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Search Results for " dil "

Targets Recommended: Others

158

抑制剂 & 化合物

12

天然产物

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化合物库

4

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name
L5510	肝脏毒性化合物库		1001 compounds
	1001 个肝脏毒性化合物的特有集合，可用于高通量、高内涵筛选，是毒理学研究的良好工具；

化合物库

肝脏毒性化合物库

Cat.No: L5510

Compounds: 1001

Cat. No.	Product Name	Target	Signaling Pathways
T70958	Dov-Val-Dil-OH TFA	Others	Others
	Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin.
T12141	N-Boc-Val-Dil-Dap-Doe	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	N-Boc-Val-Dil-Dap-Doe is used to synthesize Dolastatin 10 , which is a potent antimitotic peptide, inhibits tubulin polymerization.
T15118	DiD perchlorate	Others	Others
	DiD perchlorate 是一种远红色荧光亲脂性花青染料。它能快速稳定地与磷脂细胞膜结合，能用于细胞追踪。
T84744	Boc-Val-Dil-Dap-OH	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Boc-Val-Dil-Dap-OH为ADCs合成使用的可降解连接桥，适用于抗体活性分子结合物。
T70956	JNJ-pan-AR	Others	Others
	JNJ-pan-AR, a meylated analogue of JNJ-63576253, is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L. JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus.
T28759	Sesamodil Sesamodil fumarate,SD-3211,SD 3211,SD3211,DS-4823	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Sesamodil（SD 3211）是一种新型钙拮抗剂，可用于研究高血压。
T5391	Bepridil hydrochloride CERM 1978,盐酸苄普地尔	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Bepridil hydrochloride (CERM 1978) 是一种钙通道阻滞剂，还抑制 Na+/Ca2+ 交换(NCX)、钠通道和心脏肌膜 KATP 通道，具有抗心绞痛的作用。
T68036	Carprazidil	Others	Others
	Carprazidil 是一种强效的血管扩张剂，可用于治疗严重高血压和轻度心力衰竭。
T12478	Pinacidil monohydrate 吡那地尔一水合物,吡那地尔	Potassium Channel	Membrane transporter/Ion channel
	Pinacidil monohydrate 是一种钾通道激活剂，用作抗高血压药。
T3278	Piribedil EU-4200,Trivastan,ET-495,Trivastal	Dopamine Receptor; Histone Methyltransferase; Adrenergic Receptor	Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
	Piribedil (Trivastan) 是多巴胺 D2受体激动剂，对 hα1A-肾上腺素受体也显示出拮抗作用。
T1606	Fasudil HA-1077,AT877,法舒地尔	ROCK; Serine/threonin kinase; Calcium Channel; PKA; PKC; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	Fasudil (HA-1077) 是一种非特异性 RhoA/ROCK 抑制剂，也是 Ca2+通道拮抗剂和血管扩张剂。它对蛋白激酶有抑制作用，ROCK1 的 Ki 值为 0.33 μM，ROCK2 和 PKA、PKC、PKG 的 IC50值分别 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM。
TQ0233	Traxoprodil 曲索罗地,CP101606	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Traxoprodil (CP101606) 是一种有效的和选择性的NMDA 拮抗剂，能够保护海马神经元，其 IC50=10 nM。
T0317	Buflomedil hydrochloride Buflomedil HCl,Fonzylane,Loftyl,盐酸丁咯地尔,丁咯地尔盐酸盐	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Buflomedil hydrochloride (Fonzylane) 是一种血管扩张剂，可用于外周动脉疾病引发的一系列症状。
T4276	Hydroxyfasudil Hydrochloride Hydroxyfasudil (HA-1100) HCl,羟基法舒地尔盐酸盐,RHO-激酶抑制剂,HA 1100 hydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) 是一种ROCK 抑制剂，对ROCK1和ROCK2的IC50值分别为 0.73 和 0.72 μM。
T24612	Pentachloropseudilin PClP,Antibiotic A 15104 Y	Myosin; Antibiotic; TGF-beta/Smad	Cytoskeletal Signaling; Microbiology/Virology; Stem Cells
	Pentachloropseudilin (PClP) 是一种可逆的变构 1 型肌球蛋白抑制剂，具有抗菌活性，抑制 Myo1s 和 5 类肌球蛋白。Pentachloropseudilin 抑制生长因子-β (TGF-β) ，可阻断克氏锥虫对宿主细胞的侵袭。
T4276L	Hydroxyfasudil Hydroxy-Fasudil,HA-1100,羟基法舒地尔	ROCK; PKA	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Hydroxyfasudil (Hydroxy-Fasudil) 是一种ROCK 抑制剂，对ROCK1和ROCK2的IC50分别为 0.73 和 0.72 μM。
T1751	Eliprodil 依利罗地,SL-820715	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Eliprodil (SL-820715) 是NR2B-NMDA 受体高效选择性抑制剂，IC50值1uM。它对NR2A-和NR2C-NMDA 受体作用较弱，可用于研究帕金森病和运动障碍治疗的试验。
T5385	Radiprodil RGH-896	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Radiprodil (RGH-896) 是一种具有口服活性的、NMDA 受体 NR2B 亚类的选择性拮抗剂。它有用于神经性疼痛和其它慢性疼痛的相关研究潜力。
T60924	Verosudil AR-12286	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Verosudil (AR-12286) 是一种高效的 Rho 激酶 (ROCK) 抑制剂，对 ROCK1 和 ROCK2 的 Ki 分别为 2 和 2 nM。AR-12286 可逆转类固醇诱导的小鼠眼内压，可通过增加眼房水通过小梁网流出来减缓眼压。
T38654	Cotosudil	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Cotosudil 是一种 ROCK 激酶抑制剂，具有抗高血压活性，可用于治疗或预防白内障、心血管疾病或神经退行性疾病或神经损伤引起的疾病或病症。
T0112L	Diltiazem CRD 401 free base,CRD-401 free base,Dilticard,CRD401 free base,Dilzen	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Diltiazem (CRD 401 free base) 是一种可口服的 L 型钙通道 (L-type Ca2+ channel) 阻滞剂，具有抗高血压、抗心律失常和心脏保护作用，可预防再灌注后心肌损伤、心绞痛和与心血管相关的疾病。
T10358	Netarsudil Dihydrochloride AR-13324 Dihydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) 是 Rho 相关蛋白激酶 (ROCK) 和去甲肾上腺素转运蛋白 (NET) 的抑制剂，可有效降低眼压 (IOP)。
T13177	Taquidil	Others	Others
	Tocainide hydrochloride 是一种sodium channel 阻滞剂，它阻断神经膜中产生疼痛的病灶中的钠通道。Tocainide hydrochloride 是利多卡因 (lignocaine) 的一种伯胺类似物，可有效抑制各种情况下的室性心律失常。
T3060	Fasudil hydrochloride Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877	ROCK; Serine/threonin kinase; Calcium Channel; HIV Protease; PKA; PKC; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Fasudil hydrochloride (HA-1077) 是一种非特异性RhoA/ROCK 抑制剂，也抑制蛋白激酶，对 ROCK1、PKA、PKC 和 MLCK 的 Ki 值分别为 0.33 μM、1.0 μM、9.3 μM 和 55 μM。
T8135	Minoxidil sulfate Minoxidil sulphate,U-58838,米诺地尔硫酸盐	Potassium Channel	Membrane transporter/Ion channel
	Minoxidil sulfate (U-58838) 是米诺地尔的硫酸代谢物，是ATP 敏感的 K+通道激动剂。它被认为是血管扩张试剂，在动物实验模型中，促进头发生长。
T0327	Fendiline hydrochloride Fendiline HCl,盐酸芬他林	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Fendiline hydrochloride (Fendiline HCl) 是一种非选择性钙通道抑制剂。
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
TP1016L	Aviptadil Acetate 醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt	RAAS; SARS-CoV	Endocrinology/Hormones; Microbiology/Virology
	Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) 是模拟血管活性肠多肽类似物，具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。
T12032	Mibefradil dihydrochloride 盐酸米贝地尔,Ro 40-5967 (dihydrochloride),米贝拉地尔	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Mibefradil dihydrochloride (Ro 40-5967 (dihydrochloride)) 是一种钙离子通道抑制剂，选择性作用于 T 型 Ca2+通道，对 T 型和 L 型通道的IC50分别为 2.7 和 18.6 μM。
T0080	Trapidil 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008	PDGFR; PDE	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Trapidil (Avantrin) 是一种抗血小板药物，是一种血管扩张剂，有特异性血小板衍生生长因子。
T6600	Naftopidil dihydrochloride KT-611,KT-611 2HCl,盐酸萘哌地尔,Naftopidil DiHCl	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil dihydrochloride (KT-611 2HCl) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力Ki 分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T0451	Minoxidil 米诺地尔,U10858	Potassium Channel; COX	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Minoxidil (U10858) 是一种是 ATP 敏感的钾通道 (KATP) 开放剂，可作为有效的口服降压药和外周血管舒张药，促进血管扩张并促进头发的生长。Minoxidil 还是一种大豆脂氧合酶的有效抑制剂，IC50为 20 μM。
T34648	Sinitrodil ITF296,ITF-296,ITF 296	Guanylate cyclase	GPCR/G Protein
	Sinitrodil (ITF-296) 是一种鸟苷酸环化酶兴奋剂，可用于治疗心肌缺血和心绞痛。
T60536	Terodiline	Calcium Channel; HER; AChR	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Terodiline 是一种具有抗胆碱能和钙拮抗特性的仲胺，可阻断 hERG 电流（IC50：375 nM）。Terodiline 具有心脏毒性，可用于研究逼尿肌不稳定引起的疾病。
T25701	Levosemotiadil SD 3212,SA 3212	LDL; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Levosemotiadil（SA 3212）是一种新型钙拮抗剂，是一种非常有效的低密度脂蛋白氧化抑制剂。Levosemotiadil 可用于预防致死性心律失常。
T9220	Naftopidil hydrochloride 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,萘哌地尔盐酸盐,KT-611 hydrochloride,BM-15275 hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil hydrochloride (BM-15275 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T0696	Naftopidil KT-611,萘哌地尔,BM-15275	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil (KT-611) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力Ki 分别为 3.7 nM、20 nM 、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T0342	Carvedilol phosphate hemihydrate Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐	VEGFR; Others; Potassium Channel; LDL; Integrin; Gap Junction Protein; NADPH; Adrenergic Receptor; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种外消旋混合物，是一种非选择性β/α-1受体阻断剂，具有抗高血压活性且缺乏内在拟交感神经活性。
T0112	Diltiazem hydrochloride CRD-401,盐酸地尔硫卓,RG 83606 HCl,Diltiazem HCl	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Diltiazem hydrochloride (RG 83606 HCl) 是一种苯并硫氮卓类钙通道阻滞剂，由于其拮抗钙离子对膜功能的作用而具有血管舒张作用。
T0165	Urapidil Mediatensyl,乌拉地尔,Ebrantil,Eupressyl	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Urapidil (Ebrantil) 是交感神经抗高血压药物，可作为 5-HT1A 受体激动剂和 α1-肾上腺素受体拮抗剂。
T77433	Feladilimab GSK3359609	COX; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Neuroscience
	Feladilimab (GSK3359609) 是一种 IgG4 单克隆抗体,是一种 ICOS 激动剂。Feladilimab 与表达 ICOS 的 T 细胞结合，诱导 IFNγ，增加 PD-1/L1 表达。Feladilimab 具有抗肿瘤活性，可用于研究癌症。
T15130	Dilazep dihydrochloride	Others	Others
	Dilazep dihydrochloride 是一种腺苷摄取的抑制剂。它可抑制缺血性损伤，血小板聚集和核苷的膜转运。它能够增强腺苷的作用，进而具有脑和冠状血管舒张作用。
T5123	Pirozadil	Others	Others
	Pirozadil 是降血脂药。
T31482	Diloxanide Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida,二氯尼特	Parasite	Microbiology/Virology
	Diloxanide (RD3803) 是一种抗原虫制剂，可研究组织学内阿米巴原虫或者其他原虫感染引起的无症状肠道阿米巴病。它是一种活性的鲁米那抗阿米巴试剂，是由其前药二氯尼特糠酸酯在胃肠道中水解得来的。
T0088	Urapidil hydrochloride Urapidil HCl,盐酸乌拉地尔	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Urapidil hydrochloride (Urapidil HCl) 是α1-肾上腺素受体拮抗剂和5-HT1A 受体激动剂。
T0712	Suloctidil	ATPase; Platelet aggregation	Membrane transporter/Ion channel; Others
	Suloctidil 是一种外周血管扩张剂，作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性，可治疗痴呆和血栓形成病症。
T22463	1,2-Dilauroyl-sn-glycerol 1,2-DLG,(S)-1,2-Dilaurin,1,2-二月桂酰-SN-甘油	Others	Others
	1,2-Dilauroyl-sn-glycerol ((S)-1,2-Dilaurin) 是饱和二酰甘油的一种，可能在第二信使信号转导中发挥调节作用。
T33272	Mefenidil McN-2378,McN 2378	Others	Others
	Mefenidil (McN-2378) 是一种选择性脑血管扩张剂，在狗麻醉模型中显示出在不刺激 O2 摄取的情况下增加健康大脑中的 CBF。
T68073	Flosatidil	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Flosatidil是一种小分子电压门控性钙通道复合体(VDCCs)阻滞剂，可用于治疗神经系统疾病和心血管疾病，可用于研究心绞痛。
T69665	Zelasudil RXC007	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Zelasudil (RXC007) 是一种 Rho 相关 (ROCK) 激酶抑制剂，可用于研究特发性肺纤维化和炎症。

化合物

Dov-Val-Dil-OH TFA

Cat.No: T70958

Target: Others

N-Boc-Val-Dil-Dap-Doe

Cat.No: T12141

Target: Others, ADC Linker

DiD perchlorate

Cat.No: T15118

Target: Others

Boc-Val-Dil-Dap-OH

Cat.No: T84744

Target: Others, ADC Linker

Cat.No: T70956

Target: Others

Cat.No: T28759

Synonym: Sesamodil fumarate,SD-3211,SD 3211,SD3211,DS-4823

Target: Calcium Channel

Bepridil hydrochloride

Cat.No: T5391

Synonym: CERM 1978,盐酸苄普地尔

Target: Calcium Channel

Cat.No: T68036

Target: Others

Pinacidil monohydrate

Cat.No: T12478

Synonym: 吡那地尔一水合物,吡那地尔

Target: Potassium Channel

Cat.No: T3278

Synonym: EU-4200,Trivastan,ET-495,Trivastal

Target: Dopamine Receptor, Histone Methyltransferase, Adrenergic Receptor

Cat.No: T1606

Synonym: HA-1077,AT877,法舒地尔

Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy

Cat.No: TQ0233

Synonym: 曲索罗地,CP101606

Target: NMDAR, iGluR

Buflomedil hydrochloride

Cat.No: T0317

Synonym: Buflomedil HCl,Fonzylane,Loftyl,盐酸丁咯地尔,丁咯地尔盐酸盐

Target: Adrenergic Receptor

Hydroxyfasudil Hydrochloride

Cat.No: T4276

Synonym: Hydroxyfasudil (HA-1100) HCl,羟基法舒地尔盐酸盐,RHO-激酶抑制剂,HA 1100 hydrochloride

Target: ROCK

Pentachloropseudilin

Cat.No: T24612

Synonym: PClP,Antibiotic A 15104 Y

Target: Myosin, Antibiotic, TGF-beta/Smad

Cat.No: T4276L

Synonym: Hydroxy-Fasudil,HA-1100,羟基法舒地尔

Target: ROCK, PKA

Cat.No: T1751

Synonym: 依利罗地,SL-820715

Target: NMDAR, iGluR

Cat.No: T5385

Synonym: RGH-896

Target: NMDAR, iGluR

Cat.No: T60924

Synonym: AR-12286

Target: ROCK

Cat.No: T38654

Target: ROCK

Cat.No: T0112L

Synonym: CRD 401 free base,CRD-401 free base,Dilticard,CRD401 free base,Dilzen

Target: Calcium Channel

Netarsudil Dihydrochloride

Cat.No: T10358

Synonym: AR-13324 Dihydrochloride

Target: ROCK

Cat.No: T13177

Target: Others

Fasudil hydrochloride

Cat.No: T3060

Synonym: Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877

Target: ROCK, Serine/threonin kinase, Calcium Channel, HIV Protease, PKA, PKC, Autophagy

Minoxidil sulfate

Cat.No: T8135

Synonym: Minoxidil sulphate,U-58838,米诺地尔硫酸盐

Target: Potassium Channel

Fendiline hydrochloride

Cat.No: T0327

Synonym: Fendiline HCl,盐酸芬他林

Target: Calcium Channel

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

Aviptadil Acetate

Cat.No: TP1016L

Synonym: 醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt

Target: RAAS, SARS-CoV

Mibefradil dihydrochloride

Cat.No: T12032

Synonym: 盐酸米贝地尔,Ro 40-5967 (dihydrochloride),米贝拉地尔

Target: Calcium Channel

Cat.No: T0080

Synonym: 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008

Target: PDGFR, PDE

Naftopidil dihydrochloride

Cat.No: T6600

Synonym: KT-611,KT-611 2HCl,盐酸萘哌地尔,Naftopidil DiHCl

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T0451

Synonym: 米诺地尔,U10858

Target: Potassium Channel, COX

Cat.No: T34648

Synonym: ITF296,ITF-296,ITF 296

Target: Guanylate cyclase

Cat.No: T60536

Target: Calcium Channel, HER, AChR

Cat.No: T25701

Synonym: SD 3212,SA 3212

Target: LDL, Calcium Channel

Naftopidil hydrochloride

Cat.No: T9220

Synonym: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,萘哌地尔盐酸盐,KT-611 hydrochloride,BM-15275 hydrochloride

Target: Adrenergic Receptor

Cat.No: T0696

Synonym: KT-611,萘哌地尔,BM-15275

Target: Adrenergic Receptor

Carvedilol phosphate hemihydrate

Cat.No: T0342

Synonym: Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐

Target: VEGFR, Others, Potassium Channel, LDL, Integrin, Gap Junction Protein, NADPH, Adrenergic Receptor, Autophagy

Diltiazem hydrochloride

Cat.No: T0112

Synonym: CRD-401,盐酸地尔硫卓,RG 83606 HCl,Diltiazem HCl

Target: Calcium Channel

Cat.No: T0165

Synonym: Mediatensyl,乌拉地尔,Ebrantil,Eupressyl

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T77433

Synonym: GSK3359609

Target: COX, PD-1/PD-L1

Dilazep dihydrochloride

Cat.No: T15130

Target: Others

Cat.No: T5123

Target: Others

Cat.No: T31482

Synonym: Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida,二氯尼特

Target: Parasite

Urapidil hydrochloride

Cat.No: T0088

Synonym: Urapidil HCl,盐酸乌拉地尔

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T0712

Target: ATPase, Platelet aggregation

1,2-Dilauroyl-sn-glycerol

Cat.No: T22463

Synonym: 1,2-DLG,(S)-1,2-Dilaurin,1,2-二月桂酰-SN-甘油

Target: Others

Cat.No: T33272

Synonym: McN-2378,McN 2378

Target: Others

Cat.No: T68073

Target: Calcium Channel

Cat.No: T69665

Synonym: RXC007

Target: ROCK

Cat. No.	Product Name	Target	Signaling Pathways
T25664	Lepidiline A Macaline A	Others	Others
	Lepidiline A (Macaline A) 是一种具有抗炎症活性的黄酮木质素。Lepidiline A 对HL-60细胞具有细胞毒活性，IC50值为 32.3 μM。它是从芸苔科植物Lepidium meyenii Walpers 的活性成分，可改善小鼠内源性性激素的平衡，提高果蝇的繁殖力。Lepidiline A 靶向HSD17B1基因的机制来增强酶的活性，提高性激素的生物转化效率，提高生殖能力。Lepidiline A 具有抗癌活性。
T13302	Viquidil hydrochloride Quinotoxine hydrochloride	Others	Others
	Viquidil hydrochloride (Quinotoxine hydrochloride) 是奎尼丁的同分异构体，是一种脑血管扩张剂，具有抗血栓作用。
TN1979	Neocnidilide 新蛇床内酯,新蛇床内酯,新川芎内酯	Antifungal	Microbiology/Virology
	Neocnidilide 是一种从川芎中提取的烷基邻苯二甲酸酯，具有抑制产生真菌毒素的真菌生长和杀虫。Neocnidilide 对 D. melanogaster 幼虫的LC50 值为 9.9 μmol/mL。它可以增强苯甲酸的皮肤渗透性。
TN1048	Cnidilin Knidilin
	Cnidilin (Knidilin) 存在与Angelica dahurica 根中，具有高BBB 通透性，在治疗中枢神经系统疾病方面具有药代动力学潜力。
T1186	Ifenprodil Tartrate	Potassium Channel; NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Ifenprodil tartrate 是典型的非竞争性 NMDA 受体拮抗剂，抑制 GIRK (Kir3)，通过基底 GIRK 活性减少内向电流，有用做脑血管舒张试剂的潜力。它对 NR1A/NR2B 受体亲和力是 NR1A/NR2A 受体的 400 倍。
T67922	Lepidiline C	Others	Others
	Lepidiline C 是一种从十字花科Lepidium meenii Walpers 根中提取的新型的咪唑类生物碱，对HL-60细胞表现出细胞毒活性（IC50为：27.7 μM）。
TN1851	Lancifodilactone C 披针叶五味子二内酯 C	Others	Others
	Lancifodilactone C is a natural product
T2A2400	1,2-O-Dilinoleoyl-3-O-Beta-D-Galactopyranosylracglycerol 1-2-o-dilinoleoyl-3-o-beta-d-galactopyranosylracglycerol	Others	Others
	1,2-O-Dilinoleoyl-3-O-Beta-D-Galactopyranosylracglycerol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T2A2400，CAS号为 111187-15-6。
T25665	Lepidiline B Macaline B	Others	Others
	Lepidiline B is a flavonolignan that exhibits anti-inflammation activities. It is isolated from the roots of Lepidium meyenii Walpers (Brassicaceae).
TN3427	Aphadilactone B	Antifection	Microbiology/Virology
	Aphadilactone B shows significant antimalarial activity with the IC50 value of 1350 ± 150 nM.
TN3428	Aphadilactone C	Others	Others
	Aphadilactone C shows significant antimalarial activity with the IC50 value of 170 ± 10 nM. It shows potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 uM, selectivity index > 217).
TN1852	Lancifodilactone F 披针叶五味子二内酯 F	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Lancifodilactone F exerts minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and shows anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a selectivity index > 6.62.

天然产物

Cat.No: T25664

Synonym: Macaline A

Target: Others

Viquidil hydrochloride

Cat.No: T13302

Synonym: Quinotoxine hydrochloride

Target: Others

Cat.No: TN1979

Synonym: 新蛇床内酯,新蛇床内酯,新川芎内酯

Target: Antifungal

Cat.No: TN1048

Synonym: Knidilin

Ifenprodil Tartrate

Cat.No: T1186

Target: Potassium Channel, NMDAR, iGluR

Cat.No: T67922

Target: Others

Lancifodilactone C

Cat.No: TN1851

Synonym: 披针叶五味子二内酯 C

Target: Others

1,2-O-Dilinoleoyl-3-O-Beta-D-Galactopyranosylracglycerol

Cat.No: T2A2400

Synonym: 1-2-o-dilinoleoyl-3-o-beta-d-galactopyranosylracglycerol

Target: Others

Cat.No: T25665

Synonym: Macaline B

Target: Others

Aphadilactone B

Cat.No: TN3427

Target: Antifection

Aphadilactone C

Cat.No: TN3428

Target: Others

Lancifodilactone F

Cat.No: TN1852

Synonym: 披针叶五味子二内酯 F

Target: HIV Protease

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00467	Mindin Protein, Human, Recombinant (His) Spondin-2,Differentially expressed in cancerous and non-canc...	Human	HEK293 Cells
	Spondin-2, also referred to as mindin, belongs to the F-spondin family of secreted extracellular matrix proteins. Spondins are characterised by the presence of F-spondin domains 1 and 2 (FS1 and FS2) at the N-terminus and a thrombospondin-type 1 repeat (TSR1) domain at the C-terminus. Spondin-2 functions as a pattern-recognition molecule for bacterial and viral pathogens and as an integrin ligand for inflammatory cell recruitment and T cell priming. In addition to its roles in promoting neuron o...
TMPJ-00681	EDIL3 Protein, Human, Recombinant (His) EGF-Like Repeats and Discoidin I-Like Domains 3,EDIL	Human	HEK293 Cells
	EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. EDIL3 has been found to be re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence a...
TMPJ-01225	PDILT Protein, Human, Recombinant (His) PDILT,Protein Disulfide-Isomerase-Like Protein of t...	Human	HEK293 Cells
	Protein Disulfide-Isomerase-Like Protein of the Testis (PDILT) is a protein that belongs to the protein disulfide isomerase family. Human PDILT is synthesized as a 584 amino acid precursor that contains an 20 amino acid signal sequence and a 564 amino acid mature chain. PDILT contains 1 thioredoxin domain lacks the conserved redox-active Cys at position 417 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity. PDILT is an enzyme in the endoplasmic reticulum in eukary...
TMPH-01856	Pescadillo homolog Protein, Human, Recombinant (His & Myc) Pescadillo homolog,PES1	Human	E. coli
	Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Pescadillo homolog Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 75.4 kDa and the accession number is O00541.

重组蛋白

Mindin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00467

Species: Human

Expression System: HEK293 Cells

EDIL3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00681

Species: Human

Expression System: HEK293 Cells

PDILT Protein, Human, Recombinant (His)

Cat.No: TMPJ-01225

Species: Human

Expression System: HEK293 Cells

Pescadillo homolog Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01856

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T19136	4-Hydroxyphenyl Carvedilol-d5 4-Hydroxycarvedilol D5,4-Hydroxyphenyl Carvedilol D5	Others	Others
	4-Hydroxyphenyl Carvedilol D5 is the deuterium labeled 4-Hydroxyphenyl Carvedilol.
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...
TMID-0127	MINOXIDIL-d10
	MINOXIDIL-d10 是 MINOXIDIL 的氘代化合物。MINOXIDIL 的 CAS 号为 38304-91-5。Minoxidil 是一种是 ATP 敏感的钾通道 (KATP) 开放剂，可作为有效的口服降压药和外周血管舒张药，促进血管扩张并促进头发的生长。Minoxidil 还是一种大豆脂氧合酶的有效抑制剂，IC50为 20 μM。
T12486	Piribedil D8 ET-495 D8	Others	Others
	Piribedil D8 is the deuterium labeled Piribedil, which is an agent of antiparkinsonian.

同位素标记化合物

4-Hydroxyphenyl Carvedilol-d5

Cat.No: T19136

Synonym: 4-Hydroxycarvedilol D5,4-Hydroxyphenyl Carvedilol D5

Target: Others

Cat.No: T71402

Cat.No: TMID-0127

Cat.No: T12486

Synonym: ET-495 D8

Target: Others

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