112
2
10
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37223 |
Glucagon Receptor Antagonist I
|
Others | Others |
Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions. | |||
T36580 |
Glucagon Receptor Antagonist Inactive Control
|
Others | Others |
Glucagon Receptor Antagonist Inactive Control 是一种 Glucagon 受体拮抗剂,可用于生命科学领域的相关研究。其产品编号为 T36580,CAS号为 362482-00-6。 | |||
TQ0239 |
PF-06291874
Glucagon receptor antagonists-4 |
Glucagon Receptor | GPCR/G Protein |
PF-06291874 (Glucagon receptor antagonists-4) 是口服有活性的胰高血糖素受体非肽类拮抗剂。它正用于研究 2 型糖尿病。 | |||
T11413 |
Glucagon receptor antagonists-1
|
Others | Others |
Glucagon receptor antagonist -1 is a highly effective glucagon receptor antagonist. | |||
T11415 |
Glucagon receptor antagonists-3
|
Others | Others |
Glucagon receptor antagonist -3 is a highly effective glucagon receptor antagonist. | |||
T11414 |
Glucagon receptor antagonists-2
|
Others | Others |
Glucagon receptor antagonist -2 is a highly effective glucagon receptor antagonist. | |||
T11416 | Glucagon receptor antagonists-5 | Others | Others |
Glucagon receptor antagonists-5 is an orally bioavailable indazole-based glucagon receptor antagonist (Ki: 32 nM). It has potential for the treatment of type 2 diabetes mellitus (T2DM). | |||
T15389L |
Glucagon (1-29), bovine, human, porcine hydrochloride
盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride |
Glucocorticoid Receptor; Glucagon Receptor | Endocrinology/Hormones; GPCR/G Protein |
Glucagon (1-29), bovine, human, porcine hydrochloride 是一种由胰腺 α 细胞产生的多肽激素。它可激活 HNF4α 并促进 HNF4α 磷酸化,促进糖异生。 | |||
TQ0124 |
BETP
|
Glucagon Receptor | GPCR/G Protein |
BETP 是胰高血糖素样肽 (GLP-1) 受体激动剂,能够抑制人和大鼠的GLP-1受体,其EC50值分别为 0.66 μM 和 0.755 μM。 | |||
T11845 |
LGD-6972
|
Glucagon Receptor | GPCR/G Protein |
LGD-6972 是口服有活性的胰高血糖素受体选择性拮抗剂,能够用于研究 2 型糖尿病。 | |||
T7364 |
NNC-0640
|
Glucagon Receptor | GPCR/G Protein |
NNC-0640 是人类胰高血糖素受体阴性变构调节剂(IC50:69.2 nM)。 | |||
T8748 |
Exendin-4 acetate
|
Glucagon Receptor | GPCR/G Protein |
Exendin-4 acetate 是一种长效的 glucagon-likepeptide-1 受体激动剂(IC50:3.22 nM),是一种由39个氨基酸组成的多肽。。 | |||
TP2252 |
GLP-1 (9-36) amide
|
Glucagon Receptor | GPCR/G Protein |
GLP-1(9-36)amide 是胰高血糖素样肽-1 (7-36) amide 的主要代谢产物,对人胰腺 GLP-1受体具有拮抗作用。 | |||
T3984 |
GLP-1(7-36), amide
MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide |
Glucagon Receptor | GPCR/G Protein |
GLP-1(7-36), amide (MKC 253) 是一种生理性肠降血糖素,能够刺激胰岛素分泌。 | |||
T19850 |
Semaglutide
索玛鲁肽,司美格鲁肽,索马鲁肽 |
Glucagon Receptor | GPCR/G Protein |
Semaglutide 是人胰高血糖素样肽-1受体激动剂,是一种人胰高血糖素样肽-1 的长效类似物。它有用于 2 型糖尿病研究的潜力。 | |||
T3422 |
GRA Ex-25
GRA-Ex-25 |
Glucagon Receptor | GPCR/G Protein |
GRA Ex-25 (GRA-Ex-25) 是glucagon 受体抑制剂,其对大鼠和人的 glucagon 受体的IC50值分别为 56 和 55 nM。 | |||
T3967 |
Exendin-4
艾塞那肽,Exenatide,Exenatide Acetate |
Glucagon Receptor | GPCR/G Protein |
Exendin-4 (Exenatide) 是一种长效的 glucagon-likepeptide-1 受体激动剂(IC50: 3.22 nM),是一种由 39 个氨基酸组成的多肽。 | |||
TP1039 |
Secretin (33-59), rat
大鼠SECRETIN肽,Secretin (rat) |
Glucagon Receptor | GPCR/G Protein |
Secretin (33-59), rat (Secretin (rat)) 是由 27 个氨基酸组成的多肽。Secretin (33-59), rat 可作用于分泌素受体,能够增强胰腺的碳酸盐、酶和钾离子的分泌。 | |||
T6876 |
Liraglutide
利拉鲁肽,Liraglutidum,利拉糖肽,Victoza,Liraglutida,NN2211 |
Glucagon Receptor | GPCR/G Protein |
Liraglutide (Liraglutida) 是胰高血糖素样肽-1 受体激动剂,用于 2 型糖尿病的研究。 | |||
TP1469 |
Lixisenatide acetate (320367-13-3 free base)
Lixisenatide acetate |
Glucagon Receptor | GPCR/G Protein |
Lixisenatide acetate 是一种胰高血糖素样肽 1 受体的激动剂,可用于研究 2 型糖尿病。 | |||
TP2100 |
Avexitide
Exendin-3 (9-39) amide,Exendin (9-39),艾塞那肽 |
Glucagon Receptor | GPCR/G Protein |
Avexitide (Exendin-3 (9-39) amide) 是一种特异竞争性的glucagon-like peptide-1 (GLP-1)受体拮抗剂。 | |||
TP1376 |
GLP-1(7-37) acetate(106612-94-6 free base)
GLP-1(7-37) acetate |
Others; Glucagon Receptor | GPCR/G Protein; Others |
GLP-1(7-37) acetate 是肠道胰岛素激素,能够促进葡萄糖诱导的胰岛素分泌。 | |||
T9579 |
GLP-1 receptor agonist 9
|
Glucagon Receptor | GPCR/G Protein |
1H-Benzimidazole-6-carboxylic acid 是GLP-1 receptor 激动剂。 | |||
T60047 |
V-0219
|
Glucagon Receptor | GPCR/G Protein |
V-0219 是 GLP-1 的正变构调节剂,可用于肥胖相关糖尿病的研究。 | |||
TP1103 |
Cotadutide acetate
MEDI0382 acetate,Cotadutide acetate (1686108-82-6 Free base) |
Glucagon Receptor | GPCR/G Protein |
Cotadutide acetate (MEDI0382 acetate) 是一种有效的胰高血糖素样肽-1 (GLP-1) 和胰高血糖素受体肽双重激动剂,EC50 分别为 6.9 pM 和 10.2 pM。 | |||
T22893 |
L-168049
L-168,049 |
Glucagon Receptor | GPCR/G Protein |
L-168049 是一种选择性和非竞争性人胰高血糖素受体拮抗剂,对人、鼠和犬的 IC50 分别为 3.7 nM、63 nM 和 60 nM。 | |||
T76559 |
Survodutide
BI 456906 |
Glucagon Receptor | GPCR/G Protein |
Survodutide (BI 456906) 是一种胰高血糖素和胰高血糖素样肽 1 (GLP-1) 受体 (GLP Receptor) 双重激动剂,可降低 HbA1c16 型糖尿病的体重。 | |||
T76279 |
Retatrutide
LY3437943 |
Glucagon Receptor | GPCR/G Protein |
Retatrutide (LY3437943) 是胰高血糖素受体、葡萄糖依赖性促胰岛素多肽受体和胰高血糖素样肽-1 受体三重激动剂,对GCGR、GIPR 和 GLP-1R 具有抑制作用。Retatrutide 可用研究肥胖症。 | |||
T28182 |
NNC 92-1687
NNC92-1687,NNC-92-1687 |
Glucagon Receptor | GPCR/G Protein |
NNC 92-1687 是一种选择性胰高血糖素受体拮抗剂,可用于研究2型糖尿病。 | |||
T76279L1 |
Retatrutide sodium salt
Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt |
Glucagon Receptor | GPCR/G Protein |
Retatrutide sodium salt 是一种有效的胰高血糖素受体 (GCGR)、葡萄糖依赖性促胰岛素多肽受体 (GIPR) 和胰高血糖素样肽-1 受体 (GLP-1R) 的三重激动剂肽。Retatrutide sodium salt 可用于研究2型糖尿病和肥胖症。 | |||
T36579 |
GLP-1R Agonist DMB
|
Glucagon Receptor | GPCR/G Protein |
GLP-1R Agonist DMB 是胰高血糖素样肽1受体的激动剂(GLP-1R;重组人受体的 KB=26.3nM)。 | |||
T8355 |
Exenatide
Exendin-4,Extendin-4 |
Glucagon Receptor | GPCR/G Protein |
Exenatide (Extendin-4) 是一种胰高血糖素样蛋白 1 (GLP-1) 受体激动剂。 | |||
T19850L |
Semaglutide Acetate
索玛鲁肽醋酸盐,Semaglutide Acetate(910463-68-2 Free base) |
Glucagon Receptor | GPCR/G Protein |
Semaglutide Acetate 是胰高血糖素样肽 1 (GLP-1) 受体的激动剂,可用于治疗 2 型糖尿病的研究。 | |||
T12431 |
PF-06882961
|
Glucagon Receptor | GPCR/G Protein |
PF-06882961 是一种口服生物可利用的胰高血糖素样肽-1 受体 (GLP-1R) 激动剂。 | |||
T8876 |
PF-06882961 Tris
UNII-2HJV78O0SS |
Glucagon Receptor | GPCR/G Protein |
PF-06882961 Tris (UNII-2HJV78O0SS) 是一种口服生物可利用的胰高血糖素样肽-1 受体 (GLP-1R) 激动剂。 | |||
T11408 |
Orforglipron
LY3502970,GLP-1 receptor agonist 1 |
Glucagon Receptor | GPCR/G Protein |
Orforglipron (LY3502970; GLP-1 receptor agonist 1) 是一种可口服的胰高血糖素样肽 (GLP-1) 受体激动剂,可用于研究成人肥胖和1型糖尿病。 | |||
T60047L |
V-0219 hydrochloride
V-0219 hydrochloride(878453-71-5 Free base) |
Glucagon Receptor | GPCR/G Protein |
V-0219 hydrochloride 是一种具有口服活性的 glucagon-like peptide-1 receptor (GLP-1R) 正向别构调节剂 (PAM)。V-0219 能被用于肥胖相关糖尿病的研究。 | |||
TP2100L |
Avexitide acetate
Exendin 9-39 acetate,Avexitide acetate(133514-43-9 Free base) |
Glucagon Receptor | GPCR/G Protein |
Avexitide acetate (exendin 9-39)是一种有效的胰高血糖素样肽 1 受体 (GLP-1R) 拮抗剂,可用于研究肥胖后低血糖。 | |||
TP1976L |
Oxyntomodulin acetate
|
Glucagon Receptor | GPCR/G Protein |
Oxyntomodulin acetate 是一种 37 个氨基酸的肽激素,是一种胰高血糖素样肽 1 (GLP-1) 受体激动剂。 | |||
T78097L |
Mazdutide acetate(2259884-03-0 free base)
Mazdutide acetate(2259884-03-0 free base),OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate |
Glucagon Receptor | GPCR/G Protein |
Mazdutide acetate 是一种高效的胰高血糖素样肽 (GLP-1R) 与胰高血糖素受体 (GCGR) 的共激动剂,是一种胃泌酸调节素类似物。Mazdutide acetate可刺激小鼠胰岛的胰岛素分泌 ,可用于研究肥胖和 2 型糖尿病 (T2D) 。 | |||
T63166L |
(S, R)-LSN 3318839
(S, R)-LSN 3318839(Isomer-2764704-18-7) |
Glucagon Receptor | GPCR/G Protein |
T14130 |
Adomeglivant
LY2409021 |
Glucagon Receptor | GPCR/G Protein |
Adomeglivant (LY2409021) 是一种高效的选择性胰高血糖素受体 (GluR) 变构拮抗剂,主要用于2型糖尿病的研究。 | |||
T15387 |
GLP-1R Antagonist 1
|
Glucagon Receptor | GPCR/G Protein |
GLP-1R Antagonist 1 (compound 5d) 是口服有效的、能透过中枢神经系统的,胰高血糖素样肽 1 受体 (GLP-1R) 的非竞争性抑制,其 IC50 值为 650 nM。 | |||
T63166 |
LSN3318839
LSN-3318839,LSN 3318839 |
Glucagon Receptor | GPCR/G Protein |
LSN3318839 是一种有效且可口服的胰高血糖素样肽-1受体(GLP-1R)变构调节剂。LSN3318839可增强GLP-1R的G蛋白偶联信号传导,可用来降低血糖。 | |||
TP1111 |
Tirzepatide
LY-3298176 |
Glucagon Receptor | GPCR/G Protein |
Tirzepatide (LY-3298176) 是葡萄糖依赖性多肽 (GIP) 和胰高血糖素样肽-1 (GLP-1) 受体双重激动剂,具有神经保护活性,可改善血压并降低低密度脂蛋白 (LDL) 胆固醇和甘油三酯,可以用于研究糖尿病和肥胖症。 | |||
T12055 | MK 0893 | Others | Others |
MK 0893 is a potent, selective antagonist of glucagon receptor. | |||
T25711 |
LGD-6972 sodium
LGD 6972 sodium |
Others | Others |
LGD-6972 sodium is a glucagon receptor antagonist. | |||
T11407 |
GLP-1 receptor agonist 2
|
Others | Others |
GLP-1 receptor agonist 2 is a glucagon-like peptide-1 receptor (GLP-1R) agonist. | |||
T70712 |
PF-06412154 HCl
|
Others | Others |
PF-06412154 HCl is a glucagon receptor antagonist. | |||
T28057 |
MK3577
MK-3577,MK 3577 |
Others | Others |
MK3577 is a glucagon receptor antagonist. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3896 |
Shanzhiside methyl ester
三栀子甙甲酯,山芝皂苷甲酯 |
Glucagon Receptor | GPCR/G Protein |
Shanzhiside methyl ester 是一种小分子胰高血糖素样肽 1 受体激动剂,分离自轮状乳杆菌,能够诱导抗异常性痛觉耐受。 | |||
T37298 |
Spinacine
|
Endogenous Metabolite | Metabolism |
Spinacine 是人内源性代谢产物。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-06864 |
GLP1R Protein, Human, Recombinant (His & Avi)
glucagon-like peptide 1 receptor |
Human | HEK293 Cells |
Glucagon-like peptide (GLP)-1 receptor is encoded by GLP1R. GLP1R plays a critical role in mediating the biological actions of GLP1 in mammals and fish. The neuronal GLP1Rs mediate body weight and anorectic effects of liraglutide, but are not required for glucose-lowering effects. Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic properties in animal models and to impact glucose-dependent insulin release, satiety, memory, and learning in man. Glucagon-like p... | |||
TMPH-01383 |
GCGR Protein, Human, Recombinant (His & Myc)
GCGR,Glucagon receptor |
Human | HEK293 Cells |
GCGR Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 18.1 kDa and the accession number is P47871. | |||
TMPH-02675 |
GCGR Protein, Mouse, Recombinant (GST)
Glucagon receptor,Gcgr |
Mouse | E. coli |
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. ... | |||
TMPH-01382 |
GCGR Protein, Human, Recombinant (E. coli, His & Myc)
GCGR,Glucagon receptor |
Human | E. coli |
GCGR Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.5 kDa and the accession number is P47871. | |||
TMPH-01386 |
GLP2R Protein, Human, Recombinant (His)
GLP2R,Glucagon-like peptide 2 receptor |
Human | HEK293 Cells |
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. GLP2R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 22.0 kDa and the accession number is O95838. | |||
TMPH-01385 |
GLP1R Protein, Human, Recombinant (His)
Glucagon-like peptide 1 receptor,GLP1R |
Human | HEK293 Cells |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P43220. | |||
TMPH-02676 |
GLP1R Protein, Mouse, Recombinant (His & SUMO)
Glucagon-like peptide 1 receptor,Glp1r |
Mouse | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.4 kDa and the accession number is O35659. | |||
TMPH-01384 |
GLP1R Protein, Human, Recombinant (E. coli, His)
GLP1R,Glucagon-like peptide 1 receptor |
Human | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P43220. | |||
TMPH-03301 |
GLP1R Protein, Rat, Recombinant (E. coli, His)
Glp1r,Glucagon-like peptide 1 receptor |
Rat | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.1 kDa and the accession number is P32301. | |||
TMPH-03302 |
GLP1R Protein, Rat, Recombinant (His)
Glucagon-like peptide 1 receptor,Glp1r |
Rat | P. pastoris (Yeast) |
GLP1R Protein, Rat, Recombinant (His) is expressed in Yeast. |