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Search Results for " g protein "

Targets Recommended: PKA

275

抑制剂 & 化合物

21

天然产物

9

化合物库

7

TargetMol 试剂盒

211

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L2700	肾上腺素能受体化合物库		193 compounds
	193 种特异靶向肾上腺素受体的生物活性小分子化合物的集合，是相关疾病药物筛选的有效工具；
L1500	GPCR靶点分子库		1940 compounds
	1940 种与 G 蛋白及其耦联受体相关的生物活性小分子化合物，所有小分子都具有良好的生物和药理活性，部分是 FDA 批准的上市药物；
L2800	5-羟色胺分子库		268 compounds
	268 种生物活性小分子化合物，用于高通量、高内涵筛选；
L1580	GPCR库Plus		338 compounds
	338 种GPCR 靶向、结构新颖的化合物；
L2610	神经递质受体化合物库		1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；
L2600	神经信号分子库		2540 compounds
	2540 种CNS 相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L7200	钙通道分子库		140 compounds
	140 种钙通道相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L3300	组胺&褪黑色素化合物库		153 compounds
	153 种生物活性小分子化合物，用于高通量、高内涵筛选；
L7600	趋化因子抑制剂库		59 compounds
	59 种趋化因子或其受体抑制剂的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

肾上腺素能受体化合物库

Cat.No: L2700

Compounds: 193

GPCR靶点分子库

Cat.No: L1500

Compounds: 1940

5-羟色胺分子库

Cat.No: L2800

Compounds: 268

Cat.No: L1580

Compounds: 338

神经递质受体化合物库

Cat.No: L2610

Compounds: 1513

神经信号分子库

Cat.No: L2600

Compounds: 2540

钙通道分子库

Cat.No: L7200

Compounds: 140

组胺&褪黑色素化合物库

Cat.No: L3300

Compounds: 153

趋化因子抑制剂库

Cat.No: L7600

Compounds: 59

Cat. No.	Product Name	Form	Specificity Of Inhibition
C0104B	Protein A/G Immunomagnetic Beads Protein A/G 免疫沉淀磁珠	Suspension in bottle	IP, Co-IP, ChIP
C0116B	Protein G Immunomagnetic Beads Protein G 免疫沉淀磁珠	Suspension in bottle	IP, Co-IP, ChIP
C0108	Magrose Beads Protein G Protein G 琼脂糖磁珠	Suspension in bottle	适用于血浆、腹水、组织培养上清液等样品中的抗体纯化，也可用于抗体固定及其它相关研究。
C0116	Protein G Immunoprecipitation Kit Protein G 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP, ChIP
C0104	Protein A/G Immunoprecipitation Kit Protein A/G 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP, ChIP
C0051	Penicillin-Streptomycin Solution (100×), Sterile 青霉素-链霉素双抗溶液（100×），灭菌	Solution in bottle
C0052	Penicillin-Streptomycin-Amphotericin B Solution (100×), Sterile 青霉素-链霉素-两性霉素B三抗溶液（100×），灭菌	Solution in bottle

TargetMol 试剂盒

Protein A/G 免疫沉淀磁珠

Cat.No: C0104B

Protein G 免疫沉淀磁珠

Cat.No: C0116B

Protein G 琼脂糖磁珠

Cat.No: C0108

Protein G 免疫沉淀试剂盒

Cat.No: C0116

Protein A/G 免疫沉淀试剂盒

Cat.No: C0104

青霉素-链霉素双抗溶液（100×），灭菌

Cat.No: C0051

青霉素-链霉素-两性霉素B三抗溶液（100×），灭菌

Cat.No: C0052

Cat. No.	Product Name	Target	Signaling Pathways
T67755	Protein kinase G inhibitor-1	PKA	Tyrosine Kinase/Adaptors
	Protein kinase G inhibitor-1是有效的蛋白激酶G 抑制剂，IC50= 0.9 uM。
T9940	Protein kinase G inhibitor-2	Others	Others
	Protein kinase G inhibitor-2 具有抗菌、抗病毒和抗肿瘤活性。
TP1902L1	G-Protein antagonist peptide acetate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	G-Protein antagonist peptide acetate 是一种 substance P 相关肽，可抑制 G 蛋白与其受体的结合。G-Protein antagonist peptide acetate 竞争性和可逆性地抑制毒蕈碱型乙酰胆碱受体 M2 (M2 muscarinic receptor) 对 Gi 或 Go 的激活，并通过 β-肾上腺素受体抑制 Gs 的激活。
T14898	CCG-63808	GTPase	GPCR/G Protein
	CCG-63808 是一种有效的、可逆的G 蛋白信号调节子抑制剂。
T14897	CCG-63802	GTPase	GPCR/G Protein
	CCG-63802 是选择性的、可逆变构的G 蛋白信号调节子RGS4抑制剂。CCG-63802与RGS4特异性结合从而阻断 RGS4-Gαo 相互作用，IC50为 1.9 μM。
TP1902	G-Protein antagonist peptide
	Substance P-related peptide that inhibits binding of G proteins to their receptors. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.
T8818	TC-G 1005 (4-环丙基-3,4-二氢-1(2H)-喹喔啉基)[4-(2,5-二甲基苯氧基)-3-吡啶基]甲酮	GPCR19	GPCR/G Protein
	TC-G 1005 是具有口服活性的TGR5选择性激动剂，能够激活 hTGR5 (EC50:0.72 nM)和 mTGR5 (EC50:6.2 nM)。它能够减少小鼠体内葡萄糖水平。
T7428	SBI-115	GPCR19	GPCR/G Protein
	SBI-115 是TGR5 (GPCR19)拮抗剂，对 TGR5 降低多囊性肝病的肝囊肿形成具有抑制作用。
TP2254	GTP-Binding Protein Fragment, G alpha	Others	Others
	Using specific antisera raised against synthetic peptides, we find that three distinct GTP-binding protein alpha subunits remain bound to the plasma membrane even after activation with nonhydrolyzable GTP analog. Trypsin cleaves each alpha subunit at a si
T20731	Brilliant blue G-250 酸性蓝 90,BBG,Acid blue 90, Coomassie Brilliant Blue G,Brilliant Blue G	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	Brilliant blue G-250 (Acid blue 90, Coomassie Brilliant Blue G) 是一种可视化的染料，常用于 SDS-PAGE 分离蛋白质，染色过程简单，定量高。在 Bradford 蛋白质分析中，它能够与蛋白质结合，通过595 nm 处的吸光度确定蛋白质浓度。它也是一种安全的 P2×7R 选择性拮抗剂，有望使 NLRP3炎症体失活。
T4083	BAR501 BAR 501	GPCR19	GPCR/G Protein
	BAR501是高效选择性的 GPBAR1激动剂(EC50:1 μM)。
TQ0252	BAR502	FXR; GPCR19; Autophagy	Autophagy; GPCR/G Protein; Metabolism
	BAR502 是一种 GPBAR1 和 FXR 双重激动剂，IC50分别为0.4 μM 和 2 μM。
T4352	SB756050 SB-756050,SB 756050	GPCR19	GPCR/G Protein
	SB756050 是TGR5选择性激动剂。它用于二型糖尿病研究的潜力。
T2088	APD668 APD 668	GPR; P450; Potassium Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	APD668 是选择性的，口服有效的GPR119激动剂，对hGPR119和rGPR119的EC50分别为 2.7 nM 和 33 nM。它对除CYP2C9(Ki=0.1 μM) 以外的五种主要 CYP 亚型均无明显抑制作用。它可用于脂肪性肝炎和糖尿病的研究。
T16378	Ogerin	Others; 5-HT Receptor; Adenosine Receptor	GPCR/G Protein; Neuroscience; Others
	Ogerin 是选择性 GPR68正向别构调节剂(pEC50:6.83)。它能够抑制小鼠对恐惧记忆的回忆。它对 A2A 受体具有适中的拮抗作用(Ki:220 nM)。对 5-HT2B 受体的拮抗作用较弱(Ki:736 nM)。
T6434	CCG-50014 CCG 50014,4-[(4-氟苯基)甲基]-2-(4-甲基苯基)-1,2,4-噻二唑烷-3,5-二酮	GTPase	GPCR/G Protein
	CCG-50014 是一种有效的选择性 RGS4 抑制剂，IC50 为 30 nM。它在小鼠福尔马林试验中减少伤害性反应并增强阿片类药物介导减缓疼痛的作用。它与 RGS 共价结合，在位于变构调节位点的两个半胱氨酸残基上形成加合物。
T0843	Triamterene 氨苯蝶啶,Ademine,SKF8542	Sodium Channel; GPCR19	GPCR/G Protein; Membrane transporter/Ion channel
	Ademine 是一种压敏型上皮钠离子通道（ENaC）阻断剂，具有利尿的作用。
T1793	MBX-2982	GPR	Endocrinology/Hormones; GPCR/G Protein
	MBX2982 是口服具有活力的、选择性的 G 蛋白偶联受体 119 (GPR119) 激动剂。
T6843	GDC-0623 G-868,GDC0623,RG 7421,MEK inhibitor 1	Apoptosis; MEK	Apoptosis; MAPK
	GDC-0623 (RG 7421) 是一种 ATP 竞争性的MEK1抑制剂，Ki 值为 0.13 nM。它对 A375 细胞中 BRAFV600E 的 EC50值为 7 nM，而对 HCT116 细胞中 KRAS (G13D)的 EC50值为 42 nM。
T21874	CID 2745687	GPR	Endocrinology/Hormones; GPCR/G Protein
	CID 2745687 是可逆的、特异性 GPR35竞争性拮抗剂（Ki:12.8 nM）。
T1824	TGR5 Receptor Agonist	GPCR19	GPCR/G Protein
	TGR5 Receptor Agonist 是一种TGR5(GPCR19)激动剂。
T2701	GSK1292263	GPR	Endocrinology/Hormones; GPCR/G Protein
	GSK1292263 是口服具有活性的 GPR119 激动剂，对人和大鼠 GPR119的pEC50分别为 6.9 和 6.7，它可用于研究 2 型糖尿病 (T2DM) 。
T22996	ML-191	ERK	MAPK
	ML-191 是GPR55的拮抗剂。它可以阻断溶血磷脂酰肌醇诱导的 GPR55 信号传导，在过表达 GPR55 的 U2OS 细胞中EC50=1.076 µM；它抑制 LPI 诱导ERK1/2 磷酸化的IC50=328 nM。当浓度为达到30 µM 时，可抑制 PKCβII 的受体依赖性易位。
T8329	AR 231453	GPR	Endocrinology/Hormones; GPCR/G Protein
	AR 231453 是一种口服具有活性的、特异性的 GPR119激动剂。它能够刺激细胞增殖，改善胰岛 β 细胞的功能。
T7156	NIBR189	EBI2/GPR183	GPCR/G Protein
	NIBR189是 EBI2（GPR183）小分子拮抗剂(IC50:11 nM)。
T6313	Go 6983 Goe 6983	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Go 6983 是一种PKC 抑制剂，能够作用于PKCα、PKCβ、PKCγ、PKCδ和PKCζ，IC50值分别为 7、7、6、10 和 60 nM。
T22408	Proflavine 吡啶-3,6-二胺,3,6-Diaminoacridine	Antibacterial	Microbiology/Virology
	Proflavine (3,6-Diaminoacridine) 是吖啶染料，可用作抗菌剂。它是 DNA 嵌入剂，能够阻滞Kir3.2孔。它用作与 Kir3.2 相关的神经系统疾病的研究。
T4626	TC-O 9311 free base	GPR	Endocrinology/Hormones; GPCR/G Protein
	TC-O 9311 是一种有效的 GPR139 激动剂。
T8975	PSB-SB-487	Cannabinoid Receptor	GPCR/G Protein
	PSB-SB-487 是 GPR55 的拮抗剂。
T2036	6-OAU GTPL5846	GPR	Endocrinology/Hormones; GPCR/G Protein
	6-OAU (GTPL5846) 是 GPR84 的替代激动剂，在 Gqi5 嵌合体存在的情况下，在 HEK293 细胞中激活人 GPR84，在 PI 测定中 EC50 为 105 nM。
T3119	JNJ-63533054 JNJ 63533054	GPR	Endocrinology/Hormones; GPCR/G Protein
	JNJ-63533054 是一种选择性的，具有口服活性的GPR139激动剂，对人GPR139的EC50为 16 nM。它可穿过血脑屏障，对 GPR139 的选择性高于其他 GPCR、离子通道和转运蛋白。
T8571	ML-184 CID2440433	Cannabinoid Receptor	GPCR/G Protein
	ML-184 (CID2440433) 是一种选择性的GPR55激动剂(EC50: 250 nM)，对 GPR55 的选择性比 GPR35、CB1 和 CB2 的高100 倍以上。它可以激活 GPR55 ，诱导 ERK1/2 磷酸化并促使PKCβII 向质膜移位。它能在体外诱导神经干细胞增殖，并加速进神经元分化。
T3176	APD597 JNJ-38431055	GPR	Endocrinology/Hormones; GPCR/G Protein
	APD597 (JNJ-38431055) 是一种 GPR119 激动剂，能够作用于 hGPR119，EC50=46 nM，可用于 2 型糖尿病的研究。
T21623	AS1269574 AS 1269574	GPR; TRP/TRPV Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel
	AS1269574 是口服有效的GPR119激动剂，在表达人 GPR119 的 HEK293 细胞中EC50为 2.5 μM。它激活 TRPA1 阳离子通道，刺激胰高血糖素样肽-1分泌。它仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。它在 2 型糖尿病的研究中具有价值。
T22103	ML-193 CID 1261822	Cannabinoid Receptor	GPCR/G Protein
	ML-193 (CID 1261822) 是一种有效的选择性GPR55拮抗剂，IC50值为 221 nM，对 GPR55 的选择性比 GPR35、CB1 和 CB2 高 27 倍以上，可改善帕金森病 (PD) 大鼠的运动和感觉运动缺陷。
T23204	PSN 375963 PSN 375963 hydrochloride	GPR	Endocrinology/Hormones; GPCR/G Protein
	PSN 375963 (PSN 375963 hydrochloride) hydrochloride 是GPR119激动剂，对人和小鼠的EC50分别为 8.4 和 7.9 μM。它表现出与内源性油酰乙醇酰胺 (OEA) 相似的效力。
T9317	TAK-041 NBI-1065846	GPR	Endocrinology/Hormones; GPCR/G Protein
	TAK-041 (NBI-1065846) 是一种选择性 GPR139激动剂，EC50为 22 nM，有用于精神分裂症阴性症状的研究潜力。
T0438	Proflavine Hemisulfate 3,6-Diaminoacridine hemisulfate,Proflavin hemisulfate,硫酸原黄素	Others; Potassium Channel; DNA; Thrombin; Antibacterial; Autophagy	Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Others; Proteases/Proteasome
	Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) 是一种 DNA 嵌入剂，也是一种吖啶染料。它是抗菌剂，也可作为 Kir3.2孔阻滞剂，可研究与 Kir3.2 相关的神经系统疾病。
T4478	CID 16020046 C390-0219	Cannabinoid Receptor	GPCR/G Protein
	CID 16020046 (C390-0219) 是一种选择性 GPR55 拮抗剂，在酵母中抑制 GPR55 组成型活性，IC50 为 0.15 μM。它抑制 GPR55 介导的 Ca2+信号传导和 GPR55 介导的 ERK1/2 磷酸化，可降低内皮细胞的伤口愈合，参与血小板功能的调节。
T12883	Fezagepras PBI-4050,3-戊基苯乙酸,Setogepram	GPR	Endocrinology/Hormones; GPCR/G Protein
	Fezagepras (Setogepram) 是一种可口服的 GPR40激动剂和GPR84拮抗剂或反向激动剂。它减轻肾、肝和胰腺纤维化，具有抗纤维化、抗炎和抗增殖作用。
T4494	CLOZAPINE N-OXIDE 氯氮平N-氧化,氯氮平N-氧化物	Dopamine Receptor; 5-HT Receptor; AChR; Drug Metabolite	GPCR/G Protein; Metabolism; Neuroscience
	Clozapine N-oxide 是 Clozapine 的主要代谢产物，具有血脑屏障渗透性。Clozapine N-oxide 是一种 DREADDs 激动剂，可激活 DREADD 受体 hM3Dq 和 hM4Di。Clozapine N-oxide 也是一种多巴胺拮抗剂和选择性毒蕈碱 M4 受体激动剂。
T77805	KRAS G12C mutant protein inhibitor A-1	Others	Others
	KRAS G12C mutant protein inhibitor A-1 可用于 Ras 相关研究。
T28073	MLS1547 MLS000051547,MLS 1547,MLS-1547	Dopamine Receptor	GPCR/G Protein; Neuroscience
	MLS1547 (MLS000051547) 是一种高效的 G 蛋白偏向多巴胺 D2 受体激动剂，Ki 为 1.2 μM。 MLS1547 在钙动员试验中刺激 D2R G 蛋白介导的信号传导，EC50 为 0.37 μM。
T36036	CAY10786 GPR52 antagonist-1	GPR	Endocrinology/Hormones; GPCR/G Protein
	CAY10786 (GPR52 antagonist-1) 是 G 蛋白偶联受体 52 (GPR52, IC50 = 0.63 μM) 的拮抗剂。
T16519L	BIM-46187 4HCl PH-064 4HCl	Others	Others
	BIM-46187 4HCl (PH-064 4HCl) 是一种异源三聚体 G 蛋白复合物抑制剂。
T10363	Arazine N-Acetyl-S-farnesyl-L-cysteine	Others	Others
	Arazine (N-Acetyl-S-farnesyl-L-cysteine) 可以成为异戊二烯基半胱氨酸甲基转移酶的底物通过与异戊二烯化 G 蛋白或其受体位点竞争。 Arazine 是 G 蛋白和 GPCR 信号传导的细胞渗透性调节剂。
T7312	AX20017	Others; Antibacterial	Microbiology/Virology; Others
	AX20017是蛋白激酶G 的一个小分子抑制剂，IC50值为 0.39 μM。
T5100	DJ-V-159 DJ-V159	GPR; Androgen Receptor	Endocrinology/Hormones; GPCR/G Protein
	DJ-V-159 (DJ-V159) 是一种G 蛋白偶联受体家族C 组6 A 的激动剂。
T10572L	BMT-124110 Formate BMT-124110 Formate（1679371-59-5 Free base）	Serine/threonin kinase; TGF-beta/Smad; AAK1 (AP2 associated kinase 1)	Cell Cycle/Checkpoint; Metabolism; Neuroscience; Stem Cells
	BMT-124110 Formate 是一种具有选择性的AAK1抑制剂(IC50: 0.9 nM)，具有抗伤害感受活性。BMT-124110 Formate 抑制BMP -2诱导蛋白激酶BIKE,其IC50为 17 nM。BMT-124110 Formate 抑制细胞周期蛋白 G 相关激酶GAK，其IC50:为99 nM。
T50088	N-phenylthiophene-2-carboximidamide	Others	Others
	N-phenylthiophene-2-carboximidamide 是一种噻吩衍生物，可以作为蛋白酪氨酸激酶（PTKs）的抑制剂和 G 蛋白偶联受体（GPCR）的配体发挥作用。

化合物

Protein kinase G inhibitor-1

Cat.No: T67755

Target: PKA

Protein kinase G inhibitor-2

Cat.No: T9940

Target: Others

G-Protein antagonist peptide acetate

Cat.No: TP1902L1

Target: Adrenergic Receptor

Cat.No: T14898

Target: GTPase

Cat.No: T14897

Target: GTPase

G-Protein antagonist peptide

Cat.No: TP1902

Cat.No: T8818

Synonym: (4-环丙基-3,4-二氢-1(2H)-喹喔啉基)[4-(2,5-二甲基苯氧基)-3-吡啶基]甲酮

Target: GPCR19

Cat.No: T7428

Target: GPCR19

GTP-Binding Protein Fragment, G alpha

Cat.No: TP2254

Target: Others

Brilliant blue G-250

Cat.No: T20731

Synonym: 酸性蓝 90,BBG,Acid blue 90, Coomassie Brilliant Blue G,Brilliant Blue G

Target: P2X Receptor

Cat.No: T4083

Synonym: BAR 501

Target: GPCR19

Cat.No: TQ0252

Target: FXR, GPCR19, Autophagy

Cat.No: T4352

Synonym: SB-756050,SB 756050

Target: GPCR19

Cat.No: T2088

Synonym: APD 668

Target: GPR, P450, Potassium Channel

Cat.No: T16378

Target: Others, 5-HT Receptor, Adenosine Receptor

Cat.No: T6434

Synonym: CCG 50014,4-[(4-氟苯基)甲基]-2-(4-甲基苯基)-1,2,4-噻二唑烷-3,5-二酮

Target: GTPase

Cat.No: T0843

Synonym: 氨苯蝶啶,Ademine,SKF8542

Target: Sodium Channel, GPCR19

Cat.No: T1793

Target: GPR

Cat.No: T6843

Synonym: G-868,GDC0623,RG 7421,MEK inhibitor 1

Target: Apoptosis, MEK

Cat.No: T21874

Target: GPR

TGR5 Receptor Agonist

Cat.No: T1824

Target: GPCR19

Cat.No: T2701

Target: GPR

Cat.No: T22996

Target: ERK

Cat.No: T8329

Target: GPR

Cat.No: T7156

Target: EBI2/GPR183

Cat.No: T6313

Synonym: Goe 6983

Target: PKC

Cat.No: T22408

Synonym: 吡啶-3,6-二胺,3,6-Diaminoacridine

Target: Antibacterial

TC-O 9311 free base

Cat.No: T4626

Target: GPR

Cat.No: T8975

Target: Cannabinoid Receptor

Cat.No: T2036

Synonym: GTPL5846

Target: GPR

Cat.No: T3119

Synonym: JNJ 63533054

Target: GPR

Cat.No: T8571

Synonym: CID2440433

Target: Cannabinoid Receptor

Cat.No: T3176

Synonym: JNJ-38431055

Target: GPR

Cat.No: T21623

Synonym: AS 1269574

Target: GPR, TRP/TRPV Channel

Cat.No: T22103

Synonym: CID 1261822

Target: Cannabinoid Receptor

Cat.No: T23204

Synonym: PSN 375963 hydrochloride

Target: GPR

Cat.No: T9317

Synonym: NBI-1065846

Target: GPR

Proflavine Hemisulfate

Cat.No: T0438

Synonym: 3,6-Diaminoacridine hemisulfate,Proflavin hemisulfate,硫酸原黄素

Target: Others, Potassium Channel, DNA, Thrombin, Antibacterial, Autophagy

Cat.No: T4478

Synonym: C390-0219

Target: Cannabinoid Receptor

Cat.No: T12883

Synonym: PBI-4050,3-戊基苯乙酸,Setogepram

Target: GPR

CLOZAPINE N-OXIDE

Cat.No: T4494

Synonym: 氯氮平N-氧化,氯氮平N-氧化物

Target: Dopamine Receptor, 5-HT Receptor, AChR, Drug Metabolite

KRAS G12C mutant protein inhibitor A-1

Cat.No: T77805

Target: Others

Cat.No: T28073

Synonym: MLS000051547,MLS 1547,MLS-1547

Target: Dopamine Receptor

Cat.No: T36036

Synonym: GPR52 antagonist-1

Target: GPR

Cat.No: T16519L

Synonym: PH-064 4HCl

Target: Others

Cat.No: T10363

Synonym: N-Acetyl-S-farnesyl-L-cysteine

Target: Others

Cat.No: T7312

Target: Others, Antibacterial

Cat.No: T5100

Synonym: DJ-V159

Target: GPR, Androgen Receptor

BMT-124110 Formate

Cat.No: T10572L

Synonym: BMT-124110 Formate（1679371-59-5 Free base）

Target: Serine/threonin kinase, TGF-beta/Smad, AAK1 (AP2 associated kinase 1)

N-phenylthiophene-2-carboximidamide

Cat.No: T50088

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6512	G-418 disulfate Geneticin,G418 Sulfate,Antibiotic G-418 sulfate,遗传霉素,Geneticin sulfate	Antibacterial; Antibiotic	Microbiology/Virology
	G-418 disulfate (Geneticin sulfate) 属于氨基糖苷类抗生素，是一种蛋白质合成的抑制剂，具有真核细胞选择性。G-418 disulfate 通过抑制肽链的延伸来阻断多肽合成。
T5077	Deoxycholic acid sodium salt 脱氧胆酸钠,Sodium deoxycholate,Sodium Desoxycholate	Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Deoxycholic acid sodium salt (Sodium deoxycholate) 是 G 蛋白偶联胆汁酸受体TGR5的激活剂。
T2965	Deoxycholic acid Cholorebic,去氧胆酸,脱氧胆酸,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic	Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Deoxycholic acid (Cholanoic Acid) 是 G 蛋白偶联胆汁酸受体 TGR5的激活剂。
TN2268	Tetrahydromagnolol	Cannabinoid Receptor; GPR; GABA Receptor	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Tetrahydromagnolol 是 Magnolol 的主要代谢产物，是一种弱的GPR55受体拮抗剂。它是选择性大麻素CB2受体激动剂，EC50为 170 nM，Ki 为 416 nM，对CB2受体的选择性比 CB1 受体高 20 倍。
T0700	Ursodeoxycholic acid 熊去氧胆酸,UDCA,Ursodiol	Potassium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	Ursodeoxycholic acid (UDCA)是一种有效的肝脏特异性脂肪酸转运蛋白 5 (FATP5) 抑制剂，通过 FATP5 依赖性方式抑制原代肝细胞摄取长链脂肪酸。Ursodeoxycholic acid 能够抑制胆固醇的吸收，用于溶解胆结石，并具有研究与肥胖相关的脂肪肝疾病的潜力。
T2968	Hyodeoxycholic acid NSC 60672,猪去氧胆酸,α-Hyodeoxycholic Acid,HDCA	FXR; Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Hyodeoxycholic acid (NSC 60672) 是由肠道菌群在小肠中形成的次级胆汁酸，是TGR5(GPCR19)的激动剂， CHO 细胞中的EC50=31.6 µM。它已用于研究高胆固醇血症的治疗。
T29078	Ursodeoxycholic acid sodium UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium	FXR; Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) 是一种天然存在的次级胆汁酸，具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子，通过与胆汁酸激活受体相互作用发挥其作用，包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。
T14046	Anandamide 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。
T0508	γ-Aminobutyric acid Gamma-aminobutyric acid,4-Aminobutyric acid,4-氨基丁酸,γ-氨基丁酸,GABA,4-Aminobutanoic acid,Piperidic acid	GABA Receptor; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	γ-Aminobutyric acid (4-Aminobutyric acid) 是成年哺乳动物大脑中主要的抑制性神经递质，能够与离子移变 GABA 受体(GABAA) 受体和促代谢受体 (GABAB) 受体结合发挥作用。
T4839	Ac-Ala-OH N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
T20003	Acridone	Antibacterial; ABC	Membrane transporter/Ion channel; Microbiology/Virology
	Acridone 具有抗菌、抗疟、抗病毒和抗肿瘤活性。它可诱导细胞凋亡，抑制 ABCG2 蛋白，并调节激素水平。
T3232	Higenamine hydrochloride Higenamine HCl,Demethylcoclaurine hydrochloride,盐酸去甲乌头碱,norcoclaurine HCl,(+-)-Demethylcoclaurine hydrochloride,Higenamine Hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Higenamine hydrochloride (norcoclaurine HCl) 是一种 β2-AR 激动剂，是用于心力衰竭相关研究的中药乌头的关键成分，具有抗凋亡活性。
T5065	GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD Monosodium-GMP,cGMP sodium salt,鸟苷-3',5'-环磷酸一钠盐,Cyclic GMP	PKA	Tyrosine Kinase/Adaptors
	GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) 也称为 cGMP，是一种细胞调节剂，被描述为第二信使。它的水平随着各种激素的增加而增加，包括乙酰胆碱、胰岛素和催产素。 cGMP 激活蛋白激酶 G(PKG) 并调节离子通道电导，信号传导影响多种过程，包括平滑肌松弛和增殖、光转导和能量稳态。
T3929	Kaurenoic acid Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid	Others	Others
	Kaurenoic acid (kaurenoate) 是一种二萜，来源于 Sphagneticola trilobata 中，可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路，并抑制炎症疼痛。
T17273	YM-254890 YM254890,YM 254890	P2Y Receptor	GPCR/G Protein; Neuroscience
	YM-254890 是一种从 Chromobacterium sp 中分离的大环己肽，是一种具有选择性和高效性的 Gαq/11 蛋白抑制剂，抑制 ADP 诱导的血小板凝集，抑制 G 蛋白信号传导。
T73876	Sanggenon G	Others	Others
	Sanggenon G 是一种具有细胞渗透性的有效的 X 连锁凋亡抑制蛋白 (XIAP) 抑制剂。Sanggenon G 特异性结合XIAP 的 BIR3 结构域，结合亲和力为 34.26 μM。Sanggenon G 增强caspase 激活。
TN5580	Rediocide A
	Rediocide A, an insecticide, can inhibit calcium mobilization in Drosophila G-protein- coupled receptors (GPCR)s other than methuselah, it can induce GPCR desensitization and internalization, and such effects are mediated by the activation of conventional
T38331	Commendamide	Others	Others
	Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs). Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC50 value of 11.8 μM.
T21500	Sphingosine-1-phosphate S1P	Endogenous Metabolite; S1P Receptor; LPL Receptor	GPCR/G Protein; Metabolism
	Sphingosine-1-phosphate (S1P) 是 S1P1-5 受体 (S1P1-5 receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使，动员 Ca2+ 作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。
T38069	Aquastatin A	Others	Others
	Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K....

天然产物

G-418 disulfate

Cat.No: T6512

Synonym: Geneticin,G418 Sulfate,Antibiotic G-418 sulfate,遗传霉素,Geneticin sulfate

Target: Antibacterial, Antibiotic

Deoxycholic acid sodium salt

Cat.No: T5077

Synonym: 脱氧胆酸钠,Sodium deoxycholate,Sodium Desoxycholate

Target: Endogenous Metabolite, GPCR19

Deoxycholic acid

Cat.No: T2965

Synonym: Cholorebic,去氧胆酸,脱氧胆酸,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic

Target: Endogenous Metabolite, GPCR19

Tetrahydromagnolol

Cat.No: TN2268

Target: Cannabinoid Receptor, GPR, GABA Receptor

Ursodeoxycholic acid

Cat.No: T0700

Synonym: 熊去氧胆酸,UDCA,Ursodiol

Target: Potassium Channel, Endogenous Metabolite

Hyodeoxycholic acid

Cat.No: T2968

Synonym: NSC 60672,猪去氧胆酸,α-Hyodeoxycholic Acid,HDCA

Target: FXR, Endogenous Metabolite, GPCR19

Ursodeoxycholic acid sodium

Cat.No: T29078

Synonym: UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium

Target: FXR, Endogenous Metabolite, GPCR19

Cat.No: T14046

Synonym: 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

γ-Aminobutyric acid

Cat.No: T0508

Synonym: Gamma-aminobutyric acid,4-Aminobutyric acid,4-氨基丁酸,γ-氨基丁酸,GABA,4-Aminobutanoic acid,Piperidic acid

Target: GABA Receptor, Endogenous Metabolite

Cat.No: T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Target: Others, Endogenous Metabolite

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: T20003

Target: Antibacterial, ABC

Higenamine hydrochloride

Cat.No: T3232

Synonym: Higenamine HCl,Demethylcoclaurine hydrochloride,盐酸去甲乌头碱,norcoclaurine HCl,(+-)-Demethylcoclaurine hydrochloride,Higenamine Hydrochloride

Target: Adrenergic Receptor

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD

Cat.No: T5065

Synonym: Monosodium-GMP,cGMP sodium salt,鸟苷-3',5'-环磷酸一钠盐,Cyclic GMP

Target: PKA

Cat.No: T3929

Synonym: Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid

Target: Others

Cat.No: T17273

Synonym: YM254890,YM 254890

Target: P2Y Receptor

Cat.No: T73876

Target: Others

Cat.No: TN5580

Cat.No: T38331

Target: Others

Sphingosine-1-phosphate

Cat.No: T21500

Synonym: S1P

Target: Endogenous Metabolite, S1P Receptor, LPL Receptor

Cat.No: T38069

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01885	Human RSV (B1) glycoprotein G/RSV-G Protein (His) G Protein, RSV	RSV	HEK293 Cells
	Human RSV (B1) glycoprotein G/RSV-G Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27 kDa and the accession number is O36633-1.
TMPY-01082	Human respiratory syncytial virus (RSV) (A, rsb1734) glycoprotein G/RSV-G Protein (95% Homology) (His) G Protein, RSV	RSV	HEK293 Cells
	Human respiratory syncytial virus (RSV) (A, rsb1734) glycoprotein G/RSV-G Protein (95% Homology) (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is P27022-1.
TMPY-02283	Human respiratory syncytial virus (RSV) (A, rsb1734) glycoprotein G/RSV-G Protein (93% Homology) (His) G Protein	RSV	Baculovirus Insect Cells
	Human respiratory syncytial virus (RSV) (A, rsb1734) glycoprotein G/RSV-G Protein (93% Homology) (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P27022-1.
TMPY-05686	Human respiratory syncytial virus (RSV) glycoprotein G Protein (aa 64-321, His) G Protein	RSV	HEK293 Cells
	Human respiratory syncytial virus (RSV) glycoprotein G Protein (aa 64-321, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.59 kDa and the accession number is A0A076FRQ0.
TMPY-06474	Human respiratory syncytial virus (RSV) (strain A2) glycoprotein G Protein (His) G Protein	RSV	HEK293 Cells
	Human respiratory syncytial virus (RSV) (strain A2) glycoprotein G Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.97 kDa and the accession number is P03423.
TMPY-06111	Human respiratory syncytial virus (RSV) (subtype A, strain Long) glycoprotein G Protein (His) G Protein	RSV	HEK293 Cells
	Human respiratory syncytial virus (RSV) (subtype A, strain Long) glycoprotein G Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27 kDa and the accession number is P20895-1.
TMPY-06469	Human respiratory syncytial virus (RSV) (B, strain 18537) glycoprotein G Protein (His) G Protein	RSV	HEK293 Cells
	Human respiratory syncytial virus (RSV) (B, strain 18537) glycoprotein G Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.40 kDa and the accession number is P20896.
TMPY-00105	Recombinant Protein G		E. coli
	Protein G is a bacterial cell wall protein expressed at the cell surface of certain group C and group G Streptococcal strains. It has affinity for both Fab- and Fc-fragments of human IgG by independent and separate binding sites. Binding to the Fc region of immunoglobulins from several species by a non-immune mechanism exhibits great affinity for almost all mammalian immunoglobulin G (IgG) classes, including all human IgG subclasses (IgG1, IgG2, IgG3 and IgG4) and also rabbit, mouse, and goat Ig...
TMPY-04829	G-CSF Protein, Human, Recombinant G-CSF,colony stimulating factor 3 (g	Human	HEK293 Cells
	G-CSF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.7 kDa and the accession number is P09919-2.
TMPY-05636	G-CSF Protein, Mouse, Recombinant G-CSF,MGI-IG,Csfg,集落刺激因子...	Mouse	HEK293 Cells
	G-CSF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 19 kDa and the accession number is P09920.
TMPY-00300	Hendra virus (HeV) (isolate Horse/Autralia/Hendra/1994) Glycoprotein Protein (hFc) HeV-G Protein, HeV,Glycoprote...	HEV	HEK293 Cells
	Hendra virus (HeV) (isolate Horse/Autralia/Hendra/1994) Glycoprotein Protein (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 86.3 kDa and the accession number is O89343.
TMPH-00510	DT3C Protein, Recombinant (His) IgG-binding protein ...	Corynephage beta	E. coli
	DT3C Protein, Recombinant (His) is expressed in E. coli.
TMPY-02802	GNG13 Protein, Human, Recombinant (His) G(gamma)13,h2-35,G(γ)13,g	Human	E. coli
	GNG13 is a subunit of heterotrimeric G proteins which consist of alpha, beta, and gamma subunits. Heterotrimeric G proteins are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. Each G protein is composed of an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding...
TMPK-00743	LGR-5 Protein, Human, Recombinant (hFc) G-protein coupled receptor HG38,<...	Human	HEK293 Cells
	G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker and prognostic indicator that can promote EMT by activating the Wnt/β-catenin pathway and would thus be a novel therapeutic target for glioma.
TMPY-03280	RAMP3 Protein, Human, Recombinant (hFc) receptor (G protein-coupled) activity modi...	Human	HEK293 Cells
	RAMP3 belongs to the RAMP family. Members of this family are single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. They are required to transp...
TMPH-01907	GPR146 Protein, Human, Recombinant (His) G-protein coupled receptor PGR8,<...	Human	E. coli
	GPR146 Protein, Human, Recombinant (His) is expressed in in vitro E. coli expression system.
TMPH-01410	GPR84 Protein, Human, Recombinant (hFc) G-protein coupled receptor 84,GPR...	Human	P. pastoris (Yeast)
	Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system. GPR84 Protein, Human, Recom...
TMPY-04555	GRK5 Protein, Human, Recombinant (His) G protein-coupled receptor kinase 5,G<...	Human	Baculovirus Insect Cells
	G protein-coupled receptor kinase 5, also known as G protein-coupled receptor kinase GRK5 and GRK5, is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRKs specifically phosphorylate agonist-occupied G protein-coupled receptors at the inner surface of the plasma membrane (PM), leading to receptor desensitization. GRKs utilize a variety of mechanisms to bind tightly, and sometimes reversibly, to cellular membranes. GRKs play an important role in ...
TMPY-04409	GRK6 Protein, Human, Recombinant (His & GST) G protein-coupled receptor kinase 6,G<...	Human	Baculovirus Insect Cells
	G protein-coupled receptor kinase 6, also known as G protein-coupled receptor kinase GRK6, GRK6, and GPRK6, is a lipid-anchor protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRK6 / GPRK6 contains one AGC-kinase C-terminal domain, one protein kinase domain, and one RGS domain. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding differen...
TMPJ-01202	LYG2 Protein, Human, Recombinant (His) LYGH,Lysozyme G-Like Protein 2,LY...	Human	HEK293 Cells
	Lysozyme G-Like Protein 2 (LYG2) is a secreted protein that belongs to the glycosyl hydrolase 23 family. LYG2 contains one SLT domain, one protein domain present in bacterial lytic transglycosylase (SLT) and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the cleavage of the β-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyglucosamine (GlcNAc). LYG2 has hydrolase activity which acting on glycosyl bonds, and possess lysozyme activity.
TMPH-02694	GNG12 Protein, Mouse, Recombinant (His & Myc) Gng12,Guanine nucleotide-bindin	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
TMPH-02693	GNAI2 Protein, Mouse, Recombinant (His) Guanine nucleotide-binding protein	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
TMPY-01365	CD97 Protein, Human, Recombinant (His) CD97,adhesion G protein-coupled receptor E...	Human	HEK293 Cells
	CD97 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.6 kDa and the accession number is P48960-2.
TMPH-01422	GNAS Protein, Human, Recombinant (His & SUMO) Guanine nucleotide-binding protein	Human	E. coli
	Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. GNAS Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6...
TMPY-01683	CD97 Protein, Human, Recombinant (hFc) adhesion G protein-coupled receptor E5,TM7...	Human	HEK293 Cells
	CD97 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 68.2 kDa and the accession number is P48960-2.
TMPH-02157	SFTA2 Protein, Human, Recombinant (His & SUMO) Surfactant-associated protein 2,SFTA2,Surfactant-as...	Human	E. coli
	Putative surfactant protein.
TMPH-02022	RXFP2 Protein, Human, Recombinant (His & Myc) G-protein coupled receptor 106,Relaxin rec...	Human	E. coli
	Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). RXFP2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 21.1 kDa and the accession number is Q8WXD0.
TMPK-00528	GPRC5D Protein-VLP, Cynomolgus, Recombinant MGC129713,GPRC5D,MGC129714,orphan...	Cynomolgus	HEK293 Cells
	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Cynomolg...
TMPY-02805	GNGT1 Protein, Human, Recombinant (His) guanine nucleotide binding protein	Human	E. coli
	GNGT1 is a subunit of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. G proteins are bound to GDP in the 'off' state. GNGT1 is the gamma subunit of transducin. Ligand-receptor binding results in detachment of the ...
TMPH-00269	GPR52 Protein, Bovine, Recombinant (His & KSI) G-protein coupled receptor 52,GPR...	Bovine	E. coli
	GPR52 Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 20.4 kDa and the accession number is A6QLE7.
TMPK-01193	GPRC5D Protein-VLP, Mouse, Recombinant MGC129713,orphan G-protein couple...	Mouse	HEK293 Cells
	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Mouse, R...
TMPH-01421	GNAI3 Protein, Human, Recombinant (His) GNAI3,G(i) alpha-3,Guanine nucleo...	Human	E. coli
	GNAI3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.5 kDa and the accession number is P08754.
TMPH-02020	RGS17 Protein, Human, Recombinant (GST) Regulator of G-protein sig	Human	E. coli
	Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. R...
TMPJ-01304	C1QTNF1 Protein, Human, Recombinant (His) C1QTNF1,G Protein-Coupled Receptor-Interac...	Human	HEK293 Cells
	C1QTNF1 is a secreted protein，contains 1 C1q domain and 1 collagen-like domain. C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. C1QTNF1 is a novel adipokine, providing a significant framew...
TMPH-00189	HtpG Protein, Bacteroides fragilis, Recombinant (His & Myc & SUMO) Chaperone protein HtpG,Heat shock prot...	Bacteroides fragilis	E. coli
	Molecular chaperone. Has ATPase activity. HtpG Protein, Bacteroides fragilis, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 57.0 kDa and the accession number is Q5LCH4.
TMPH-02838	GPR146 Protein, Mouse, Recombinant (His) Gpr146,Probable G-protein coupled...	Mouse	E. coli
	Orphan receptor. GPR146 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 39.4 kDa and the accession number is Q99LE2.
TMPH-01423	GNAZ Protein, Human, Recombinant (His & SUMO) GNAZ,Gz-alpha,G(x) alpha chain,	Human	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. GNAZ Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.8 kDa and the accession number is P19086.
TMPH-01082	CMKLR1 Protein, Human, Recombinant (His) CMKLR1,G-protein coupled receptor ChemR23,...	Human	E. coli
	CMKLR1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 45.1 kDa and the accession number is Q99788.
TMPH-00594	HtpG Protein, E. coli, Recombinant (His) Chaperone protein HtpG,Heat shock prot...	E. coli	E. coli
	Molecular chaperone. Has ATPase activity.
TMPH-00595	HtpG Protein, E. coli, Recombinant High temperature protein G,Heat s...	E. coli	E. coli
	Molecular chaperone. Has ATPase activity.
TMPH-01326	FBXO44 Protein, Human, Recombinant (His & Myc) F-box only protein 44,F-box/G-domain p...	Human	E. coli
	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXO44 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.2 kDa and the accession number is Q9H4M3.
TMPK-00876	G-CSFR/CD114 Protein, Mouse, Recombinant (His) CD114,G CSF R,G-CSF-R,G-CSF R,CSF...	Mouse	HEK293 Cells
	The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal.
TMPH-01640	MRGPRX2 Protein, Human, Recombinant (His) Mas-related G-protein coupled receptor mem...	Human	E. coli
	Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway c...
TMPH-02695	GNAO1 Protein, Mouse, Recombinant (His) Gnao1,Guanine nucleotide-binding ...	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Stimulated by RGS14. The G(o) protein function is not clear.
TMPH-01611	LGR6 Protein, Human, Recombinant (His) LGR6,Leucine-rich repeat-containing G<...	Human	E. coli
	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to t...
TMPH-01733	DDAH2 Protein, Human, Recombinant (GST & His) Inactive dimethylarginine dimethylaminohydrolase 2,...	Human	E. coli
	Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. DDAH2 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 61.2 kDa and the accession number is O95865.
TMPH-02696	GNAQ Protein, Mouse, Recombinant (His & Myc) Guanine nucleotide-binding protein	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).
TMPH-02021	RGS2 Protein, Human, Recombinant (His & SUMO) Regulator of G-protein sig	Human	E. coli
	RGS2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-02276	GPR56 Protein, Human, Recombinant (His) BFPP,UNQ540/PRO1083,DKFZp781L1398,TM7LN4,adhesion G...	Human	HEK293 Cells
	ADGRG1 (Adhesion G Protein-Coupled Receptor G1, also known as GPR56) is a Protein Coding gene. GPR56 is a member of an adhesion G protein-coupled receptor family with a very long N-terminal stalk and seven transmembrane domains. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. GPR56 may be a target for the treatment of type 2 diabetes. GPR56 inhibits melanoma metastatic growth by impeding the exp...
TMPY-02717	GPR37 Protein, Human, Recombinant (His) hET(B)R-LP,PAELR,G protein-coupled recepto...	Human	HEK293 Cells
	GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They only exist in eukaryotes, including yeast, choanoflagellates, and animals. These receptors are bonded and activated by light-sensitive compounds, odors, pheromones, hormones, and n...
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重组蛋白

Human RSV (B1) glycoprotein G/RSV-G Protein (His)

Cat.No: TMPY-01885

Species: RSV

Expression System: HEK293 Cells

Human respiratory syncytial virus (RSV) (A, rsb1734) glycoprotein G/RSV-G Protein (95% Homology) (His)

Cat.No: TMPY-01082

Species: RSV

Expression System: HEK293 Cells

Human respiratory syncytial virus (RSV) (A, rsb1734) glycoprotein G/RSV-G Protein (93% Homology) (His)

Cat.No: TMPY-02283

Species: RSV

Expression System: Baculovirus Insect Cells

Human respiratory syncytial virus (RSV) glycoprotein G Protein (aa 64-321, His)

Cat.No: TMPY-05686

Species: RSV

Expression System: HEK293 Cells

Human respiratory syncytial virus (RSV) (strain A2) glycoprotein G Protein (His)

Cat.No: TMPY-06474

Species: RSV

Expression System: HEK293 Cells

Human respiratory syncytial virus (RSV) (subtype A, strain Long) glycoprotein G Protein (His)

Cat.No: TMPY-06111

Species: RSV

Expression System: HEK293 Cells

Human respiratory syncytial virus (RSV) (B, strain 18537) glycoprotein G Protein (His)

Cat.No: TMPY-06469

Species: RSV

Expression System: HEK293 Cells

Recombinant Protein G

Cat.No: TMPY-00105

Expression System: E. coli

G-CSF Protein, Human, Recombinant

Cat.No: TMPY-04829

Species: Human

Expression System: HEK293 Cells

G-CSF Protein, Mouse, Recombinant

Cat.No: TMPY-05636

Species: Mouse

Expression System: HEK293 Cells

Hendra virus (HeV) (isolate Horse/Autralia/Hendra/1994) Glycoprotein Protein (hFc)

Cat.No: TMPY-00300

Species: HEV

Expression System: HEK293 Cells

DT3C Protein, Recombinant (His)

Cat.No: TMPH-00510

Species: Corynephage beta

Expression System: E. coli

GNG13 Protein, Human, Recombinant (His)

Cat.No: TMPY-02802

Species: Human

Expression System: E. coli

LGR-5 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00743

Species: Human

Expression System: HEK293 Cells

RAMP3 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03280

Species: Human

Expression System: HEK293 Cells

GPR146 Protein, Human, Recombinant (His)

Cat.No: TMPH-01907

Species: Human

Expression System: E. coli

GPR84 Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01410

Species: Human

Expression System: P. pastoris (Yeast)

GRK5 Protein, Human, Recombinant (His)

Cat.No: TMPY-04555

Species: Human

Expression System: Baculovirus Insect Cells

GRK6 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04409

Species: Human

Expression System: Baculovirus Insect Cells

LYG2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01202

Species: Human

Expression System: HEK293 Cells

GNG12 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02694

Species: Mouse

Expression System: E. coli

GNAI2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02693

Species: Mouse

Expression System: E. coli

CD97 Protein, Human, Recombinant (His)

Cat.No: TMPY-01365

Species: Human

Expression System: HEK293 Cells

GNAS Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01422

Species: Human

Expression System: E. coli

CD97 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01683

Species: Human

Expression System: HEK293 Cells

SFTA2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02157

Species: Human

Expression System: E. coli

RXFP2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02022

Species: Human

Expression System: E. coli

GPRC5D Protein-VLP, Cynomolgus, Recombinant

Cat.No: TMPK-00528

Species: Cynomolgus

Expression System: HEK293 Cells

GNGT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02805

Species: Human

Expression System: E. coli

GPR52 Protein, Bovine, Recombinant (His & KSI)

Cat.No: TMPH-00269

Species: Bovine

Expression System: E. coli

GPRC5D Protein-VLP, Mouse, Recombinant

Cat.No: TMPK-01193

Species: Mouse

Expression System: HEK293 Cells

GNAI3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01421

Species: Human

Expression System: E. coli

RGS17 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02020

Species: Human

Expression System: E. coli

C1QTNF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01304

Species: Human

Expression System: HEK293 Cells

HtpG Protein, Bacteroides fragilis, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00189

Species: Bacteroides fragilis

Expression System: E. coli

GPR146 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02838

Species: Mouse

Expression System: E. coli

GNAZ Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01423

Species: Human

Expression System: E. coli

CMKLR1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01082

Species: Human

Expression System: E. coli

HtpG Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00594

Species: E. coli

Expression System: E. coli

HtpG Protein, E. coli, Recombinant

Cat.No: TMPH-00595

Species: E. coli

Expression System: E. coli

FBXO44 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01326

Species: Human

Expression System: E. coli

G-CSFR/CD114 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00876

Species: Mouse

Expression System: HEK293 Cells

MRGPRX2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01640

Species: Human

Expression System: E. coli

GNAO1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02695

Species: Mouse

Expression System: E. coli

LGR6 Protein, Human, Recombinant (His)

Cat.No: TMPH-01611

Species: Human

Expression System: E. coli

DDAH2 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01733

Species: Human

Expression System: E. coli

GNAQ Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02696

Species: Mouse

Expression System: E. coli

RGS2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02021

Species: Human

Expression System: E. coli

GPR56 Protein, Human, Recombinant (His)

Cat.No: TMPY-02276

Species: Human

Expression System: HEK293 Cells

GPR37 Protein, Human, Recombinant (His)

Cat.No: TMPY-02717

Species: Human

Expression System: HEK293 Cells

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Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0494	Higenamine-d4 HCl
	Higenamine-d4 HCl 是 Higenamine HCl 的氘代化合物。Higenamine HCl 的 CAS 号为 11041-94-4。Higenamine hydrochloride 是一种 β2-AR 激动剂，是用于心力衰竭相关研究的中药乌头的关键成分，具有抗凋亡活性。
T35790	Palmitic acid-1,2,3,4-13C4 Palmitic Acid-13C (C1, C2, C3, and C4 labeled)
	Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula...

同位素标记化合物

Higenamine-d4 HCl

Cat.No: TMIJ-0494

Palmitic acid-1,2,3,4-13C4

Cat.No: T35790

Synonym: Palmitic Acid-13C (C1, C2, C3, and C4 labeled)

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