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Search Results for " eukaryotic initiation factor (eif) "

Targets Recommended: Others Autophagy

10

抑制剂 & 化合物

1

天然产物

14

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11375	GCN2iB	Others; Autophagy	Autophagy; Others
	GCN2iB 是一种 ATP 竞争性的一般控制非抑制性 2 抑制剂，IC50 为 2.4 nM。
T1742	4E1rcat	PERK; Autophagy	Apoptosis; Autophagy
	4E1RCat 是 cap 依赖性翻译抑制剂，可抑制 eIF4 g 与 eIF4E 的结合，IC50 为 3.2 μM。
T14044	4E2RCat	PERK	Apoptosis
	4E2RCat 是一种 eIF4E-eIF4G 相互作用的抑制剂，IC50为13.5 μM。
T2665	4EGI-1 4EGI 1	Apoptosis; PERK; Autophagy	Apoptosis; Autophagy
	4EGI-1 是一种竞争性 eIF4E/eIF4 g 相互作用抑制剂，与 eIF4E 结合，Kd 值为 25 μM。
T11374	GCN2-IN-6	Others; PERK	Apoptosis; Others
	GCN2-IN-6 经酶法和细胞分析证实，是一种口服有效GCN2抑制剂，IC50分别为1.8 nM 和9.3 nM。GCN2-IN-6 还是 eIF2α 激酶PERK 抑制剂，在酶法测定和细胞测定中的IC50分别为 0.26 nM 和 230 nM。
T3207	Briciclib ON 014185	CDK; PERK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint
	Briciclib (ON 014185) 是一种 ON 013100 衍生物，是一种抑制 Y 细胞中 cyclin D1 积累的小分子。它可靶作用于eIF4E，有抑制实体瘤的潜力。
T11373	GCN2-IN-1 A-92	Others	Others
	GCN2-IN-1 (A-92) 是一种有效的一般性调控阻遏蛋白激酶 2 抑制剂，可作为化疗药物用于癌症治疗的研究。
T9149	2BAct 2B-Act,2B Act	PERK	Apoptosis
	2BAct 是一种具有口服活性的高选择性真核起始因子eIF2B 活化剂，EC50为 33 nM。它可防止由慢性综合应激反应引起的神经系统缺陷。
T5173	SBI-0640756 SBI 0640756,SBI-756	PERK; Autophagy	Apoptosis; Autophagy
	SBI-0640756 (SBI-756) 是一种靶向 eIF4G1 并破坏 eIF4F 复合物的抑制剂。
TP2247	eukaryotic translation initiation factor 3	Others	Others
	Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated in preventing the large ribosomal subunit from binding the small subunit before it is ready to commence elongation.

化合物

Cat.No: T11375

Target: Others, Autophagy

Cat.No: T1742

Target: PERK, Autophagy

Cat.No: T14044

Target: PERK

Cat.No: T2665

Synonym: 4EGI 1

Target: Apoptosis, PERK, Autophagy

Cat.No: T11374

Target: Others, PERK

Cat.No: T3207

Synonym: ON 014185

Target: CDK, PERK, Autophagy

Cat.No: T11373

Synonym: A-92

Target: Others

Cat.No: T9149

Synonym: 2B-Act,2B Act

Target: PERK

Cat.No: T5173

Synonym: SBI 0640756,SBI-756

Target: PERK, Autophagy

eukaryotic translation initiation factor 3

Cat.No: TP2247

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TQ0131	Rocaglamide Rocaglamide A,楝酰胺,Roc-A	HSP; NF-κB; PERK	Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB
	Rocaglamide (Roc-A) 是从米仔兰中分离出来的一种天然产物，具有抗癌特性，可用于咳嗽，受伤，哮喘和炎症性皮肤病。它是一种有效的选择性热休克因子 1 活化抑制剂，IC50约为 50 nM。它是 T 细胞中 NF-κB 活化的有效抑制剂，还抑制翻译起始因子eIF4A 的功能。

天然产物

Cat.No: TQ0131

Synonym: Rocaglamide A,楝酰胺,Roc-A

Target: HSP, NF-κB, PERK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03184	EIF5 Protein, Human, Recombinant (GST) EIF-5A,eukaryotic translation initiati...	Human	E. coli
	EIF5 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 44.1 kDa and the accession number is P55010.
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His) eIF5AII,eukaryotic translation initiat...	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe...
TMPY-04108	EIF5A Protein, Human, Recombinant (His) EIF5A1,eukaryotic translation initiati...	Human	E. coli
	EIF5A Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.9 kDa and the accession number is P63241-1.
TMPJ-00973	EIF1AX Protein, Human, Recombinant (His) eIF-1A X Isoform,Eukaryotic Translation	Human	E. coli
	Eukaryotic Translation Initiation Factor 1A, X-Chromosomal (EIF1AX) is an essential eukaryotic translation initiation factor that belongs to the eIF-1A family. EIF1AX is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA and has been shown to interact with IPO13. EIF1AX contains one S1-like domain and seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the bind...
TMPJ-00507	EIF4E Protein, Human, Recombinant eIF-4F 25 kDa subunit,EIF4F,eIF-4...	Human	E. coli
	Eukaryotic translation initiation factor 4E is a 217 amino acids protein that belongs to the eukaryotic initiation factor 4E family. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners.It can recognize and bind the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facil...
TMPH-01306	EIF4A1 Protein, Human, Recombinant (His & Myc) eIF4A-I,EIF4A1,eIF-4A-I,Eukar...	Human	E. coli
	ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. EIF4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The ...
TMPH-01309	EIF3F Protein, Human, Recombinant (His) eIF3 p47,eIF-3-epsilon,EIF3S5,	Human	E. coli
	EIF3F Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 43.5 kDa and the accession number is O00303.
TMPH-03289	EIF3I Protein, Rat, Recombinant (E. coli, His) eIF3 p36,eIF3i,eIF-3-beta,Euk...	Rat	E. coli
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an...
TMPH-01313	EIF4G1 Protein, Human, Recombinant (His) EIF4G,eIF-4-gamma 1,Eukaryotic tr...	Human	P. pastoris (Yeast)
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.6 kDa and the accession number is Q04637.
TMPH-01312	EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) eIF-4G 1,EIF4G,Eukaryotic transla...	Human	E. coli
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) is expressed in E. coli expression system with N-10xHis-B2M-JD and C-Myc tag. The predicted molecular weight is 46.6 kDa and the accession nu...
TMPH-03288	EIF3I Protein, Rat, Recombinant (His) eIF3i,Eif3s2,eIF-3-beta,Eukar...	Rat	Baculovirus Insect Cells
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an...
TMPH-01307	EIF4A2 Protein, Human, Recombinant (GST) EIF4A2,eIF4A-II,Eukaryotic in...	Human	E. coli
	EIF4A2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 73.4 kDa and the accession number is Q14240.
TMPH-01310	EIF3G Protein, Human, Recombinant (His & SUMO) eIF3 p42,eIF-3-delta,eIF3 p44,	Human	E. coli
	EIF3G Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 51.5 kDa and the accession number is O75821.
TMPY-03343	EIF3K Protein, Human, Recombinant (His & GST) PRO1474,eukaryotic translation initiation ...	Human	Baculovirus Insect Cells
	EIF3K is a member of the eIF3 subunit K family. It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 4S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). It stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. EIF3K i...

重组蛋白

EIF5 Protein, Human, Recombinant (GST)

Cat.No: TMPY-03184

Species: Human

Expression System: E. coli

EIF5A2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03795

Species: Human

Expression System: E. coli

EIF5A Protein, Human, Recombinant (His)

Cat.No: TMPY-04108

Species: Human

Expression System: E. coli

EIF1AX Protein, Human, Recombinant (His)

Cat.No: TMPJ-00973

Species: Human

Expression System: E. coli

EIF4E Protein, Human, Recombinant

Cat.No: TMPJ-00507

Species: Human

Expression System: E. coli

EIF4A1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01306

Species: Human

Expression System: E. coli

EIF3F Protein, Human, Recombinant (His)

Cat.No: TMPH-01309

Species: Human

Expression System: E. coli

EIF3I Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPH-03289

Species: Rat

Expression System: E. coli

EIF4G1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01313

Species: Human

Expression System: P. pastoris (Yeast)

EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc)

Cat.No: TMPH-01312

Species: Human

Expression System: E. coli

EIF3I Protein, Rat, Recombinant (His)

Cat.No: TMPH-03288

Species: Rat

Expression System: Baculovirus Insect Cells

EIF4A2 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01307

Species: Human

Expression System: E. coli

EIF3G Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01310

Species: Human

Expression System: E. coli

EIF3K Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03343

Species: Human

Expression System: Baculovirus Insect Cells

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