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Search Results for " dehydroepiandrosterone "

Targets Recommended: Others

6

抑制剂 & 化合物

6

天然产物

4

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T36920	16α-hydroxy Dehydroepiandrosterone	Others	Others
	16α-hydroxy Dehydroepiandrosterone is a metabolite of the endogenous steroid hormone dehydroepiandrosterone .116α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosteronevia16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol .2 1.Miller, K.K.M., Cai, J., Ripp, S.L., et al.Stereo- and regioselectivity account for the diversity of dehydro...
T26366L	Prasterone sulfate sodium hydrate Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate	Others	Others
	Prasterone is an endogenous steroid hormone. Prasterone acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activities, including enhancing working me
T8401	Efonidipine hydrochloride monoethanolate NZ-105 hydrochloride monoethanolate,依福地平,盐酸依福地平一乙醇盐	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) 是 T 型和 L 型钙离子通道双重阻断剂。
T73671	7β-Hydroxy-epi-androsterone	Others	Others
	7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) 是一种与ERβ结合的内源性雄激素衍生物，具有抗炎和神经保护特性。该化合物来源于dehydroepiandrosterone。
T84943	5-Androstenetriol Δ5-AT	Others	Others
	5-Androstenetriol, a steroid and active metabolite of dehydroepiandrosterone (DHEA), demonstrates significant therapeutic effects. Administered at 0.75 mg/25 g body weight, it mitigates radiation-induced mortality and facilitates hematopoietic recovery from surviving stem cells in mice. Moreover, a dosage of 40 mg/kg enhances survival rates in rats subjected to surgical trauma-induced sepsis. Additionally, elevated urinary levels of 5-androstenetriol are observed in women suffering from androgen...
T73779	5β-Androstan-3β-ol-17-one	Others	Others
	5β-Androstan-3β-ol-17-one（3β-Etiocholanolone；5β-Epiandrosterone），为5β还原型类固醇，主要是脱氢表雄酮（DHEA）的关键代谢物之一。在C57BL/KsJ基因型糖尿病（db/db）小鼠中，该化合物显示出显著的降糖效果，并且具有对神经元的抑制活性。

化合物

16α-hydroxy Dehydroepiandrosterone

Cat.No: T36920

Target: Others

Prasterone sulfate sodium hydrate

Cat.No: T26366L

Synonym: Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate

Target: Others

Efonidipine hydrochloride monoethanolate

Cat.No: T8401

Synonym: NZ-105 hydrochloride monoethanolate,依福地平,盐酸依福地平一乙醇盐

Target: Calcium Channel

7β-Hydroxy-epi-androsterone

Cat.No: T73671

Target: Others

5-Androstenetriol

Cat.No: T84943

Synonym: Δ5-AT

Target: Others

5β-Androstan-3β-ol-17-one

Cat.No: T73779

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T26366	Dehydroepiandrosterone sulfate PB 005,PB005,Prasterone sulfate,DHEA sulfate,DHEAS,PB-005	Others	Others
	Dehydroepiandrosterone sulfate (PB-005) 影响神经元的迁移、树突的分枝和新突触的形成。
T0856	Dehydroisoandrosterone 3-acetate Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,醋酸去氢表雄酮,androstenolone acetate	Androgen Receptor	Endocrinology/Hormones
	Dehydroisoandrosterone 3-acetate (Prasterone acetate) 是一种雄性激素/雌性激素的前体物质，是一种由肾上腺皮质产生的主要 C19 类固醇，能够调节脊椎动物的攻击性行为。
T41329	Dehydroepiandrosterone sulfate sodium salt
	Dehydroepiandrosterone sulfate sodium salt 影响神经元的迁移、树突的分枝和新突触的形成。
TN7320	7-keto Dehydroepiandrosterone 7-keto DHEA	Others	Others

TN7319	7-keto Dehydroepiandrosterone Acetate 7-keto DHEA Acetate	Others	Others

T10048	17a-Hydroxypregnenolone	Endogenous Metabolite	Metabolism
	17a-Hydroxypregnenolone 是一种孕烷类固醇, 是形成脱氢表雄酮的激素原。17a-Hydroxypregnenolone 是一种神经调节剂。

天然产物

Dehydroepiandrosterone sulfate

Cat.No: T26366

Synonym: PB 005,PB005,Prasterone sulfate,DHEA sulfate,DHEAS,PB-005

Target: Others

Dehydroisoandrosterone 3-acetate

Cat.No: T0856

Synonym: Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,醋酸去氢表雄酮,androstenolone acetate

Target: Androgen Receptor

Dehydroepiandrosterone sulfate sodium salt

Cat.No: T41329

7-keto Dehydroepiandrosterone

Cat.No: TN7320

Synonym: 7-keto DHEA

Target: Others

7-keto Dehydroepiandrosterone Acetate

Cat.No: TN7319

Synonym: 7-keto DHEA Acetate

Target: Others

17a-Hydroxypregnenolone

Cat.No: T10048

Target: Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01587	SULT2A1 Protein, Human, Recombinant (His) hSTa,HST,ST2,ST2A1,STD,DHEAS,ST2A3,sulfotransferase family, ...	Human	E. coli
	Hydroxysteroid sulfotransferase ( SULT2A1 ) is a key enzyme in the testicular and hepatic metabolism of 5alpha-androstenone, which is a major component of the off-odor and off-flavor in pork known as boar taint. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar amon...
TMPH-01303	HSD17B11 Protein, Human, Recombinant (His & Myc) Estradiol 17-beta-dehydrogenase 11,HSD17B11,Retinal short-ch...	Human	E. coli
	Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. HSD17B11 Prot...
TMPY-01660	SULT1E1 Protein, Human, Recombinant (His) ST1E1,EST,sulfotransferase family 1E member 1,EST-1,STE,MGC3...	Human	E. coli
	Estrogen sulfotransferase, also known as Sulfotransferase, estrogen-preferring, Sulfotransferase 1E1, SULT1E1 and ST1E1, is a cytoplasm enzyme that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1E1 may control the level of the estrogen receptor by sulfurylating free estradio...
TMPH-02139	CYP17A1 Protein, Human, Recombinant (GST) Cytochrome P450 17A1,CYPXVII,CYP17A1,CYP17,S17AH,Cytochrome ...	Human	E. coli
	A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, follow...

重组蛋白

SULT2A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01587

Species: Human

Expression System: E. coli

HSD17B11 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01303

Species: Human

Expression System: E. coli

SULT1E1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01660

Species: Human

Expression System: E. coli

CYP17A1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02139

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0179	Dehydroepiandrosterone-d2
	Dehydroepiandrosterone-d2 是 Dehydroepiandrosterone 的氘代化合物。
TMID-0115	Dehydroepiandrosterone-2,2,3,4,4,6-d6 DHEA-d6
	Dehydroepiandrosterone-2,2,3,4,4,6-d6 是 Dehydroepiandrosterone 的氘代化合物。Dehydroepiandrosterone 的 CAS 号为 53-43-0。Dehydroepiandrosterone 是一种类固醇激素。它通过多种信号传导途径介导其作用，并通过转化成雄激素和雌激素衍生物（例如，雄激素，雌激素，7α和7β DHEA (Prasterone)，以及7α和7β表雄甾酮衍生物）在特异性受体上起作用。
TMIJ-0319	Dehydroepiandrosterone Sulfate Sodium Salt-d6
	Dehydroepiandrosterone Sulfate Sodium Salt-d6 是 Dehydroepiandrosterone Sulfate Sodium Salt 的氘代化合物。Dehydroepiandrosterone Sulfate Sodium Salt 的 CAS 号为 1099-87-2。
TMID-0147	17a-Hydroxypregnenolone-d3
	17a-Hydroxypregnenolone-d3 是 17a-Hydroxypregnenolone 的氘代化合物。17a-Hydroxypregnenolone 的 CAS 号为 387-79-1。17a-Hydroxypregnenolone 是一种孕烷类固醇, 是形成脱氢表雄酮的激素原。17a-Hydroxypregnenolone 是一种神经调节剂。

同位素标记化合物

Dehydroepiandrosterone-d2

Cat.No: TMIH-0179

Dehydroepiandrosterone-2,2,3,4,4,6-d6

Cat.No: TMID-0115

Synonym: DHEA-d6

Dehydroepiandrosterone Sulfate Sodium Salt-d6

Cat.No: TMIJ-0319

17a-Hydroxypregnenolone-d3

Cat.No: TMID-0147

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