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Search Results for " fto "

Targets Recommended: Others

57

抑制剂 & 化合物

4

天然产物

1

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T40222	FTO-IN-3	Others	Others
	FTO-IN-3 是一种 FTO 抑制剂，可以抑制胶质母细胞瘤干细胞自我更新。
T9089	FTO-IN-1 UUN44923	Others	Others
	UUN44923 是脂肪及肥胖相关酶(FTO) 抑制剂(IC50<1 μM)。其中FTO-IN-1 (UUN44923) 可用于研究癌症。
T40221	FTO-IN-2	Others	Others
	FTO-IN-2 is a FTO inhibitor that impairs self-renewal in glioblastoma stem cells.
T27393	FTO-IN-7d	Others	Others
	FTO-IN-7d is the first inhibitor of the RNA demethylase FTO with anticonvulsant activity.
T63740	FTO-IN-4	Others	Others
	FTO-IN-4 是有效的、选择性的脂肪量和肥胖相关蛋白（FTO）抑制剂。
T63843	FTO-IN-5	Others	Others
	FTO-IN-5 是一种有效且选择性的脂肪量和肥胖相关蛋白（FTO）抑制剂。
T82368	FTO-IN-10	Autophagy	Autophagy
	FTO-IN-10（化合物7）是一种针对人类去甲基酶FTO（脂肪量和肥胖相关蛋白）的有效抑制剂，其IC50值为4.5 μM。该化合物通过疏水作用和氢键相互作用与FTO的结构域II的结合口袋相结合。在A549细胞中，FTO-IN-10能够诱导DNA损伤和自噬性细胞死亡。
T63447	FTO-IN-1 TFA	Others	Others
	FTO-IN-1 TFA 是脂肪和肥胖相关酶 (FTO) 抑制剂 (IC50<1 μM)。FTO-IN-1 TFA 能够用于研究癌症。
T60994	FTO-IN-6	Others	Others
	FTO-IN-6是脂肪量和肥胖相关蛋白（FTO）的选择性抑制剂。
T61152	FTO-IN-8	Others	Others
	FTO-IN-8, also known as FTO-43, is an inhibitor of N6-methyladenosine demethylase FTO (fat mass- and obesity-associated protein). It exhibits an IC50 value of 5.5 μM and displays anti-cancer cell proliferative activity [1].
T8874	FB23	Others	Others
	FB23 是FTO 去甲基化酶选择性抑制剂(IC50:60 nM)。它能够直接与FTO 结合，选择性的抑制FTO 的 mRNA N6-甲基腺嘌呤脱甲基酶活性。
T2216	Entacapone OR-611,恩他卡朋	Transferase	Metabolism
	Entacapone (OR-611) 是可逆的、具有口服活性的、外周作用的儿茶酚-O-甲基转移酶抑制剂。它对大鼠脑、红细胞和肝脏 COMT 有抑制作用。它对 COMT 的选择性优于其他儿茶酚胺代谢酶。它抑制 FTO 去甲基化活性，可用于研究代谢紊乱。它可用于研究帕金森病。
T11990	Meclofenamic acid 甲氯芬那酸,Meclofenamate	Others; Gap Junction Protein	Cytoskeletal Signaling; Others
	Meclofenamic acid (Meclofenamate) 是一种非特异性 gap-junction 阻滞剂和特异性脂肪量和肥胖相关 (FTO) 酶抑制剂。 Meclofenamic acid 具有抗炎活性。
T6600	Naftopidil dihydrochloride KT-611,KT-611 2HCl,盐酸萘哌地尔,Naftopidil DiHCl	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil dihydrochloride (KT-611 2HCl) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力Ki 分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T30293	Bamocaftor VX-659	CFTR	Membrane transporter/Ion channel
	Bamocaftor是一种CFTR通道（DeltaF508-CFTR突变）矫正器，适用于 CF 跨膜传导调节器，被设计用于恢复 F508del-CFTR 蛋白功能。联合使用 tezacaftor 和 VX-561 治疗 F508del/MF 的囊性纤维化患者。
T2595	Lumacaftor 鲁玛卡托,VX-809,VRT 826809	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Lumacaftor (VRT 826809) 是一种 CFTR 调节剂，可纠正 CFTR 蛋白的折叠和运输。它增强了 FRT 细胞中 F508del-CFTR 蛋白的成熟，EC50为100 nM。
T10483	Lisaftoclax Bcl-2/Bcl-xl inhibitor 1,APG-2575	BCL	Apoptosis
	Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) 是一种双重 Bcl-2 和 Bcl-xl 抑制剂(IC50：2 nM 和 5.9 nM)，具有抗肿瘤活性。
T40475	Ceftobiprole medocaril BAL5788,头孢比普酯	Antibacterial	Microbiology/Virology
	Ceftobiprole medocaril (BAL5788) 是 Ceftobiprole 的前药。Ceftobiprole 是一种广谱的头孢菌素，对耐甲氧西林金黄色葡萄球菌具有活性。
T9499	Icenticaftor QBW251	CFTR	Membrane transporter/Ion channel
	Icenticaftor (QBW251) 是一种具有口服活性CFTR 通道增强剂，可用于慢性阻塞性肺疾病 (COPD) 和囊性纤维化研究，对F508del 和G551D CFTR 的EC50分别为 79 和 497 nM。
T14219	Aminaftone Aminaphthone	Endothelin Receptor	GPCR/G Protein
	Aminaftone 是 4-氨基苯甲酸的衍生物，可抑制内皮素-1 (ET-1) 的产生，可用于研究高血压和系统硬化症。
T9220	Naftopidil hydrochloride 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,萘哌地尔盐酸盐,KT-611 hydrochloride,BM-15275 hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil hydrochloride (BM-15275 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T0696	Naftopidil KT-611,萘哌地尔,BM-15275	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil (KT-611) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力Ki 分别为 3.7 nM、20 nM 、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T16681	Nesolicaftor PTI-428	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Nesolicaftor (PTI-428) 特异性增强囊性纤维化跨膜电导调节蛋白合成。
TQ0077	Ceftobiprole Ro 63-9141,BAL 9141,头孢吡普	Antibacterial	Microbiology/Virology
	Ceftobiprole (Ro 63-9141) 是一种广谱头孢菌素，对甲氧西林耐受的金黄色葡萄球菌的MIC90值为 2 μg/mL。
T2588	Ivacaftor Ivacaftor (VX-770),VX-770,依伐卡托	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Ivacaftor (VX-770) 是一种 CFTR 增强剂，靶向G551D-CFTR 和F508del-CFTR 的EC50分别为100 和 25 nM。
T39585	Ziftomenib KO-539	Histone Methyltransferase	Chromatin/Epigenetic
	Ziftomenib (KO-539) 是一种具有抗肿瘤活性的 menin-MLL 相互作用抑制剂，可以用于研究白血病。
T2263	Tezacaftor VX661,1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Tezacaftor (VX661) 是一种小分子，可用作囊性纤维化跨膜电导调节器基因功能的校正剂。
T14935	Elexacaftor VX-445	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Elexacaftor (VX-445) 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。它促进CFTR 的加工和转运，增加细胞表面CFTR 的数量。
T8877	Bonafton 1,2-萘醌,6-溴-,Bonaphthone	Antiviral	Immunology/Inflammation
	Bonafton (Bonaphthone) 是一种抗病毒剂。
T78240	(R)-Elexacaftor (R)-VX-445	CFTR	Membrane transporter/Ion channel
	(R)-Elexacaftor，Elexacaftor (Compound 1) 的对映异构体，为囊性纤维化跨膜电导调节因子（CFTR）校正剂，其针对CFTR dF508突变体的EC50值为0.29 uM。
T13742L	Ivacaftor hydrate VX-770 hydrate	Others	Others
	Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.
T75230	(Rac)-Tezacaftor	Others	Others
	(Rac)-Tezacaftor ((Rac)-VX-661) 是Tezacaftor 的外消旋体。Tezacaftor 是一种F508delCFTR 校正子。(Rac)-Tezacaftor 可以用于囊性纤维化的研究。
T39633	Navocaftor GLPG 3067,ABBV-3067	Others	Others
	Navocaftor, as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator (US 20200377491 Al, example 1).
T30790	Ceftolozane sulfate FR 264205,FR264205,FR-264205	Others	Others
	Ceftolozane Sulfate may be used to treat urinary tract infections.
T74748	Zatonacaftor	Others	Others
	Zatonacaftor 是囊性纤维化跨膜调节剂(CFTR)蛋白的调节剂，主要应用于囊性纤维化的研究。
T72141	Ceftobiprole medocaril sodium 头孢比普酯钠盐,BAL5788 sodium	Others	Others
	Ceftobiprole medocaril (BAL5788) sodium 是 Ceftobiprole 的胃肠外前药。Ceftobiprole 是一种非肠道吡咯烷酮头孢菌素。Ceftobiprole 是一种广谱头孢菌素，对甲氧西林 (MRSA) 和耐万古霉素葡萄球菌 (VRSA) 和耐青霉素链球菌具有高水平的体外活性。Ceftobiprole 也抑制革兰氏阳性和革兰氏阴性病原体。
T35925	(R)-Posenacaftor sodium	Others	Others
	(R)-Posenacaftor ((R)-PTI-801) sodium, the R enantiomer of Posenacaftor, is a cystic fibrosis transmembrane regulator (CFTR) protein modulator. It corrects the folding and trafficking of the CFTR protein, and is utilized in the research of cystic fibrosis (CF)[1].
T72860	(R)-Olacaftor (R)-VX-440	Others	Others
	(R)-Olacaftor ((R)-VX-440)，一种对囊性纤维化 (CF) 具有研究潜力的囊性纤维化跨膜调节因子 (CFTR) 调节剂。
T29693L	Aftobetin	Others	Others
	Aftobetin is a biochemical.
T25849	Naftoxate Naftoxatum,Naftoxato	Others	Others
	Naftoxate is an antimicotic. It is effective against both gram-positive and gram-negative bacteria as well as yeasts and other fungi in plant cell culture.
T39596	Dirocaftor PTI-808	Others	Others
	Dirocaftor (PTI-808) is a CFTR potentiator that augments CFTR protein function via the activation of chloride channels. Dirocaftor holds potential utility for research pertaining to cystic fibrosis (CF).
T29693	Aftobetin HCl ANCA11,NCE 11,NCE11,NCE-11	Others	Others
	Aftobetin, also known as ANCA11 and NCE-11, is a novel amyloid–binding compound applied topically in the form of an ophthalmic ointment. Aftobetin may be of useful as an aid in the diagnosis Alzheimer's disease.
T84699	(R)-Vanzacaftor (R)-VX-121	Others	Others
	(R)-Vanzacaftor ((R)-VX-121) 为一种作用于囊性纤维化跨膜传导调节剂(CFTR)的调节剂。
T68866	Ceftolozane	Others	Others
	Ceftolozane, also known as FR-264,205 and CXA-101; is an antibiotic drug from the cephalosporin family, approved for the treatment of infections with gram-negative bacteria, or gram-positive bacteria. Ceftolozane is of great benefit due to its ability to target bacteria that have become resistant to conventional antibiotics. Ceftolozane is combined with the β-lactamase inhibitor tazobactam, as multi-drug resistant bacterial infections will generally show resistance to all β-lactam antibiotics un...
T22252	Galicaftor	Others	Others
	ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).
T74417	Vanzacaftor	Others	Others
	Vanzacaftor 是一种囊性纤维化跨膜电导调节体（CFTR）的调节剂，用于研究囊性纤维化。
T84730	(Rac)-Lisaftoclax (Rac)-APG-2575	Others	Others
	(Rac)-Lisaftoclax ((Rac)-APG-2575)为Bcl-2抑制剂，主要应用于血液恶性肿瘤研究(CN112898295A)。
T13742	Ivacaftor benzenesulfonate VX-770 benzenesulfonate	Others	Others
	Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.
T36519	Posenacaftor sodium	Others	Others
	Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1].
T32373	Kefton-2	Others	Others
	Kefton-2 is bioactive chemical.

化合物

Cat.No: T40222

Target: Others

Cat.No: T9089

Synonym: UUN44923

Target: Others

Cat.No: T40221

Target: Others

Cat.No: T27393

Target: Others

Cat.No: T63740

Target: Others

Cat.No: T63843

Target: Others

Cat.No: T82368

Target: Autophagy

Cat.No: T63447

Target: Others

Cat.No: T60994

Target: Others

Cat.No: T61152

Target: Others

Cat.No: T8874

Target: Others

Cat.No: T2216

Synonym: OR-611,恩他卡朋

Target: Transferase

Meclofenamic acid

Cat.No: T11990

Synonym: 甲氯芬那酸,Meclofenamate

Target: Others, Gap Junction Protein

Naftopidil dihydrochloride

Cat.No: T6600

Synonym: KT-611,KT-611 2HCl,盐酸萘哌地尔,Naftopidil DiHCl

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T30293

Synonym: VX-659

Target: CFTR

Cat.No: T2595

Synonym: 鲁玛卡托,VX-809,VRT 826809

Target: CFTR, Autophagy

Cat.No: T10483

Synonym: Bcl-2/Bcl-xl inhibitor 1,APG-2575

Target: BCL

Ceftobiprole medocaril

Cat.No: T40475

Synonym: BAL5788,头孢比普酯

Target: Antibacterial

Cat.No: T9499

Synonym: QBW251

Target: CFTR

Cat.No: T14219

Synonym: Aminaphthone

Target: Endothelin Receptor

Naftopidil hydrochloride

Cat.No: T9220

Synonym: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,萘哌地尔盐酸盐,KT-611 hydrochloride,BM-15275 hydrochloride

Target: Adrenergic Receptor

Cat.No: T0696

Synonym: KT-611,萘哌地尔,BM-15275

Target: Adrenergic Receptor

Cat.No: T16681

Synonym: PTI-428

Target: CFTR, Autophagy

Cat.No: TQ0077

Synonym: Ro 63-9141,BAL 9141,头孢吡普

Target: Antibacterial

Cat.No: T2588

Synonym: Ivacaftor (VX-770),VX-770,依伐卡托

Target: CFTR, Autophagy

Cat.No: T39585

Synonym: KO-539

Target: Histone Methyltransferase

Cat.No: T2263

Synonym: VX661,1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺

Target: CFTR, Autophagy

Cat.No: T14935

Synonym: VX-445

Target: CFTR, Autophagy

Cat.No: T8877

Synonym: 1,2-萘醌,6-溴-,Bonaphthone

Target: Antiviral

(R)-Elexacaftor

Cat.No: T78240

Synonym: (R)-VX-445

Target: CFTR

Ivacaftor hydrate

Cat.No: T13742L

Synonym: VX-770 hydrate

Target: Others

(Rac)-Tezacaftor

Cat.No: T75230

Target: Others

Cat.No: T39633

Synonym: GLPG 3067,ABBV-3067

Target: Others

Ceftolozane sulfate

Cat.No: T30790

Synonym: FR 264205,FR264205,FR-264205

Target: Others

Cat.No: T74748

Target: Others

Ceftobiprole medocaril sodium

Cat.No: T72141

Synonym: 头孢比普酯钠盐,BAL5788 sodium

Target: Others

(R)-Posenacaftor sodium

Cat.No: T35925

Target: Others

Cat.No: T72860

Synonym: (R)-VX-440

Target: Others

Cat.No: T29693L

Target: Others

Cat.No: T25849

Synonym: Naftoxatum,Naftoxato

Target: Others

Cat.No: T39596

Synonym: PTI-808

Target: Others

Cat.No: T29693

Synonym: ANCA11,NCE 11,NCE11,NCE-11

Target: Others

(R)-Vanzacaftor

Cat.No: T84699

Synonym: (R)-VX-121

Target: Others

Cat.No: T68866

Target: Others

Cat.No: T22252

Target: Others

Cat.No: T74417

Target: Others

(Rac)-Lisaftoclax

Cat.No: T84730

Synonym: (Rac)-APG-2575

Target: Others

Ivacaftor benzenesulfonate

Cat.No: T13742

Synonym: VX-770 benzenesulfonate

Target: Others

Posenacaftor sodium

Cat.No: T36519

Target: Others

Cat.No: T32373

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3898	Schaftoside 夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside	Dynamin; Antioxidant; TLR; MyD88; Mitochondrial Metabolism; Autophagy	Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; oxidation-reduction
	Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) 是在多种中草药中发现的一种黄酮类天然产物。它抑制 TLR4 和 Myd88 表达，还降低 Drp1 表达和磷酸化，并减少线粒体分裂，具有抗氧化和抗癌活性。
T3897	Isoschaftoside	Anti-infection; Antifungal	Microbiology/Virology
	Isoschaftosid 是从 Desmodium uncinatum 根部分泌物中提取的 c- 糖基黄酮类天然产物，有抗肿瘤、抗氧化和抗菌活性，它还对 M. incognita 具有很强的杀线虫活性。
TN6567	Neoschaftoside
	Neoschaftoside has antioxidant activity.
TN6779	Clausine E	Others	Others
	Clausine E 是脂肪量和肥胖相关蛋白 (FTO) 脱甲基酶活性的抑制剂。 Clausine E 与 FTO 的结合是由正熵和负焓变化驱动的。

天然产物

Cat.No: T3898

Synonym: 夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside

Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy

Cat.No: T3897

Target: Anti-infection, Antifungal

Cat.No: TN6567

Cat.No: TN6779

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00920	FTO Protein, Human, Recombinant (His & Myc) U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylas...	Human	E. coli
	FTO Protein, Human, Recombinant (His & Myc) is expressed in E. coli.

重组蛋白

FTO Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00920

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T27098	Ivacaftor-D9 deutivacaftor,CTP-656
	CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.
TMIH-0568	Tezacaftor-d4 VX-661-d4
	Tezacaftor-d4 是 Tezacaftor 的氘代化合物。Tezacaftor 的 CAS 号为 1152311-62-0。VX-661 是一种小分子，可用作囊性纤维化跨膜电导调节器基因功能的校正剂。

同位素标记化合物

Cat.No: T27098

Synonym: deutivacaftor,CTP-656

Cat.No: TMIH-0568

Synonym: VX-661-d4

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