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Search Results for " fk506-binding protein "

Targets Recommended: Apoptosis Others Fatty Acid Synthase

12

抑制剂 & 化合物

4

天然产物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T14298	Rimiducid	Apoptosis; Others; Fatty Acid Synthase	Apoptosis; Metabolism; Others
	Rimiducid 是一种可渗透脂质的他克莫司类似物，是一种二聚剂，通过交联 FKBP 结构域起作用。它将 Caspase 9 自杀开关二聚化并迅速诱导细胞凋亡。
T13884	Shield-1	Others	Others
	Shield-1 是 FK506 结合蛋白 12 (FKBP) 的特异性、高亲和力和细胞渗透性配体，通过与突变的 FKBP (mtFKBP) 结合来逆转不稳定性，允许 mtFKBP 融合蛋白的条件表达。它可以稳定整个融合蛋白。
T14299	AP20187 B/B Homodimerizer	Others	Others
	AP20187 (B/B Homodimerizer) 是一种细胞渗透性配体，用于二聚化 FK506 结合蛋白 (FKBP) 融合蛋白。它启动生物信号级联和基因表达或破坏蛋白质-蛋白质相互作用。
T1784	Everolimus 依维莫司,RAD001,SDZ-RAD	Apoptosis; Others; mTOR; Autophagy	Apoptosis; Autophagy; Others; PI3K/Akt/mTOR signaling
	Everolimus (SDZ-RAD) 是 Rapamycin 的衍生物，是一种 mTOR1 抑制剂，具有选择性和口服活性。Everolimus 具有免疫抑制和抗肿瘤活性，可以抑制肿瘤细胞增殖、诱导细胞凋亡和自噬。
T11451	GPI-1046 1-(1,2-二氧代-3,3-二甲基戊基)-L脯氨酸-(3-吡啶基)-丙酯	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	GPI-1046 是一种无抗生素作用的亲免素配体，部分通过上调 PFC 和 NAc 核心中的谷氨酸转运蛋白 1 来减少乙醇摄入。
T2567	Etonogestrel 3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Progesterone Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Others
	Etonogestrel (Implanon) 是孕激素去氧孕烯的生物活性代谢物，与靶器官中的孕酮受体和雌激素受体高亲和力地结合，可诱导FKBP51mRNA 和蛋白表达。它是一种甾体孕激素，用作激素避孕药。
T16836	SAFit2	FKBP	Apoptosis; Autophagy; Immunology/Inflammation
	SAFit2是一种高效、具有选择性的fk506结合蛋白51(FKBP51)抑制剂（Ki：6 nM）。SAFit2能增强AKT2-AS160的结合，参与体内糖皮质激素释放的下游反应，是治疗肥胖、慢性疼痛、抑郁和焦虑的候选化合物。
T16835	SAFit1	Others	Others
	SAFit1 is an inhibitor of FK506 binding protein 51 (FKBP51)-specific (Ki: 4±0.3 nM).
T71771	Supradamal	Others	Others
	Supradamal is a potent Inhibitor of Plasmodium FK506 Binding Protein 35 (FKBD35). It also acts as an HIV inhibitor.
T13888	SLF	Others	Others
	SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synthesis of PROTAC.
T73817	SLF TFA	Others	Others
	SLF TFA 是 FK506 结合蛋白 (FKBP) 的合成配体，对FKBP51的亲和力为 3.1 μM，对FKBP12的IC50为 2.6 μM，可用于合成PROTAC 分子。
TP2079	AD 01
	FKBPL (FK506-binding protein like)-based peptide. Binds to and upregulates expression of CD44. Inhibits breast cancer stem cell (BCSC) growth. Decreases pluripotency markers and promotes differentiation of BCSCs. Also inhibits endothelial cell migration a

化合物

Cat.No: T14298

Target: Apoptosis, Others, Fatty Acid Synthase

Cat.No: T13884

Target: Others

Cat.No: T14299

Synonym: B/B Homodimerizer

Target: Others

Cat.No: T1784

Synonym: 依维莫司,RAD001,SDZ-RAD

Target: Apoptosis, Others, mTOR, Autophagy

Cat.No: T11451

Synonym: 1-(1,2-二氧代-3,3-二甲基戊基)-L脯氨酸-(3-吡啶基)-丙酯

Target: Others, HIV Protease

Cat.No: T2567

Synonym: 3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite

Cat.No: T16836

Target: FKBP

Cat.No: T16835

Target: Others

Cat.No: T71771

Target: Others

Cat.No: T13888

Target: Others

Cat.No: T73817

Target: Others

Cat.No: TP2079

Cat. No.	Product Name	Target	Signaling Pathways
T2144	Tacrolimus 他克莫司,Fujimycin,FK506,FR900506	Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
	Tacrolimus (Fujimycin) 属于大环内酯类抗生素，可以与 FKBP12 结合形成高亲和力复合物 (Ki=0.2 nM)，抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。Tacrolimus 是一种免疫抑制剂，通过抑制 IL-2 的释放，全面抑制 T 淋巴细胞的作用。
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。
T1537	Rapamycin Sirolimus,AY 22989,雷帕霉素,NSC-2260804	Others; Endogenous Metabolite; Antibiotic; mTOR; Autophagy; Antifungal	Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
	Rapamycin (AY 22989) 属于大环内酯类天然产物，是一种 mTOR 抑制剂，具有特异性（HEK293 细胞：IC50=0.1 nM）。Rapamycin 具有免疫抑制活性，并能诱导自噬。
T2481	Ascomycin FK520,Immunomycin,子囊霉素,FR-900520	Phosphatase; Others; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology; Others
	Ascomycin (Immunomycin) 是 Tacrolimus 的乙基类似物，具有免疫抑制特性。它也是一种大环聚酮类抗生素，具有抗疟疾、抗真菌和抗痉挛等多种生物活性。它可防止移植排斥，并具有用于各种皮肤病研究的潜力。

天然产物

Cat.No: T2144

Synonym: 他克莫司,Fujimycin,FK506,FR900506

Target: Phosphatase, Others, Antibacterial, Antibiotic, mTOR, Autophagy

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Cat.No: T1537

Synonym: Sirolimus,AY 22989,雷帕霉素,NSC-2260804

Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal

Cat.No: T2481

Synonym: FK520,Immunomycin,子囊霉素,FR-900520

Target: Phosphatase, Others, Antibiotic, Parasite, Antifungal

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02962	FKBP7 Protein, Human, Recombinant (hFc) FKBP23,PPIase,FK506 binding	Human	HEK293 Cells
	FKBP7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.4 kDa and the accession number is Q9Y680-2.
TMPY-03148	FKBP7 Protein, Human, Recombinant (His) FK506 binding protein 7,...	Human	HEK293 Cells
	FKBP7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.8 kDa and the accession number is Q9Y680-2.
TMPY-01662	FKBP12 Protein, Mouse, Recombinant (His) FK506 binding protein 1A...	Mouse	E. coli
	FKBP12 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.7 kDa and the accession number is P26883.
TMPY-00510	FKBP11 Protein, Human, Recombinant (mFc) FKBP19,FK506 binding	Human	HEK293 Cells
	FKBP11 serve as biomarker and/or therapeutic target for Acute aortic dissection (AAD). FKBP11 during the development of HCC and FKBP11 has the potential to be an early marker for HCC.
TMPJ-01076	FKBP4 Protein, Human, Recombinant (His) FKBP4,HSP-binding immunophilin,immunophili...	Human	E. coli
	FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
TMPJ-00919	FKBP2 Protein, Human, Recombinant (His) also named 13 kDa FK506-binding <...	Human	HEK293 Cells
	Peptidyl-prolyl cis-trans isomerase FKBP2(FKBP2 for short), also named 13 kDa FK506-binding protein, FK506-binding protein 2, Immunophilin FKBP13, Rotamase, is a endoplasmic reticulum peripheral membrane protein. It contains 1 PPIase FKBP-type domain and belongs to the FKBP-type PPIase family, FKBP2 subfamily which takes part in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP2 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 an...
TMPY-03385	FKBP14 Protein, Human, Recombinant (His) IPBP12,EDSKMH,FK506 binding p...	Human	HEK293 Cells
	FKBP14 belongs to the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. Defects in FKBP14 can cause Ehler...
TMPY-02259	FKBP25/FKBP3 Protein, Human, Recombinant (GST) FKBP-25,PPIase,FKBP25,FK506	Human	E. coli
	FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation during NSCLC development.
TMPJ-01068	FKBP25/FKBP3 Protein, Human, Recombinant (His) 25 kDa FKBP,FKBP-3,Peptidyl-prolyl cis-tra...	Human	E. coli
	FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a...
TMPY-00808	FKBP12 Protein, Human, Recombinant (His) FKBP12,FKBP1,FKBP-1A,PKCI2,FK...	Human	E. coli
	FKBP12 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.9 kDa and the accession number is P62942.
TMPH-02089	mTOR Protein, Human, Recombinant (His & Myc) FKBP12-rapamycin complex-associated protein	Human	E. coli
	mTOR Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.2 kDa and the accession number is P42345.

重组蛋白

FKBP7 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02962

Species: Human

Expression System: HEK293 Cells

FKBP7 Protein, Human, Recombinant (His)

Cat.No: TMPY-03148

Species: Human

Expression System: HEK293 Cells

FKBP12 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01662

Species: Mouse

Expression System: E. coli

FKBP11 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00510

Species: Human

Expression System: HEK293 Cells

FKBP4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01076

Species: Human

Expression System: E. coli

FKBP2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00919

Species: Human

Expression System: HEK293 Cells

FKBP14 Protein, Human, Recombinant (His)

Cat.No: TMPY-03385

Species: Human

Expression System: HEK293 Cells

FKBP25/FKBP3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02259

Species: Human

Expression System: E. coli

FKBP25/FKBP3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01068

Species: Human

Expression System: E. coli

FKBP12 Protein, Human, Recombinant (His)

Cat.No: TMPY-00808

Species: Human

Expression System: E. coli

mTOR Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02089

Species: Human

Expression System: E. coli

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