51
8
10
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9558 |
KL-11743
|
transporter | Metabolism |
KL-11743 是葡萄糖竞争性 I 类葡萄糖转运蛋白抑制剂,口服有活性,能够抑制GLUT1 (IC50:115 nM) 、GLUT2 (IC50:137 nM) 、GLUT3 (IC50:90 nM) 及GLUT4 (IC50:68 nM) 。它能够特异性阻断葡萄糖代谢,也可与电子传递抑制剂协同作用诱导细胞死亡。 | |||
T3713 |
BAY-876
|
transporter | Metabolism |
BAY-876 是口服有效的,选择性的葡萄糖转运蛋白 1 (GLUT1) 抑制剂(IC50= 2 nM)。BAY-876 对 GLUT1 选择性比 GLUT2,GLUT3 和 GLUT4 高(>130 倍)。BAY-876 对糖酵解代谢和卵巢癌生长也有有效的抑制作用。 | |||
T2363 |
STF-31
|
transporter; Autophagy | Autophagy; Metabolism |
STF31 是一种葡萄糖转运蛋白 1 的选择性抑制剂,IC50为 1 μM。 | |||
T7018 |
WZB117
|
transporter | Metabolism |
WZB117 是葡萄糖转运蛋白 1 抑制剂,可下调糖酵解,诱导细胞周期停滞,有抗癌细胞生长的作用。 | |||
T8616 |
Fasentin
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide |
transporter | Metabolism |
Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) 是葡萄糖摄取抑制剂,可抑制GLUT-1/GLUT-4转运蛋白,优先抑制 GLUT4,IC50为 68 μM。它是死亡受体刺激敏化剂,可敏化细胞对 FAS 诱导的细胞死亡,具有抗血管生成活性。 | |||
T8732 |
CTPI-2
|
Others; Mitochondrial Metabolism | Metabolism; Others |
CTPI-2 是一种特异性线粒体柠檬酸盐载体SLC25A1抑制剂,KD=3.5 μM,具有抗肿瘤作用。它能够抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。它阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变,防止演变为脂肪性肝炎,减少肝脏和脂肪组织中炎性巨噬细胞的浸润,并显著减轻由高脂肪饮食引起的肥胖。 | |||
T4182 |
lavendustin B
薰草菌素B |
Tyrosinase; transporter; HIV Protease | Metabolism; Microbiology/Virology; Proteases/Proteasome |
Lavendustin B 是一种酪氨酸激酶抑制剂,是 HIV-1 整合酶 (IN) 与其同源细胞辅助因子、晶状体上皮衍生生长因子 (LEDGF/p75) 相互作用的抑制剂。 | |||
T38843 |
Enavogliflozin
DWP-16001 |
SGLT | GPCR/G Protein |
Enavogliflozin (DWP-16001) 是一种口服有效的,选择性的钠-葡萄糖协同转运体 -2 抑制剂,具有抗糖尿病的功效。 | |||
T9590 |
T-1095
|
SGLT; transporter | GPCR/G Protein; Metabolism |
T-1095 是一种口服有活性的Na+-葡萄糖协同转运蛋白选择性抑制剂,能够抑制 SGLT1 (IC50:22.8 µm) 及 SGLT2 (IC50:2.3 µm) 。它可用于研究糖尿病。 | |||
T22317 |
DRB18
|
transporter | Metabolism |
DRB18 is a highly effective pan-class inhibitor of glucose transporter proteins (GLUT). It significantly modulates energy-related metabolism in A549 cells by inducing alterations in the abundance of metabolites associated with glucose-related pathways. DRB18 exerts its effects by promoting G1/S phase arrest, increasing oxidative stress, and prompting necrotic cell death, ultimately displaying notable anti-tumor activity [1]. | |||
T3547 |
Sotagliflozin
LX-4211,LP-802034 |
SGLT | GPCR/G Protein |
Sotagliflozin (LP-802034) 是有效的SGLT1/2抑制剂,用作抗糖尿病剂。 | |||
T1782 |
Canagliflozin
卡格列净,JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754 |
SGLT | GPCR/G Protein |
Canagliflozin (JNJ 28431754AAA) 是SGLT2的选择性抑制剂,在表达 mSGLT2,rSGLT2 和 hSGLT2 的 CHO 细胞上,IC50分别为 2 nM,3.7 nM 和 4.4 nM。 | |||
T33412 |
MitoPQ
MitoParaquat |
Glucokinase; transporter | Metabolism |
MitoPQ (MitoParaquat) 是一个线粒体靶向的小分子化合物。MitoPQ 选择性加强线粒体超氧化物和过氧化氢的含量,抑制胰岛素刺激的葡萄糖摄取和葡萄糖转运蛋白 4 (GLUT4) 向脂肪细胞和肌管中质膜的易位。MitoPQ 可用于研究线粒体氧化应激与调节的 GLUT4 转运。 | |||
T2389 |
Dapagliflozin
达格列净,BMS-512148 |
SGLT; HIF | Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein |
Dapagliflozin (BMS-512148) 是一种葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可与靶点竞争性结合。Dapagliflozin 可用于 2 型糖尿病的治疗,可以减少肾脏的葡萄糖重吸收,增加尿液中葡萄糖的排泄,从而降低血浆葡萄糖水平。 | |||
T7217 |
Bexagliflozin
THR-1442,EGT1442,EGT0001442 |
SGLT | GPCR/G Protein |
Bexagliflozin (EGT1442) 是一种选择性的,口服有效的钠葡萄糖协同转运蛋白-2 (SGLT2) 抑制剂,对人 SGLT2 和 SGLT1 作用的 IC50值分别为 2 nM 和 5.6 μM。EGT1442在 2 型糖尿病中有研究价值。 | |||
T1782L |
Canagliflozin hemihydrate
JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754 |
SGLT | GPCR/G Protein |
Canagliflozin hemihydrate (TA 7284) (JNJ28431754 hemihydrate) 是一种选择性的 SGLT2 抑制剂,作用于表达 mSGLT2,rSGLT2 和 hSGLT2 的 CHO 细胞,IC50 分别为 2 nM,3.7 nM 和 4.4 nM。 | |||
T16083 |
Mizagliflozin
GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base |
SGLT | GPCR/G Protein |
Mizagliflozin (GSK-1614235 free base) 是口服有效的、选择性的 SGLT1抑制剂,对人 SGLT1 的 Ki 值为 27 nM。Mizagliflozin 对 SGLT1 的选择性是 SGLT2的303 倍。它是抗糖尿病药物,可以改善餐后血糖波动。它在改善慢性便秘方面具有潜在的作用。 | |||
T4460 |
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate |
SGLT | GPCR/G Protein |
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) 是 Dapagliflozin 1,2-propanediol, hydrate 的 S 型异构体,是竞争性葡萄糖协同转运蛋白2 抑制剂,可促进尿液中葡萄糖的排泄,可用于糖尿病的研究。它诱导 HIF1表达并减轻肾脏 IR 损伤。 | |||
T40413 |
SW157765
|
transporter | Metabolism |
SW157765 是一种选择性葡萄糖转运体 GLUT8(SLC2A8)抑制剂,是很多化合物的前药,以剂量依赖性方式选择性地抑制SW157765敏感细胞中荧光 2-脱氧葡萄糖 (2DG) 的摄取 ,可用于研究肺癌。 | |||
T11420 | GLUT4 activator 1 | Others | Others |
GLUT4 activator 1 is a potent glucose transporter type 4 (GLUT4) translocation activator (EC50: 0.14 μM). | |||
T29188 |
YM-543 trimethylamine
ASP 543,ASP-543,ASP543 |
Others | Others |
YM-543, a sodium-glucose transporter 2 (SGLT-2) inhibitor, is used potentially for the treatment of type 2 diabetes. | |||
T24708 |
Remogliflozin
GSK189074,Remogliflozin A,GSK-189074,GSK 189074 |
Others | Others |
Remogliflozin is an effective sodium-glucose transporter 2 inhibitor (Kis = 12.4 and 26 nM for human and rat SGLT2, respectively). | |||
T12893 |
SGLT inhibitor-1
|
SGLT | GPCR/G Protein |
SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively). | |||
T10957 |
Dapagliflozin impurity
|
Others | Others |
Dapagliflozin impurity is the enantiomer of Dapagliflozin, Dapagliflozin is a sodium glucose transporter 2 inhibitor. | |||
T71340 |
Mizagliflozin sebacate
|
Others | Others |
Mizagliflozin sebacate is a sodium-glucose transporter inhibitor. It is expected to improve postprandial hyperglycemia by suppressing glucose absorption from the intestine with a novel mechanism of action different from that of conventional alpha-glucosidase inhibitors. Mizagliflozin blocks intestinal glucose absorption and reduce GIP secretion in rats and humans, suggesting SGLT1 glucose transport is critical for GIP release. | |||
T38539 |
Luseogliflozin hydrate
鲁格列净水合物,TS 071 hydrate |
Others | Others |
Luseogliflozin (TS 071) hydrate, a second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor, exhibits selective potency and oral activity, with an IC50 of 2.26 nM. This compound is utilized in research for the treatment of type 2 diabetes mellitus (T2DM). | |||
T78184 |
MMV009085
|
Others | Others |
MMV009085是一种针对恶性疟原虫己糖转运体PfHT1的特异性抑制剂,具有潜在的抗疟效果。它同时抑制人葡萄糖转运蛋白,强效抑制葡萄糖吸收(IC50:2.6 μM)及恶性疟原虫3D7株的生长(EC50:1.23±0.04 μM)。 | |||
T82294 |
GLUT1-IN-3
|
Others | Others |
GLUT1-IN-3 (Compd 4b) 是针对1型葡萄糖转运蛋白缺乏综合症相关疾病研究的化合物,具有有效抑制癫痫发作的作用。 | |||
T36142 |
10-PAHSA
|
Others | Others |
10-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid is esterified to 10-hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue. As other FAHFAs improve glucose tolerance, stimulate insulin secretion, and have anti-... | |||
T79263 |
Antitumor agent-102
|
Topoisomerase | DNA Damage/DNA Repair |
Antitumor agent-102(compound 10)是拓扑异构酶 I(topoisomerase I)抑制剂SN38与葡萄糖转运蛋白(glucose transporter)抑制剂缀合物,专门针对结直肠癌。相较于伊立替康,该化合物在肿瘤组织中可诱导游离SN38的更高浓度。 | |||
T84422 |
13-OAHSA
|
Others | Others |
13-OAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), results from the esterification of oleic acid to 13-hydroxy stearic acid. It represents a significant component of the FAHFA family, most abundantly expressed in the serum of glucose-tolerant AG4OX mice that exhibit adipose tissue-specific overexpression of the Glut4 glucose transporter. Similar to other FAHFAs which are known to enhance glucose tolerance, stimulate insulin secretion, and exert anti-inflammatory effects, 13-O... | |||
T37118 |
ADP-Glucose (sodium salt)
ADPG,Adenosine-5'-diphosphoglucose,ADP-Glucose (sodium salt) |
Others | Others |
ADP-Glucose (ADPG) is an immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.[1],[2] It is used by amylose synthases or starch synthases in plastids in the production of amylose, amylopectins, starch, and other polysaccharides. ADPG is normally generated within plastids, although it can be biosynthesized in the cytoplasm of certain grasses and imported in... | |||
T84421 |
13-POHSA
|
Others | Others |
13-POHSA (palmitoleic acid esterified to 13-hydroxy stearic acid) is a type of branched fatty acid esters of hydroxy fatty acids (FAHFAs), which have recently been discovered as endogenous lipids whose levels are modulated by fasting and high-fat diets, and are linked to insulin sensitivity in mice. Notably, the concentration of 13-POHSA in the serum significantly increases in glucose tolerant AG4OX mice, a model that overexpresses the Glut4 glucose transporter in adipose tissue, suggesting its ... | |||
T70390 |
YM-543 choline
|
Others | Others |
YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and its inhibition may present a novel therapeutic strategy for treating diabetes. YM543 potently and selectively inhibited mouse and human SGLT2 activities at nanomolar ranges. In vivo single oral administration of YM543 dose-dependently and significantly reduced blood glucose level... | |||
T84420 |
13-SAHSA
|
Others | Others |
13-SAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), has been found to be involved in metabolic regulation, particularly in relation to fasting, high-fat feeding, and insulin sensitivity. This compound is a synthesis of stearic acid and 13-hydroxy stearic acid. Notably, 13-SAHSA levels are found to be moderately increased in the serum of AG4OX mice, which are characterized by their glucose tolerance and expression of the Glut4 glucose transporter specifically in their adipose t... | |||
T84387 |
10-SAHSA
|
Others | Others |
10-SAHSA, an endogenous lipid recently discovered, is part of the FAHFAs, a group of branched fatty acid esters of hydroxy fatty acids. It specifically consists of stearic acid esterified to 10-hydroxy stearic acid. Notably, PAHSAs, closely related to 10-SAHSA, are significantly present in the adipose tissue of AG4OX mice that are glucose tolerant due to the overexpression of the Glut4 glucose transporter in their adipose tissue. Similar to other FAHFAs, which are known to improve glucose tolera... | |||
T84424 |
5-SAHSA
|
Others | Others |
15-SAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), is recognized for its involvement in metabolic regulation. This compound comprises stearic acid esterified to 5-hydroxy stearic acid and is notably influenced by dietary changes, such as fasting and high-fat consumption, with a link to insulin sensitivity. SAHSA levels are specifically found to be moderately increased in the serum of AG4OX mice, which are characterized by their glucose tolerance through the overexpression of ... | |||
T84425 |
5-POHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs), endogenous lipids influenced by fasting and high-fat diets, are linked to improved insulin sensitivity in mice. These molecules consist of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) bonded to a C-16 or C-18 hydroxy fatty acid. A specific FAHFA, 5-POHSA, features palmitoleic acid esterified with hydroxy stearic acid at the 5th carbon. Elevated levels of 5-POHSA in the serum of AG4OX mice, which expres... | |||
T69622 |
Ritivixibat
|
Others | Others |
Ritivixibat为回肠胆汁酸转运蛋白(IBAT)抑制剂,同时也是胆汁酸调节剂,主要适用于心血管疾病、脂肪酸代谢及葡萄糖利用障碍、胃肠道和肝脏疾病的研究。 | |||
T84386 |
10-OAHSA
|
Others | Others |
10-OAHSA is a newly discovered endogenous lipid categorized within the group of branched fatty acid esters of hydroxy fatty acids (FAHFAs). This specific FAHFA comprises oleic acid esterified to 10-hydroxy stearic acid. It stands out among its FAHFA counterparts for its potential bioactive properties, similar to other members of its family such as PAHSAs, which are notably prevalent in the adipose tissue of AG4OX mice exhibiting glucose tolerance due to overexpression of the Glut4 glucose transp... | |||
T84407 |
13-PAHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are lipids influenced by dietary changes, playing a crucial role in insulin sensitivity. These compounds typically consist of a C-16 or C-18 fatty acid (for example, palmitoleic, palmitic, oleic, or stearic acid) linked to a hydroxy fatty acid with the same carbon chain length. 13-PAHSA, a derivative where palmitic acid is esterified to 13-hydroxy stearic acid, is notably prevalent in the adipose tissue of glucose-tolerant AG4OX mice, wh... | |||
T84427 |
9-OAHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of endogenous lipids whose levels are modulated by fasting and high-fat diets and are linked to insulin sensitivity. These compounds typically consist of a C-16 or C-18 fatty acid, such as palmitoleic, palmitic, oleic, or stearic acid, esterified to a hydroxylated C-16 or C-18 lipid. One specific form of FAHFA, known as 9-OAHSA, involves the esterification of oleic acid to 9-hydroxy stearic acid. Within the FAHFA family, OAHS... | |||
T84426 |
5-OAHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous lipids that are influenced by fasting and high-fat diets and linked to improved insulin sensitivity in mice. These compounds typically feature a chain of either 16 or 18 carbon atoms (for example, palmitoleic, palmitic, oleic, or stearic acid) esterified with a hydroxy fatty acid chain of similar length. One specific FAHFA, known as 5-OAHSA, consists of oleic acid bonded to the fifth carbon of hydroxy stearic acid. Within ... | |||
T60629 |
PF-06649298
|
Others | Others |
PF-06649298 是一种钠偶联柠檬酸盐转运蛋白抑制剂,可用于调节糖代谢以及脂代谢的研究。PF-06649298 在人类肝细胞中与 NaCT 特异性结合从而抑制柠檬酸盐的转运,IC50值为 16.2 μM。 | |||
T84428 |
9-POHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are recent discoveries in endogenous lipids that are influenced by dietary changes such as fasting and high-fat diets, showing a link with enhanced insulin sensitivity in mice. These compounds typically feature a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) bound to a hydroxy group on another C-16 or C-18 fatty chain. A specific FAHFA, 9-POHSA, consists of palmitoleic acid connected at the hydroxy stearic... | |||
T84429 |
12-POHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) have emerged as significant regulators of metabolic processes, influenced by dietary changes such as fasting and high-fat diets, and are linked to improved insulin sensitivity in mice. These compounds typically feature a fatty acid chain, either C-16 or C-18 in length (for example, palmitoleic, palmitic, oleic, or stearic acid), esterified to a hydroxy fatty acid of similar length. A specific FAHFA, 12-POHSA, involves the esterification ... | |||
T84432 |
12-SAHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are lipids recently discovered to be modulated by dietary influences such as fasting and high-fat feeding, and they play a role in enhancing insulin sensitivity. These compounds typically feature a carbon-16 or carbon-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) esterified to a carbon-16 or carbon-18 hydroxy fatty acid. A specific example is 12-SAHSA, which consists of stearic acid linked to 12-hydroxy stearic acid... | |||
T84430 |
12-OAHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are recently discovered lipids that play a role in the body's response to fasting and high-fat diets, with a link to insulin sensitivity. These compounds consist of a long-chain fatty acid (such as palmitoleic, palmitic, oleic, or stearic acid) bonded to a hydroxy fatty acid, both ranging in length from C-16 to C-18. Specifically, 12-OAHSA is a type of FAHFA where oleic acid is attached to the 12th carbon of hydroxy stearic acid. Within ... | |||
T73734 |
Acetoacetic acid
|
Others | Others |
Acetoacetic acid是一种存在于脑脊液中的内源代谢物,主要应用于脑膜炎、妊娠、3-羟基-3-甲基戊二酰辅酶A裂解酶缺乏症、子痫前期/子痫、2型糖尿病、1型葡萄糖转运蛋白缺乏综合征及琥珀酰辅酶A:3-氧酸辅酶A转移酶缺乏症的研究中。 | |||
T74962 |
GLUT1-IN-1
|
Others | Others |
GLUT1-IN-1 是一种GLUT1 (葡萄糖转运蛋白 1) 抑制剂,显著特异性地失活GLUT1。该化合物对HeLa、A549 及HepG2 细胞线呈现浓度依赖性的细胞毒性,其IC50 值分别为5.49 μM、11.14 μM 与8.73 μM。GLUT1-IN-1 主要应用于光动力疗法(PDT)与癌症研究领域。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1118 |
Tormentic acid
2Α,19Α-二羟基熊果酸,委陵菜酸 |
Immunology/Inflammation related | Immunology/Inflammation |
Tormentic acid 是一种分离自 Rosa rugosa 中的三萜,具有抗炎、降血脂和抗动脉粥样硬化活性。 | |||
T4S1545 |
Licarin B
(-)-Licarin B,Licarine B,(-)-利卡灵B |
transporter; Antibacterial; PPAR | DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Licarin B (Licarine B) 是来源于肉豆蔻种子的一种天然产物,是 NO 生成抑制剂,可通过激活 IRS-1/PI3K/AKT 通路中的PPARγ和GLUT4 改善胰岛素敏感性。 | |||
T2924 |
Phloretin
根皮素,Dihydronaringenin,NSC 407292,RJC 02792 |
SGLT; transporter; Endogenous Metabolite | GPCR/G Protein; Metabolism |
Phloretin (NSC-407292) 是从苹果树叶中提取的一种查耳酮,具有抗炎、抗氧化和抗癌活性。它是真核尿素转运蛋白抑制剂,可阻断 VacA 介导的尿素和离子转运,有潜力用于类风湿性关节炎和过敏性气道炎症的相关研究。 | |||
T6S0117 |
Avicularin
Fenicularin,扁蓄苷 |
ERK | MAPK |
Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中,它通过抑制 ERK 信号通路产生抗炎活性。 | |||
TN1033 |
Sennidin A
|
HCV Protease; transporter; Akt; PI3K | Cytoskeletal Signaling; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Sennidin A 是从狭叶番泻分离得到的一种天然产物,能够抑制 HCV NS3 解旋酶,其 IC50值为0.8 μM。它诱导 Akt 和葡萄糖转运蛋白4的磷酸化,刺激葡萄糖掺入。 | |||
TN1034 |
Sennidin B
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HCV Protease; transporter; Akt; PI3K | Cytoskeletal Signaling; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Sennidin B 是从Cassia angustifolia 分离得到的Sennidin A 异构体,它刺激葡萄糖掺入,诱导Akt 和葡萄糖转运蛋白4 的磷酸化。 | |||
T2755 |
Rhoifolin
野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside |
Others; p38 MAPK; NF-κB; transporter; IGF-1R; Autophagy | Autophagy; MAPK; Metabolism; NF-κB; Others; Tyrosine Kinase/Adaptors |
Rhoifolin (Apigenin 7-O-neohesperidoside) 是从琯溪蜜柚叶子分离的一种黄酮糖苷。它通过 RANKL 诱导的NF-κB 和MAPK 途径改善钛颗粒刺激的骨溶解并减少破骨细胞生成。它通过增强脂联素分泌,胰岛素受体-β的酪氨酸磷酸化和GLUT4易位有助于治疗糖尿病并发症。 | |||
T72172 |
4,6-O-Ethylidene-α-D-glucose
Ethylidene-glucose |
Others | Others |
4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物,是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂,对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。 |
Cat. No. | Product Name | Species | Expression System |
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TMPH-02122 |
SLC2A1 Protein, Human, Recombinant (His & Myc)
Glucose transporter type 1, erythrocyte/br... |
Human | E. coli |
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. SLC2A1 ... | |||
TMPH-02123 |
SLC2A9 Protein, Human, Recombinant (His)
Urate transporter,SLC2A9,Glucose trans... |
Human | E. coli |
Urate transporter, which may play a role in the urate reabsorption by proximal tubules. Does not transport glucose, fructose or galactose. | |||
TMPH-03373 |
SLC2A1 Protein, Rat, Recombinant (His & Myc)
Glucose transporter type 1, erythrocyte/br... |
Rat | E. coli |
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. SLC2A1 ... | |||
TMPY-03962 |
AFM Protein, Human, Recombinant (His)
afamin,ALBA,ALB2,ALF |
Human | HEK293 Cells |
Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of... | |||
TMPH-01389 |
G6PC Protein, Human, Recombinant (His)
Glucose-6-phosphatase,Glucose-6-phosphatas... |
Human | P. pastoris (Yeast) |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. G6PC Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 5.6 kDa and the accession number is P35575. | |||
TMPH-02119 |
SLC5A2 Protein, Human, Recombinant (His & Myc)
Solute carrier family 5 member 2,Low affinity sodium-glu... |
Human | E. coli |
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. | |||
TMPH-01390 |
G6PC Protein, Human, Recombinant (His & SUMO)
Glucose-6-phosphatase alpha,G6PC1,Glucose-... |
Human | E. coli |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. G6PC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 17.1 kDa and the accession number i... | |||
TMPY-03857 |
MMGT1 Protein, Human, Recombinant (His)
membrane magnesium transporter 1,TMEM32,EMC5 |
Human | HEK293 Cells |
MMGT1 (Membrane Magnesium Transporter 1, also known as EMC5 and TMEM32) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The encoded protein belongs to the membrane magnesium transporter (TC 1.A.67) family which is a group of magnesium transporters that are part of the TOG superfamily. It mediates Mg(2+) transport. MMGT1 is described as having 335 amino acids and five TMSs with an N-terminal cleavage site and some phosphorylation sites. It is widely expressed ... | |||
TMPY-02979 |
HMGN3 Protein, Human, Recombinant (His)
PNAS-24,TRIP7,PNAS-25,high mobility group nucleosomal bindin... |
Human | E. coli |
HMGN3 belongs to the HMGN family and is expressed in the kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate, and uterus. Members of the HMGN family bind to nucleosomes without any specificity for the underlying DNA sequence. They affect the global and local structure of chromatin, as well as the levels of histone modifications, and thus play a role in epigenetic regulation of gene expression. HMGN3 regulates the expression of the glucose transporter ... | |||
TMPH-02873 |
RAB10 Protein, Mouse, Recombinant (His & SUMO)
Ras-related protein Rab-10,Rab10 |
Mouse | E. coli |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, f... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0133 |
Empagliflozin-d4
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Empagliflozin-d4 是 Empagliflozin 的氘代化合物。Empagliflozin 的 CAS 号为 864070-44-0。Empagliflozin 是有效的、选择性的钠葡萄糖协同转运蛋白-2 (SGLT-2) 抑制剂,对人 SGLT-2 的IC50为 3.1 nM。 | |||
TMIH-0013 |
(S)-Empagliflozin-d4
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(S)-Empagliflozin-d4 是 (S)-Empagliflozin 的氘代化合物。(S)-Empagliflozin 的 CAS 号为 864070-44-0。Empagliflozin 是有效的、选择性的钠葡萄糖协同转运蛋白-2 (SGLT-2) 抑制剂,对人 SGLT-2 的IC50为 3.1 nM。 | |||
TMIJ-0153 |
Dapagliflozin-13C6 (glucitol-13C6)
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Dapagliflozin-13C6 (glucitol-13C6) 是 Dapagliflozin 的 13C 的标记化合物。Dapagliflozin 的 CAS 号为 461432-26-8。Dapagliflozin竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可促进尿液中葡萄糖的排泄,在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导HIF1表达并减轻肾脏 IR 损伤。 | |||
T71981 |
Gliclazide-d4
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Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin... |