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Search Results for " f-box "

Targets Recommended: Apoptosis

5

抑制剂 & 化合物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8956	BC-1258 BC-1258	Apoptosis	Apoptosis
	BC-1258 是一种 F-box/LRR-重复蛋白 2激活剂，可诱导致瘤细胞凋亡，并显著抑制小鼠的肿瘤形成，还可以稳定和上调 FBXL2 水平。
T5821	BC-1215	Others; Ligand for E3 Ligase	Others; PROTAC
	BC-1215 是一种 F-box protein 3 抑制剂。它能够稳定 TRAF1-TRAF6 来抑制 Fbxo3-TRAF 激活途径。它与 ApaG 相互作用，阻碍来自人 PBMC 广谱 TH1 细胞因子的分泌。
T23371	SMER3 SMER 3	Others; Ligand for E3 Ligase	Others; PROTAC
	SMER3 是选择性的 Skp1-Cullin-F-box (SCF)Met30泛素连接酶抑制剂。SMER 3 通过抑制 SCFMet30来增强 Rapamycin 的生长抑制作用。
T4603	PEO-IAA 2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid	Others	Others
	PEO-IAA (2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid) 是一种生长素拮抗剂，是一种吲哚-3-乙酸拮抗剂，能够与转运抑制剂响应蛋白 1/生长素信号 F-box 蛋白 (TIR1/AFBs) 结合。
T78194	Skp2 inhibitor 2	E1/E2/E3 Enzyme	Ubiquitination
	Skp2 inhibitor 2 (14f)为F-box蛋白S期激酶相关蛋白2（Skp2）的抑制剂，其IC50值为10.2 μM（针对Skp2-Cks1复合体）。该化合物是cullin-RING 连接酶的组成部分，负责招募并使底物泛素化，从而涉及蛋白质的水解和非水解相关过程。

化合物

Cat.No: T8956

Synonym: BC-1258

Target: Apoptosis

Cat.No: T5821

Target: Others, Ligand for E3 Ligase

Cat.No: T23371

Synonym: SMER 3

Target: Others, Ligand for E3 Ligase

Cat.No: T4603

Synonym: 2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid

Target: Others

Skp2 inhibitor 2

Cat.No: T78194

Target: E1/E2/E3 Enzyme

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01327	FBXO48 Protein, Human, Recombinant (His & Myc) F-box protein 48,F-box o...	Human	E. coli
	FBXO48 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.7 kDa and the accession number is Q5FWF7.
TMPH-01328	FBXL2 Protein, Human, Recombinant (His & SUMO) FBXL2,F-box and leucine-rich repe...	Human	E. coli
	FBXL2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.1 kDa and the accession number is Q9UKC9.
TMPH-01326	FBXO44 Protein, Human, Recombinant (His & Myc) F-box only protein 44,F-box	Human	E. coli
	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXO44 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.2 kDa and the accession number is Q9H4M3.
TMPH-02651	Fbxo3 Protein, Mouse, Recombinant (His & Myc) Muscle atrophy F-box protein,Atrogin-1,	Mouse	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
TMPH-01329	FBXW7 Protein, Human, Recombinant (His) F-box protein FBX30,hCdc4,F	Human	E. coli
	FBXW7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 83.7 kDa and the accession number is Q969H0.
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO) S-phase kinase-associated protein 2,SKP2,F-box<...	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB...
TMPK-00044	SKP1 Protein, Human, Recombinant (His, Avi) OCP-II,TCEB1L,SIII,p19A,OCP-2,EMC19,OCP2,SKP1A	Human	HEK293 Cells
	The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradation, thereby playing a critical role in the regulation of downstream biological processes. SKP1 Protein, Human, Recombinant (His, Avi) is expressed in HEK293 mammalian cells with N-His and C-Avi tag. The predicted molecular weight is 21.43 kDa and the...
TMPK-00045	SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated SIII,OCP-2,TCEB1L,EMC19,OCP-II,OCP2,SKP1A,p19A	Human	HEK293 Cells
	The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradation, thereby playing a critical role in the regulation of downstream biological processes. SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His and C-Avi tag. The predicted molecular weight is 21....
TMPJ-00331	IFNAR1 Protein, Rhesus macaque, Recombinant (His) IFN-al,CRF2-1,IFN-alpha/beta rece...	Rhesus	HEK293 Cells
	Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphory...
TMPH-02633	TRIM21 Protein, Mouse, Recombinant (His) Tripartite motif-containing protein 21,E3 ubiquitin...	Mouse	Baculovirus Insect Cells
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...
TMPH-02632	TRIM21 Protein, Mouse, Recombinant (E. coli, His) Trim21,52 kDa ribonucleoprotein autoantigen Ro/SS-A,Triparti...	Mouse	E. coli
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...

重组蛋白

FBXO48 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01327

Species: Human

Expression System: E. coli

FBXL2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01328

Species: Human

Expression System: E. coli

FBXO44 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01326

Species: Human

Expression System: E. coli

Fbxo3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02651

Species: Mouse

Expression System: E. coli

FBXW7 Protein, Human, Recombinant (His)

Cat.No: TMPH-01329

Species: Human

Expression System: E. coli

SKP2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02131

Species: Human

Expression System: E. coli

SKP1 Protein, Human, Recombinant (His, Avi)

Cat.No: TMPK-00044

Species: Human

Expression System: HEK293 Cells

SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated

Cat.No: TMPK-00045

Species: Human

Expression System: HEK293 Cells

IFNAR1 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00331

Species: Rhesus

Expression System: HEK293 Cells

TRIM21 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02633

Species: Mouse

Expression System: Baculovirus Insect Cells

TRIM21 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02632

Species: Mouse

Expression System: E. coli

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