Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2393 |
Efavirenz
EFV,依非韦伦,DMP 266,依法韦仑,Sustiva,Stocrin,L-743726 |
HIV Protease; Reverse Transcriptase; Autophagy | Autophagy; Microbiology/Virology; Proteases/Proteasome |
Efavirenz (DMP 266) 是一种人类免疫缺陷病毒 1 非核苷类似物逆转录酶抑制剂。它也是一种野生型HIV-1 RT 抑制剂,Ki 为 2.93 nM,有效抑制 HIV-1 复制,IC95为 1.5 nM。 | |||
T37162 |
8-hydroxy Efavirenz
|
Others | Others |
8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 μM. | |||
T34250 |
Rac-Efavirenz
L 741211,L-741211,Racemic-Efavirenz,L741211 |
Others | Others |
Rac-Efavirenz is a non stereospecific structure of Efavirenz. | |||
T25363 |
Efavirenz, (R)-
L 743725,L-743725,L743725 |
Others | Others |
Efavirenz, (R)- is an antiviral agent and a nonnucleoside HIV-1 reverse transcriptase inhibitor. | |||
T27442 |
GSK 224876
GSK-224876,GSK224876 |
Others | Others |
GSK 224876 is a novel next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI). It has activity against efavirenz-resistant strains in the treatment of treatment-naive HIV-1-infected subjects. |