
TMPH-03342 |
GBA2 Protein, Rat, Recombinant (His)
Bile acid glucosyl transferase GBA2,Glucosylceramidase 2,Non... |
Rat | E. coli |
GBA2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 42.6 kDa and the accession number is Q5M868. |