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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78187 |
FOXO1-IN-3
|
Others | Others |
FOXO1-IN-3 是口服活性的高度选择性FOXO1抑制剂,能够降低小鼠肝脏中的葡萄糖产生,并在db/db小鼠中改善胰岛素敏感性及血糖控制,同时不引起体重增加。 | |||
T9243 |
PFI-90
|
Histone Demethylase; Others | Chromatin/Epigenetic; Others |
PFI-90 是组蛋白去甲基化酶 (KDM3B) 的选择性抑制剂,可抑制 PAX3-FOXO1 的作用。它具有抗肿瘤活性的潜力,可诱导细胞凋亡和成肌分化,导致细胞死亡增加。 | |||
T6762 |
AS1842856
|
Autophagy; FOXO1 | Apoptosis; Autophagy |
AS1842856 是一种特异性的Foxo1抑制剂,IC50为 30 nM。它抑制自噬,直接与 FoxO1 结合而降低 FoxO1 的活性。 | |||
T73578 |
JY-2
|
FOXO1 | Apoptosis |
JY-2 是一种具有口服活性和选择性的叉头转录因子 O1 (FoxO1) 抑制剂,具有抗糖尿病活性,对 FoxO1 转录有抑制作用。JY-2 可用于研究银屑病和糖尿病。 | |||
T16077 |
MIR96-IN-1
|
MALT | Immunology/Inflammation |
MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells. | |||
T26661 |
AS1708727
|
Others | Others |
AS1708727 is a Foxo1 inhibitor, exerting anti-hypertriglyceridemic and anti-diabetic effects by improving triglyceride and blood glucose metabolism at the gene expression level. | |||
T76648 |
Acetyl-Exenatide
|
||
Acetyl-Exenatide为Exenatide的乙酰化衍生物,具有类似胰岛素的功能,适用于2型糖尿病研究。它能促进Th17细胞分化,同时抑制Treg细胞分化,并下调PI3K/Akt/FoxO1的磷酸化水平。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3773 |
Oxypaeoniflorin
氧化芍药苷,Oxypaeoniflora |
Others | Others |
Oxypaeoniflorin 从 Paeoniae 中分离得到的单萜糖苷化合物,是一种抗氧化剂,是具有神经保护和抗炎作用。 | |||
TN1911 |
Marein
马里苷,马里甙 |
transporter; Akt; HDAC; AMPK | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
Marein 能通过CaMKK/AMPK/GLUT1促进葡萄糖摄取,IRS/Akt/GSK-3β增加糖原合成,并通过Akt/FoxO1减少糖异生,从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。它对甲基乙二醛诱导的 PC12 细胞损伤具有神经保护作用,还有抗氧化、降压、降血脂和抗糖尿病作用。 | |||
TN4390 |
Kihadanin B
|
Akt; PPAR; FOXO1 | Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes. | |||
T27564 |
Hymenidin
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Hymenidin是一种从冲绳海绵Hymeniacidon sp。中分离出的生物碱,是一种5-羟色胺能受体拮抗剂和电压门控钾通道抑制剂,具有潜在的抗原生动物作用,可选择性结合 FOXO1 DNA ,可降低去极化诱导的细胞钙升高。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-01034 |
SEMA4B Protein, Mouse, Recombinant (His)
SEMA4B,SemC,Semaphorin-C,MGC131831 |
Mouse | HEK293 Cells |
Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC. | |||
TMPK-00368 |
MMP-9 Protein, Human, Recombinant (His & Avi), Biotinylated
Gelatinase B,MMP-9,MANDP2,CLG4B,GELB |
Human | HEK293 Cells |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address mechanisms of impaired re-epithelialization we examined MMP9 expression in vivo in full thickness dermal scalp wounds created in experimental K14. MMP-9 Protein, Human, Recombina... | |||
TMPK-00503 |
MMP-9 Protein, Cynomolgus, Recombinant (His)
MMP-9,CLG4B,Gelatinase B,MANDP2,GELB |
Cynomolgus | HEK293 Cells |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address mechanisms of impaired re-epithelialization we examined MMP9 expression in vivo in full thickness dermal scalp wounds created in experimental K14. MMP-9 Protein, Cynomolgus, Reco... | |||
TMPK-00367 |
MMP-9 Protein, Human, Recombinant (His & Avi)
MANDP2,CLG4B,Gelatinase B,GELB,MMP-9 |
Human | HEK293 Cells |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address mechanisms of impaired re-epithelialization we examined MMP9 expression in vivo in full thickness dermal scalp wounds created in experimental K14. MMP-9 Protein, Human, Recombina... | |||
TMPH-02131 |
SKP2 Protein, Human, Recombinant (His & SUMO)
S-phase kinase-associated protein 2,SKP2,F-box protein Skp2,... |
Human | E. coli |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB... |