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Search Results for " fadd "

Targets Recommended: VEGFR Akt

5

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3560	Desmethylanethol trithione ADT-OH	VEGFR; Akt	Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡，并对体内黑色素瘤的形成具有一定的抑制作用，可用于研究癌症疾病。
T9095	Necrostatin-34 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4	RIP kinase	Apoptosis; NF-κB
	Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) 是一种 RIPK1 激酶抑制剂，通过在激酶结构域中占据一个独特的结合口袋，将 RIPK1 激酶稳定在非活性构象中。
T11259	FadD32 Inhibitor-1	Others	Others
	FadD32 inhibitor -1 has anti-tuberculosis activity and is an effective FadD32 inhibitor.
T37558	Necrostatin-5 Nec-5	RIP kinase; Necroptosis	Apoptosis; NF-κB
	Necrostatin-5 (Nec-5)是一种RIP1激酶的选择性抑制剂，也是一种细胞坏死抑制剂，可防止TNF-α处理的fadd 缺陷Jurkat 细胞死亡，EC50值为240 nM。
T12203L	Necrostatin 2	Others	Others
	Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.

化合物

Desmethylanethol trithione

Cat.No: T3560

Synonym: ADT-OH

Target: VEGFR, Akt

Cat.No: T9095

Synonym: 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4

Target: RIP kinase

FadD32 Inhibitor-1

Cat.No: T11259

Target: Others

Cat.No: T37558

Synonym: Nec-5

Target: RIP kinase, Necroptosis

Cat.No: T12203L

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01315	CASR Protein, Human, Recombinant (GST) CAP4,MCH5,Caspase-8,CASP-8,CASP8,FADD-homologous IC...	Human	E. coli
	CASR Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 93.6 kDa and the accession number is P41180.
TMPH-01057	Caspase-8 Protein, Human, Recombinant (His) Caspase-8,CAP4,Apoptotic cysteine protease,FLICE,FADD	Human	E. coli
	Caspase-8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.9 kDa and the accession number is Q14790.
TMPH-02650	FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO) Fas apoptotic inhibitory molecule 3,Immunoglobulin mu Fc rec...	Mouse	E. coli
	May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
TMPK-00277	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc) TRAIL R2,TNFRSF10B,TRICK2,KILLER,DR5,TRAIL receptor 2,Fas-li...	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His) Cell death protein RIP,Receptor-interacting protein 1,Ripk1,...	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, i...
TMPJ-00215	Fas/CD95 Protein, Mouse, Recombinant (hFc) CD95,Apoptosis-mediating surface antigen FAS,TNFRSF6,Fas,Tum...	Mouse	HEK293 Cells
	Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which...
TMPJ-00696	NOL3 Protein, Human, Recombinant Apoptosis Repressor With CARD,Nucleolar Protein of 30 kDa,Nu...	Human	E. coli
	Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex ...
TMPY-02213	RAIDD Protein, Human, Recombinant (His) RAIDD,MRT34,CASP2 and RIPK1 domain containing adaptor with d...	Human	E. coli
	Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the ...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc) Pycard,PYD and CARD domain-containing protein,Apoptosis-asso...	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved ...

重组蛋白

CASR Protein, Human, Recombinant (GST)

Cat.No: TMPH-01315

Species: Human

Expression System: E. coli

Caspase-8 Protein, Human, Recombinant (His)

Cat.No: TMPH-01057

Species: Human

Expression System: E. coli

FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02650

Species: Mouse

Expression System: E. coli

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00277

Species: Human

Expression System: HEK293 Cells

RIPK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02876

Species: Mouse

Expression System: E. coli

Fas/CD95 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00215

Species: Mouse

Expression System: HEK293 Cells

NOL3 Protein, Human, Recombinant

Cat.No: TMPJ-00696

Species: Human

Expression System: E. coli

RAIDD Protein, Human, Recombinant (His)

Cat.No: TMPY-02213

Species: Human

Expression System: E. coli

PYCARD Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02521

Species: Mouse

Expression System: E. coli

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