29
2
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3458 |
EED226
|
Histone Methyltransferase | Chromatin/Epigenetic |
EED226 是多梳抑制复合物 2 抑制剂,是一种有效的、选择性的、可口服的胚胎外胚层发育 (EED) 抑制剂,IC50 为 22 nM,具有强抗肿瘤活性。当 H3K27me0 肽用作体外酶法测定的底物时,它抑制 PRC2的 IC50为 23.4 nM。 | |||
T12554 |
PROTAC EED degrader-2
|
Others; PROTACs | Others; PROTAC |
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11. | |||
T12553 |
PROTAC EED degrader-1
|
Others; PROTACs | Others; PROTAC |
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17. | |||
T61825 |
EED ligand 1
|
Others | Others |
EED ligand 1 is a highly versatile, potent, and effective inhibitor that specifically targets the EED subunit of the polycomb repressive complex 2 (PRC2) methyltransferase. | |||
T17649 |
Boc-GABA-OH
|
Others; PROTAC Linker | Others; PROTAC |
Boc-GABA-OH 是一种 PROTAC linker,可用于 UNC6852 的合成。其中 UNC6852 是靶向 EED 的 PROTAC 降解剂。 | |||
T13954 |
UNC6852
|
Histone Methyltransferase; Ligands for Target Protein for PROTAC; PROTACs | Chromatin/Epigenetic; PROTAC |
UNC6852 包含一个 EED 配体 (IC50 = 247 nM) 和一个 von Hippel-Lindau 配体,是一种基于 PROTAC 的特异性多梳抑制复合物 2 (PRC2) 降解剂。 | |||
T9681 |
MAK-683 hydrochloride
|
Histone Methyltransferase | Chromatin/Epigenetic |
MAK683 hydrochloride 是胚胎外胚层发育 (EED) 抑制剂。MAK683 hydrochloride 在 EED Alphascreen, ELISA 和 LC-MS 试验中测得的IC50 值分别为 59,26,89 nM。 | |||
T17931 |
EED226-COOH
|
Others | Others |
EED226-COOH, derived from EED226, serves as a ligand targeting the EED protein for PROTAC applications. It attaches to a VHL ligand through a linker, culminating in the formation of UNC6852, which specifically degrades PRC2[1]. | |||
T22322 |
EEDi-5285
UM-EEDi-5285,EEDI5285 |
Histone Methyltransferase | Chromatin/Epigenetic |
EEDi-5285 是一种非常有效且具有口服活性的胚胎外胚层发育 (EED) 抑制剂,结合 EED 蛋白的 IC50 值为 0.2 nM,并具有抗癌活性。 | |||
T40223 |
EEDi-5273
|
Others | Others |
EEDi-5273 is a highly potent and orally efficacious inhibitor of EED, with an approximate IC50 value of 0.2 nM. This compound exhibits exceptional activity, capable of achieving complete and persistent regression of tumors. | |||
T71923 |
EEDQ
|
Others | Others |
EEDQ is an irreversible dopamine-receptor antagonist.EEDQ is also a highly specific reagent for carboxyl groups. It enables the coupling of acylamino acids with amino acid esters in high yield and without racemization. | |||
T124238 |
Rheediaxanthone A
|
Others | Others |
Rheediaxanthone A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124238。 | |||
T76665 |
Z-LEED-FMK
|
||
Z-LEED-FMK 是 caspase-13和 caspase-4抑制剂。Z-LEED-FMK 还能抑制S. typhimurium 感染的巨噬细胞中caspase-1的加工。 | |||
T15201 |
MAK683
|
Histone Methyltransferase | Chromatin/Epigenetic |
MAK683 是胚胎外胚层发育 (EED) 抑制剂。在 EED Alphascreen 结合、LC-MS 和 ELISA 测定中,IC50值为 59、89 和 26 nM。 | |||
T10205 |
A-395
|
Histone Methyltransferase | Chromatin/Epigenetic |
A-395 是一种多梳抑制复合物 2 (PRC2) 蛋白质-蛋白质相互作用的拮抗剂,可有效抑制三聚体 PRC2 复合物 (EZH2-EED-SUZ12),IC50为 18 nM。 | |||
T61874 |
DN02
|
Others | Others |
DN02 是一种具有选择性和高效性的 BRD8 溴域探针。DN02 对 BRD8 (1) 和 BRD8 (2) 有亲和力。 | |||
T13765 |
MAK683-CH2CH2COOH
|
Others | Others |
MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。基于MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体,设计了靶向EED 的PROTACs, PROTAC EED degrader-1 和 PROTAC EED degrader-2 。 | |||
T73945 |
MAK683-CH2CH2COOH hydrochloride
|
Others | Others |
MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体设计了 PROTACEED degrader-1 和 PROTACEED degrader-2 。 | |||
T18673 |
(S,R,S)-AHPC-O-Ph-PEG1-NH2
VH032-O-Ph-PEG1-NH2 |
Others | Others |
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) serves as an E3 ligase ligand-linker conjugate, integrating a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is utilized in PROTAC EED degrader-1, a PROTAC that targets EED with a potency (pKD) of 9.02[1]. | |||
T17660 |
Boc-NH-PEG1-Ph-O-CH2COOH
|
Others | Others |
Boc-NH-PEG1-Ph-O-CH2COOH is a PROTAC Linker which is used for the EED-targeted PROTAC[1]. | |||
T18672 |
(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc
VH032-O-Ph-PEG1-NH-Boc |
Others | Others |
(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is an E3 ligase ligand-linker conjugate, specifically designed for targeting the EED protein in PROTAC applications[1]. | |||
T18665 |
(S,R,S)-AHPC-C4-NH2 dihydrochloride
VH032-C4-NH2 dihydrochloride |
Others | Others |
(S,R,S)-AHPC-C4-NH2 dihydrochloride is a chemically derived E3 ligase ligand-linker conjugate, consisting of the (S,R,S)-AHPC VHL ligand and a linker specifically designed for EED-Targeted PROTAC[1]. | |||
T17653 |
Boc-NH-C4-acid
Boc-5-氨基戊酸 |
Others; PROTAC Linker | Others; PROTAC |
Boc-NH-C4-acid 是一种属于 Alkyl/ether 类的 PROTAC linker,可用于 PROTAC1 的合成,并且可以降解 PRC2 中的 EED,EZH2,和 SUZ12。 | |||
T18664 |
(S,R,S)-AHPC-C3-NH2
VH032-C3-NH2 |
Others | Others |
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized conjugate consisting of an E3 ligase ligand-linker and the VH032 based VHL ligand, which is commonly used in PROTAC technology. This compound serves as a key component in the synthesis of various PROTACs, including UNC6852. UNC6852 is a bivalent chemical degrader specifically targeting EED [1]. | |||
T61975 |
Pociredir
|
Others | Others |
Pociredir (FTX-6058) 是一种有效的、选择性的、具有口服活性的胚胎外胚层发育蛋白 (EED) 小分子抑制剂(KD= 0.163 nM)。Pociredir (FTX-6058) 在研究炎症或血红蛋白病中具有研究价值,如镰状细胞病 (SCD)。 | |||
T18666 |
(S,R,S)-AHPC-C4-NH2
VH032-C4-NH2 |
Others | Others |
(S,R,S)-AHPC-C4-NH2 is a custom-synthesized conjugate of an E3 ligase ligand-linker, which combines the VHL ligand based on (S,R,S)-AHPC and a linker specifically designed for EED-Targeted PROTAC[1]. | |||
T40154 |
FTX-6058
|
Others | Others |
FTX-6058 is a potent orally active inhibitor targeting Embryonic Ectoderm Development (EED). It effectively induces HbF protein expression in both cell and murine models. This compound holds significant potential for researching select hemoglobinopathies such as sickle cell disease and β-thalassemia. | |||
T40155 |
FTX-6058 hydrochloride
|
Others | Others |
FTX-6058 hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED), with the ability to induce HbF protein expression in both cell and murine models. This compound is particularly valuable in the research of select hemoglobinopathies, such as sickle cell disease and β-thalassemia. | |||
T18663 |
(S,R,S)-AHPC-C3-NH2 TFA (2361119-88-0 free base)
(S,R,S)-AHPC-C3-NH2 TFA,VH032-C3-NH2 TFA |
Others | Others |
(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, suc |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6520 |
Grape Seed Extract
Grape Seed P.E.,葡萄籽提取物 |
Apoptosis; Others | Apoptosis; Others |
Grape Seed Extract (Grape Seed P.E.) 是葡萄植物 Vitis vinifera 的种子分泌物,能诱导人类结肠直肠癌细胞凋亡,具有抗炎和抗增殖作用。它对脂肪代谢酶、胰脂肪酶和脂蛋白脂肪酶有抑制作用。 | |||
T13626 |
Cottonseed oil
|
Others | Others |
Cottonseed oil 是一种提取自棉花种子中的食用油,是一种植物油中杀虫能力极强的油。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02379 |
EED Protein, Human, Recombinant (His & GST)
HEED,WAIT1,embryonic ectoderm development |
Human | Baculovirus Insect Cells |
EED is essential for regulating the repressive histone modification, histone 3 lysine 27 tri-methylation (H3K27me3) at many developmental genes. EED depletion significantly impeded erythroid maturation. EED depletion impaired the generation of hematopoietic stem cells. The function of EED within polycomb repressive complex 2 (PRC2) is mediated by a complex network of protein-protein interactions. The targeted disruption of EED's reader function can lead to allosteric inhibition of PRC2 catalyti... | |||
TMPY-04492 |
Influenza A H5N8 (A/breeder duck/Korea/Gochang1/2014) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N8 | HEK293 Cells |
Influenza A H5N8 (A/breeder duck/Korea/Gochang1/2014) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.2 kDa and the accession number is W8P1W5. | |||
TMPH-00319 |
Type III secretion system needle Protein, Burkholderia thailandensis, Recombinant (His)
yscF |
Burkholderia thailandensis | P. pastoris (Yeast) |
Type III secretion system needle Protein, Burkholderia thailandensis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 11.9 kDa and the accession number is Q2T727. | |||
TMPY-04737 |
Influenza A H5N8 (A/breeder duck/Korea/Gochang1/2014) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N8 | Baculovirus Insect Cells |
Influenza A H5N8 (A/breeder duck/Korea/Gochang1/2014) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60 kDa and the accession number is W8P1W5. | |||
TMPY-06800 |
Amb a 1 Protein, Short ragweed, Recombinant
|
Short ragweed | E. coli |
Amb a 1 Protein, Short ragweed, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 39.5 kDa. |