Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24088 |
GGTI-2133
GGTI2133,GGTI 2133 |
Transferase | Metabolism |
GGTI-2133 是一种有效的仿肽基香叶基转移酶 I 型抑制剂(GGTase I),IC50值为38 nM。GGTI-2133 可抑制小鼠实验性哮喘中炎症细胞向气道的侵袭。 | |||
T85180 |
GGTI 2133 TFA
|
Others | Others |
GGTI 2133, a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I; IC50= 38 nM), exhibits 140-fold selectivity towards GGTase I compared to farnesyltransferase (IC50= 5,400 nM). The compound effectively inhibits the geranylgeranylation of RAP1A (IC50= 10 µM) without affecting the farnesylation of H-Ras (IC50= >30 µM). Moreover, GGTI 2133 reduces the growth, migration, and invasion of oral squamous cell carcinoma (OSSC) cells to 75, 45, and 27% of control levels, respectively. ... |