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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3635 |
IQ 1
IQ1,IQ-1 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
IQ 1 有多种作用,如保持小鼠ESCs 的多功能性、降低Wnt 刺激的磷酸化、阻止PP2A/Nkd 的相互作用等等。 | |||
T8005 |
Cardiogenol C hydrochloride
2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Cardiogenol C hydrochloride (Cardiogenol C) 是一种细胞渗透性嘧啶诱导剂,能够促使 ESCs 分化为心肌细胞。在有限的可塑性范围内,它可以对已经沿袭的祖细胞类型产生心肌生成效应,是一种心肌生成试剂,在动物模型中可以用作细胞移植研究中提高心脏修复的工具。 | |||
T70520 |
TWS-119
|
Others | Others |
TWS-119 is an inhibitor of glycogen synthase kinase-3β (GSK-3β) that induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs). | |||
T16941 |
Stauprimide
|
Others | Others |
Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription. | |||
T2161 |
Cardiogenol C
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Cardiogenol C 是一种细胞渗透性嘧啶诱导剂,能够诱导 ESCs 分化为心肌细胞(EC50:100 nM)。在有限的可塑性范围内,它可以对已经沿袭的祖细胞类型产生心肌病,是一种心肌发生剂。 | |||
T76068 |
Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA
|
||
Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA 是一种环状RGD多肽, 对αvβ3有高亲和性,能干扰细胞整合素之间的相互作用。此化合物能抑制胚胎干细胞(ESC)的多潜能性基因表达,并可在体内减少mESC的致瘤潜力,因此适用于肿瘤研究领域。 | |||
T10667 |
Calmidazolium chloride
R 24571,钙调蛋白抑制剂 |
CaMK; Autophagy | Autophagy; Neuroscience |
Calmidazolium chloride (R 24571) 是一种钙调蛋白拮抗剂,对CaM 依赖性磷酸二酯酶和钙调蛋白诱导的红细胞Ca2+转运ATP 酶活化有拮抗作用,IC50分别为0.15和0.35 μM。Calmidazolium chloride 结合CaMK 的Kd 值为3 nM。Calmidazolium chloride 在抗癌领域有研究的价值。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05004 |
FGF-4 Protein, Human, Recombinant
HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4 |
Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a... | |||
TMPY-04466 |
STK40 Protein, Human, Recombinant (His & GST)
SHIK,SgK495,serine/threonine kinase 40 |
Human | Baculovirus Insect Cells |
STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk40 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk40 in ES... | |||
TMPK-01186 |
B7-H5/Gi24/VISTA Protein, Human, Recombinant (His)
VSIR,B7H5,4632428N05Rik,SISP1,PP2135,Dies1,PD-1H,VISTA,C10or... |
Human | HEK293 Cells |
B7-H5, also known as VISTA , B7H5, Dies1, SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. B7-H5/Gi24/VISTA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 19 kDa and the accession number is Q9H7M9. | |||
TMPK-01185 |
B7-H5/Gi24/VISTA Protein, Human, Recombinant (hFc)
PP2135,SISP1,VISTA,Gi24,B7H5,4632428N05Rik,Dies1,PD1H,VSIR,B... |
Human | HEK293 Cells |
B7-H5, also known as VISTA , B7H5, Dies1, SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. B7-H5/Gi24/VISTA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is Q9H7M9. | |||
TMPY-02950 |
WWP2 Protein, Human, Recombinant (His & GST)
WW domain containing E3 ubiquitin protein ligase 2,AIP2,WWp2... |
Human | Baculovirus Insect Cells |
WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-6... |