5
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13166 |
TK216
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
TK216 是一种口服有效的 E26 转录因子抑制剂,具有抗癌活性。它直接结合 EWS-FLI1 并抑制 EWS-FLI1 蛋白质相互作用,也可阻止 EWS-FLI1 与 RNA 解旋酶 A 的结合。 | |||
T1892 |
Kobe2602
|
Raf; Ras | GPCR/G Protein; MAPK |
Kobe2602 是 Ras-Raf 相互作用抑制剂,具有抗癌化疗活性。它抑制 H-Ras·GTP 与 c-Raf-1 RBD 结合的Ki 值为 149 μM。 | |||
T4638 |
E260
Fer and FerT inhibitor |
Fer/FerT kinase | Others |
E260 (Fer and FerT inhibitor) 是Fer/FerT 激酶抑制剂。 | |||
TP2468 |
PNU-145156E (FCE26644)
FCE 26644,FCE26644,PNU-145156E,PNU145156E,FCE-26644,PNU 145156E |
||
PNU-145156E (FCE26644) a novel angiogenesis inhibitor, has been shown to block circulating angiogenesis promoting growth factor in animal studies and has shown anti-tumor effects in solid tumors in mice. | |||
T24267 |
Kobe2601
Kobe 2601,Kobe-2601 |
Others | Others |
Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00854 |
ETS1 Protein, Human, Recombinant (His)
V-ets Erythroblastosis Virus E26 Oncogene Homolog 1... |
Human | E. coli |
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As... |