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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79381 |
Galectin-3/galectin-8-IN-2
|
Galectin | Immunology/Inflammation |
Galectin-3/galectin-8-IN-2(Compound 57)是一种针对Galectin-3和galectin-8C末端结构域的双重抑制剂,其Kd值分别为12.8 μM和2.06 μM。该化合物能够抑制MRC-5肺成纤维细胞的迁移,适用于癌症和组织纤维化研究领域。 | |||
T79380 |
Galectin-3/galectin-8-IN-1
|
Galectin | Immunology/Inflammation |
Galectin-3/galectin-8-IN-1 (Compound 53) 是抑制Galectin-3和galectin-8C末端结构域的双重抑制剂,其Kd值分别为4.12 μM和6.04 μM。该化合物有效抑制MRC-5肺成纤维细胞的迁移,可用于癌症和组织纤维化的研究。 | |||
T62454 |
Galectin-3-IN-1
|
Others | Others |
Galectin-3-IN-1 (Compound 1) 是一种多价半乳糖凝集素-3 (Gal-3) 的有效抑制剂。其中 Galectin-3 参与许多与癌症相关的代谢过程。 | |||
T64040 |
Galectin-3-IN-2
|
Others | Others |
Galectin-3-IN-2 是多价半乳糖凝集素-3 的有效抑制剂,对 Gal-3 的 IC50 值为 8.3 μM。Galectin-3 可参与很多与癌症相关的代谢过程。 | |||
T82605 |
DB21, Galectin-1 Antagonist
|
Galectin | Immunology/Inflammation |
DB21, Galectin-1 Antagonist 是一种用于抑制galectin-1 (GAL1)与细胞表面聚糖结合的二苯并呋喃缀合肽模拟物。在黑色素瘤、肺腺癌和卵巢癌模型中,该化合物能增强血管生成和肿瘤生长的抑制效果。 | |||
T74538 | Galectin-3 antagonist 2 | Galectin | Immunology/Inflammation |
Galectin-3,作为β-半乳糖苷特异性的识别蛋白(凝集素),具备促进B细胞前体急性淋巴细胞白血病(BCP-ALL)细胞迁移及耐受药物治疗的功能。 | |||
T61014 |
Galectin-8-IN-1
|
Others | Others |
Galectin-8-IN-1 是galectin-8N-末端结构域的选择性配体,Kd 值为 48 μM。Galectin-8-IN-1 的选择性是 galectin-3 的 15 倍,甚至优于其他哺乳动物的 galectins。 | |||
T16413 |
OTX008
Calixarene 0118,PTX008 |
Galectin | Immunology/Inflammation |
OTX008 (PTX008) 是半乳糖凝集素 1 选择性抑制剂。 | |||
T5121 |
TD139
|
Galectin | Immunology/Inflammation |
TD139 是一种吸入型 galectin-3 抑制剂(Kd:14 nM)。 | |||
T15372 |
GB1107
(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol |
Galectin | Immunology/Inflammation |
GB1107 是一种有效的选择性 Galectin-3 抑制剂,Kd 为 37 nM。 | |||
T11346L |
G3-C12 acetate(848301-94-0 free base)
|
Galectin | Immunology/Inflammation |
G3-C12 acetate(848301-94-0 free base) 显示出抗癌活性。是一种半乳糖凝集素 3 结合肽,Kd 为 88 nM。 | |||
T38074 |
Thiodigalactoside
|
Galectin | Immunology/Inflammation |
Thiodigalactoside 是一种具有口服活性的,有效的半乳凝素 (GAL) 抑制剂,对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM,49 μM。Thiodigalactoside 是一种不可代谢的二糖,具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加。 | |||
T69874 |
LLS30
|
Others | Others |
LLS30 is an allosteric inhibitor of Galectin-1 (Gal-1). LLS30 decreases Gal-1 binding affinity to its binding partners, and potentially overcomes metastatic castration-resistant prostate cancer (mCRPC). | |||
T75986 |
G3-C12 TFA
|
||
G3-C12 (TFA) 是 galectin-3 结合肽,Kd 值为 88 nM,具有抗肿瘤活性。 | |||
T11346 |
G3-C12
|
Others | Others |
G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM. | |||
T16620 |
Propargyl-PEG5-acid
Propargyl-PEG4-C2-acid |
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3[1]. | |||
TP1294 |
G3-C12 TFA (848301-94-0 free base)
G3-C12 TFA |
||
G3-C12 TFA Salt is a specific galectin-3 binding peptide with Ksubdsub of 88 nM and shows anticancer activity. | |||
T63485 |
Apoptosis inducer 8
|
Others | Others |
Apoptosis inducer 8 是一种galectin-1 (gal-1)介导的凋亡 (apoptosis) 诱导剂,也是一种PET 显像剂,能够明显减少 gal-1 蛋白水平,可用于全球主要的肺癌的研究。 | |||
T16624 |
Propargyl-PEG4-CH2CH2-Boc
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based non-cleavable ADC linker. Propargyl-PEG5-Boc can used to synthesize ADC inhibitors of Galectin-3[1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0265 |
Indolelactic acid
|
Endogenous Metabolite | Metabolism |
Indolelactic acid 是 Azotobacter vinelandii 培养中的色氨酸分解代谢物。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00022 |
Galectin-1 Protein, Human, Recombinant (hFc)
GAL1,LGALS1,Galectin-1,S-Lac lectin 1,DKFZp686E2310... |
Human | HEK293 Cells |
Galectin 1 (Gal-1), a β-galactoside binding mammalian lectin of 14KDa, is implicated in many signalling pathways, immune responses associated with cancer progression and immune disorders. Inhibition of human Gal-1 has been regarded as one of the potential therapeutic approaches for the treatment of cancer, as it plays a major role in tumour development and metastasis by modulating various biological functions viz. apoptosis, angiogenesis, migration, cell immune escape. | |||
TMPY-00976 |
Galectin-1 Protein, Human, Recombinant
GBP,Galectin-1,lectin, galactoside-binding, soluble... |
Human | E. coli |
Galectin-1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is A0A384MR27. | |||
TMPJ-00659 |
Galectin-9 Protein, Mouse, Recombinant (GST)
Gal-9,Galectin-9,Lgals9 |
Mouse | E. coli |
Galectin-9 Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 58 KDa and the accession number is O08573-2. | |||
TMPK-00829 |
Galectin-1 Protein, Mouse, Recombinant (hFc)
GBP,DKFZp686E23103,S-Lac lectin 1,GAL1,Galectin-1,H... |
Mouse | HEK293 Cells |
Galectin 1(Gal-1), a β-galactoside binding mammalian lectin of 14KDa, is implicated in many signalling pathways, immune responses associated with cancer progression and immune disorders. Inhibition of human Gal-1 has been regarded as one of the potential therapeutic approaches for the treatment of cancer, as it plays a major role in tumour development and metastasis by modulating various biological functions viz. apoptosis, angiogenesis, migration, cell immune escape. | |||
TMPY-06685 |
Galectin-1 Protein, Human, Recombinant (His)
GBP,GAL1,lectin, galactoside-binding, soluble, 1,Galecti... |
Human | E. coli |
Galectin-1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 16.07 kDa and the accession number is NP_002296.1. | |||
TMPK-00831 |
Galectin-3 Protein, Mouse, Recombinant (His)
Galectin3,LGALS2,AGE-R3,L31,LGALS3,Mac-2,GAL3,L29,G... |
Mouse | HEK293 Cells |
Galectin-3 (Gal-3) is a 30 kDa β-galactose, highly conserved and widely distributed intracellularly and extracellularly. Gal-3 has been demonstrated in recent years to be a novel inflammatory factor participating in the process of intravascular inflammation, lipid endocytosis, macrophage activation, cellular proliferation, monocyte chemotaxis, and cell adhesion. | |||
TMPJ-01455 |
Galectin-9 Protein, Human, Recombinant (His)
LGALS9,Tumor Antigen HOM-HD-21,Ecalectin,Gal-9,Galectin<... |
Human | HEK293 Cells |
Galectin-9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 49 KDa and the accession number is Q3B8N1-2. | |||
TMPY-04989 |
Galectin-9 Protein, Human, Recombinant (hFc)
LGALS9A,lectin, galactoside-binding, soluble, 9,HUAT |
Human | HEK293 Cells |
LGALS9 (Galectin 9) is a Protein Coding gene. 6 alternatively spliced human isoforms have been reported. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or i... | |||
TMPH-02668 |
Galectin-4/LGALS4 Protein, Mouse, Recombinant (His)
Galectin-4,Lactose-binding lectin 4,Lgals4 |
Mouse | P. pastoris (Yeast) |
Galectin that binds lactose and a related range of sugars. | |||
TMPJ-01024 |
Galectin-4 Protein, Human, Recombinant (His)
gal-4,Antigen NY-CO-27,L36LBP,galectin 4,LGALS4,Lac... |
Human | E. coli |
Galectins are a family of carbohydrate-binding proteins with specificity for N-acetyl-lactosamine-containing glycoproteins. Galectin-4 is a 36 kDa tandem-repeat galectin found throughout the gastrointestinal tract, but also present in well-differentiated breast and liver carcinomas. Galectin-4 expression is concentrated within microvilli in the gastrointestinal epithelium, where it can interact with CD3 and bind activated T cells in the lamina propria during intestinal inflammation. | |||
TMPJ-00203 |
Galectin-9 Protein, Human, Recombinant (GST)
Gal-9delta5,Ecalectin,LGALS9,Galectin-9,Gal-9δ5,Gal... |
Human | E. coli |
Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galectin-9 binds galactosides and has high affinity for the Forssman pentasaccharide. Galectin-9 plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. Galectin-9 is a ligand for HAVCR2/TIM3 and induces T-helper type 1 lymphocyte (Th1) death. In addition, Galectin-9 suppresses t... | |||
TMPY-02102 |
Galectin-1 Protein, Mouse, Recombinant
L-14.5,Galbp,AA410090,lectin, galactoside-binding, soluble, ... |
Mouse | E. coli |
Galectin-1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P16045. | |||
TMPH-03299 |
Galectin-4/LGALS4 Protein, Rat, Recombinant
Galectin-4,L-36 lactose-binding protein,Lactose-bin... |
Rat | E. coli |
Galectin that binds lactose and a related range of sugars. Galectin-4/LGALS4 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 36.3 kDa and the accession number is P38552. | |||
TMPH-01364 |
Galectin-9/LGALS9 Protein, Human, Recombinant (GST & His)
Tumor antigen HOM-HD-21,LGALS9,Galectin-9,Ecalectin |
Human | E. coli |
Galectin-9/LGALS9 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 65.9 kDa and the accession number is O00182. | |||
TMPH-01363 |
Galectin-8/LGALS8 Protein, Human, Recombinant (GST)
Po66 carbohydrate-binding protein,LGALS8,Prostate carcinoma ... |
Human | E. coli |
Galectin-8/LGALS8 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 62.8 kDa and the accession number is O00214. | |||
TMPH-03298 |
Galectin-4/LGALS4 Protein, Rat, Recombinant (His & SUMO)
Lactose-binding lectin 4,L-36 lactose-binding protein,Ga... |
Rat | E. coli |
Galectin that binds lactose and a related range of sugars. Galectin-4/LGALS4 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.3 kDa and the accession number is P38552. | |||
TMPH-03296 |
Galectin-3/LGALS3 Protein, Rat, Recombinant (His)
Lgals3,IgE-binding protein,Carbohydrate-binding protein 35,L... |
Rat | E. coli |
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autop... | |||
TMPH-00266 |
Galectin-1/LGALS1 Protein, Bovine, Recombinant (His & SUMO)
Galectin-1,S-Lac lectin 1,14 kDa lectin,LGALS1,Beta... |
Bovine | E. coli |
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Galectin-1/LGALS1 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.6 kDa and the accession number is P11116. | |||
TMPY-02319 |
Galectin-3 Protein, Human, Recombinant
GALBP,CBP35,GAL3,GALIG,MAC2,LGALS2,lectin, galactoside-bindi... |
Human | E. coli |
LGALS3 (Galectin 3) is a Protein Coding gene. This gene encodes a member of the galectin family of carbohydrate-binding proteins. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. LGALS3 is a beta-galactoside-binding lectin and plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion, and T-cell regulation. LGALS3 has an important role in tumor progression through... | |||
TMPY-03131 |
Galectin-1 Protein, Rat, Recombinant
lectin, galactoside-binding, soluble, 1 |
Rat | E. coli |
Galectin-1 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P11762. | |||
TMPY-02611 |
Galectin-8 Protein, Human, Recombinant
lectin, galactoside-binding, soluble, 8,PCTA-1,Po66-CBP,Gal-... |
Human | E. coli |
Galectin-8 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 35.5 kDa and the accession number is AAF19370.1. | |||
TMPK-00837 |
Galectin-3 Protein, Human, Recombinant (His)
LGALS2,GAL3,MAC2GAL3,Galectin3,L31,Mac-2,GALBPCBP35... |
Human | HEK293 Cells |
Human Galectin-3, also known as Mac-2, L29, CBP35, and epsilon BP, is classified as a chimeric member of the Galectin superfamily and contains one carbohydrate recognition domain (CRD) linked to a nonlectin domain.Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). | |||
TMPY-02773 |
Galectin-8 Protein, Rat, Recombinant (GST)
lectin, galactoside-binding, soluble, 8 |
Rat | E. coli |
Galectin-8 Protein, Rat, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 63.2 kDa and the accession number is Q6IN24. | |||
TMPY-02774 |
Galectin-7 Protein, Human, Recombinant (GST)
LGALS7A,lectin, galactoside-binding, soluble, 7,GAL7 |
Human | E. coli |
Galectin-7 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 41.8 kDa and the accession number is P47929. | |||
TMPJ-01146 |
LGALSL Protein, Human, Recombinant (His)
Lectin Galactoside-Binding-Like Protein,HSPC159,Galectin... |
Human | E. coli |
Galectin-Related Protein (LGALSL) is a 172 amino acid protein that contains one Galectin domain. LGALSL does not appear to bind carbohydrates or lactose as the critical residues required for binding are not conserved. LGALSL may play a significant role in stimulating smooth muscle growth in developing alveolar wall vessels and the development of pulmonary capillaries. | |||
TMPY-02326 |
Galectin-8 Protein, Human, Recombinant (GST)
PCTA1,Po66-CBP,PCTA-1,lectin, galactoside-binding, soluble, ... |
Human | E. coli |
Galectin-8 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 62.7 kDa and the accession number is AAF19370.1. | |||
TMPK-01273 |
Galectin-3 Protein, Cynomolgus, Recombinant (His)
LGALS2,L29,AGE-R3,GALIG,Lectin L-29,MAC2GAL3,Mac-2,L31,CBP35... |
Cynomolgus | HEK293 Cells |
Galectin-3, also known as Mac-2, L29, CBP35, and epsilon BP, is classified as a chimeric member of the Galectin superfamily and contains one carbohydrate recognition domain (CRD) linked to a nonlectin domain.Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). | |||
TMPY-04109 |
Galectin-7 Protein, Human, Recombinant (His)
lectin, galactoside-binding, soluble, 7,LGALS7A,GAL7 |
Human | E. coli |
Galectin-7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.2 kDa and the accession number is P47929. | |||
TMPJ-00022 |
LGALS7 Protein, Human, Recombinant
Galectin-7,Gal-7,LGALS7,PI7,PIG1,LGALS7B,p53-Induce... |
Human | E. coli |
The Galectin family of proteins, with specificity for Nacetyllactosamine containing glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs).They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide; they can be secreted ... | |||
TMPJ-00525 |
LGALS14 Protein, Human, Recombinant (His)
Galectin-14,PPL13,Placental Protein 13-Like,LGALS14... |
Human | HEK293 Cells |
Galectin-14 is a member of the Galectin family of carbohydrate binding proteins. The members of Galectin family contain one or two carbohydrate recognition domains, which can bind β-Galactoside. LGALS14 is expressed intracellularly in placenta and eosinophils, and is released by eosinophils following allergen stimulation. LGALS14 may be involved in the development of allergic inflammation. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. | |||
TMPJ-00654 |
LGALS8 Protein, Human, Recombinant
Prostate Carcinoma Tumor Antigen 1,Po66-CBP,Galectin |
Human | E. coli |
The Galectin family of proteins, with specificity for Nacetyllactosaminecontaining glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide, galectins can also be... | |||
TMPH-03297 |
LGALS3BP Protein, Rat, Recombinant (His)
Protein 90K,Mac-2-binding protein,Galectin-3-bindin... |
Rat | E. coli |
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. | |||
TMPH-01362 |
LGALS3BP Protein, Human, Recombinant (His)
LGALS3BP,Lectin galactoside-binding soluble 3-binding protei... |
Human | E. coli |
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. LGALS3BP Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 67.4 kDa and the accession number is Q08380. | |||
TMPJ-00563 |
LGALS3 Protein, Human, Recombinant (His)
Galactose-Specific Lectin 3,LGALS3,35 kDa Lectin,Gal-3,MAC2,... |
Human | HEK293 Cells |
Galectin-3(LGALS3) is also known as Galactose-specific lectin 3, Mac-2 antigen, Carbohydrate-binding protein 35, Laminin-binding protein and Galactoside-binding protein. LGALS3 is highly expressed in early stages of papillary carcinoma, and lowly during tumor progression. LGALS3 is probably forms homo- or heterodimers and secreted by a non-classical secretory pathway and associates with the cell surface. LGALS3 plays an important role during the acquisition of vasculogenic mimicry and angiogenic... | |||
TMPJ-00021 |
LGALS1 Protein, Human, Recombinant (His)
HPL,S-Lac Lectin 1,Lactose-Binding Lectin 1,14 kDa Lectin,Be... |
Human | E. coli |
Galectin-1 is a member of growing family of evolutionary conserved animal lectins. Galectin-1 is widely expressed in many cells and tissues. Galectins consists of a Galectin domain and two Beta-galactoside binding domains. Galectin-1 can binds LGALS3BP and interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Galectin-1 may act as an autocrine negative growth factor which regulates apoptosis, cell proliferation and cell differentiation. In addition, Galectin-1 plays improtant roles in immunosuppress... | |||
TMPH-03577 |
Staphopain B Protein, S. aureus, Recombinant (GST)
Staphopain B,sspB,Staphylopain B,Staphylococcal cysteine pro... |
Staphylococcus aureus | E. coli |
Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and monocytes by inducing their death in a proteolytic activity-dependent manner. Decreases surface expression of the 'don't eat me' signal CD31 on neutrophils. Cleaves host galectin-3/LGALS3, thereby inhibiting the neutrophil-activating ability of the lectin. Staphopain B Protein, S.... | |||
TMPJ-00189 |
TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)
HAVCR2,Tim-3,TIM3,T cell immunoglobulin and mucin domain3 |
Cynomolgus | HEK293 Cells |
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance... | |||
TMPJ-01432 |
CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated
mucin 16, cell surface associated,CA-125,CA125 ovarian cance... |
Human | HEK293 Cells |
MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC... | |||
TMPY-01268 |
SMYD3 Protein, Human, Recombinant (GST)
SET and MYND domain containing 3,ZMYND1,KMT3E,ZNFN3A1,bA74P1... |
Human | Baculovirus Insect Cells |
SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional reg... |