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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7041 |
Donepezil
E2020,Donepezilo,Aricept,多奈哌齐 |
AChE | Neuroscience |
Donepezil (Aricept) 是一种AChE 抑制剂,对牛 AChE 和人 AChE 的IC50分别为 8.12 nM 和 11.6 nM。 | |||
T6478 |
Donepezil Hydrochloride
Aricept,BNAG,E2020,Donepezil HCl,盐酸多奈哌齐 |
AChR; AChE | Neuroscience |
Donepezil HCl(Aricept) 是可逆的选择性AChE 抑制剂,IC50=6.7 nM,对 AChE 的选择性高于 BuChE。Donepezil Hydrochloride (Aricept) 对 Aβ42 神经毒性具有神经保护作用。 | |||
T0537 |
Desbenzyl Donepezil Hydrochloride
|
Others | Others |
Desbenzyl Donepezil Hydrochloride 是 Donepezil 的杂质。 | |||
T70714 |
(-)-Donepezil
|
Others | Others |
(-)-Donepezil is an isomer of Donepezil -- a nootropic acting as an inhibitor of acetylcholinesterase. | |||
T35831 |
Deoxy Donepezil (hydrochloride)
|
Others | Others |
Deoxy donepezil is a potential impurity found in bulk preparations of the acetylcholinesterase inhibitor donepezil .1It is produced as a by-product during donepezil synthesis.2 1.Krishna Reddy, K.V.S.R., Moses Babu, J., Anil Kumar, P., et al.Identification and characterization of potential impurities of donepezilJ. Pharm. Biomed. Anal.35(5)1047-1058(2004) 2.Krizmanic, I., Lerman, L., Samardzic, Z., et al.Impurities of donepezil(2009) | |||
T70697 |
(+)-Donepezil
|
Others | Others |
(+)-Donepezil is an isomer of Donepezil -- a nootropic acting as an inhibitor of acetylcholinesterase. | |||
T71258 |
Dehydrodeoxy donepezil
|
Others | Others |
Dehydrodeoxy donepezil is an inhibitor of acetylcholinesterase (AChE) | |||
T36795 |
Donepezil N-oxide
|
Others | Others |
Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil . Donepezil N-oxide inhibits cholinesterase (ChE) activity in human erythrocytes in a concentration-dependent manner, exhibiting 45.5% inhibition when used at a concentration of 20 μM. | |||
T37360 |
6-O-desmethyl Donepezil
|
Others | Others |
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil . It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6. It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 μM in HEK293 cells expressing hERG). | |||
T61638 |
Dihydro Donepezil
|
Others | Others |
Dihydro Donepezil, also known as Dihydro E2020, is a metabolite derived from Donepezil. Donepezil is a highly specific and potent inhibitor of acetylcholinesterase (AChE) with IC50 values of 8.12 nM and 11.6 nM for butyrylcholinesterase (bAChE) and human acetylcholinesterase (hAChE), respectively [1]. | |||
T12532 |
PQM130
|
Beta Amyloid | Neuroscience |
PQM130是一种魏罗酮-多奈哌齐杂化化合物,能透过大脑。PQM130是多靶点的候选药物,可用于Aβ1-42低聚物引起的神经毒性,还具有抗炎活性。它是具有神经保护作用的、有潜力的抗 AD 药物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0200 |
Donepezil-d7 Hydrochloride
|
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Donepezil-d7 Hydrochloride 是 Donepezil Hydrochloride 的氘代化合物。 | |||
TMIJ-0120 |
Donepezil-d5
|
||
Donepezil-d5 是 Donepezil 的氘代化合物。Donepezil 的 CAS 号为 120014-06-4。Donepezil 是一种AChE抑制剂,对牛 AChE 和人 AChE 的IC50分别为 8.12 nM 和 11.6 nM。 | |||
TMIJ-0121 |
(±)-Donepezil-d4 HCl
|
||
(±)-Donepezil-d4 HCl 是 (±)-Donepezil HCl 的氘代化合物。(±)-Donepezil HCl 的 CAS 号为 110119-84-1。 |