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Cat. No. | Product Name | Target | Signaling Pathways |
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T15387 |
GLP-1R Antagonist 1
|
Glucagon Receptor | GPCR/G Protein |
GLP-1R Antagonist 1 (compound 5d) 是口服有效的、能透过中枢神经系统的,胰高血糖素样肽 1 受体 (GLP-1R) 的非竞争性抑制,其 IC50 值为 650 nM。 | |||
T36579 |
GLP-1R Agonist DMB
|
Glucagon Receptor | GPCR/G Protein |
GLP-1R Agonist DMB 是胰高血糖素样肽1受体的激动剂(GLP-1R;重组人受体的 KB=26.3nM)。 | |||
T40997 |
GLP-1R modulator C16
GLP-1R modulator C16 |
Glucagon Receptor | GPCR/G Protein |
GLP-1R modulator C16 是一种变构调节剂,显著增加了 GLP-4 的结合亲和力。 | |||
T40279 |
GLP-1R modulator L7-028
GLP-1R modulator L7-028 |
cAMP; Glucagon Receptor | GPCR/G Protein |
GLP-1R modulator L7-028 是一种变构调节剂,增强了对 GLP-1 的亲和力和 cAMP 信号转导。 | |||
T19850 |
Semaglutide
索玛鲁肽,司美格鲁肽,索马鲁肽 |
Glucagon Receptor | GPCR/G Protein |
Semaglutide 是人胰高血糖素样肽-1受体激动剂,是一种人胰高血糖素样肽-1 的长效类似物。它有用于 2 型糖尿病研究的潜力。 | |||
T80565 |
Gulgafafusp alfa
|
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Gulgafafusp alfa 为人源化IgG2κ类抗体,专一性靶向GLP1R(胰高血糖素样肽1受体)。 | |||
T76279 |
Retatrutide
LY3437943 |
Glucagon Receptor | GPCR/G Protein |
Retatrutide (LY3437943) 是胰高血糖素受体、葡萄糖依赖性促胰岛素多肽受体和胰高血糖素样肽-1 受体三重激动剂,对GCGR、GIPR 和 GLP-1R 具有抑制作用。Retatrutide 可用研究肥胖症。 | |||
T76279L1 |
Retatrutide sodium salt
Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt |
Glucagon Receptor | GPCR/G Protein |
Retatrutide sodium salt 是一种有效的胰高血糖素受体 (GCGR)、葡萄糖依赖性促胰岛素多肽受体 (GIPR) 和胰高血糖素样肽-1 受体 (GLP-1R) 的三重激动剂肽。Retatrutide sodium salt 可用于研究2型糖尿病和肥胖症。 | |||
T17242 |
VU0453379
|
Others | Others |
VU0453379 is a highly selective and central nervous system penetrant positive allosteric modulator of glucagon-like peptide-1R (EC50: 1.3 μM). |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01385 |
GLP1R Protein, Human, Recombinant (His)
Glucagon-like peptide 1 receptor,GLP1R |
Human | HEK293 Cells |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P43220. | |||
TMPH-03302 |
GLP1R Protein, Rat, Recombinant (His)
Glucagon-like peptide 1 receptor,Glp1r |
Rat | P. pastoris (Yeast) |
GLP1R Protein, Rat, Recombinant (His) is expressed in Yeast. | |||
TMPH-02676 |
GLP1R Protein, Mouse, Recombinant (His & SUMO)
Glucagon-like peptide 1 receptor,Glp1r |
Mouse | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.4 kDa and the accession number is O35659. | |||
TMPH-01384 |
GLP1R Protein, Human, Recombinant (E. coli, His)
GLP1R,Glucagon-like peptide 1 receptor |
Human | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P43220. | |||
TMPH-03301 |
GLP1R Protein, Rat, Recombinant (E. coli, His)
Glp1r,Glucagon-like peptide 1 receptor |
Rat | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.1 kDa and the accession number is P32301. | |||
TMPY-06864 |
GLP1R Protein, Human, Recombinant (His & Avi)
glucagon-like peptide 1 receptor |
Human | HEK293 Cells |
Glucagon-like peptide (GLP)-1 receptor is encoded by GLP1R. GLP1R plays a critical role in mediating the biological actions of GLP1 in mammals and fish. The neuronal GLP1Rs mediate body weight and anorectic effects of liraglutide, but are not required for glucose-lowering effects. Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic properties in animal models and to impact glucose-dependent insulin release, satiety, memory, and learning in man. Glucagon-like p... |