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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9720 |
T3Inh-1
|
Others | Others |
T3Inh-1 是一种有效的选择性 ppGalNAc-T3 抑制剂,IC50 为 7 µM。 T3Inh-1 可预防乳腺癌细胞。 T3Inh-1 降低组织细胞和小鼠中的 FGF23 激素水平,而不会引起任何毒副作用。 | |||
T61122 |
ZINC12409120
R-4584 |
ERK | MAPK |
ZINC12409120 (R-4584) 是一种具有选择性的 ERK 抑制剂。ZINC12409120 对ERK具有抑制作用,IC50 为 5.0 μM。ZINC12409120 通过干扰 FGF23:α-Klotho 的相互作用而抑制 ERK 活性。 | |||
T77455 |
Burosumab
KRN23 |
Others | Others |
Burosumab(KRN23) 是一种靶向成纤维细胞生长因子 23 (FGF23) 的人单克隆抗体,用于治疗皮肤骨骼低磷血症综合征(CSHS)和肿瘤诱导的骨软化症。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03294 |
FGF-23 Protein, Rat, Recombinant (His)
Fibroblast growth factor 23,Fgf23 |
Rat | P. pastoris (Yeast) |
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL. FGF-23 Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 27.5 kDa and the accession number is Q8VI82. | |||
TMPH-03293 |
FGF-23 Protein, Rat, Recombinant (E. coli, His)
Fgf23,Fibroblast growth factor 23 |
Rat | E. coli |
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL. |