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12

抑制剂 & 化合物

11

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
TMAZ-0124P Anti-ERBB4 Monoclonal Antibody-PE

TMAZ-0124A Anti-ERBB4 Monoclonal Antibody-APC

TMAZ-0124B Anti-ERBB4 Monoclonal Antibody-Biotin

TMAZ-0124A5 Anti-ERBB4 Monoclonal Antibody-AF555

T21954 EGFR/ErbB-2/ErbB-4 inhibitor-2

EGFR/ErbB2 Inhibitor

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) 是EGFR 和ErbB 的抑制剂,对EGFR、ErbB2 和 ErbB4 的IC50分别为 0.017、0.08 和 1.91 μM。
TMAZ-0124A6 Anti-ERBB4 Monoclonal Antibody-AF647

TMAZ-0124A4 Anti-ERBB4 Monoclonal Antibody-AF488

T5410 PD158780

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
PD158780是一种EGFR 家族抑制剂,对EGFR、ErbB2、ErbB3和ErbB4的IC50值分别为8 μM、49、52 和 52 nM。
T2483 Dacomitinib

达克替尼,PF-299804,PF-00299804,PF299

Apoptosis; EGFR Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Dacomitinib (PF299) 是一种不可逆的特异性ERBB 家族抑制剂,作用于EGFR、ERBB2和ERBB4的IC50分别为 6 nM、45.7 nM 和 73.7 nM。
T2491 AZ-5104

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
AZ5104是 AZD 9291的活性去甲基化代谢物,是一种有效的 EGFR 抑制剂,抑制 EGFRL858R/T790M、EGFRL858R、EGFRL861Q、EGFR 和 ErbB4的 IC50值分别为1、6、1、25 和 7 nM。
T6331 Allitinib tosylate

艾力替尼,AST-1306 TsOH,AST-6,Allitinib,AST-1306,AST-1306 (TsOH)

EGFR; FLT Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Allitinib tosylate (AST-1306) 是EGFR 和ErbB2抑制剂,IC50分别为 0.5 和 3 nM。它具有抗癌活性,还抑制ErbB4,IC50为 0.8 nM。
T14336 Allitinib

AST-1306,ALS 1306

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Allitinib (AST-1306) 是可口服的 EGFR 和 ErbB2不可逆抑制剂,IC50分别为 0.5 和 3 nM。它具有抗癌活性,抑制 ErbB4,IC50为 0.8 nM。

化合物

Anti-ERBB4 Monoclonal Antibody-PE
Cat.No: TMAZ-0124P
Synonym:
Target:
Anti-ERBB4 Monoclonal Antibody-APC
Cat.No: TMAZ-0124A
Synonym:
Target:
Anti-ERBB4 Monoclonal Antibody-Biotin
Cat.No: TMAZ-0124B
Synonym:
Target:
Anti-ERBB4 Monoclonal Antibody-AF555
Cat.No: TMAZ-0124A5
Synonym:
Target:
EGFR/ErbB-2/ErbB-4 inhibitor-2
Cat.No: T21954
Synonym: EGFR/ErbB2 Inhibitor
Target: EGFR
Anti-ERBB4 Monoclonal Antibody-AF647
Cat.No: TMAZ-0124A6
Synonym:
Target:
Anti-ERBB4 Monoclonal Antibody-AF488
Cat.No: TMAZ-0124A4
Synonym:
Target:
PD158780
Cat.No: T5410
Synonym:
Target: EGFR
Dacomitinib
Cat.No: T2483
Synonym: 达克替尼,PF-299804,PF-00299804,PF299
Target: Apoptosis, EGFR
AZ-5104
Cat.No: T2491
Synonym:
Target: EGFR
Allitinib tosylate
Cat.No: T6331
Synonym: 艾力替尼,AST-1306 TsOH,AST-6,Allitinib,AST-1306,AST-1306 (TsOH)
Target: EGFR, FLT
Allitinib
Cat.No: T14336
Synonym: AST-1306,ALS 1306
Target: EGFR
Cat. No. Product Name Species Expression System
TMPK-00448 HER4/ERBB4 Protein, Human, Recombinant (His & Avi)

HER4,ALS19,4ICD,p180erbB4

Human HEK293 Cells
Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS. HER4/ERBB4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted mol...
TMPY-02813 ErbB4 Protein, Human, Rhesus, Recombinant (His)

erb-b2 receptor tyrosine kinase 4

Human,Rhesus HEK293 Cells
ErbB4 Protein, Human, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is Q15303-1.
TMPK-00449 HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated

E4ICD,ALS19,ErbB4,4ICD,H...

Human HEK293 Cells
Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS. HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The...
TMPY-03021 ErbB4 Protein, Mouse, Recombinant (His)

c-erbB-4,Her4,erb-b2 receptor tyr...

Mouse HEK293 Cells
ErbB4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.5 kDa and the accession number is Q99P91.
TMPY-03822 ErbB4 Protein, Rat, Recombinant (His)

erb-b2 receptor tyrosine kinase 4

Rat HEK293 Cells
ErbB4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is AAQ77349.1.
TMPY-03158 ErbB4 Protein, Rat, Recombinant (hFc)

erb-b2 receptor tyrosine kinase 4

Rat HEK293 Cells
ErbB4 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.9 kDa and the accession number is AAQ77349.1.
TMPY-02814 ErbB4 Protein, Human, Rhesus, Recombinant (hFc)

erb-b2 receptor tyrosine kinase 4

Human,Rhesus HEK293 Cells
ErbB4 Protein, Human, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.6 kDa and the accession number is Q15303-1.
TMPH-03764 YAP1 Protein, Human, Recombinant (His)

YAP1-2gamma,YAP2L,YAP65

Human P. pastoris (Yeast)
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,...
TMPJ-01286 proHB-EGF Protein, Human, Recombinant (His)

heparin-binding EGF-like growth factor,HB-EGF,HEGFL,DTS,Diph...

Human HEK293 Cells
Heparin-binding EGF-like growth factor (HB-EGF) is a 12­16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF­like domain, and a heparin-binding motif. Mature HB­EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB­EGF shows 76% and 73% aa sequence identity with rat and mouse HB­EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may b...
TMPY-02708 NRG4 Protein, Human, Recombinant

HRG4,neuregulin 4

Human E. coli
NRG4 (neuregulin 4) is a member of the neuregulin protein family. The neuregulins consist of four structurally-related proteins that are part of the EGF family of proteins. It has been shown that these proteins have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis including cardiac development, Schwann cell, and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular s...
TMPJ-00448 NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)

NRG1β,HGL,NDF,NRG1,HRGA,HRG1-beta 1,Pro-neuregulin-1,HRG1-β1...

Human E. coli
Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and ...

重组蛋白

HER4/ERBB4 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00448
Species: Human
Expression System: HEK293 Cells
ErbB4 Protein, Human, Rhesus, Recombinant (His)
Cat.No: TMPY-02813
Species: Human,Rhesus
Expression System: HEK293 Cells
HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00449
Species: Human
Expression System: HEK293 Cells
ErbB4 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03021
Species: Mouse
Expression System: HEK293 Cells
ErbB4 Protein, Rat, Recombinant (His)
Cat.No: TMPY-03822
Species: Rat
Expression System: HEK293 Cells
ErbB4 Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-03158
Species: Rat
Expression System: HEK293 Cells
ErbB4 Protein, Human, Rhesus, Recombinant (hFc)
Cat.No: TMPY-02814
Species: Human,Rhesus
Expression System: HEK293 Cells
YAP1 Protein, Human, Recombinant (His)
Cat.No: TMPH-03764
Species: Human
Expression System: P. pastoris (Yeast)
proHB-EGF Protein, Human, Recombinant (His)
Cat.No: TMPJ-01286
Species: Human
Expression System: HEK293 Cells
NRG4 Protein, Human, Recombinant
Cat.No: TMPY-02708
Species: Human
Expression System: E. coli
NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)
Cat.No: TMPJ-00448
Species: Human
Expression System: E. coli
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