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Search Results for " ep1 "

Targets Recommended: Prostaglandin Receptor

46

抑制剂 & 化合物

1

天然产物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10031	EP1-antagonist-1 EP1-antanoist-1,EP1 antagonist 1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP1-antagonist-1 (EP1 antagonist 1) 是 EP1 的拮抗剂，pKi 和 pIC50 分别为 7.54 和 8.5。
T5841	Travoprost 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Travoprost (Fluprostenol isopropyl ester) 是一种异丙基酯前药，是一种高亲和力的，选择性的 FP 前列腺素全受体激动剂。它能够降低眼压，有潜力应用于青光眼和眼高压。
T78846	EP12	Apoptosis	Apoptosis
	EP12是一种c-Myc抑制剂及c-MycG4稳定剂，能够诱导多发性骨髓瘤细胞的细胞凋亡(apoptosis)及DNA损伤，并通过干扰NF-κB信号通路破坏P65/P50的核转位，从而抑制多发性骨髓瘤的生长。
TP2197	Pep1-TGL	Others	Others
	Peptide containing the 'TGL' motif that corresponds to the C-terminus of GluR1 subunit
T74445	ZA3-Ep10	Others	Others
	ZA3-Ep10是一种两性离子的脂质，用于合成脂质纳米颗粒，用于体内 RNA 传递和非病毒 CRISPR/Cas 基因编辑。
T11210	EP1013 F1013	Caspase	Apoptosis; Proteases/Proteasome
	EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.
T80420	TAT-NEP1-40 acetate	Apoptosis	Apoptosis
	TAT-NEP1-40 acetate 是促进脑卒中后轴突再生和功能恢复的候选分子。该化合物能够抵御PC12细胞的氧和葡萄糖剥夺(OGD)损伤，并促进神经突生长。它通过抑制神经元凋亡(apoptosis)作用，保护大脑免受缺血再灌注伤害，并能有效传递至大鼠的脑内。
T80419	TAT-NEP1-40 TFA	Apoptosis	Apoptosis
	TAT-NEP1-40 TFA 是一种能够穿透血脑屏障的多肽。它能够保护 PC12 细胞抵御缺氧和葡萄糖剥夺 (OGD) 的损害，并促进神经突的生长。此外，TAT-NEP1-40 TFA 可通过减少缺血性脑损伤中的细胞凋亡，以改善神经系统功能。该化合物在中枢神经系统损伤，包括中风后轴突再生及功能恢复的研究中具有潜在应用价值。
T76273	Pep19-2.5
	Pep19-2.5为合成抗毒素肽，能阻断内毒素信号级联。通过抑制跨膜及胞质模式识别受体（PRRs）介导的脂肽（LP）与脂多糖（LPS）的信号通路，Pep19-2.5关键调控与炎症及细胞焦亡（pyroptosis）相关的信号级联。
T81517	PEP1
	PEP1为具生物活性的肽类化合物。它在低浓度时能够与POPC SLB结合，在高浓度下则会引起POPC SLB的裂解。
T80418	TAT-NEP1-40	Apoptosis	Apoptosis
	TAT-NEP1-40是一种能够穿透血脑屏障的多肽。它能够保护PC12细胞不受缺氧和葡萄糖剥夺(OGD)所致的损伤，同时促进神经突的生长。此外，TAT-NEP1-40通过阻断缺血性脑损伤中的细胞凋亡，对缺血后的神经功能恢复具有积极作用。该化合物适用于中枢神经系统损伤，特别是中风后的轴突再生与功能恢复方面的研究。
TP2196	Pep1-AGL	Others	Others
	Analog of Pep1-TGL
T14148	AH 6809	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	AH 6809 是 EP 和 DP 受体的拮抗剂，对小鼠 EP2受体的 Ki 值为 350 nM，对克隆的人类 EP1，EP2，EP3-III 和 DP 受体的 Ki 值分别为 1217、1150、1597 和 1415 nM。
T21976	ONO-8130	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	ONO-8130 是前列腺素 EP1 受体选择性拮抗剂，口服有活力，能够阻断 L6 脊髓中ERK 的磷酸化。它可缓解环磷酰胺致膀胱炎小鼠的膀胱疼痛，可用于研究间质性膀胱炎。
T15689	L-798106 L 798106,CM9,GW-671021,CM-9,GW671021	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-798106 (CM9) 是一种具有选择性和高效性的前列腺素类 EP3 受体拮抗剂，抑制 EP4，EP1 和 EP2 受体，抑制动脉粥样硬化中促炎细胞因子的水平，可减弱 PGE2 诱导的咳嗽。
T11211	EP4 receptor antagonist 1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP4 receptor antagonist 1 是一种有效的特异性前列腺素 EP4受体拮抗剂，对人和小鼠 EP4受体的 IC50分别为6.1 nM 和16.2 nM。 EP4 receptor antagonist 1 可用于癌症免疫治疗的研究。
T63667	ONO-8713	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	ONO-8713 是一种选择性的前列腺素E受体亚型EP1拮抗剂，可用于研究圣经系统疾病和代谢相关疾病。
T14975	CJ-42794 CJ-042794	Others	Others
	CJ-42794 (CJ-042794)是前列腺素受体 EP4的选择性拮抗剂, 抑制[3H]-PGE2与 EP4受体结合的平均 pKi 为8.5, 对 EP4选择性比 EP1, EP2和 EP3高200多倍。
T63349	Treprostinil diethanolamine UT-15C	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil diethanolamine (UT-15C) 是EP2、DP1和IP 的有效激动剂，对EP2、DP1、IP、EP1、EP4、EP3 和 FPKi 的值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 能够促使 cAMP 的上调，进而维持血管系统内的稳态，并造成人肺动脉的血管扩张。
T3306	PF-04418948 PF 04418948,PF04418948	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	PF-04418948 是一种可口服的，选择性的前列腺素EP2受体拮抗剂，IC50为16 nM。
T5482	TG4-155	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TG4-155 是一种脑渗透性 EP2 拮抗剂，对 EP2 和 DP1 具有低纳摩尔的拮抗活性。它作用于 EP2 的 KB 为 2.4 nM，比对 DP1 受体的选择性高 14 倍，比对 EP1、EP3、EP4 和 IP 的选择性比高 550-4750 倍。
T23330	SC 19220	Others	Others
	EP1 receptor antagonist
T23332	SC 51322	Others	Others
	SC 51322 is an EP1 prostanoid receptor antagonist.
T27466	GSK-269984B	Others	Others
	GSK-269984B is a novel antagonist of EP1 receptor.
T15421	GSK-269984A	Others	Others
	GSK-269984A is an antagonist of Prostaglandin E2 Receptor 1 (EP1) (pIC50: 7.9).
T22125	ONO-8711	Others	Others
	ONO-8711 是一种有效且选择性的 EP1 受体竞争性拮抗剂(对人和小鼠 EP1 的 Ki 分别为 0.6 和 1.7 nM)。ONO-8711 在结肠癌、乳腺癌和口腔癌小鼠模型中的有效降低肿瘤发生率和多样性。
T23404	Sulprostone	Others	Others
	EP3 and EP1 receptor agonist
T15642	KAG-308	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing,
T16388	Omidenepag isopropyl	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropy
T69229	ONO-8539	Others	Others
	ONO-8539 is a prostanoid EP1 receptor antagonist.
T27517	GW848687X GW-848687X,GW 848687X	Others	Others
	GW848687X, a potent and selective prostaglandin EP1 receptor antagonist, is used for the treatment of inflammatory pain.
T69602	ONO-DI-004	Others	Others
	ONO-DI-004 is a selective EP1 Prostanoid receptor agonist.
T72513	SC 51089 free base	Others	Others
	SC 51089 free base 是一种选择性的前列腺素受体EP1拮抗剂，对EP1，TP，EP3和FP 受体的Ki 值分别为 1.3，11.2，17.5 和 61.1 μM。SC 51089 free base 具有神经保护活性。
T37996	17-phenyl trinor Prostaglandin E2 ethyl amide 17-phenyl trinor Prostaglandin E2 ethyl amide	Others	Others
	17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to inc...
T16389	Omidenepag UR-7276	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Omidenepag (UR-7276) 是一种具有选择性和高效性的前列腺素 E2 受体 2 (EP2)激动剂，也是一种新型局部眼部降压药。Omidenepag可用于研究青光眼和高眼压症。
T36212	16(S)-Iloprost	Others	Others
	Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(S)-Iloprost potently inhibits platelet aggregation with an IC50 value of 3.5 nM.
T26925	Butaprost Butaprostum,TR-4979,(R)-Butaprost	Others	Others
	Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butaprost demonstrates lower activity against murine EP1, EP3, and EP4 receptors. Furthermore, it effectively attenuates fibrosis by inhibiting the TGF-β/Smad2 signaling pathway [1] [2] [3].
T37778	19(R)-hydroxy Prostaglandin E1 19(R)-hydroxy Prostaglandin E1	Others	Others
	19(R)-hydroxy Prostaglandin E1 是 EP1 和 EP3 受体亚型的激动剂，并对平滑肌表现出收缩活性，也是灵长类动物精液中的主要前列腺素。
T36080	Rivenprost ONO-4819	Others	Others
	Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]
T21869	BW A868C	Others	Others
	BW A868C 是一种乙内酰脲化合物，是 BW245C 结构类似物。BW A868C 是一种选择性强的前列腺素 D2 (PGD2) 竞争性拮抗剂。BW A868C 对其他前列腺素受体 (IP、EP1、EP2、TP 和 FP) 没有影响。
T29907	Alprostadil sodium PGE1 sodium salt,Prostaglandin E1 sodium	Others	Others
	Alprostadil sodium 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。
T38171	Ro 1138452 hydrochloride	Others	Others
	Selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable. Clark et al (2004) Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg.Med.Chem.Lett. 14 1053 PMID:15013022 \|Jones et al (2006) Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel ...
T84590	17-phenyl trinor Prostaglandin E2 17-phenyl trinor PGE2	Others	Others
	17-Phenyl trinor Prostaglandin E2 (17-phenyl trinor PGE2) is a synthetic analog of PGE2, functioning as an agonist at the EP1 and EP3 receptors. It induces contraction of the guinea pig ileum at a 11 µM concentration and displays slightly less potency than PGE2 in stimulating the gerbil colon and rat uterus. Notably, with an ED50 value of 350 µg/kg, 17-phenyl trinor PGE2 exhibits 4.4 times greater antifertility efficacy in hamsters compared to PGE2.
T36211	16(R)-Iloprost	Others	Others
	Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(R)-Iloprost inhibits platelet aggregation with an IC50 value of 65 nM.
T23331	SC 51089 SC 51089 free base	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	SC 51089 是一种选择性的前列腺素受体 PGE2 拮抗剂，对前列腺素受体亚型具有选择性，具有抗伤害活性，可改善亨廷顿病 R6/1 小鼠模型中的运动缺陷并挽救记忆力下降。
T84587	15(R)-Prostaglandin E2 15-epi PGE2	Others	Others
	15(R)-Prostaglandin E2, the C-15 epimer of the more physiologically abundant 15(S)-PGE2 (sc-201225) isomer, is produced mainly from arachidonic acid (sc-200770) via the action of COX and PGES enzymes. Present in nearly all cell types, PGE2 interacts with four distinct receptors, EP1 to EP4, leading to a wide range of biological effects. However, 15(R)-Prostaglandin E2 exhibits significantly lower efficacy in most biological assays compared to its 15(S) counterpart. Notably, acid catalyzed epimer...

化合物

EP1-antagonist-1

Cat.No: T10031

Synonym: EP1-antanoist-1,EP1 antagonist 1

Target: Prostaglandin Receptor

Cat.No: T5841

Synonym: 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221

Target: Prostaglandin Receptor

Cat.No: T78846

Target: Apoptosis

Cat.No: TP2197

Target: Others

Cat.No: T74445

Target: Others

Cat.No: T11210

Synonym: F1013

Target: Caspase

TAT-NEP1-40 acetate

Cat.No: T80420

Target: Apoptosis

TAT-NEP1-40 TFA

Cat.No: T80419

Target: Apoptosis

Cat.No: T76273

Cat.No: T81517

Cat.No: T80418

Target: Apoptosis

Cat.No: TP2196

Target: Others

Cat.No: T14148

Target: Prostaglandin Receptor

Cat.No: T21976

Target: Prostaglandin Receptor

Cat.No: T15689

Synonym: L 798106,CM9,GW-671021,CM-9,GW671021

Target: Prostaglandin Receptor

EP4 receptor antagonist 1

Cat.No: T11211

Target: Prostaglandin Receptor

Cat.No: T63667

Target: Prostaglandin Receptor

Cat.No: T14975

Synonym: CJ-042794

Target: Others

Treprostinil diethanolamine

Cat.No: T63349

Synonym: UT-15C

Target: Prostaglandin Receptor

Cat.No: T3306

Synonym: PF 04418948,PF04418948

Target: Prostaglandin Receptor

Cat.No: T5482

Target: Prostaglandin Receptor

Cat.No: T23330

Target: Others

Cat.No: T23332

Target: Others

Cat.No: T27466

Target: Others

Cat.No: T15421

Target: Others

Cat.No: T22125

Target: Others

Cat.No: T23404

Target: Others

Cat.No: T15642

Target: Prostaglandin Receptor

Omidenepag isopropyl

Cat.No: T16388

Target: Prostaglandin Receptor

Cat.No: T69229

Target: Others

Cat.No: T27517

Synonym: GW-848687X,GW 848687X

Target: Others

Cat.No: T69602

Target: Others

SC 51089 free base

Cat.No: T72513

Target: Others

17-phenyl trinor Prostaglandin E2 ethyl amide

Cat.No: T37996

Synonym: 17-phenyl trinor Prostaglandin E2 ethyl amide

Target: Others

Cat.No: T16389

Synonym: UR-7276

Target: Prostaglandin Receptor

Cat.No: T36212

Target: Others

Cat.No: T26925

Synonym: Butaprostum,TR-4979,(R)-Butaprost

Target: Others

19(R)-hydroxy Prostaglandin E1

Cat.No: T37778

Synonym: 19(R)-hydroxy Prostaglandin E1

Target: Others

Cat.No: T36080

Synonym: ONO-4819

Target: Others

Cat.No: T21869

Target: Others

Alprostadil sodium

Cat.No: T29907

Synonym: PGE1 sodium salt,Prostaglandin E1 sodium

Target: Others

Ro 1138452 hydrochloride

Cat.No: T38171

Target: Others

17-phenyl trinor Prostaglandin E2

Cat.No: T84590

Synonym: 17-phenyl trinor PGE2

Target: Others

Cat.No: T36211

Target: Others

Cat.No: T23331

Synonym: SC 51089 free base

Target: Prostaglandin Receptor

15(R)-Prostaglandin E2

Cat.No: T84587

Synonym: 15-epi PGE2

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。

天然产物

Prostaglandin E1

Cat.No: T1626

Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil

Target: Endogenous Metabolite, Prostaglandin Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03329	DPEP1 Protein, Human, Recombinant (His) MBD1,dipeptidase 1,MDP,RDP	Human	HEK293 Cells
	Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correlated with parameters of pathological aggressiveness and poor prognosis. The overexpression of DPEP1 suppressed tumor cells invasiveness and increased sensitivity to chemotherapeutic agent Gemcitabine. Growth factor EGF treatment decreased DPEP1 expression. Dehydropeptidase-I m...
TMPH-02158	SVEP1 Protein, Human, Recombinant (hFc) Selectin-like osteoblast-derived protein,SVEP1<...	Human	HEK293 Cells
	May play a role in the cell attachment process.
TMPY-01737	Meprin alpha/MEP1A Protein, Human, Recombinant (His) meprin A, α (PABA peptide hydrolase),m...	Human	HEK293 Cells
	Meprin alpha/MEP1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.7 kDa and the accession number is Q16819.
TMPY-01318	Meprin alpha/MEP1A Protein, Mouse, Recombinant (His) meprin A, alpha (PABA peptide hydrolase),A...	Mouse	HEK293 Cells
	Meprin alpha/MEP1A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69 kDa and the accession number is A0A0R4J043.
TMPJ-01351	XPNPEP1 Protein, Human, Recombinant (His) Xaa-Pro Aminopeptidase 1,X-Prolyl Aminop	Human	E. coli
	X-Prolyl Aminopeptidase (XPNPEP1) is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of any unsubstituted N-terminal amino acid that is adjacent to a penultimate proline residue. Because of its specificity toward proline, it has been suggested that X-Prolyl Aminopeptidase is important in the maturation and degradation of peptide hormones, neuropeptides, and tachykinins, as well as in the digestion of otherwise resistant dietary protein fragments, thereby compleme...
TMPH-02185	TEP1 Protein, Human, Recombinant (His) p80 telomerase homolog,TEP1,Telomerase pro...	Human	E. coli
	Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC. TEP1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weigh...

重组蛋白

DPEP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03329

Species: Human

Expression System: HEK293 Cells

SVEP1 Protein, Human, Recombinant (hFc)

Cat.No: TMPH-02158

Species: Human

Expression System: HEK293 Cells

Meprin alpha/MEP1A Protein, Human, Recombinant (His)

Cat.No: TMPY-01737

Species: Human

Expression System: HEK293 Cells

Meprin alpha/MEP1A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01318

Species: Mouse

Expression System: HEK293 Cells

XPNPEP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01351

Species: Human

Expression System: E. coli

TEP1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02185

Species: Human

Expression System: E. coli

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