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Targets Recommended: Others

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Cat. No. Product Name Target Signaling Pathways
T39916 GNE-274

Others Others
GNE-274, a non-degrader compound structurally similar to GDC-0927 (an ER degrader), serves as a partial ER agonist in breast cancer cell lines without triggering ER turnover. Notably, GNE-274 enhances chromatin accessibility at ER-DNA binding sites, unlike GDC-0927. Acting as a potent inhibitor of the ER-ligand binding domain (LBD), GNE-274 exhibits potential for cancer research purposes.

化合物

GNE-274
Cat.No: T39916
Synonym:
Target: Others
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