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Search Results for " focal adhesion kinase "

Targets Recommended: FAK IGF-1R ALK

31

抑制剂 & 化合物

3

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10285	ALK inhibitor 1	FAK; IGF-1R; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	ALK inhibitor 1 是嘧啶类 ALK 的有效抑制剂。它是一种睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2;IC50=31 nM) 和粘着斑激酶 (FAK;IC50=2 nM) 抑制剂。
T9973	FAK-IN-7	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	FAK-IN-7 有潜在的抗增殖活性，是一种 FAK 抑制剂。
T3041	ALK inhibitor 2	FAK; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	ALK inhibitor 2 是嘧啶类 ALK 的有效抑制剂。它是一种睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2;IC50=37 nM) 和粘着斑激酶 (FAK;IC50=5 nM) 抑制剂。
T2001	PF-573228 PF 573228	Apoptosis; FAK	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-573228是一种选择性的 FAK 抑制剂，对 FAK 纯化重组催化片段的 IC50值为4 nM。
T9576	AMP-945	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	AMP-945 是一种粘着斑激酶抑制剂。
T2314	PF-431396	FAK; PYK2	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF 431396 是一种具有口服活性的 FAK (IC50:2 nM) 和 Pyk2 (IC50:11 nM)的抑制剂。
T6997	SU6656	FAK; Akt; Src	Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	SU6656 是Src 家族激酶抑制剂，抑制 Src，Yes，Lyn，Fyn 的IC50分别为 280，20，130，170 nM。它还能抑制p-AKT。它可抑制FAK Y576/577、 Y925、Y861位点的磷酸化。
T2655	CEP-37440 CEP37440	FAK; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CEP-37440 是一种新型的 FAK (IC50:2.3 nM) 和 ALK (IC50:120 nM) 双重抑制剂。
T2281	GSK2256098 GSK 2256098,GSK-2256098,GTPL7939	Apoptosis; FAK	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	GSK2256098 (GTPL7939) 是一种选择性FAK 激酶抑制剂，抑制胰腺癌细胞的生长和存活。
T5480	BI-4464	FAK; Ligands for Target Protein for PROTAC	Angiogenesis; Cytoskeletal Signaling; PROTAC; Tyrosine Kinase/Adaptors
	BI-4464 是一种高选择性的 ATP 竞争性 PTK2/FAK 抑制剂，IC50=17 nM。它可用于PROTAC 降解剂的 PTK2 配体。
T6177	PF-562271 besylate PF-00562271 Besylate	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 besylate (PF-00562271 Besylate) 是一种可逆的，有效的，ATP 竞争性的 FAK(IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T2465	PF-562271 PF562271,PF 562271	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 是一种可逆的，有效的，ATP 竞争性的 FAK (IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T0263	Chloropyramine hydrochloride Nilfan,盐酸氯吡胺,Alergosan,Halopyramine hydrochloride	FAK; VEGFR; Histamine Receptor	Angiogenesis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Neuroscience; Tyrosine Kinase/Adaptors
	Chloropyramine hydrochloride (Alergosan) 是一种组胺受体 H1 拮抗剂，可抑制VEGFR-3和FAK 的生化功能。
T1996	Defactinib PF-04554878,VS-6063	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Defactinib (VS-6063) 是新型的 FAK 抑制剂，能够时间和剂量依赖性的抑制 FAK 在 Tyr397 位点磷酸化。
T2609	Masitinib AB1010,马赛替尼	Apoptosis; FAK; c-Fms; FGFR; Bcr-Abl; PDGFR; Src; c-Kit; Hck	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Masitinib (AB1010) 是生物口服可利用的选择性 c-Kit 抑制剂 (对于人重组c-Kit，IC50=200 nM)，它还抑制PDGFRα/β(IC50s=540/800 nM)，Lyn(对 LynB 的IC50=510 nM)，Lck，较小程度上抑制FGFR3和FAK。它有抗增殖，促凋亡活性，且毒性低。
T21768	PF-562271 hydrochloride PF-562271 HCl	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 hydrochloride (PF-562271 HCl) 是一种可逆的，有效的，ATP 竞争性的 FAK (IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T24730	Roslin 2 bromide Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2	FAK; p53	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Roslin 2 bromide (Benzylhexamethylenetetramine bromide) 是一种 p53 再激活剂，可破坏 FAK 和 p53 的结合。 Roslin 2 bromide 具有抗癌作用。
T1918	NVP-TAE 226 TAE226	Apoptosis; FAK; c-Met/HGFR; PYK2; IGF-1R	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	NVP-TAE 226 (TAE226) 是一种具有 ATP 竞争性的双重FAK 和IGF-1R 抑制剂，IC50分别为 5.5 nM、140 nM。它还抑制Pyk2、胰岛素受体，IC50分为 3.5 nM、40 nM。
T1950	PND-1186 PND1186,PND 1186,VS-4718,SR-2516	Apoptosis; FAK	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PND-1186 (VS-4718) 是一种高特异性的FAK 可逆抑制剂，IC50为 1.5 nM。它选择性促进肿瘤细胞凋亡。
T7119	Y15 1,2,4,5-苯四胺四盐酸盐,1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) 是一种特异性的粘着斑激酶抑制剂，能够降低其自身磷酸化活性，抑制癌细胞的活力，阻断肿瘤生长。
T67843	GSK215	FAK; PROTACs	Angiogenesis; Cytoskeletal Signaling; PROTAC; Tyrosine Kinase/Adaptors
	GSK215是一种强效和选择性的粘着斑激酶（FAK）PROTAC 降解剂（pDC50=8.4）。GSK215包含 FAK 抑制剂 VS-4718和 VHL E3连接酶的粘合剂。GSK215可以诱导 FAK 的快速和长期降解。
T23539	Y 11	Others	Others
	focal adhesion kinase (FAK) inhibitor
T28277	OXA-11 OXA 11	Others	Others
	OXA-11 is a potent inhibitor of focal adhesion kinase (FAK) with anti-tumor activity.
T70724	GSK-2256098 HCl	Others	Others
	GSK-2256098 HCl is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
T22397	PF-4618433	Others	Others
	PF-4618433 is a dual inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2).
T11260	FAK inhibitor 2	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .
T35075	VSWRAPTA	Others	Others
	VSWRAPTA is a promoter of neuronal branching via transcellular activation of the focal adhesion kinase (FAK) and the ERK1/2 signaling pathway in vitro.
T68740	NVP-TAC544	Others	Others
	NVP-TAC544 is a novel focal adhesion kinase (FAK) inhibitor, potently blocking kinase activity of FAK along with Aurora A, activated Cdc42-associated kinase 1 (ACK1), Met, insulin receptor (IR), TrkA, and IGF-1R.
T13840	PROTAC FAK degrader 1	Others; PROTACs	Others; PROTAC
	PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).
T70352	PH11	Others	Others
	PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL...
T83680	Azurin (50-77) (P. aeruginosa) TFA Azurin p28,p28
	Azurin (50-77)是一种含铜细菌蛋白azurin的肽段，存在于P. aeruginosa中，具有细胞周期停滞、抑制癌细胞增殖和调节血管生成活性。作为VEGFR2的抑制剂（IC20约为10.7 µM），Azurin (50-77)（20 µM）能在MCF-7乳腺癌细胞中诱导G2/M期的细胞周期停滞。在50 µM的浓度下，减少MCF-7和ZR-75-1乳腺癌细胞的增殖。Azurin (50-77)以25 µM的浓度减少VEGF-A诱导的毛细管管腔形成（IC50 = 12 µM），降低人脐静脉内皮细胞（HUVECs）中与细胞膜相关的F-actin、焦点粘附激酶（FAK）和paxillin的水平，并增加胞外的血小板内皮细胞粘附分子-1（PECAM-1）的水平。在体内，Azurin (50-77)（每日10 mg/kg）在MCF-7小鼠异种移植模型中减少肿瘤体积。

化合物

ALK inhibitor 1

Cat.No: T10285

Target: FAK, IGF-1R, ALK

Cat.No: T9973

Target: FAK

ALK inhibitor 2

Cat.No: T3041

Target: FAK, ALK

Cat.No: T2001

Synonym: PF 573228

Target: Apoptosis, FAK

Cat.No: T9576

Target: FAK

Cat.No: T2314

Target: FAK, PYK2

Cat.No: T6997

Target: FAK, Akt, Src

Cat.No: T2655

Synonym: CEP37440

Target: FAK, ALK

Cat.No: T2281

Synonym: GSK 2256098,GSK-2256098,GTPL7939

Target: Apoptosis, FAK

Cat.No: T5480

Target: FAK, Ligands for Target Protein for PROTAC

PF-562271 besylate

Cat.No: T6177

Synonym: PF-00562271 Besylate

Target: FAK, PYK2, CDK

Cat.No: T2465

Synonym: PF562271,PF 562271

Target: FAK, PYK2, CDK

Chloropyramine hydrochloride

Cat.No: T0263

Synonym: Nilfan,盐酸氯吡胺,Alergosan,Halopyramine hydrochloride

Target: FAK, VEGFR, Histamine Receptor

Cat.No: T1996

Synonym: PF-04554878,VS-6063

Target: FAK

Cat.No: T2609

Synonym: AB1010,马赛替尼

Target: Apoptosis, FAK, c-Fms, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Hck

PF-562271 hydrochloride

Cat.No: T21768

Synonym: PF-562271 HCl

Target: FAK, PYK2, CDK

Roslin 2 bromide

Cat.No: T24730

Synonym: Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2

Target: FAK, p53

Cat.No: T1918

Synonym: TAE226

Target: Apoptosis, FAK, c-Met/HGFR, PYK2, IGF-1R

Cat.No: T1950

Synonym: PND1186,PND 1186,VS-4718,SR-2516

Target: Apoptosis, FAK

Cat.No: T7119

Synonym: 1,2,4,5-苯四胺四盐酸盐,1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14

Target: FAK

Cat.No: T67843

Target: FAK, PROTACs

Cat.No: T23539

Target: Others

Cat.No: T28277

Synonym: OXA 11

Target: Others

GSK-2256098 HCl

Cat.No: T70724

Target: Others

Cat.No: T22397

Target: Others

FAK inhibitor 2

Cat.No: T11260

Target: FAK

Cat.No: T35075

Target: Others

Cat.No: T68740

Target: Others

PROTAC FAK degrader 1

Cat.No: T13840

Target: Others, PROTACs

Cat.No: T70352

Target: Others

Azurin (50-77) (P. aeruginosa) TFA

Cat.No: T83680

Synonym: Azurin p28,p28

Cat. No.	Product Name	Target	Signaling Pathways
TN1433	Batatasin III	FAK; Others; Akt	Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭，并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用，显示出抑制萌发活性。
T5S0761	Nitidine chloride	Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite	Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。
T3122	Fangchinoline Tetrandrine B,防己诺林碱,(+)-Limacine,Hanfangichin B,防己醇灵,(+)-Fangchinoline	Apoptosis; FAK; HIV Protease; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Fangchinoline (Tetrandrine B) 是从Stephaniatetrandra 中分离出来的，一种具有广泛生物学活性的天然产物。它是新型HIV-1抑制剂，通过损害 gp160 蛋白水解过程来抑制 HIV-1 复制。它靶向Focal adhesion kinase (FAK)并抑制肿瘤细胞中 FAK 介导的的信号传导途径。

天然产物

Cat.No: TN1433

Target: FAK, Others, Akt

Nitidine chloride

Cat.No: T5S0761

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Cat.No: T3122

Synonym: Tetrandrine B,防己诺林碱,(+)-Limacine,Hanfangichin B,防己醇灵,(+)-Fangchinoline

Target: Apoptosis, FAK, HIV Protease, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00678	STX6 Protein, Human, Recombinant STX6,Syntaxin-6	Human	E. coli
	Syntaxin-6 (STX6) is a single-pass type IV membrane protein, which belongs to the Syntaxin family. STX6 is mainly localized in the plasma membrane. STX6 contains one t-SNARE coiled-coil homology domain and involved in intracellular vesicle trafficking. When STX6 function is inhibited, internalization through caveolae is dramaticaliy reduced, whereas other endocytic mechanisms are unaffected. It is reported that STX6 is necessary for proper expression of focal adhesion kinase and integrin alpha5 ...
TMPH-01539	ILK Protein, Human, Recombinant (His) ILK-1,ILK,Integrin-linked protein kinase,59 kDa ser...	Human	Baculovirus Insect Cells
	Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. P...
TMPY-03060	Parvin alpha/PARVA Protein, Human, Recombinant (GST) parvin, alpha,parvin, α,MXRA2,CH-ILKBP,Parvin α/PARVA	Human	E. coli
	Actopaxin, also known as alpha-parvin, belongs to the parvin family. It is widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Actopaxin contains 2 CH (calponin-homology) domains and probably plays a role in the regulation of cell adhesion and cytoskeleton organization. It interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Actopaxin binds directly to both F-actin and paxillin LD1 and LD4 motifs. Actopaxin also e...
TMPY-02198	ILKAP Protein, Human, Recombinant (His) ILKAP3,PP2C-δ,PP2C-DELTA,integrin-linked kinase-ass...	Human	HEK293 Cells
	Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest levels expressed in striated muscle. Much lower levels are evident in various smooth muscle tissues. ILKAP may play a role in the regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferat...

重组蛋白

STX6 Protein, Human, Recombinant

Cat.No: TMPJ-00678

Species: Human

Expression System: E. coli

ILK Protein, Human, Recombinant (His)

Cat.No: TMPH-01539

Species: Human

Expression System: Baculovirus Insect Cells

Parvin alpha/PARVA Protein, Human, Recombinant (GST)

Cat.No: TMPY-03060

Species: Human

Expression System: E. coli

ILKAP Protein, Human, Recombinant (His)

Cat.No: TMPY-02198

Species: Human

Expression System: HEK293 Cells

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