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Search Results for " follicle-stimulating hormone receptor "

Targets Recommended: GNRH Receptor

12

抑制剂 & 化合物

3

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T3630	Relugolix RVT-601,瑞卢戈利,TAK-385	GNRH Receptor	GPCR/G Protein
	Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T21375	Clomifene Omifin,D,Chloramiphene,Clomiphene,Clomiphene free base,Citrate	Others	Others
	Clomifene is a selective estrogen receptor modulator (SERM), it has both estrogenic and anti-estrogenic activities. This agent causes the release of the pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH), leading to ov
TP2010	Kisspeptin 10 (dog)
	Endogenous ligand for the canine KISS1 receptor (Kisspeptin receptor or GPR54). Stimulates section of luteinizing hormone, follicle stimulating hormone and estradiol in vivo.
T85273	Gonadorelin acetate	Others	Others
	Gonadorelin, a gonadotropin-releasing hormone receptor (GNRHR; Ki= 13 nM in CHO cells expressing the human receptor) agonist and tropic hormone, effectively stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from rat anterior pituitary cultures at 0.1 μg doses. Additionally, it triggers LH release from bovine anterior pituitary cultures at a 1 μM concentration. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (ED50= 610.3 ng/kg). ...
T84706	DCOIT Kathon 930	Others	Others
	DCOIT是一种典型的异噻唑啉酮，能激活促性腺激素释放激素受体(GnRHR)在大脑中引发卵泡刺激素和黄体生成素的合成。此外，DCOIT干扰了G蛋白偶联受体、MAPK和Ca2+信号传递途径。
T72835	FSHR agonist 1	Others	Others
	FSHR agonist 1是一种对卵泡刺激素(FSH)受体(FSHR)具有高亲和力并能引起变构的激动剂，具有pEC50值为7.72。它通过与TMD广泛相互作用直接激活FSHR。
T76222	hFSH-β-(33-53) (TFA)
	hFSH-β-(33-53) TFA 是一种含有硫醇的肽，对应于第二个 FSH 受体结合域，是 FSHR(卵泡刺激素受体) 拮抗剂。hFSH-β-(33-53) TFA 抑制 FSH 与受体的结合，是 Sertoli 细胞中雌二醇合成的部分激动剂。
T68292	GTX-758	Others	Others
	GTX-758, also known as Capesaris, is a n orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in ...
T70309	Dicetrorelix pamoate	Others	Others
	Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein...
T69492	Ozarelix
	Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer,...
T76047	TAK-683 TFA
	TAK-683 TFA是一种高效的全KISS1R激动剂(IC50=170 pM)，拥有较好的代谢稳定性，是九肽metastin的类似物，对KISS1R有激动效应，其对人和大鼠EC50值分别为0.96 nM和1.6 nM。TAK-683 TFA能够降低下丘脑GnRH水平，进而减少血浆FSH、LH、睾酮的浓度，显示出对激素依赖性前列腺癌研究的可能性。
T76566	Fsh receptor-binding inhibitor fragment(bi-10)
	FSHreceptor-binding inhibitor fragment(bi-10) 是一种有效的 FSH 拮抗剂。FSHreceptor-binding inhibitor fragment(bi-10) 阻断 FSH 与 FSHR 的结合，并在受体水平上改变 FSH 的作用。FSHreceptor-binding inhibitor fragment(bi-10) 导致小鼠排卵抑制和卵泡闭锁。FSHreceptor-binding inhibitor fragment(bi-10) 通过下调卵巢中 FSHR 和 ERβ的过度表达来抑制卵巢癌发生。

化合物

Cat.No: T3630

Synonym: RVT-601,瑞卢戈利,TAK-385

Target: GNRH Receptor

Cat.No: T21375

Synonym: Omifin,D,Chloramiphene,Clomiphene,Clomiphene free base,Citrate

Target: Others

Kisspeptin 10 (dog)

Cat.No: TP2010

Gonadorelin acetate

Cat.No: T85273

Target: Others

Cat.No: T84706

Synonym: Kathon 930

Target: Others

Cat.No: T72835

Target: Others

hFSH-β-(33-53) (TFA)

Cat.No: T76222

Cat.No: T68292

Target: Others

Dicetrorelix pamoate

Cat.No: T70309

Target: Others

Cat.No: T69492

Cat.No: T76047

Fsh receptor-binding inhibitor fragment(bi-10)

Cat.No: T76566

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01348	FSHR Protein, Human, Recombinant (His) Follitropin receptor,FSHR,Follicle-sti...	Human	HEK293 Cells
	G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 43.5 kDa and the accession number is P23945.
TMPH-01347	FSHR Protein, Human, Recombinant (E. coli, His) Follicle-stimulating hormone ...	Human	E. coli
	G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P23945.
TMPY-04307	GNRH2 Protein, Human, Recombinant (hFc) LH-RHII,gonadotropin releasing hormone 2,GnRH-II,GN...	Human	HEK293 Cells
	GNRH2 (Gonadotropin-Releasing Hormone 2) is a Protein Coding gene. This gene is a member of the gonadotropin-releasing hormone (GnRH) gene family. Proteins encoded by members of this gene family are proteolytically cleaved to form neuropeptides which, in part, regulate reproductive functions by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). 3 alternatively spliced human isoforms have been reported. The second mammalian...

重组蛋白

FSHR Protein, Human, Recombinant (His)

Cat.No: TMPH-01348

Species: Human

Expression System: HEK293 Cells

FSHR Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01347

Species: Human

Expression System: E. coli

GNRH2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04307

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0268	Relugolix-d6
	Relugolix-d6 是 Relugolix 的氘代化合物。Relugolix 的 CAS 号为 737789-87-6。Relugolix 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的IC50值分别为0.33 nM和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。

同位素标记化合物

Cat.No: TMIJ-0268

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