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Search Results for " gls1 inhibitor "

Targets Recommended: Others

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Cat. No.	Product Name	Target	Signaling Pathways
T37222	GLS1 Inhibitor	Others	Others
	GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50= 0.021 μM).1It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cellsin vitro(GI50= 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model. 1.Finlay, M.R.V., Anderton, M., Bailey, A., et al.Discovery of a thiadiazole-pyridazine-based allosteric glutaminase 1 inhibitor series that demons...
T72679	GLS1 Inhibitor-4	Glutaminase	Proteases/Proteasome
	GLS1 Inhibitor-4 (compound 41e)作为一种高效的GLS1抑制剂，具有11.86 nM的IC50值。该化合物展现了抗增殖效果、优秀的代谢稳定性以及强大的GLS1结合亲和力。它通过阻断谷氨酰胺代谢和诱导ROS生成，能够引发细胞凋亡并表现出对抗肿瘤的活性。
T64211	GLS1 Inhibitor-3	Others	Others
	GLS1 Inhibitor-3 (compound C147) 是一种 GLS1 的有效抑制剂 (IC50: 27.98 nM)，表现出抗增殖作用。
T64259	GLS1 Inhibitor-5	Others	Others
	GLS1 Inhibitor-5 (compound 24y) 是一种选择性的、口服具有活力的谷氨酰胺酶 1 (GLS1) 抑制剂 (IC50: 68 nM)。GLS1 Inhibitor-5 能够诱导细胞凋亡 (apoptosis)，表现出抗肿瘤效果。
T72708	GLS1 Inhibitor-6	Others	Others
	GLS1 Inhibitor-6 是一种具有口服活性的、强效和选择性的谷氨酰胺酶 1 (GLS1) 抑制剂 (IC50=68 nM)，对 GLS2 显示出 220 倍的选择性。GLS1 Inhibitor-6 可诱导凋亡，并表现出良好的抗肿瘤活性和抗癌细胞增殖活性。
T79340	GLS1 Inhibitor-7	Glutaminase	Proteases/Proteasome
	GLS1 Inhibitor-7 (compound 4d) 作为一种GLS1 抑制剂，表现出抑制浓度50%所需浓度（IC50）为46.7 μM，潜在用途涉及抗癌、抗衰老和抗肥胖。
T37385	Glutaminase-IN-3	Glutaminase	Proteases/Proteasome
	Glutaminase-IN-3 是一种有效的的 Glutaminase 1 抑制剂，具有潜在的抗肿瘤活性，对 GLS1 具有抑制作用，可用于研究癌症。
T6791	BPTES	transporter; Glutaminase	Metabolism; Proteases/Proteasome
	BPTES 是一种特异性 GlutamiN/Ase GLS1 (KGA) 抑制剂，IC50=0.16 μM。
T11412	IPN60090 GLS1-IN-1	Others; transporter	Metabolism; Others
	IPN60090是一种新型、强效、口服生物利用度高的肾型谷氨酰胺酶（GLS1）特异性抑制剂，对GLS1的IC50值为31 nM。IPN60090 具有潜在的抗癌和免疫刺激/免疫调节活性，可选择性地靶向、结合并抑制人谷氨酰胺酶，可用于研究 GLS1 介导的疾病。
T6797	Telaglenastat CB 839,CB839,CB-839	transporter; Glutaminase; Autophagy	Autophagy; Metabolism; Proteases/Proteasome
	Telaglenastat (CB 839) 是一种谷氨酰胺酶 1 (GLS1) 抑制剂，具有选择性、可逆性和口服活性。Telaglenastat 具有抗肿瘤活性，可以诱导细胞自噬。
T39309	Telaglenastat hydrochloride CB-839 hydrochloride	Others	Others
	Telaglenastat (CB-839) hydrochloride is a first-in-class, reversible, and orally active inhibitor of glutaminase 1 (GLS1). It selectively inhibits the splice variants of GLS1, specifically KGA (kidney-type glutaminase) and GAC (glutaminase C), as compared to GLS2. Telaglenastat hydrochloride has an IC50 of 23 nM for endogenous glutaminase in mouse kidney and 28 nM in the brain. In addition, it induces autophagy and exhibits antitumor activity.
T73458	LWG-301	Others	Others
	LWG-301是一种针对Glutaminase1(GLS1)的变构抑制剂，具有(IC50=7 nM)。通过显著阻断谷氨酰胺代谢并增加细胞内ROS，LWG-301能够诱导细胞凋亡(apoptosis)。在HCT116异种移植模型中，LWG-301展示出中等抗肿瘤活性。
T39544	IPN60090 dihydrochloride IPN60090 dihydrochloride	Others	Others
	IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.

化合物

GLS1 Inhibitor

Cat.No: T37222

Target: Others

GLS1 Inhibitor-4

Cat.No: T72679

Target: Glutaminase

GLS1 Inhibitor-3

Cat.No: T64211

Target: Others

GLS1 Inhibitor-5

Cat.No: T64259

Target: Others

GLS1 Inhibitor-6

Cat.No: T72708

Target: Others

GLS1 Inhibitor-7

Cat.No: T79340

Target: Glutaminase

Glutaminase-IN-3

Cat.No: T37385

Target: Glutaminase

Cat.No: T6791

Target: transporter, Glutaminase

Cat.No: T11412

Synonym: GLS1-IN-1

Target: Others, transporter

Cat.No: T6797

Synonym: CB 839,CB839,CB-839

Target: transporter, Glutaminase, Autophagy

Telaglenastat hydrochloride

Cat.No: T39309

Synonym: CB-839 hydrochloride

Target: Others

Cat.No: T73458

Target: Others

IPN60090 dihydrochloride

Cat.No: T39544

Synonym: IPN60090 dihydrochloride

Target: Others

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