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Search Results for " e3 ligase "

Targets Recommended: E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase Ligand for E3 Ligase

450

抑制剂 & 化合物

5

天然产物

78

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9809	E3 ligase Ligand 23	Ligand for E3 Ligase	PROTAC
	E3 ligase Ligand 23 是一种 cereblon 结合剂，可通过泛素蛋白酶体降解 Ikaros 或 Aiolos。
T17879	E3 ligase Ligand 8	Others; Ligand for E3 Ligase	Others; PROTAC
	E3 ligase Ligand 8 是 E3 泛素连接酶配体。它能够利用 linker 与靶蛋白配体连接，形成 PROTAC 分子。PROTAC 可诱导促癌蛋白发生泛素化降解。
T17871	E3 ligase Ligand 13	Others	Others
	E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
T7763	Thalidomide-4-OH Cereblon ligand 2,E3 ligase Ligand 2	Ligand for E3 Ligase	PROTAC
	Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T7756	Pomalidomide-PEG4-Ph-NH2	Ligand for E3 Ligase	PROTAC
	Pomalidomide-PEG4-Ph-NH2 是一种合成的 E3 连接酶配体- linker 偶联物，结合了基于 Pomalidomide 的 cereblon 配体和 4 单元 PEG linker。
T17872	E3 ligase Ligand 14	Others	Others
	E3 ligase Ligand 14 is a ligand that binds to E3 ubiquitin ligase and can be conjugated to a protein ligand via a linker to create PROTACs. These PROTACs are capable of promoting ubiquitination-mediated degradation of cancer-promoting proteins[1].
T17868	E3 ligase Ligand 10	Others	Others
	E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].
T17870	cIAP1 ligand 1 E3 ligase Ligand 12	Others	Others
	cIAP1 ligand 1 (E3 ligase Ligand 12) 是基于 LCL161 衍生物的细胞凋亡蛋白配体，可募集 IAP 泛素连接酶以降解靶蛋白，可用于和雄激素受体配体欧联开发蛋白降解剂，可用于研究前列腺癌。
T18064	Lenalidomide-Br	Ligand for E3 Ligase	PROTAC
	Lenalidomide-Br 是一种用于 E3 泛素连接酶的 cereblon (CRBN) 配体 Lenalidomide 的类似物，用于 CRBN 蛋白的募集。它能够利用 linker 连接到蛋白质配体上形成 PROTAC，如 PROTAC STAT3 降解剂 SD-36。
T17876	E3 ligase Ligand 18	Others	Others
	E3 ligase Ligand 18 is a ligand that binds to E3 ubiquitin ligase, and it can be chemically attached to a protein ligand through a linker to create PROTACs. The resulting PROTACs function as inducers of ubiquitination-mediated degradation, targeting cancer-promoting proteins[1].
T17880	E3 ligase Ligand 9	Others	Others
	E3 ligase Ligand 9 is a compound that serves as a ligand for E3 ubiquitin ligase. It can be linked to the protein ligand through a linker, forming PROTACs or SNIPERs. These PROTACs are known to induce the degradation of cancer-promoting proteins through ubiquitination-mediated mechanisms[1].
T7752	(S,R,S)-AHPC-Me VHL ligand 2,E3 ligase Ligand 1A	Ligand for E3 Ligase	PROTAC
	(S,R,S)-AHPC-Me是基于 (S,R,S)-AHPC 的的 VHL 配体，可用于募集 von Hippel-Lindau (VHL) 蛋白。它可有效降解去势抵抗性前列腺癌细胞中的 BET 蛋白，DC50<1 nM。它可用于合成 ARV-771。
T5334	VL285	Others; Ligand for E3 Ligase	Others; PROTAC
	VL285 是VHL 配体，IC50=0.34 μM。
T18066	Lenalidomide-OH	Ligand for E3 Ligase	PROTAC
	Lenalidomide-OH 是一种用于 E3 泛素连接酶 (CRBN) 的 cereblon 配体 Lenalidomide 的类似物，用于 CRBN 蛋白的募集。它能够利用 linker 连接到蛋白质配体上形成 PROTAC。
T18831	Thalidomide-propargyl	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-propargyl 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到含 IMiD 的 PROTAC。
T40503	Thalidomide-5-methyl	Ligand for E3 Ligase	PROTAC
	Thalidomide-5-methyl 是基于 Thalidomide 的 CRBN 配体，可以用于CRBN 的招募。
T7753	Thalidomide-O-COOH Cereblon ligand 3,E3 ligase Ligand 3,TCE35031	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T17877	VH032-cyclopropane-F VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101	Others; Ligand for E3 Ligase	Others; PROTAC
	VH032-cyclopropane-F 是基于 VH032 的 VHL 配体。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子，如 PROTAC 1。PROTAC 1 是 SMARCA2 和 SMARCA4 的部分降解剂。
T7755	Thalidomide 4-fluoride E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮	IRAK; Ligand for E3 Ligase	Immunology/Inflammation; NF-κB; PROTAC
	Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。
T13671	(S,R,S)-AHPC-Me hydrochloride VHL ligand 2 hydrochloride,E3 ligase Ligand 1	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein.
TQ0121	VH-298	Others; HIF; Ligand for E3 Ligase	Angiogenesis; Chromatin/Epigenetic; Others; PROTAC
	VH-298 是一种高效的 VHL:HIF-α 相互作用抑制剂(Kd:80-90 nM)。它可用于PROTAC 技术中。
T17916	Pomalidomide-PEG4-C2-NH2 Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22	Others; Ligand for E3 Ligase	Others; PROTAC
	Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体- linker 偶联物，用于 PROTAC 技术中。
T14893	CC-885	Others; Ligand for E3 Ligase	Others; PROTAC
	CC-885 是一种 CRBN 蛋白调节剂，有抗肿瘤的潜能。
T0213	Thalidomide Thalomid,沙利度胺,Sedoval	Apoptosis; TNF; Autophagy; Ligand for E3 Ligase; Molecular Glues	Apoptosis; Autophagy; PROTAC
	Thalidomide (Thalomid) 能够抑制 cereblon，即 cullin-4 E3 泛素连接酶复合物 CUL4-RBX1-DDB1 的一部分，Kd 值约为 250 nM，具有免疫调节、抗炎、抗肿瘤作用。它可以作为分子胶来增强底物。
T17919	Thalidomide-O-amido-C6-NH2 TFA E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。可用于 PROTAC 的合成分子。
T17325	Pomalidomide-PEG4-C-COOH Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T40019	Thalidomide-5-NH2-CH2-COOH	Others	Others
	Thalidomide-5-NH2-CH2-COOH (compound 114) 是原肌球蛋白受体激酶的选择性抑制剂。它是 E3 连接酶的配体，具有研究一种或多种疾病的潜力。
T15189	Thalidomide-O-amido-C4-N3 E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) 是一种 E3 连接酶配体- linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 linker。
T22922	Lenalidomide hemihydrate	TNF; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Lenalidomide hemihydrate 是 Thalidomide 的衍生物，也是具有口服活性免疫调节剂，以分子胶的方式作用。它是泛素 E3 连接酶 cereblon 的配体，通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。
T7759	Thalidomide-O-amido-C4-NH2 TFA E3 ligase Ligand-Linker Conjugates 19 TFA,Cereblon Ligand-Linker Conjugates 6 TFA	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide-O-amido-C4-NH2 TFA (E3 ligase Ligand-Linker Conjugates 19 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T7760	Thalidomide-O-amido-C3-NH2 TFA Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA	E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase	PROTAC
	Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，。
T17918	Thalidomide-O-amido-PEG2-C2-NH2 TFA E3 Ligase Ligand-Linker Conjugates 24 TFA,Cereblon Ligand-Linker Conjugates 10 TFA	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) 包含基于 Thalidomide 的 cereblon 配体和 2 个单元的 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T7758	Thalidomide-O-amido-PEG3-C2-NH2 TFA E3 ligase Ligand-Linker Conjugates 14 TFA,Cereblon Ligand-Linker Conjugates 3 (TFA)	Others; E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) 包含基于 Thalidomide 的 cereblon 配体和 3 个单元的 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T8824	CRBN modulator-1 WUN29654	Others; Ligand for E3 Ligase	Others; PROTAC
	CRBN modulator-1 (WUN29654) 是一种 Thalidomide 类似物。它是一种 CRBN 调节剂，结合 CRBN 的 IC50=3.5 μM，Ki=0.98 μM。
T18640	(S,R,S)-AHPC-C4-NH2 hydrochloride VH032-C4-NH2 hydrochloride,E3 ligase Ligand-Linker Conjugates 28,VHL Ligand-Linker Conjugates 13	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) 是一种合成的 E3 连接酶配体- linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 linker。
T17909	(S,R,S)-AHPC-PEG3-N3 VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12	Others; E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T17920	(S,R,S)-AHPC-PEG1-N3 VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) 是 E3 连接酶配体和linker 连接得到的偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 1 个单元 PEG linker。
T10359	AR antagonist 1	Androgen Receptor; Ligand for E3 Ligase; Ligands for Target Protein for PROTAC	Endocrinology/Hormones; PROTAC
	AR antagonist 1 是 AR 拮抗剂，能够与 E3 连接酶配体结合，与 VHL 蛋白结合亲和力较弱，用于 PROTACARD-266 合成。
T60024	CFT7455 Cemsidomide	Ligand for E3 Ligase	PROTAC
	CFT7455 (Cemsidomide) 是一种抗癌剂，对 cereblon E3 连接酶具有高亲和力，Kd 为 0.9 nM。 CFT7455 是锌指转录因子 Ikaros (IKZF1) 和 Aiolos (IKZF3) 的口服活性降解剂。
T2384	Pomalidomide CC-4047,泊马度胺	Apoptosis; TNF; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Pomalidomide (CC-4047) 是一种抗血管生成剂和免疫调节剂，以分子胶的方式作用。它与 E3 连接酶 cereblon 相互作用，诱导必需的 Ikaros 转录因子的降解。
T15190L	(S,R,S)-AHPC-PEG4-NH2 VHL Ligand-Linker Conjugates 4,E3 ligase Ligand-Linker Conjugates 7 Free Base,VH032-PEG4-NH2	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) 是一种合成的 E3 连接酶配体-接头偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 4 单元 PEG 接头。
T1642	Lenalidomide 来那度胺,CC-5013	Apoptosis; TNF; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Lenalidomide (CC-5013) 是 Thalidomide 的衍生物，也是具有口服活性免疫调节剂，以分子胶的方式作用。它是泛素 E3 连接酶 cereblon (CRBN) 的配体，可通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。
T5821	BC-1215	Others; Ligand for E3 Ligase	Others; PROTAC
	BC-1215 是一种 F-box protein 3 抑制剂。它能够稳定 TRAF1-TRAF6 来抑制 Fbxo3-TRAF 激活途径。它与 ApaG 相互作用，阻碍来自人 PBMC 广谱 TH1 细胞因子的分泌。
T17921	(S,R,S)-AHPC-PEG4-N3 VH032-PEG4-N3,VHL Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 4	Others; PROTAC Linker	Others; PROTAC
	(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology.
T8564	BC-1382	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	BC-1382 是E3泛素连接酶HECTD2抑制剂，能够特异性破坏 HECTD2/PIAS1 相互作用 (IC50≈ 5 nM)。BC-1382具有抗炎活性。
T24136	Heclin	E1/E2/E3 Enzyme	Ubiquitination
	Heclin 是一种 HECT E3 泛素连接酶抑制剂，通过抑制 Smurf2、Nedd4 和 WWP1 起作用，IC50 值分别为 6.8、6.3 和 6.9 μM。
T17924	(S,R,S)-AHPC-PEG2-NH2 hydrochloride VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 的合成分子。
T9291	Thalidomide-5-OH 4 - 羟基沙利度胺,2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) 是基于 Thalidomide 的的cereblon 配体，可用于募集CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T17922	(S,R,S)-AHPC-PEG3-NH2 hydrochloride VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) 是一种 E3 ligase ligand-linker conjugate，包含了 (S,R,S)-AHPC-based VHL ligand 和 3-unit PEG linker。
T7791	Iberdomide CC-220	Apoptosis; Ligand for E3 Ligase	Apoptosis; PROTAC
	Iberdomide (CC-220) 是一种口服有效的 cereblon E3 连接酶调节剂，对 cereblon 结合亲和力的 IC50约为150 nM。它是沙利度胺的衍生物，具有抗肿瘤和免疫刺激活性。

化合物

E3 ligase Ligand 23

Cat.No: T9809

Target: Ligand for E3 Ligase

E3 ligase Ligand 8

Cat.No: T17879

Target: Others, Ligand for E3 Ligase

E3 ligase Ligand 13

Cat.No: T17871

Target: Others

Thalidomide-4-OH

Cat.No: T7763

Synonym: Cereblon ligand 2,E3 ligase Ligand 2

Target: Ligand for E3 Ligase

Pomalidomide-PEG4-Ph-NH2

Cat.No: T7756

Target: Ligand for E3 Ligase

E3 ligase Ligand 14

Cat.No: T17872

Target: Others

E3 ligase Ligand 10

Cat.No: T17868

Target: Others

Cat.No: T17870

Synonym: E3 ligase Ligand 12

Target: Others

Lenalidomide-Br

Cat.No: T18064

Target: Ligand for E3 Ligase

E3 ligase Ligand 18

Cat.No: T17876

Target: Others

E3 ligase Ligand 9

Cat.No: T17880

Target: Others

(S,R,S)-AHPC-Me

Cat.No: T7752

Synonym: VHL ligand 2,E3 ligase Ligand 1A

Target: Ligand for E3 Ligase

Cat.No: T5334

Target: Others, Ligand for E3 Ligase

Lenalidomide-OH

Cat.No: T18066

Target: Ligand for E3 Ligase

Thalidomide-propargyl

Cat.No: T18831

Target: Others, Ligand for E3 Ligase

Thalidomide-5-methyl

Cat.No: T40503

Target: Ligand for E3 Ligase

Thalidomide-O-COOH

Cat.No: T7753

Synonym: Cereblon ligand 3,E3 ligase Ligand 3,TCE35031

Target: Others, Ligand for E3 Ligase

VH032-cyclopropane-F

Cat.No: T17877

Synonym: VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101

Target: Others, Ligand for E3 Ligase

Thalidomide 4-fluoride

Cat.No: T7755

Synonym: E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮

Target: IRAK, Ligand for E3 Ligase

(S,R,S)-AHPC-Me hydrochloride

Cat.No: T13671

Synonym: VHL ligand 2 hydrochloride,E3 ligase Ligand 1

Target: Others, Ligand for E3 Ligase

Cat.No: TQ0121

Target: Others, HIF, Ligand for E3 Ligase

Pomalidomide-PEG4-C2-NH2

Cat.No: T17916

Synonym: Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22

Target: Others, Ligand for E3 Ligase

Cat.No: T14893

Target: Others, Ligand for E3 Ligase

Cat.No: T0213

Synonym: Thalomid,沙利度胺,Sedoval

Target: Apoptosis, TNF, Autophagy, Ligand for E3 Ligase, Molecular Glues

Thalidomide-O-amido-C6-NH2 TFA

Cat.No: T17919

Synonym: E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA

Target: Others, Ligand for E3 Ligase

Pomalidomide-PEG4-C-COOH

Cat.No: T17325

Synonym: Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1

Target: Others, E3 Ligase Ligand-Linker Conjugate

Thalidomide-5-NH2-CH2-COOH

Cat.No: T40019

Target: Others

Thalidomide-O-amido-C4-N3

Cat.No: T15189

Synonym: E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4

Target: Others, Ligand for E3 Ligase

Lenalidomide hemihydrate

Cat.No: T22922

Target: TNF, Ligand for E3 Ligase, Molecular Glues

Thalidomide-O-amido-C4-NH2 TFA

Cat.No: T7759

Synonym: E3 ligase Ligand-Linker Conjugates 19 TFA,Cereblon Ligand-Linker Conjugates 6 TFA

Target: E3 Ligase Ligand-Linker Conjugate

Thalidomide-O-amido-C3-NH2 TFA

Cat.No: T7760

Synonym: Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA

Target: E3 Ligase Ligand-Linker Conjugate, Ligand for E3 Ligase

Thalidomide-O-amido-PEG2-C2-NH2 TFA

Cat.No: T17918

Synonym: E3 Ligase Ligand-Linker Conjugates 24 TFA,Cereblon Ligand-Linker Conjugates 10 TFA

Target: Others, E3 Ligase Ligand-Linker Conjugate

Thalidomide-O-amido-PEG3-C2-NH2 TFA

Cat.No: T7758

Synonym: E3 ligase Ligand-Linker Conjugates 14 TFA,Cereblon Ligand-Linker Conjugates 3 (TFA)

Target: Others, E3 Ligase Ligand-Linker Conjugate, Ligand for E3 Ligase

CRBN modulator-1

Cat.No: T8824

Synonym: WUN29654

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-C4-NH2 hydrochloride

Cat.No: T18640

Synonym: VH032-C4-NH2 hydrochloride,E3 ligase Ligand-Linker Conjugates 28,VHL Ligand-Linker Conjugates 13

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG3-N3

Cat.No: T17909

Synonym: VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12

Target: Others, E3 Ligase Ligand-Linker Conjugate, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG1-N3

Cat.No: T17920

Synonym: VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3

Target: Others, Ligand for E3 Ligase

AR antagonist 1

Cat.No: T10359

Target: Androgen Receptor, Ligand for E3 Ligase, Ligands for Target Protein for PROTAC

Cat.No: T60024

Synonym: Cemsidomide

Target: Ligand for E3 Ligase

Cat.No: T2384

Synonym: CC-4047,泊马度胺

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

(S,R,S)-AHPC-PEG4-NH2

Cat.No: T15190L

Synonym: VHL Ligand-Linker Conjugates 4,E3 ligase Ligand-Linker Conjugates 7 Free Base,VH032-PEG4-NH2

Target: Others, Ligand for E3 Ligase

Cat.No: T1642

Synonym: 来那度胺,CC-5013

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

Cat.No: T5821

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG4-N3

Cat.No: T17921

Synonym: VH032-PEG4-N3,VHL Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 4

Target: Others, PROTAC Linker

Cat.No: T8564

Target: Others, E1/E2/E3 Enzyme

Cat.No: T24136

Target: E1/E2/E3 Enzyme

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

Cat.No: T17924

Synonym: VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6

Target: Others, E3 Ligase Ligand-Linker Conjugate

Thalidomide-5-OH

Cat.No: T9291

Synonym: 4 - 羟基沙利度胺,2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

Cat.No: T17922

Synonym: VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl

Target: Others, E3 Ligase Ligand-Linker Conjugate

Cat.No: T7791

Synonym: CC-220

Target: Apoptosis, Ligand for E3 Ligase

Cat. No.	Product Name	Target	Signaling Pathways
T4S0181	Hinokiflavone 日本扁柏黄酮,扁柏双黄酮	MMP; BCL; E1/E2/E3 Enzyme	Apoptosis; Proteases/Proteasome; Ubiquitination
	Hinokiflavone 是pre-mRNA 剪接活性的新型调节剂，通过抑制剪接体装配来阻止pre-mRNA 底物的剪接，特别是阻止 B complex 的形成。它是SUMO protease 蛋白酶抑制剂，能够抑制前哨蛋白特异性蛋白酶 1 的活性。
T9352	hydrocotarnine	Others	Others
	hydrocotarnine 是 Cbl 的抑制剂。
T4036	Solasodine Solancarpidine,Purapuridine,澳洲茄铵,Solasodin	Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal	Apoptosis; Microbiology/Virology; Others; Ubiquitination
	Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。
T6S2123	Ginkgolic Acid Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	Ginkgolic Acid (Romanicardic acid) 是一种天然化合物，在体外实验中抑制SUMOylation，IC50=3.0 μM。
T2947	Indole-3-carbinol 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol	E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination
	Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。

天然产物

Cat.No: T4S0181

Synonym: 日本扁柏黄酮,扁柏双黄酮

Target: MMP, BCL, E1/E2/E3 Enzyme

Cat.No: T9352

Target: Others

Cat.No: T4036

Synonym: Solancarpidine,Purapuridine,澳洲茄铵,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

Cat.No: T6S2123

Synonym: Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1

Target: Others, E1/E2/E3 Enzyme

Indole-3-carbinol

Cat.No: T2947

Synonym: 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol

Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00361	Pellino-1 Protein, Human, Recombinant (His & GST) pellino E3 ubiquitin protein ligase 1,PRIS...	Human	Baculovirus Insect Cells
	PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant cell death and maintaining cellular homeostasis. PELI1 might participate in B-cell maturation or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages.
TMPH-02631	PRKN Protein, Mouse, Recombinant (GST) E3 ubiquitin-protein ligase parkin,Prkn,Pa...	Mouse	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det...
TMPH-03281	PRKN Protein, Rat, Recombinant (His & Myc) E3 ubiquitin-protein ligase parkin,Parkin ...	Rat	Baculovirus Insect Cells
	PRKN Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 55.6 kDa and the accession number is Q9JK66.
TMPK-01001	RNF43 Protein, Mouse, Recombinant (hFc) Rnf43,RING finger protein 43,RING-type E3 ubiquitin...	Mouse	HEK293 Cells
	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
TMPH-01263	PRKN Protein, Human, Recombinant (His & SUMO) PRKN,Parkin RBR E3 ubiquitin-protein ligase	Human	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det...
TMPH-01273	TRIP12 Protein, Human, Recombinant (His & Myc) Thyroid receptor-interacting protein 12,E3 ubiquiti...	Human	E. coli
	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag...
TMPH-01262	PRKN Protein, Human, Recombinant (His & Myc) Parkinson juvenile disease protein 2,E3 ubiquitin-p...	Human	Baculovirus Insect Cells
	PRKN Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 55.6 kDa and the accession number is O60260.
TMPH-01269	SMURF2 Protein, Human, Recombinant (His) SMAD ubiquitination regulatory factor 2,E3 ubiquiti...	Human	E. coli
	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com...
TMPH-00085	SIZ1 Protein, Arabidopsis thaliana, Recombinant (His) E3 SUMO-protein ligase SIZ1,SIZ1,E3	Arabidopsis thaliana	E. coli
	E3 SUMO protein ligase involved in regulation processes. Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses. Functions as an upstream negative regulator of salicylic acid (SA) accumulation and subsequent SA-mediated systemic acquired resistance (SAR) signaling. Probably not involved in jasmonic acid (JA)-mediated defense response. Participates in abiotic stress-induced sumoylation. Controls heat shock-induced SUMO1 and SUMO2 conjugat...
TMPY-01654	ITCH Protein, Human, Recombinant (aa 526-903) itchy E3 ubiquitin protein ligase,NAPP1,dJ...	Human	E. coli
	E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and contains four WW domains. ITCH acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-...
TMPH-01265	PELI3 Protein, Human, Recombinant (His) PELI3,E3 ubiquitin-protein ligase pellino ...	Human	E. coli
	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. PELI3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.8 kDa and the access...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc) RING finger protein 8,RNF8,E3 ubiquitin-protein	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...
TMPH-01261	NEDD4L Protein, Human, Recombinant (GST) NEDD4L,HECT-type E3 ubiquitin transferase NED4L,Ned...	Human	E. coli
	NEDD4L Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 138.5 kDa and the accession number is Q96PU5.
TMPH-03391	TRIM2 Protein, Rat, Recombinant (His) Trim2,Tripartite motif-containing protein 2,E3 ubiq...	Rat	E. coli
	E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. TRIM2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.5 kDa and the accession number is D3ZQG6.
TMPH-03508	IpaH9.8 Protein, Shigella flexneri, Recombinant (His) E3 ubiquitin-protein ligase ipaH9.8,ipaH9....	Shigella flexneri	P. pastoris (Yeast)
	Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. IpaH9.8 Protein, Shigella flexneri, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 64.0 kDa and the accession number is D2AJU0.
TMPH-01266	RNF13 Protein, Human, Recombinant (His) RING finger protein 13,E3 ubiquitin-protein lig...	Human	E. coli
	RNF13 Protein, Human, Recombinant (His) is expressed in E. coli with N-terminal 10xHis tag. The predicted molecular weight is 26.2 kDa. Accession number: O43567
TMPY-03510	Cbl-c Protein, Human, Recombinant (His & GST) Cbl proto-oncogene C, E3 ubiquitin protein liga...	Human	Baculovirus Insect Cells
	CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c g...
TMPY-02950	WWP2 Protein, Human, Recombinant (His & GST) WW domain containing E3 ubiquitin protein ligas...	Human	Baculovirus Insect Cells
	WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-6...
TMPH-01268	SIAH1 Protein, Human, Recombinant (GST) SIAH1,RING-type E3 ubiquitin transferase SIAH1,Siah...	Human	E. coli
	SIAH1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 61.6 kDa and the accession number is Q8IUQ4.
TMPH-01274	ZNRF3 Protein, Human, Recombinant (His & SUMO) RING-type E3 ubiquitin transferase ZNRF3,E3	Human	E. coli
	E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ...
TMPH-02210	TRAF6 Protein, Human, Recombinant (His & SUMO) RING finger protein 85,E3 ubiquitin-protein lig...	Human	E. coli
	TRAF6 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 75.6 kDa and the accession number is Q9Y4K3.
TMPH-01275	ZNRF3 Protein, Human, Recombinant (His) ZNRF3,RING-type E3 ubiquitin transferase ZNRF3,RING...	Human	HEK293 Cells
	E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ...
TMPH-01272	TRIM9 Protein, Human, Recombinant (His & SUMO) RING finger protein 91,RING-type E3 ubiquitin trans...	Human	E. coli
	E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
TMPH-01264	PELI1 Protein, Human, Recombinant (His) E3 ubiquitin-protein ligase pellino homolo...	Human	Baculovirus Insect Cells
	PELI1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 48.8 kDa and the accession number is Q96FA3.
TMPH-02630	MDM2 Protein, Mouse, Recombinant (His) E3 ubiquitin-protein ligase Mdm2,RING-type...	Mouse	E. coli
	MDM2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.6 kDa and the accession number is P23804.
TMPH-01270	TRAIP Protein, Human, Recombinant (His) E3 ubiquitin-protein ligase TRAIP,TRAF-int...	Human	E. coli
	E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm...
TMPH-03282	TRIM63 Protein, Rat, Recombinant (His & Myc) Muscle-specific RING finger protein 1,Tripartite motif-conta...	Rat	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate...
TMPH-02634	TRIM63 Protein, Mouse, Recombinant (His & Myc) Trim63,Muscle-specific RING finger protein 1,Tripartite moti...	Mouse	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate...
TMPH-01904	HERC1 Protein, Human, Recombinant (His & Myc) HECT domain and RCC1-like domain-containing protein 1,p619,H...	Human	E. coli
	HERC1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-02050	RNF114 Protein, Human, Recombinant (GST) Zinc finger protein 313,RING finger protein 114,RNF114,E...	Human	E. coli
	RNF114 Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-01950	PML Protein, Human, Recombinant (His) PML,Tripartite motif-containing protein 19,Protein PML,RING ...	Human	E. coli
	PML Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is P29590.
TMPH-01259	AMFR Protein, Human, Recombinant (His) Autocrine motility factor receptor,AMF receptor,gp78,RNF45,R...	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add...
TMPH-02221	TRIM24 Protein, Human, Recombinant (His & SUMO) Transcription intermediary factor 1-alpha,E3 ubiqui...	Human	E. coli
	Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apopt...
TMPH-01949	PML Protein, Human, Recombinant (His & Myc) PML,Tripartite motif-containing protein 19,RING-type E3<...	Human	Baculovirus Insect Cells
	PML Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 24.5 kDa and the accession number is P29590.
TMPH-01260	AMFR Protein, Human, Recombinant (hFc) gp78,RNF45,AMF receptor,RING finger protein 45,E3 u...	Human	HEK293 Cells
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add...
TMPY-06026	VHL Protein, Human, Recombinant (His & Avi) RCA1,HRCA1,pVHL,VHL1,von Hippel-Lindau tumor suppressor,	Human	E. coli
	VHL Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is A0A024R2F2.
TMPH-01271	TRIM63 Protein, Human, Recombinant (His & Myc) TRIM63,Striated muscle RING zinc finger protein,RING-type	Human	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate...
TMPJ-01386	STUB1 Protein, Human, Recombinant Carboxy Terminus of Hsp70-Interacting Protein,STIP1 Homology...	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation....
TMPH-02632	TRIM21 Protein, Mouse, Recombinant (E. coli, His) Trim21,52 kDa ribonucleoprotein autoantigen Ro/SS-A,Triparti...	Mouse	E. coli
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...
TMPY-01216	XIAP Protein, Human, Recombinant (Avi) hIAP-3,IAP-3,MIHA,ILP1,BIRC4,hIAP3,API3,XLP2,X-linked inhibi...	Human	E. coli
	XIAP Protein, Human, Recombinant (Avi) is expressed in E. coli expression system with AVI tag. The predicted molecular weight is 29.1 kDa and the accession number is P98170.
TMPH-02633	TRIM21 Protein, Mouse, Recombinant (His) Tripartite motif-containing protein 21,E3 ubiquitin...	Mouse	Baculovirus Insect Cells
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...
TMPY-02922	XIAP Protein, Human, Recombinant (His) hIAP-3,API3,XLP2,ILP1,MIHA,X-linked inhibitor of apoptosis, ...	Human	E. coli
	XIAP Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.3 kDa and the accession number is P98170.
TMPH-02288	UBE2D3 Protein, Human, Recombinant (His & SUMO) (E3-independent) E2 ubiquitin-conjugating enzyme D3...	Human	E. coli
	UBE2D3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.7 kDa and the accession number is P61077.
TMPH-03364	RBCK1 Protein, Rat, Recombinant (His & Myc) Heme-oxidized IRP2 ubiquitin ligase 1 homolog,RING-...	Rat	E. coli
	RBCK1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 65.1 kDa and the accession number is Q62921.
TMPY-04153	RNF43 Protein, Human, Recombinant (His) ring finger protein 43,URCC,RNF43,RNF124	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and t...
TMPY-02521	HIST3H2A Protein, Human, Recombinant histone cluster 3, H2a,MGC3165	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machinery that set them are crucial regulators that can control cellular proliferation, differentiation,...
TMPH-01204	DCAF4 Protein, Human, Recombinant (His & SUMO) DCAF4,DDB1- and CUL4-associated factor 4,WDR21,WDR21A,WD rep...	Human	E. coli
	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
TMPH-02136	SPSB1 Protein, Human, Recombinant (His) SPSB1,SPRY domain-containing SOCS box protein 1	Human	E. coli
	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
TMPH-03526	Cap8A Protein, S. aureus, Recombinant (His) MAGEB2,MAGE XP-2 antigen,DAM6,MAGE-B2 antigen,Melanoma-assoc...	Staphylococcus aureus	E. coli
	May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Cap8A Protein, S. aureus, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is O15479.
TMPJ-00441	CDH1 Protein, Human, Recombinant (His) CDH1 protein,CDH1	Human	HEK293 Cells
	Cdh1 is one of the substrate adaptor protein of the anaphase-promoting complex (APC) in the budding yeast Saccharomyces cerevisiae. Functioning as an activator of the APC/C, Cdh1 regulates the activity and substrate specificity of this ubiquitin E3-ligase.
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重组蛋白

Pellino-1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-00361

Species: Human

Expression System: Baculovirus Insect Cells

PRKN Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02631

Species: Mouse

Expression System: E. coli

PRKN Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03281

Species: Rat

Expression System: Baculovirus Insect Cells

RNF43 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01001

Species: Mouse

Expression System: HEK293 Cells

PRKN Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01263

Species: Human

Expression System: E. coli

TRIP12 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01273

Species: Human

Expression System: E. coli

PRKN Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01262

Species: Human

Expression System: Baculovirus Insect Cells

SMURF2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01269

Species: Human

Expression System: E. coli

SIZ1 Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00085

Species: Arabidopsis thaliana

Expression System: E. coli

ITCH Protein, Human, Recombinant (aa 526-903)

Cat.No: TMPY-01654

Species: Human

Expression System: E. coli

PELI3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01265

Species: Human

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

NEDD4L Protein, Human, Recombinant (GST)

Cat.No: TMPH-01261

Species: Human

Expression System: E. coli

TRIM2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03391

Species: Rat

Expression System: E. coli

IpaH9.8 Protein, Shigella flexneri, Recombinant (His)

Cat.No: TMPH-03508

Species: Shigella flexneri

Expression System: P. pastoris (Yeast)

RNF13 Protein, Human, Recombinant (His)

Cat.No: TMPH-01266

Species: Human

Expression System: E. coli

Cbl-c Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03510

Species: Human

Expression System: Baculovirus Insect Cells

WWP2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02950

Species: Human

Expression System: Baculovirus Insect Cells

SIAH1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01268

Species: Human

Expression System: E. coli

ZNRF3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01274

Species: Human

Expression System: E. coli

TRAF6 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02210

Species: Human

Expression System: E. coli

ZNRF3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01275

Species: Human

Expression System: HEK293 Cells

TRIM9 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01272

Species: Human

Expression System: E. coli

PELI1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01264

Species: Human

Expression System: Baculovirus Insect Cells

MDM2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02630

Species: Mouse

Expression System: E. coli

TRAIP Protein, Human, Recombinant (His)

Cat.No: TMPH-01270

Species: Human

Expression System: E. coli

TRIM63 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03282

Species: Rat

Expression System: E. coli

TRIM63 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02634

Species: Mouse

Expression System: E. coli

HERC1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01904

Species: Human

Expression System: E. coli

RNF114 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02050

Species: Human

Expression System: E. coli

PML Protein, Human, Recombinant (His)

Cat.No: TMPH-01950

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (His)

Cat.No: TMPH-01259

Species: Human

Expression System: E. coli

TRIM24 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02221

Species: Human

Expression System: E. coli

PML Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01949

Species: Human

Expression System: Baculovirus Insect Cells

AMFR Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01260

Species: Human

Expression System: HEK293 Cells

VHL Protein, Human, Recombinant (His & Avi)

Cat.No: TMPY-06026

Species: Human

Expression System: E. coli

TRIM63 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01271

Species: Human

Expression System: E. coli

STUB1 Protein, Human, Recombinant

Cat.No: TMPJ-01386

Species: Human

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02632

Species: Mouse

Expression System: E. coli

XIAP Protein, Human, Recombinant (Avi)

Cat.No: TMPY-01216

Species: Human

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02633

Species: Mouse

Expression System: Baculovirus Insect Cells

XIAP Protein, Human, Recombinant (His)

Cat.No: TMPY-02922

Species: Human

Expression System: E. coli

UBE2D3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02288

Species: Human

Expression System: E. coli

RBCK1 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03364

Species: Rat

Expression System: E. coli

RNF43 Protein, Human, Recombinant (His)

Cat.No: TMPY-04153

Species: Human

Expression System: HEK293 Cells

HIST3H2A Protein, Human, Recombinant

Cat.No: TMPY-02521

Species: Human

Expression System: E. coli

DCAF4 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01204

Species: Human

Expression System: E. coli

SPSB1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02136

Species: Human

Expression System: E. coli

Cap8A Protein, S. aureus, Recombinant (His)

Cat.No: TMPH-03526

Species: Staphylococcus aureus

Expression System: E. coli

CDH1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00441

Species: Human

Expression System: HEK293 Cells

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