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Search Results for " f-10 "

Targets Recommended: Others

24

抑制剂 & 化合物

5

天然产物

6

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T29448	50F10 50 F 10,50-F-10	Others	Others
	50F10 is a stabilizer for the active LPL dimer. It can act by preventing angptl4- and heat-induced inactivation of LPL and reducing postprandial triglyceride levels.
T79883	9-Chloromethyl-10-hydroxy-11-F-Camptothecin	Topoisomerase	DNA Damage/DNA Repair
	9-Chloromethyl-10-Hydroxy-11-F-Camptothecin是一款喜树碱类衍生化合物，具有DNA拓扑异构酶I (Topo I)抑制活性，应用于癌症治疗的研究领域。
T66988	10-Bromo-5H-dibenzo[b,f]azepine-5-carboxamide	Others	Others
	10-Bromo-5H-dibenzo[b,f]azepine-5-carboxamide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66988，CAS号为 59690-97-0。
T32261	Janthitrem F Janthitrem E monoacetate	Others	Others
	Janthitrem f, as a 10-0-acetyljanthitrem e or janthitrem e monoacetate, is a type ofnaphthopyran. Janthitrem F is prepared by Penicillium janthinellum. Tremorgenic mycotoxi.
T13907	Sulfo-ara-F-NMN CZ-48	Others	Others
	Sulfo-ara-F-NMN 是一种具有细胞渗透性的烟酰胺单核苷酸 (NMN) 的类似物。Sulfo-ara-F-NMN 对激活 SARM1具有选择性，对 CD38具有抑制作用， IC50 约为 10 μM。Sulfo-ara-F-NMN 对具有更高的环化酶活性 CZ-48或 NMN 的激活会引起 SARM1的构象变化，导致 cADPR 的产生、NAD 的消耗和非凋亡细胞死亡。
T64635	8-Phenyl-2,6-diethyl-BODIPY 505/515	Others	Others
	2,8-Diethyl-5,5-difluoro-1,3,7,9-tetramethyl-10-phenyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64635。
T74670	KTX-951	PROTACs	PROTAC
	KTX-951为一种PROTAC，专门针对IRAK4进行降解（DC50=18 nM）。在大鼠模型中，KTX-951（10 mg/kg）的口服生物利用率达到22%。该化合物展现出显著的抗癌潜力。
T27595	Imarikiren HCl TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl \|,TAK272,TAK 272,TAK-272	Others	Others
	Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as cathepsin D (IC50 >
TP2514	BPC 157 acetate Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val,GEPPPGKPADDAGLV	Others	Others
	Body Protection Compound 157 (BPC 157) is a pentadecapeptide derived from BPC, identified in gastric juice, exhibiting diverse biological activities. At 2 µg/ml, BPC 157 enhances primary rat tendon fibroblast cell migration and F-actin formation. Furthermore, doses of 0.01 and 10 µg/kg, intraperitoneally (i.p.), mitigate paw swelling, bone erosion, and mononuclear cell infiltration in the joints of rats with rheumatoid arthritis induced by complete Freund's adjuvant (CFA). It also diminishes gas...
T36498	CAY10762 CAY10762	Others	Others
	CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50= 34.1 nM).1It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain. 1.Castelli, R., Scalvini, L., Vacondio, F., et al.Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteinesJ. Med. Chem.63(...
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXC...
T37939	N-Desethyl Bimatoprost 17-phenyl trinor Prostaglandin F2α amide	Others	Others
	N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids ...
T69831	RPR-200765A Mesylayte	Others	Others
	RPR-200765A is a potent and selective inhibitor of p38 MAP kinase (IC50 = 50 nM). It inhibits LPS-stimulated TNFalpha release both in vitro, from human monocytes (EC50 = 110 nM), and in vivo in Balb/c mice (ED50 = 6 mg/kg). At oral doses between 10 and 30 mg/kg/day it reduces the incidence and progression in the rat streptococcal cell wall (SCW) arthritis model when administered in either prophylactic or therapeutic dosing regimens. The compound, which is a mesylate salt and exists as a stable m...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe...
T35979	Benastatin C	Others	Others
	Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50= 10 μg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner. 1.Xu, Z., Schenk, A., and Hertweck, C.Molecul...
T38143	Elaidamide	Others	Others
	Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and human synovial phospholipase A2 (PLA2).3 In vivo, elaidamide (10 mg/animal) induces physiological sleep in rats.1References1. Cravatt, B.F., Prospero-Garcia, O., Siuzdak, G., et al. Chemical characterization of a family of brain lipids that induce sleep. Science 268(5216), 1506-150...
T83680	Azurin (50-77) (P. aeruginosa) TFA Azurin p28,p28
	Azurin (50-77)是一种含铜细菌蛋白azurin的肽段，存在于P. aeruginosa中，具有细胞周期停滞、抑制癌细胞增殖和调节血管生成活性。作为VEGFR2的抑制剂（IC20约为10.7 µM），Azurin (50-77)（20 µM）能在MCF-7乳腺癌细胞中诱导G2/M期的细胞周期停滞。在50 µM的浓度下，减少MCF-7和ZR-75-1乳腺癌细胞的增殖。Azurin (50-77)以25 µM的浓度减少VEGF-A诱导的毛细管管腔形成（IC50 = 12 µM），降低人脐静脉内皮细胞（HUVECs）中与细胞膜相关的F-actin、焦点粘附激酶（FAK）和paxillin的水平，并增加胞外的血小板内皮细胞粘附分子-1（PECAM-1）的水平。在体内，Azurin (50-77)（每日10 mg/kg）在MCF-7小鼠异种移植模型中减少肿瘤体积。
TP1816	Urotensin II, mouse
	Jump to search UTS2 Identifiers Aliases UTS2, PRO1068, U-II, UCN2, UII, urotensin 2 External IDs OMIM: 604097 MGI: 1346329 HomoloGene: 4939 GeneCards: UTS2 hide Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 7,843,083 bp[1] En
T35799	MBX-8025 (sodium salt)	Others	Others
	MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).2 It also decreases serum alanine transamin...
T35893	rac-1,2-bis-Palmitoyl-3-chloropropanediol	Others	Others
	rac-1,2-bis-Palmitoyl-3-chloropropanediol is a 3-monochloropropane-1,2-diol (3-MCPD) ester.1It has been found as a contaminant in edible olive oils, with the lowest and highest concentrations in extra virgin and olive pomace oils, respectively.rac-1,2-bis-Palmitoyl-3-chloropropanediol has also been found in cottonseed and palm oils, as well as in shortening.2It induces renal tubular necrosis and a decrease in spermatids, but no gross pathological changes, in mice.3 1.Hung, W.-C., Peng, G.-J., Ts...
T35975	6,9-Dichloro-1,2,3,4-tetrahydroacridine	Others	Others
	6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3 1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylchol...
T36629	Givinostat	Others	Others
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...
T37347	6'-Sialyllactose Sodium Salt 6'-Sialyllactose Sodium Salt,6'-N-Acetylneuraminyl-D-lactose	Others	Others
	6'-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose. Both are major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus.[1],[2],[3],[4],[5],[6] These compounds can be used to differentiate and characterize the binding domains of viruses that recognize N-acetylne...
T38174	Mpro inhibitor N3 hemihydrate	Others	Others
	Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC50 of 4.0 μM, 8.8 μM, and 2.7 μM, respectively[1][2]. Mpro inhibitor N3 hemihydrate (0-0.64 μM) is able to penetrate cells to inhibit the replication of IBV viruses...

化合物

Cat.No: T29448

Synonym: 50 F 10,50-F-10

Target: Others

9-Chloromethyl-10-hydroxy-11-F-Camptothecin

Cat.No: T79883

Target: Topoisomerase

10-Bromo-5H-dibenzo[b,f]azepine-5-carboxamide

Cat.No: T66988

Target: Others

Cat.No: T32261

Synonym: Janthitrem E monoacetate

Target: Others

Sulfo-ara-F-NMN

Cat.No: T13907

Synonym: CZ-48

Target: Others

8-Phenyl-2,6-diethyl-BODIPY 505/515

Cat.No: T64635

Target: Others

Cat.No: T74670

Target: PROTACs

Cat.No: T27595

Synonym: TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl |,TAK272,TAK 272,TAK-272

Target: Others

BPC 157 acetate

Cat.No: TP2514

Synonym: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val,GEPPPGKPADDAGLV

Target: Others

Cat.No: T36498

Synonym: CAY10762

Target: Others

β-Defensin-3 (human) (trifluoroacetate salt)

Cat.No: T35452

N-Desethyl Bimatoprost

Cat.No: T37939

Synonym: 17-phenyl trinor Prostaglandin F2α amide

Target: Others

RPR-200765A Mesylayte

Cat.No: T69831

Target: Others

β-Defensin-2 (human) (trifluoroacetate salt)

Cat.No: T35451

Cat.No: T35979

Target: Others

Cat.No: T38143

Target: Others

Azurin (50-77) (P. aeruginosa) TFA

Cat.No: T83680

Synonym: Azurin p28,p28

Urotensin II, mouse

Cat.No: TP1816

MBX-8025 (sodium salt)

Cat.No: T35799

Target: Others

rac-1,2-bis-Palmitoyl-3-chloropropanediol

Cat.No: T35893

Target: Others

6,9-Dichloro-1,2,3,4-tetrahydroacridine

Cat.No: T35975

Target: Others

Cat.No: T36629

Target: Others

6'-Sialyllactose Sodium Salt

Cat.No: T37347

Synonym: 6'-Sialyllactose Sodium Salt,6'-N-Acetylneuraminyl-D-lactose

Target: Others

Mpro inhibitor N3 hemihydrate

Cat.No: T38174

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN6864	Prosaikogenin F 前柴胡皂苷F	Others	Others
	Prosaikogenin F ((2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol) 是一种单糖苷，具有溶血和抗癌特性。
TMA0958	Forsythoside F 连翘酯苷F,Arenarioside,三糖苯丙素苷	Xanthine Oxidase	Metabolism
	Forsythoside F (Arenarioside) 是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，具有抗高尿酸活性。
TN5750	Petiolin F
	Petiolin F 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5750，CAS号为 1204251-10-4。
TN5988	16,25-Di-O-acetylcucurbitacin F 16,25-O-Diacetyl-cucurbitane F,Cucurbitacin F 16,25-diacetate
	16,25-Di-O-acetylcucurbitacin F 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5988，CAS号为 2062685-10-1。
TN5599	12-Demethylneocaesalpin F
	12-Demethylneocaesalpin F 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5599，CAS号为 1228964-10-0。

天然产物

Prosaikogenin F

Cat.No: TN6864

Synonym: 前柴胡皂苷F

Target: Others

Cat.No: TMA0958

Synonym: 连翘酯苷F,Arenarioside,三糖苯丙素苷

Target: Xanthine Oxidase

Cat.No: TN5750

16,25-Di-O-acetylcucurbitacin F

Cat.No: TN5988

Synonym: 16,25-O-Diacetyl-cucurbitane F,Cucurbitacin F 16,25-diacetate

12-Demethylneocaesalpin F

Cat.No: TN5599

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00707	Coagulation factor X/F10 Protein, Mouse, Recombinant (His) Stuart factor,Coagulation factor X,F	Mouse	HEK293 Cells
	Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin K-dependent plasma protease that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. The two chains of F10 are formed from a single-chain precursor by the excision of two Arg residues. A single-chain precursor is initiall...
TMPH-01329	FBXW7 Protein, Human, Recombinant (His) F-box protein FBX30,hCdc4,F-box a...	Human	E. coli
	FBXW7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 83.7 kDa and the accession number is Q969H0.
TMPY-01751	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) TRAMP,TR3,WSL-1,TNFRSF12,DR3,WSL-LR,tumor ...	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-02300	BIN1 Protein, Human, Recombinant (His) AMPHL,bridging integrator 1,AMPH2,SH3P9	Human	E. coli
	Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased...
TMPY-05760	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated TRAMP,tumor necrosis factor receptor superf	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-00961	ADAM15 Protein, Human, Recombinant (His) MDC15,ADAM metallopeptidase domain 15	Human	HEK293 Cells
	ADAM15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is Q13444-10.

重组蛋白

Coagulation factor X/F10 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00707

Species: Mouse

Expression System: HEK293 Cells

FBXW7 Protein, Human, Recombinant (His)

Cat.No: TMPH-01329

Species: Human

Expression System: E. coli

DR3/TNFRSF25 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01751

Species: Human

Expression System: HEK293 Cells

BIN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02300

Species: Human

Expression System: E. coli

DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05760

Species: Human

Expression System: HEK293 Cells

ADAM15 Protein, Human, Recombinant (His)

Cat.No: TMPY-00961

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T35698	Octanoic Acid-13C
	Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d...
T35775	HT-2 Toxin-13C22 HT-2 Toxin-13C22
	HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human...

同位素标记化合物

Octanoic Acid-13C

Cat.No: T35698

HT-2 Toxin-13C22

Cat.No: T35775

Synonym: HT-2 Toxin-13C22

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