21
3
6
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18966 |
DAF-2DA
DAF2DA,DAF 2DA,5,6-Diaminofluorescein diacetat |
Others | Others |
DAF 2DA is widely used as a probe for NO measurement. | |||
T18965 |
DAF-FM DA
Diaminofluorescein-FM diacetate |
Others | Others |
DAF-FM DA (Diaminofluorescein-FM diacetate) 是一种用于检测一氧化氮 (NO)和活性氮 (RNS) 水平的活性染料,可用于生物成像 (Ex/Em=495/515 nm)。 | |||
T10953 |
Dafadine-A
|
P450 | Metabolism |
Dafadine-A 是dafadine 的类似物,是C. elegans DAF-9 细胞色素P450抑制剂,同时对哺乳动物的CYP27A1具有抑制作用。 | |||
T4986 |
Imidafenacin
咪达那新,KRP-197,ONO-8025 |
AChR | Neuroscience |
Imidafenacin (KRP-197) 是一种有效的和选择性的 M3受体抑制剂,Kb 值为0.317nM。 | |||
T3726 |
Erdafitinib
厄达替尼,JNJ-42756493 |
Apoptosis; FGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Erdafitinib (JNJ-42756493) 是一种广谱的 FGFR 抑制剂,可以抑制 FGFR1/2/3/4 (IC50=1.2/2.5/3.0/5.7 nM)。Erdafitinib 具有抗肿瘤活性,可以诱导细胞凋亡。 | |||
T27808 |
Lefradafiban
BIBU 104,BIBU104,BIBU-104 |
Others | Others |
Lefradafiban(BIBU-104) 是一种口服血小板糖蛋白 IIb/IIIa 受体拮抗剂,可用于研究心绞痛和急性冠状动脉综合症。 | |||
T67787 |
Adafosbuvir PM
AL-335 PM |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Adafosbuvir PM (AL-335 PM) 是一种具有抗病毒活性的化合物。 | |||
T6334 |
Ridaforolimus
AP23573,Deforolimus,MK-8669 |
mTOR; Autophagy | Autophagy; PI3K/Akt/mTOR signaling |
Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物,具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂,在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。 | |||
T4262 |
BisfluoroModafinil
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
BisfluoroModafinil 是一种莫达非的常见替代品,具有增强认知能力的潜力。其中莫达非尼通常用于研究性嗜睡症。 | |||
T26370 |
(25S)-delta7-Dafachronic acid
|
Others | Others |
(25S)-delta7-Dafachronic acid, an orphan nuclear receptor DAF-12 ligand, inhibits the dauer-promoting activity of DAF-12. | |||
T11322 |
Fradafiban
BIBU-52 |
Others | Others |
Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist. | |||
T80597 |
Dafsolimab
SPV-T3a |
||
Dafsolimab (SPV-T3a)为IgG2a型小鼠单克隆抗体,主要针对CD3。通过调节及激活CD3/T细胞受体复合物,Dafsolimab能够诱导细胞凋亡,常用于移植物抗宿主病(GVHD)的研究领域。 | |||
T29638 |
Adafenoxate
Adafenoxato |
Others | Others |
Adafenoxate is an intelligent compound related to centrophenoxine. | |||
T36662 |
Imidafenacin Metabolite M4
Imidafenacin Metabolite M4 |
Others | Others |
Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. 1.Kanayama, N., Kanari, C., Masuda, Y., et al.Drug-drug interactions in the metabolism of imidafenacin: Role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymesXenobiotica37(2)139-154(2007) | |||
T26560 |
Adafosbuvir
|
Others | Others |
Adafosbuvir has antiviral activity. | |||
T73638 |
Fradafiban hydrochloride
|
Others | Others |
Fradafiban (BIBU-52) hydrochloride 是一种非肽血小板糖蛋白 IIb/IIIa 复合体拮抗剂,其与人血小板 GP IIb/IIIa 复合体结合,Kd 值为 148 nM。 | |||
T78297 |
Aldafermin
NGM282 |
||
Aldafermin (NGM282),一种成纤维细胞生长因子19的类似物,主要用于非酒精性脂肪性肝炎(NASH)的研究。 | |||
T63818 |
Omesdafexor
|
Others | Others |
Omesdafexor 是 FXR 激动剂,能够用于研究肝病或代谢性炎症引起的疾病。 | |||
T20806 |
Pyridafenthion
|
Others | Others |
Pyridafenthion is an agricultural chemical which is suitable for rice. | |||
T31190 |
Dafphedyn
|
Others | Others |
Dafphedyn, [D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN) is an effective analog of strong endorphin 1-13 and produces diuretic and deep analgesia when administered intravenously in rats. | |||
T85140 |
27-hydroxy Cholestenone
|
Others | Others |
27-Hydroxy Cholestenone, an oxysterol, exhibits elevated levels in Cyp46a-/- mouse brain. It serves as an intermediate in synthesizing dafachronic acid ligands, targeting the DAF-12 nuclear hormone receptor. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1072 |
Lappaol A
|
P-gp; JNK | MAPK; Membrane transporter/Ion channel; Neuroscience |
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an | |||
TN4410 |
Lappaol C
|
P-gp; JNK | MAPK; Membrane transporter/Ion channel; Neuroscience |
Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an | |||
TN4411 |
Lappaol F
|
CDK; P-gp; JNK | Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience |
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-06679 |
CD55/DAF Protein, Mouse, Recombinant (hFc)
Daf,CD55 molecule, decay accelerating factor for co... |
Mouse | HEK293 Cells |
CD55/DAF Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.48 kDa and the accession number is Q61475. | |||
TMPY-02616 |
CD55/DAF Protein, Mouse, Recombinant (His)
GPI-DAF,Daf-GPI,Daf,Daf1... |
Mouse | HEK293 Cells |
CD55/DAF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is Q61475. | |||
TMPK-00550 |
CD55/DAF Protein, Cynomolgus, Recombinant (His)
TC,DAF-GPI,CR,CROM,Daf1,CD55,Cd55a,DAF... |
Cynomolgus | HEK293 Cells |
Decay Accelerating Factor (or CD55) is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. | |||
TMPY-01292 |
CD55/DAF Protein, Human, Recombinant (His)
CD55 molecule, decay accelerating factor for complement (Cro... |
Human | HEK293 Cells |
CD55/DAF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P08174-1. | |||
TMPY-00713 |
CD55/DAF Protein, Human, Recombinant (hFc)
CR,CD55 molecule, decay accelerating factor for complement (... |
Human | HEK293 Cells |
CD55/DAF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.7 kDa and the accession number is P08174-1. | |||
TMPY-03004 |
CD55/DAF Protein, Rat, Recombinant (hFc)
CD55 molecule, decay accelerating factor for complement (Cro... |
Rat | HEK293 Cells |
CD55/DAF Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.5 kDa and the accession number is Q9Z0M0. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0353 |
Modafinil-d5
|
||
Modafinil-d5 是 Modafinil 的氘代化合物。Modafinil 的 CAS 号为 68693-11-8。 | |||
TMIJ-0336 |
Imidafenacin-d10
|
||
Imidafenacin-d10 是 Imidafenacin 的氘代化合物。Imidafenacin 的 CAS 号为 170105-16-5。Imidafenacin 是一种有效的和选择性的M3受体抑制剂,Kb值为0.317nM。 |