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Search Results for " erlotinib "

Targets Recommended: EGFR Autophagy

14

抑制剂 & 化合物

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T0373	Erlotinib OSI-744,NSC 718781,CP358774,埃罗替尼,R1415	EGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Erlotinib (CP358774) 是一种 EGFR 一代抑制剂，抑制 EGFR 19 Del 和 L858R 突变。Erlotinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。Erlotinib 用药会产生 EGFR C797S 耐药突变。
T6328	Desmethyl Erlotinib OSI-420,CP-473420,O-Desmethyl Erlotinib	EGFR; Drug Metabolite	Angiogenesis; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
	Desmethyl Erlotinib (CP-473420) 是 Erlotinib 的活性代谢物。Erlotinib 是 EGFR 酪氨酸激酶抑制剂。
T6619	Desmethyl Erlotinib hydrochloride OSI420,OSI-420,DesMethyl Erlotinib (CP-473420) HCl,去甲厄洛替尼,CP-473420,Desmethyl Erlotinib,OSI 420	EGFR; Drug Metabolite	Angiogenesis; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
	Desmethyl Erlotinib hydrochloride (OSI 420) 是 Erlotinib 的活性代谢物。Erlotinib 是 EGFR 酪氨酸激酶抑制剂。
T0373L	Erlotinib hydrochloride 盐酸埃罗替尼,OSI-744,NSC 718781,Erlotinib HCl,CP-358774	EGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Erlotinib hydrochloride (NSC 718781) 抑制EGFR 激酶的IC50为 2 nM，用于治疗非小细胞肺癌。
T0373L1	Erlotinib mesylate CP-358774,CP-358,774,埃罗替尼甲磺酸盐,OSI-774,CP358774,OSI 774	Others	Others
	Erlotinib is an epidermal growth factor receptor inhibitor. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor.
T31055	CP-457493 OSI-493,Erlotinib metabolite M6,CP457493,UNII-X0JH558S7E	Others	Others
	CP-457493 is a bio-active chemical.
T35528	TD52	Apoptosis; Phosphatase; Akt	Apoptosis; Cytoskeletal Signaling; Metabolism; PI3K/Akt/mTOR signaling
	TD52 是 PP2A (CIP2A) 癌性抑制剂的口服活性抑制剂。 TD52 是厄洛替尼衍生物，通过干扰 Elk1 与 CIP2A 启动子的结合间接降低了 CIP2A。
T35528L	TD52 dihydrochloride TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti...
T73472	Erasin	Others	Others
	Erasin 是一种有效的 Erlotinib 抗性STAT3抑制剂，对STAT3和STAT1的IC50分别为 9.7 和 24 μM。Erasin 诱导癌细胞凋亡(apoptosis)。
T34892	TM608 TM-608,TM 608	Others	Others
	TM608 is a potent selective c-Met inhibitor that targets mitochondria and kills erlotinib-resistant lung cancer cells, rapidly accumulates in mitochondria, and inhibits MET activation in high MET expression, erlotinib-resistant HCC827B cells (total cell l
T35147	WZ4002-hydroxy WZ4002 analog, WZ4002 demethyl derivate,WZ 4002-hydroxy,WZ-4002-hydroxy	Others	Others
	WZ4002-hydroxyl is a WZ4002 derivative or WZ4002 analogue in which methoxy is replaced by hydroxyl and can be detected in 50% of patients with clinical resistance to gefitinib or erlotinib. WZ4002 has a basic chemical skeleton (covalent pyrimidine) that d
T36102	4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline	Others	Others
	4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer compounds.1,2,3It is also a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib , with antiproliferative activity.4,5
T71526	CH5164840	Others	Others
	CH5164840 is a potent and selective HSP90 inhibitor. CH5164840 showed remarkable antitumor activity against NSCLC cell lines and xenograft models. CH5164840 has potent antitumor activity and is highly effective in combination with erlotinib against NSCLC tumors with EGFR overexpression and mutations.
T69888	SB02024	Others	Others
	SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity...

化合物

Cat.No: T0373

Synonym: OSI-744,NSC 718781,CP358774,埃罗替尼,R1415

Target: EGFR, Autophagy

Desmethyl Erlotinib

Cat.No: T6328

Synonym: OSI-420,CP-473420,O-Desmethyl Erlotinib

Target: EGFR, Drug Metabolite

Desmethyl Erlotinib hydrochloride

Cat.No: T6619

Synonym: OSI420,OSI-420,DesMethyl Erlotinib (CP-473420) HCl,去甲厄洛替尼,CP-473420,Desmethyl Erlotinib,OSI 420

Target: EGFR, Drug Metabolite

Erlotinib hydrochloride

Cat.No: T0373L

Synonym: 盐酸埃罗替尼,OSI-744,NSC 718781,Erlotinib HCl,CP-358774

Target: EGFR, Autophagy

Erlotinib mesylate

Cat.No: T0373L1

Synonym: CP-358774,CP-358,774,埃罗替尼甲磺酸盐,OSI-774,CP358774,OSI 774

Target: Others

Cat.No: T31055

Synonym: OSI-493,Erlotinib metabolite M6,CP457493,UNII-X0JH558S7E

Target: Others

Cat.No: T35528

Target: Apoptosis, Phosphatase, Akt

TD52 dihydrochloride

Cat.No: T35528L

Synonym: TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl

Target: Others

Cat.No: T73472

Target: Others

Cat.No: T34892

Synonym: TM-608,TM 608

Target: Others

Cat.No: T35147

Synonym: WZ4002 analog, WZ4002 demethyl derivate,WZ 4002-hydroxy,WZ-4002-hydroxy

Target: Others

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cat.No: T36102

Target: Others

Cat.No: T71526

Target: Others

Cat.No: T69888

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T35915	Erlotinib-13C6 Erlotinib-13C6
	Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]...
T19312	Erlotinib-d6 hydrochloride CP-358774 D6 hydrochloride,NSC 718781 D6 hydrochloride,Erlotinib D6 hydrochloride,OSI-774 D6 hydrochloride	Others	Others
	Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib D6 hydrochloride a deuterium labeled Erlotinib Hydrochloride.
T11229	Erlotinib-d6 OSI-774 D6,NSC 718781 D6,CP-358774 D6	Others	Others
	Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR. Erlotinib D6 is a deuterium labeled Erlotinib .

同位素标记化合物

Erlotinib-13C6

Cat.No: T35915

Synonym: Erlotinib-13C6

Erlotinib-d6 hydrochloride

Cat.No: T19312

Synonym: CP-358774 D6 hydrochloride,NSC 718781 D6 hydrochloride,Erlotinib D6 hydrochloride,OSI-774 D6 hydrochloride

Target: Others

Cat.No: T11229

Synonym: OSI-774 D6,NSC 718781 D6,CP-358774 D6

Target: Others

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