Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T41164 |
FC 11
|
PROTACs | PROTAC |
FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC®Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells. | |||
T84314 |
BFC1108
|
Apoptosis | Apoptosis |
BFC1108 可靶向 Bcl-2 并将其转化为促凋亡蛋白,抑制Bcl-2高表达的三阴性乳腺癌异种移植物的生长,抑制乳腺癌肺转移,促使表达 Bcl-2 的癌症细胞凋亡。 | |||
T70821 |
FC11409B
|
Others | Others |
FC11409B is a CAIX inhibitor, inhibiting breast cancer invasion and metastasis. |