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Search Results for " fkbp "

Targets Recommended: FKBP Others PROTACs

23

抑制剂 & 化合物

4

天然产物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T18610	PROTAC FKBP Degrader-3	Others; PROTACs	Others; PROTAC
	PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].
T14298	Rimiducid	Apoptosis; Others; Fatty Acid Synthase	Apoptosis; Metabolism; Others
	Rimiducid 是一种可渗透脂质的他克莫司类似物，是一种二聚剂，通过交联 FKBP 结构域起作用。它将 Caspase 9 自杀开关二聚化并迅速诱导细胞凋亡。
T13884	Shield-1	Others	Others
	Shield-1 是 FK506 结合蛋白 12 (FKBP) 的特异性、高亲和力和细胞渗透性配体，通过与突变的 FKBP (mtFKBP) 结合来逆转不稳定性，允许 mtFKBP 融合蛋白的条件表达。它可以稳定整个融合蛋白。
T14299	AP20187 B/B Homodimerizer	Others	Others
	AP20187 (B/B Homodimerizer) 是一种细胞渗透性配体，用于二聚化 FK506 结合蛋白 (FKBP) 融合蛋白。它启动生物信号级联和基因表达或破坏蛋白质-蛋白质相互作用。
T1784	Everolimus 依维莫司,RAD001,SDZ-RAD	Apoptosis; Others; mTOR; Autophagy	Apoptosis; Autophagy; Others; PI3K/Akt/mTOR signaling
	Everolimus (SDZ-RAD) 是 Rapamycin 的衍生物，是一种 mTOR1 抑制剂，具有选择性和口服活性。Everolimus 具有免疫抑制和抗肿瘤活性，可以抑制肿瘤细胞增殖、诱导细胞凋亡和自噬。
T11451	GPI-1046 1-(1,2-二氧代-3,3-二甲基戊基)-L脯氨酸-(3-吡啶基)-丙酯	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	GPI-1046 是一种无抗生素作用的亲免素配体，部分通过上调 PFC 和 NAc 核心中的谷氨酸转运蛋白 1 来减少乙醇摄入。
T13694	FKBP12 PROTAC RC32 RC32	Others; PROTACs	Others; PROTAC
	FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.
T2567	Etonogestrel 3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Progesterone Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Others
	Etonogestrel (Implanon) 是孕激素去氧孕烯的生物活性代谢物，与靶器官中的孕酮受体和雌激素受体高亲和力地结合，可诱导FKBP51mRNA 和蛋白表达。它是一种甾体孕激素，用作激素避孕药。
T71840	FKBP12-IN-Q2	Others	Others
	FKBP12-IN-Q2 is an inhibitor of FKBP12.
T11291	FKBP12 PROTAC dTAG-13 dTAG-13	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader.
T11292	FKBP12 PROTAC dTAG-7 dTAG-7	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally, it serves as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
T79184	FKBP51F67V-selective antagonist Ligand2	FKBP	Apoptosis; Autophagy; Immunology/Inflammation
	FKBP51F67V-selective antagonist Ligand2（示例3-3）是针对杏仁核中由FKBP51 F67V过表达引起的焦虑表型的有效逆转剂。本物质特异性地结合到FKBP51 F67V，与野生型FKBP51及FKBP52无亲和力。
T18597	dFKBP-1	Others; PROTACs	Others; PROTAC
	dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].
T6033	Zotarolimus ABT-578,佐他莫司,咗他莫司,A 179578	mTOR	PI3K/Akt/mTOR signaling
	Zotarolimus (ABT-578) 是一种免疫抑制剂，是雷帕霉素的衍生物，具有抗增殖活性。它被专门开发作为局部输送支架用于预防冠状动脉再狭窄。
T2648	Pimecrolimus SDZ-ASM 981,ASM 981,吡美莫司	Others	Others
	Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体，能与胞质受体特异性的结合。
T24788	Shield-2	Others	Others
	Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand.
T13914	SLF-amido-C2-COOH PROTAC FKBP12-binding moiety 1	Others	Others
	SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.
T73817	SLF TFA	Others	Others
	SLF TFA 是 FK506 结合蛋白 (FKBP) 的合成配体，对FKBP51的亲和力为 3.1 μM，对FKBP12的IC50为 2.6 μM，可用于合成PROTAC 分子。
T13549	AP1867-3-(aminoethoxy)	Others	Others
	AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.
T76622	Suc-Ala-Leu-Pro-Phe-pNA
	Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) 是一种 FK-506 结合蛋白 (FKBP) 的底物。
T13888	SLF	Others	Others
	SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synthesis of PROTAC.
T80928	TSPO ligand-3	AUTACs	PROTAC
	TSPO ligand-3为AUTAC2的配体，其中AUTAC2包含p-氟苄基鸟嘌呤(FBnG)及FKBP合成配体(SLF)两部分，能在HeLa细胞中显著沉默FKBP12蛋白。
T74026	AUTAC2	Others	Others
	AUTAC2 是一种 FKBP12靶向自噬介导降解体 (AUTAC)。AUTAC2 包含一个 FBnG 和 SLF 部分，其中 SLF 与 FKBP12 非共价结合。

化合物

PROTAC FKBP Degrader-3

Cat.No: T18610

Target: Others, PROTACs

Cat.No: T14298

Target: Apoptosis, Others, Fatty Acid Synthase

Cat.No: T13884

Target: Others

Cat.No: T14299

Synonym: B/B Homodimerizer

Target: Others

Cat.No: T1784

Synonym: 依维莫司,RAD001,SDZ-RAD

Target: Apoptosis, Others, mTOR, Autophagy

Cat.No: T11451

Synonym: 1-(1,2-二氧代-3,3-二甲基戊基)-L脯氨酸-(3-吡啶基)-丙酯

Target: Others, HIV Protease

FKBP12 PROTAC RC32

Cat.No: T13694

Synonym: RC32

Target: Others, PROTACs

Cat.No: T2567

Synonym: 3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite

Cat.No: T71840

Target: Others

FKBP12 PROTAC dTAG-13

Cat.No: T11291

Synonym: dTAG-13

Target: Epigenetic Reader Domain, PROTACs

FKBP12 PROTAC dTAG-7

Cat.No: T11292

Synonym: dTAG-7

Target: Epigenetic Reader Domain, PROTACs

FKBP51F67V-selective antagonist Ligand2

Cat.No: T79184

Target: FKBP

Cat.No: T18597

Target: Others, PROTACs

Cat.No: T6033

Synonym: ABT-578,佐他莫司,咗他莫司,A 179578

Target: mTOR

Cat.No: T2648

Synonym: SDZ-ASM 981,ASM 981,吡美莫司

Target: Others

Cat.No: T24788

Target: Others

SLF-amido-C2-COOH

Cat.No: T13914

Synonym: PROTAC FKBP12-binding moiety 1

Target: Others

Cat.No: T73817

Target: Others

AP1867-3-(aminoethoxy)

Cat.No: T13549

Target: Others

Suc-Ala-Leu-Pro-Phe-pNA

Cat.No: T76622

Cat.No: T13888

Target: Others

Cat.No: T80928

Target: AUTACs

Cat.No: T74026

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2144	Tacrolimus 他克莫司,Fujimycin,FK506,FR900506	Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
	Tacrolimus (Fujimycin) 属于大环内酯类抗生素，可以与 FKBP12 结合形成高亲和力复合物 (Ki=0.2 nM)，抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。Tacrolimus 是一种免疫抑制剂，通过抑制 IL-2 的释放，全面抑制 T 淋巴细胞的作用。
T1537	Rapamycin Sirolimus,AY 22989,雷帕霉素,NSC-2260804	Others; Endogenous Metabolite; Antibiotic; mTOR; Autophagy; Antifungal	Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
	Rapamycin (AY 22989) 属于大环内酯类天然产物，是一种 mTOR 抑制剂，具有特异性（HEK293 细胞：IC50=0.1 nM）。Rapamycin 具有免疫抑制活性，并能诱导自噬。
T2481	Ascomycin FK520,Immunomycin,子囊霉素,FR-900520	Phosphatase; Others; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology; Others
	Ascomycin (Immunomycin) 是 Tacrolimus 的乙基类似物，具有免疫抑制特性。它也是一种大环聚酮类抗生素，具有抗疟疾、抗真菌和抗痉挛等多种生物活性。它可防止移植排斥，并具有用于各种皮肤病研究的潜力。
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。

天然产物

Cat.No: T2144

Synonym: 他克莫司,Fujimycin,FK506,FR900506

Target: Phosphatase, Others, Antibacterial, Antibiotic, mTOR, Autophagy

Cat.No: T1537

Synonym: Sirolimus,AY 22989,雷帕霉素,NSC-2260804

Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal

Cat.No: T2481

Synonym: FK520,Immunomycin,子囊霉素,FR-900520

Target: Phosphatase, Others, Antibiotic, Parasite, Antifungal

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02259	FKBP25/FKBP3 Protein, Human, Recombinant (GST) FKBP-25,PPIase,FKBP25,FK506 binding protei...	Human	E. coli
	FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation during NSCLC development.
TMPY-01662	FKBP12 Protein, Mouse, Recombinant (His) FK506 binding protein 1A,Fkbp1,FKBP12,...	Mouse	E. coli
	FKBP12 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.7 kDa and the accession number is P26883.
TMPJ-01068	FKBP25/FKBP3 Protein, Human, Recombinant (His) 25 kDa FKBP,FKBP-3,Peptidyl-prolyl cis-tra...	Human	E. coli
	FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a...
TMPY-00808	FKBP12 Protein, Human, Recombinant (His) FKBP12,FKBP1,FKBP-1A,PKCI2,FK506 ...	Human	E. coli
	FKBP12 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.9 kDa and the accession number is P62942.
TMPH-00622	FkpA Protein, E. coli, Recombinant (His & Myc) fkpA,FKBP-type peptidyl-prolyl cis-trans isomerase ...	E. coli	E. coli
	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.2 kDa and the accession number is P45523.
TMPY-00510	FKBP11 Protein, Human, Recombinant (mFc) FKBP19,FK506 binding protein 11, 19 kDa	Human	HEK293 Cells
	FKBP11 serve as biomarker and/or therapeutic target for Acute aortic dissection (AAD). FKBP11 during the development of HCC and FKBP11 has the potential to be an early marker for HCC.
TMPJ-01076	FKBP4 Protein, Human, Recombinant (His) FKBP4,HSP-binding immunophilin,immunophilin FKB...	Human	E. coli
	FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
TMPY-02962	FKBP7 Protein, Human, Recombinant (hFc) FKBP23,PPIase,FK506 binding protein 7	Human	HEK293 Cells
	FKBP7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.4 kDa and the accession number is Q9Y680-2.
TMPY-03148	FKBP7 Protein, Human, Recombinant (His) FK506 binding protein 7,FKBP23,PPIase	Human	HEK293 Cells
	FKBP7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.8 kDa and the accession number is Q9Y680-2.
TMPH-00686	FkpA Protein, E. coli O6:H1, Recombinant (His & SUMO) fkpA,Rotamase,FKBP-type peptidyl-prolyl cis-trans i...	E. coli	E. coli
	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA Protein, E. coli O6:H1, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 42.3 kDa and the accession number is P65764.
TMPH-00030	FkpA Protein, Aeromonas hydrophila, Recombinant (His & SUMO) fkpA,Rotamase,FKBP-type peptidyl-prolyl cis-trans i...	Aeromonas hydrophila	E. coli
	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins. FkpA Protein, Aeromonas hydrophila, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 42.7 kDa and the accession number is O08437.
TMPY-03385	FKBP14 Protein, Human, Recombinant (His) IPBP12,EDSKMH,FK506 binding protein 14, 22 kDa,FKBP...	Human	HEK293 Cells
	FKBP14 belongs to the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. Defects in FKBP14 can cause Ehler...
TMPJ-00919	FKBP2 Protein, Human, Recombinant (His) also named 13 kDa FK506-binding protein,FK506-binding protei...	Human	HEK293 Cells
	Peptidyl-prolyl cis-trans isomerase FKBP2(FKBP2 for short), also named 13 kDa FK506-binding protein, FK506-binding protein 2, Immunophilin FKBP13, Rotamase, is a endoplasmic reticulum peripheral membrane protein. It contains 1 PPIase FKBP-type domain and belongs to the FKBP-type PPIase family, FKBP2 subfamily which takes part in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP2 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 an...

重组蛋白

FKBP25/FKBP3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02259

Species: Human

Expression System: E. coli

FKBP12 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01662

Species: Mouse

Expression System: E. coli

FKBP25/FKBP3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01068

Species: Human

Expression System: E. coli

FKBP12 Protein, Human, Recombinant (His)

Cat.No: TMPY-00808

Species: Human

Expression System: E. coli

FkpA Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00622

Species: E. coli

Expression System: E. coli

FKBP11 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00510

Species: Human

Expression System: HEK293 Cells

FKBP4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01076

Species: Human

Expression System: E. coli

FKBP7 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02962

Species: Human

Expression System: HEK293 Cells

FKBP7 Protein, Human, Recombinant (His)

Cat.No: TMPY-03148

Species: Human

Expression System: HEK293 Cells

FkpA Protein, E. coli O6:H1, Recombinant (His & SUMO)

Cat.No: TMPH-00686

Species: E. coli

Expression System: E. coli

FkpA Protein, Aeromonas hydrophila, Recombinant (His & SUMO)

Cat.No: TMPH-00030

Species: Aeromonas hydrophila

Expression System: E. coli

FKBP14 Protein, Human, Recombinant (His)

Cat.No: TMPY-03385

Species: Human

Expression System: HEK293 Cells

FKBP2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00919

Species: Human

Expression System: HEK293 Cells

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