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Search Results for " ep3 "

43

抑制剂 & 化合物

1

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T80383	EP3
	EP3是一种具有抗细菌和抗真菌活性的抗菌肽。该化合物对E. gallinarum、P. pyocyanea、A. baumanii、K. terrigena展示出MIC值为11.4 μg/mL的抑制效果。EP3也显示了对癌细胞的抗肿瘤作用，并能诱导细胞凋亡(apoptosis)。
T77630	EP3 antagonist 4	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP3 antagonist 4 是一种 EP3 拮抗剂，对 hEP 有抑制作用， Ki 值为 2 nM。EP3 antagonist 4 在大鼠完整 PK 研究中显示出较低的体内清除率、高口服 AUC 和良好的生物利用度。EP3 antagonist 4 可用于研究糖尿病和细胞功能障碍。
T61357	EP3 antagonist 3	Others	Others
	EP3 antagonist 3 (compound 2) is a highly effective and specific antagonist of the EP3 receptor. It displays significant oral bioavailability and exhibits a strong pKi value of 8.3. Furthermore, EP3 antagonist 3 possesses excellent pharmacokinetic characteristics, making it a suitable candidate for experimental investigations involving overactive bladder (OAB) research [1].
T5841	Travoprost 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Travoprost (Fluprostenol isopropyl ester) 是一种异丙基酯前药，是一种高亲和力的，选择性的 FP 前列腺素全受体激动剂。它能够降低眼压，有潜力应用于青光眼和眼高压。
T7264	CBP/EP300-IN-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	CBP/EP300-IN-1是一种 CBP/EP300 溴结构域抑制剂。
TP1539	AtPep3
	AtPep3 is a hormone-like peptide that plays a role in the salinity stress tolerance of plants.
TP1614	AtPep3 TFA (902781-14-0 free base) AtPep3 TFA
	AtPep3 TFA is a hormone-like peptide that plays a role in the salinity stress tolerance of plants.
T82942	AtPep3 TFA
	AtPep3 TFA 为一种具激素特性的肽类化合物，能够提升植物对盐分的耐受能力，并能防止盐分诱导下幼苗叶绿素发生漂白现象。
T73576	EP39	Others	Others
	EP39 是一种有效的HIV-1成熟抑制剂。EP39 与 Gag 的 SP1 结构域相互作用。EP39 通过与 SP1 结构域的 QVT 基序结合来降低 CA-SP1 连接的动力学，并通过稳定瞬态 α 螺旋结构来扰乱 SP1 结构域两侧的自然螺旋平衡。EP39 通过阻止HIV-1的成熟而起作用，从而阻断其感染性。
T73920	Ep300/CREBBP-IN-8	Others	Others
	Ep300/CREBBP-IN-8 (Example 37) 是一种有效的和具有口服活性的 Ep300和CREBBP 抑制剂，IC50分别为 0.014 μM 和 0.018 μM。Ep300/CREBBP-IN-8 可用于癌症研究。
T73921	Ep300/CREBBP-IN-2	Others	Others
	Ep300/CREBBP-IN-2 (Example 73) 是一种有效的和具有口服活性的Ep300和CREBBP 抑制剂，IC50分别为 0.052 μM 和 0.148 μM。Ep300/CREBBP-IN-2 可用于癌症研究。
T73922	Ep300/CREBBP-IN-3	Others	Others
	Ep300/CREBBP-IN-3 (Example 61) 是一种有效的Ep300和CREBBP 抑制剂，IC50分别为 0.056 μM 和 0.095 μM。Ep300/CREBBP-IN-3 可用于癌症研究。
T73923	Ep300/CREBBP-IN-4	Others	Others
	Ep300/CREBBP-IN-4 (Example 56) 是一种有效的Ep300和CREBBP 抑制剂，IC50分别为 0.024 μM 和 0.064 μM。Ep300/CREBBP-IN-4 可用于癌症研究。
T15108	DG-041	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	DG-041 是高亲和力，选择性的，有效的 EP3受体拮抗剂，在结合和 FLIPR 试验中，IC50分别为 4.6 nM 和 8.1 nM。DG-041通过抑制 PGE2促进血小板聚集。DG-041具有血脑屏障渗透性。
T15689	L-798106 L 798106,CM9,GW-671021,CM-9,GW671021	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-798106 (CM9) 是一种具有选择性和高效性的前列腺素类 EP3 受体拮抗剂，抑制 EP4，EP1 和 EP2 受体，抑制动脉粥样硬化中促炎细胞因子的水平，可减弱 PGE2 诱导的咳嗽。
T14148	AH 6809	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	AH 6809 是 EP 和 DP 受体的拮抗剂，对小鼠 EP2受体的 Ki 值为 350 nM，对克隆的人类 EP1，EP2，EP3-III 和 DP 受体的 Ki 值分别为 1217、1150、1597 和 1415 nM。
T11211	EP4 receptor antagonist 1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP4 receptor antagonist 1 是一种有效的特异性前列腺素 EP4受体拮抗剂，对人和小鼠 EP4受体的 IC50分别为6.1 nM 和16.2 nM。 EP4 receptor antagonist 1 可用于癌症免疫治疗的研究。
T14975	CJ-42794 CJ-042794	Others	Others
	CJ-42794 (CJ-042794)是前列腺素受体 EP4的选择性拮抗剂, 抑制[3H]-PGE2与 EP4受体结合的平均 pKi 为8.5, 对 EP4选择性比 EP1, EP2和 EP3高200多倍。
T63349	Treprostinil diethanolamine UT-15C	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil diethanolamine (UT-15C) 是EP2、DP1和IP 的有效激动剂，对EP2、DP1、IP、EP1、EP4、EP3 和 FPKi 的值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 能够促使 cAMP 的上调，进而维持血管系统内的稳态，并造成人肺动脉的血管扩张。
T3306	PF-04418948 PF 04418948,PF04418948	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	PF-04418948 是一种可口服的，选择性的前列腺素EP2受体拮抗剂，IC50为16 nM。
T5482	TG4-155	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TG4-155 是一种脑渗透性 EP2 拮抗剂，对 EP2 和 DP1 具有低纳摩尔的拮抗活性。它作用于 EP2 的 KB 为 2.4 nM，比对 DP1 受体的选择性高 14 倍，比对 EP1、EP3、EP4 和 IP 的选择性比高 550-4750 倍。
T70042	PF-06748962	Others	Others
	PF-06748962 is a potent and selective lactam-based prostaglandin EP3 receptor antagonist.
T23404	Sulprostone	Others	Others
	EP3 and EP1 receptor agonist
T84402	EP4 receptor agonist 2	Others	Others
	EP4 receptor agonist 2（compound 31）是一种有效的EP4 receptor激动剂，其EC50值为0.8 nM；而对EP2、EP3、EP4的Ki值分别为>100000、38000、3.1 nM。
T28252	ONO-AE-248	Others	Others
	ONO-AE-248 is a selective agonist of EP3 receptor.
T15642	KAG-308	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing,
T37996	17-phenyl trinor Prostaglandin E2 ethyl amide 17-phenyl trinor Prostaglandin E2 ethyl amide	Others	Others
	17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to inc...
T37778	19(R)-hydroxy Prostaglandin E1 19(R)-hydroxy Prostaglandin E1	Others	Others
	19(R)-hydroxy Prostaglandin E1 是 EP1 和 EP3 受体亚型的激动剂，并对平滑肌表现出收缩活性，也是灵长类动物精液中的主要前列腺素。
T72513	SC 51089 free base	Others	Others
	SC 51089 free base 是一种选择性的前列腺素受体EP1拮抗剂，对EP1，TP，EP3和FP 受体的Ki 值分别为 1.3，11.2，17.5 和 61.1 μM。SC 51089 free base 具有神经保护活性。
T29907	Alprostadil sodium PGE1 sodium salt,Prostaglandin E1 sodium	Others	Others
	Alprostadil sodium 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。
T26925	Butaprost Butaprostum,TR-4979,(R)-Butaprost	Others	Others
	Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butaprost demonstrates lower activity against murine EP1, EP3, and EP4 receptors. Furthermore, it effectively attenuates fibrosis by inhibiting the TGF-β/Smad2 signaling pathway [1] [2] [3].
T84590	17-phenyl trinor Prostaglandin E2 17-phenyl trinor PGE2	Others	Others
	17-Phenyl trinor Prostaglandin E2 (17-phenyl trinor PGE2) is a synthetic analog of PGE2, functioning as an agonist at the EP1 and EP3 receptors. It induces contraction of the guinea pig ileum at a 11 µM concentration and displays slightly less potency than PGE2 in stimulating the gerbil colon and rat uterus. Notably, with an ED50 value of 350 µg/kg, 17-phenyl trinor PGE2 exhibits 4.4 times greater antifertility efficacy in hamsters compared to PGE2.
T36080	Rivenprost ONO-4819	Others	Others
	Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]
T84585	11-deoxy-16,16-dimethyl Prostaglandin E2 11-deoxy-16,16-dimethyl PGE2	Others	Others
	11-Deoxy-16,16-dimethyl Prostaglandin E2 (11-deoxy-16,16-dimethyl PGE2) is a stable synthetic analog of Prostaglandin E2 (PGE2), acting as an agonist for both EP2 and EP3 receptors. It effectively inhibits gastric acid secretion and ulcer formation in rats, with ED50 values of 1 mg/kg and 0.021 mg/kg, respectively. This compound is also 900 times more potent than Prostaglandin F2α (PGF2α) in inducing contraction of human respiratory tract smooth muscle in vitro.
T5150	Treprostinil LRX-15,曲前列环素,Orenitram,曲前列尼尔,Remodulin	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil (Orenitram) 是有效的 DP1、IP 和 EP2 激动剂，EC50分别为0.6、1.9 和 6.2 nM。
T84444	ONO-AE3-208 sodium	Others	Others
	ONO-AE3-208 is an EP4 receptor antagonist with a Ki of 1.3 nM, exhibiting less potent activity against EP3, FP, and TP receptors (Ki values of 30, 790, and 2,400 nM, respectively), while showing no effect on other prostanoid receptors. In wild type mice, treatment with ONO-AE3-208, in conjunction with 3% dextran sodium sulfate, results in severe colitis characterized by epithelial loss, crypt damage, and inflammation, thereby mimicking the effects of EP4 deletion. Further, this compound has been...
T23331	SC 51089 SC 51089 free base	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	SC 51089 是一种选择性的前列腺素受体 PGE2 拮抗剂，对前列腺素受体亚型具有选择性，具有抗伤害活性，可改善亨廷顿病 R6/1 小鼠模型中的运动缺陷并挽救记忆力下降。
T4981	Anisotropine Methylbromide	Prostaglandin Receptor; AChR	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Anisotropine Methylbromide 是一种抗胆碱能药物，已用于缓解胃肠道痉挛和抑制胃酸分泌。
TQ0290	ONO-AE3-208 AE 3-208	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	ONO-AE3-208 (AE 3-208) 是一种 EP4 拮抗剂，可抑制前列腺癌的细胞迁移、侵袭和转移。
T37441	KMN-80	Others	Others
	The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis. KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other pro...
T40738	CAY10580 CAY10580	Others	Others
	CAY10580 is a potent and selective prostaglandin EP 4 receptor agonist ( K i =35 nM).
T20142	Tafluprost acid UNII-WTV8EPZ396	Others	Others
	Tafluprost acid is a selective agonist at the prostaglandin F receptor.
T15828	L 888607	Others	Others
	L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).

化合物

Cat.No: T80383

EP3 antagonist 4

Cat.No: T77630

Target: Prostaglandin Receptor

EP3 antagonist 3

Cat.No: T61357

Target: Others

Cat.No: T5841

Synonym: 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221

Target: Prostaglandin Receptor

Cat.No: T7264

Target: Epigenetic Reader Domain

Cat.No: TP1539

AtPep3 TFA (902781-14-0 free base)

Cat.No: TP1614

Synonym: AtPep3 TFA

Cat.No: T82942

Cat.No: T73576

Target: Others

Ep300/CREBBP-IN-8

Cat.No: T73920

Target: Others

Ep300/CREBBP-IN-2

Cat.No: T73921

Target: Others

Ep300/CREBBP-IN-3

Cat.No: T73922

Target: Others

Ep300/CREBBP-IN-4

Cat.No: T73923

Target: Others

Cat.No: T15108

Target: Prostaglandin Receptor

Cat.No: T15689

Synonym: L 798106,CM9,GW-671021,CM-9,GW671021

Target: Prostaglandin Receptor

Cat.No: T14148

Target: Prostaglandin Receptor

EP4 receptor antagonist 1

Cat.No: T11211

Target: Prostaglandin Receptor

Cat.No: T14975

Synonym: CJ-042794

Target: Others

Treprostinil diethanolamine

Cat.No: T63349

Synonym: UT-15C

Target: Prostaglandin Receptor

Cat.No: T3306

Synonym: PF 04418948,PF04418948

Target: Prostaglandin Receptor

Cat.No: T5482

Target: Prostaglandin Receptor

Cat.No: T70042

Target: Others

Cat.No: T23404

Target: Others

EP4 receptor agonist 2

Cat.No: T84402

Target: Others

Cat.No: T28252

Target: Others

Cat.No: T15642

Target: Prostaglandin Receptor

17-phenyl trinor Prostaglandin E2 ethyl amide

Cat.No: T37996

Synonym: 17-phenyl trinor Prostaglandin E2 ethyl amide

Target: Others

19(R)-hydroxy Prostaglandin E1

Cat.No: T37778

Synonym: 19(R)-hydroxy Prostaglandin E1

Target: Others

SC 51089 free base

Cat.No: T72513

Target: Others

Alprostadil sodium

Cat.No: T29907

Synonym: PGE1 sodium salt,Prostaglandin E1 sodium

Target: Others

Cat.No: T26925

Synonym: Butaprostum,TR-4979,(R)-Butaprost

Target: Others

17-phenyl trinor Prostaglandin E2

Cat.No: T84590

Synonym: 17-phenyl trinor PGE2

Target: Others

Cat.No: T36080

Synonym: ONO-4819

Target: Others

11-deoxy-16,16-dimethyl Prostaglandin E2

Cat.No: T84585

Synonym: 11-deoxy-16,16-dimethyl PGE2

Target: Others

Cat.No: T5150

Synonym: LRX-15,曲前列环素,Orenitram,曲前列尼尔,Remodulin

Target: Prostaglandin Receptor

ONO-AE3-208 sodium

Cat.No: T84444

Target: Others

Cat.No: T23331

Synonym: SC 51089 free base

Target: Prostaglandin Receptor

Anisotropine Methylbromide

Cat.No: T4981

Target: Prostaglandin Receptor, AChR

Cat.No: TQ0290

Synonym: AE 3-208

Target: Prostaglandin Receptor

Cat.No: T37441

Target: Others

Cat.No: T40738

Synonym: CAY10580

Target: Others

Tafluprost acid

Cat.No: T20142

Synonym: UNII-WTV8EPZ396

Target: Others

Cat.No: T15828

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。

天然产物

Prostaglandin E1

Cat.No: T1626

Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil

Target: Endogenous Metabolite, Prostaglandin Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01350	XPNPEP3 Protein, Human, Recombinant (His) XPNPEP3,X-Pro Aminopeptidase ...	Human	E. coli
	Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 which is a disorder with features of nephronophthisis, a cystic kidney disease leading to end-s...
TMPJ-01010	PLA2G16 Protein, Human, Recombinant (His) Renal Carcinoma Antigen NY-REN-65,HRAS-Like Suppressor 1,HRS...	Human	E. coli
	Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differentiation and survival. PLA2G16 regulates adipocyte lipolysis and release of fatty acids through a G-protein coupled pathway involving prostaglandin and EP3. It has also been reported to play a crucial role in the development of obesity in mouse models.
TMPY-03498	ING4 Protein, Human, Recombinant (His) inhibitor of growth family, member 4,p29ING4,my036	Human	E. coli
	ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. ING4 protein can bind TP53 and EP3/p3, a component of the histone acetyltransferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. ING4 is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activi...

重组蛋白

XPNPEP3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01350

Species: Human

Expression System: E. coli

PLA2G16 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01010

Species: Human

Expression System: E. coli

ING4 Protein, Human, Recombinant (His)

Cat.No: TMPY-03498

Species: Human

Expression System: E. coli

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