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Search Results for " dpp "

Targets Recommended: DPP-4 JAK

106

抑制剂 & 化合物

7

天然产物

19

重组蛋白

6

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T79608	DPP	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	DPP，一种含紫檀芪衍生轴向配体的铂(IV)络合物，能够抑制乳腺癌(BC)细胞的JAK2-STAT3通路并显示出抗增殖特性。它通过激活caspase-3和裂解聚ADP-核糖聚合酶诱导细胞凋亡(apoptosis)，同时促进树突状细胞成熟及抗原呈现功能，并已证明体内具有安全性。
T11526	DPP-IV-IN-2 H-Lys(4-nitro-Z)-pyrrolidide	DPP-4	Proteases/Proteasome
	DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) 是二肽基肽酶 IV 和DP8/9的抑制剂， IC50分别为 0.1 和 0.95 μM。
T21501	5,15-DPP	Others	Others
	5,15-Diphenylporphyrin (5,15-DPP) 是一种选择性STAT3-SH2拮抗剂，其对于STAT3 和 STAT1 的IC50值分别为 0.28 μM 和 10 μM。
T24016	DPP-4-PIOL DPP4PIOL	Others	Others
	DPP-4-PIOL is an antagonist of GABAA. In dentate gyrus granule cells, it acts by selectively antagonizing tonic over phasic GABAergic currents.
T10082	DPP-IV-IN-1	Others	Others
	DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM).
T21691	NVP DPP 728 dihydrochloride	Others	Others
	NVP-DPP728 是一种有效、可逆、腈依赖性二肽基肽酶 IV (DPP-IV)抑制剂，Ki 值为 11 nM。NVP-DPP728 可抑制胰高血糖素样肽-1 (GLP-1)的降解，从而增强响应于葡萄糖摄入的胰岛素释放。NVP-DPP728 可用于糖尿病研究。
T84524	Isopropyl 5-(Diphenylphosphoryl)pentanoate DPP isopropyl ester	Others	Others
	Latanoprost, the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α, serves as a prodrug for the free acid form, a potent FP receptor agonist in the eye. Isopropyl 5-(diphenylphosphoryl)pentanoate may exist as a potential trace impurity in commercial latanoprost preparations.
T39481	NVP-DPP728 dihydrochloride NVP-DPP728 dihydrochloride	Others	Others
	NVP-DPP728 dihydrochloride is a highly potent, selective, and orally active inhibitor of dipeptidyl peptidase IV (DPP-IV), with a binding affinity (K i ) of 11 nM. This compound proves useful for investigating diabetes mellitus in research studies.
T61422	DPP-4-IN-1	Others	Others
	DPP-4-IN-1 (compound d1) is a highly potent inhibitor of DPP-4 (dipeptidyl peptidase 4) with an IC 50 of 49 nM, making it suitable for diabetes research [1]. It shares structural similarities to Alogliptin and can be effectively utilized for studying diabetes-related mechanisms.
T61018	DPP-4-IN-2	Others	Others
	DPP-4-IN-2 (compound b2) 是 Alogliptin 的结构类似物，可以用于研究糖尿病。DPP-4-IN-2 是二肽基肽酶 4 (DPP-4)的有效抑制剂，IC50值为 79 nM。
T79256	DPP-4-IN-8	Others	Others
	DPP-4-IN-8 (compound 27) 是一种高效的选择性DPP4抑制剂，具有 0.96 μM 的 Ki。该化合物能够抑制 Caco-2 和 HepG-2 细胞中的 DPP4 二肽酶活性，并剂量依赖性地降低 TNF-α、IL-6 和 IL-1β 的表达水平[1]。
T61414	DPP-4 inhibitor 3	Others	Others
	DPP-4 inhibitor 3 (Compound 5a) 是一种有效的二肽基肽酶 IV (DPP-IV) 抑制剂，IC50为 0.75 nM。DPP-4 inhibitor 3 具有极好的抗氧化和胰岛素性活性。
T74528	DPP-4/GPR119 modulator 1	Others	Others
	DPP-4/GPR119 modulator 1 (Compound 22) 是一种具有口服活性的二肽基肽酶 IV (DPP-IV) 抑制剂和 GPR119激动剂。DPP-4/GPR119 modulator 1 具有降血糖作用，抑制hERG 通道，IC50值为 4.9 µM。DPP-4/GPR119 modulator 1 可用于糖尿病的研究。
T7133	Anagliptin SK-0403,阿拉格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Anagliptin (SK-0403) 是一种选择性的二肽酰肽酶 4 抑制剂，IC50=3.8 nM，对 DPP-8/9 的选择性相对较弱，IC50分别为 68 和 60 nM。
T63964	DPP-4/GPR119 modulator 2	Others	Others
	DPP-4/GPR119 modulator 2 是二肽基肽酶 IV (DPP-IV) 抑制剂 (IC50: 0.22 μM)，也是一种 GPR119 激动剂 (EC50: 0.95 μM)。DPP-4/GPR119 modulator 2 能够用于研究糖尿病。
T6192	Alogliptin SYR-322,阿格列汀,阿洛利停	Ferroptosis; Proteasome; DPP-4	Apoptosis; Proteases/Proteasome; Ubiquitination
	Alogliptin (SYR-322) 是一种具有选择性口服活性的DPP-4的抑制剂，IC50值小于 10 nM，比对 DPP-8 和 DPP-9 的抑制性高 10000 倍以上，可研究 2 型糖尿病。
T74978	DPP IV/hCA II-IN-1	Others	Others
	DPP IV/hCA II-IN-1 是一种有效的选择性二肽肽酶 IV (DPP IV) 和碳酸酐酶 (CA) 抑制剂，抑制 DPP IV 的 IC50值为 0.049 μM, 抑制 CA II、CA VB、CA VA、CA IX、CA I 和 CA IV 的 Ki 值分别为 0.0361、0.0428、0.0941、0.1328、0.2615 和 3.034 μM。
T12710	Retagliptin Phosphate SP 2086,瑞格列汀磷酸盐	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Retagliptin Phosphate (SP 2086) 是一种选择性、竞争性、口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。Retagliptin phosphate 能够用于 2 型糖尿病 (T2DM) 的研究。
T15079	DBPR108	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	DBPR108是新型、具有口服活性、选择性的DPP4抑制剂，IC50=为15nM，对DPP8和DPP9基本无抑制。
T6203	Saxagliptin BMS-477118,沙克列汀,Onglyza,沙格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Saxagliptin (BMS-477118) 是一种选择性，可逆性，竞争性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin 能够用于 2 型糖尿病的研究。
T7369	Gemigliptin 吉格列汀酒石酸盐,LC15-0444	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Gemigliptin (LC15-0444) 是一种选择性的，可逆的，竞争性的二肽基肽酶 4 (DPP-4) 抑制剂，对人重组 DPP-4 的 IC50=10.3 nM。Gemigliptin 具有很强的抗糖基化活性，能够用于晚期糖基化终产物相关的糖尿病并发症的研究。
T2401	Alogliptin Benzoate 苯甲酸阿格列汀,SYR 322,Alogliptin(SYR-322)benzoate	Ferroptosis; Proteasome; DPP-4	Apoptosis; Proteases/Proteasome; Ubiquitination
	Alogliptin Benzoate (SYR 322) 是一种有效且特异性的 DPP-4 抑制剂，IC50值小于 10 nM，其选择性比 DPP-8/9 高 10,000 倍以上，可用于研究 2 型糖尿病。
T1502	Vildagliptin 维达列汀,NVP-LAF 237,维格列汀,LAF237	Apoptosis; Ferroptosis; Proteasome; DPP-4	Apoptosis; Proteases/Proteasome; Ubiquitination
	Vildagliptin (LAF237) 是一种选择性二肽基肽酶IV (DPP-IV) 抑制剂，在人 Caco-2 细胞中抑制 DPP-IV 的IC50为 3.5 nM。它具有出色的口服生物利用度和降血糖活性。
T0242	Sitagliptin 西他列汀,MK0431,西格列汀	Proteasome; DPP-4; Autophagy	Autophagy; Proteases/Proteasome; Ubiquitination
	Sitagliptin (MK0431) 是一种有效的 DPP4抑制剂，在 Caco-2 细胞中，IC50值为 19 nM。它是一种新型口服降糖药，可单独使用或与二甲双胍或噻唑烷二酮联合用于治疗 2 型糖尿病。
T4042	Talabostat mesylate Val-boroPro,PT100	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Talabostat mesylate (PT100) 是一种具有口服活性和非选择性的二肽基肽酶 IV 抑制剂(IC50< 4 nM;Ki= 0.18 nM)。Talabostat mesylate 是成纤维细胞活化蛋白的第一个临床抑制剂(IC50= 560 nM)，抑制 DPP8/9 (IC50= 4/11 nM;Ki= 1.5/0.76 nM)，静息细胞脯氨酸二肽酶(IC50= 310 nM)、DPP2 和一些其他 DASH 家族酶。Talabostat mesylate 具有抗肿瘤和造血刺激活性。
T0191	Linagliptin BI 1356,利格列汀,利拉利汀	Ferroptosis; Proteasome; DPP-4; Autophagy	Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination
	Linagliptin (BI 1356) 是一种有效的、可口服的、基于二氢嘌呤二酮的二肽基肽酶 4 抑制剂，具有降血糖活性。
T0178	Saxagliptin hydrate 沙格列汀单水化合物,Onglyza hydrate,BMS-477118 hydrate	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Saxagliptin hydrate (Onglyza hydrate) 是一种选择性，竞争性，可逆性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin hydrate 能够用于 2 型糖尿病的研究。
T6237	Trelagliptin SYR-472,曲格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Trelagliptin (SYR-472) 是一种有效的，具有口服活性的DPP-4抑制剂，IC50=4 nM。它可以改善体内血糖控制，能够用于2 型糖尿病 (T2DM) 的研究。
T16684	Puromycin aminonucleoside 维生素E醋酸酯,NSC 3056	Apoptosis; Proteasome; Aminopeptidase; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	Puromycin aminonucleoside (NSC-3056) 是一种氨基核苷类抗生素，是嘌呤霉素类似物。它可逆抑制二肽基肽酶和胞浆丙氨酸氨基肽酶。它通过以氧化应激依赖性方式调节 ZO-1 来增加足细胞通透性。它诱导细胞凋亡。
T25340	Diprotin A Ile-Pro-Ile,抑二肽素A	DPP-4	Proteases/Proteasome
	Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
TQ0038	Brensocatib AZD7986,INS 1007	Proteasome	Proteases/Proteasome; Ubiquitination
	Brensocatib (AZD7986) 是一种二肽基肽酶 1 (DPP1) 抑制剂，在人，小鼠，大鼠，狗和兔中的pIC50分别为 6.85, 7.6, 7.7, 7.8 和 7.8。
T4467	UAMC00039 dihydrochloride UAMC 00039 dihydrochloride	Proteasome	Proteases/Proteasome; Ubiquitination
	UAMC00039 dihydrochloride 是可逆、竞争性的 dipeptidyl peptidase II 高效抑制剂，IC50=为0.48 nM。
T6999	Teneligliptin hydrobromide Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)	Others; Proteasome; DPP-4	Others; Proteases/Proteasome; Ubiquitination
	Teneligliptin hydrobromide (MP-513(hydrobromide)) 是β2肾上腺素能受体 (β2AR) 阻滞剂，具有抗高血压、抗氧化、清除自由基的活性。
T2316	Omarigliptin MK-3102,奥格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Omarigliptin (MK-3102) 是高效选择性 DPP4抑制剂，IC50=为1.6nM。
T8550	NDMC101	Others; NF-κB; Proteasome	NF-κB; Others; Proteases/Proteasome; Ubiquitination
	NDMC101 是有效的破骨细胞形成抑制剂，通过下调 NFATc1 调控基因表达抑制破骨细胞分化。它与 DPP4底物相似，通过抑制DPP4抑制早期 T 细胞激活。它能够用于骨疾病的研究，如类风湿关节炎、滑膜炎等。
T1674	Nateglinide 那格列奈,A4166,Senaglinide	Potassium Channel; Proteasome; PPAR	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome; Ubiquitination
	Nateglinide (Senaglinide) 是 D-苯丙氨酸的一种衍生物，是口服有效的、短效促胰岛素释放化合物，也是 DPP IV 抑制剂。 Nateglinide 抑制胰岛 β 细胞中 ATP 敏感的 K+通道。Nateglinide 在 2 型糖尿病中具有研究价值。
T23358	Sitagliptin phosphate 磷酸西他列汀,Januvia,MK-0431 phosphate,Sitagliptin (phosphate)	DPP-4; Autophagy	Autophagy; Proteases/Proteasome
	Sitagliptin phosphate (MK-0431 phosphate) 是一种二肽基肽酶 4 (DPP4) 抑制剂，在 Caco-2 细胞中，IC50值为 19 nM。
T7369L	Gemigliptin Tartrate(911637-19-9 free base) 吉格列汀酒石酸盐,LC15-0444 tartrate	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Gemigliptin Tartrate (LC15-0444 tartrate) 是一种选择性的，可逆的，竞争性的二肽基肽酶 4 (DPP-4) 抑制剂，对于人重组 DPP-4 的IC50=10.3 nM。Gemigliptin tartrate 具有很强的抗糖基化活性，能够用于晚期糖基化终产物相关的糖尿病并发症的研究。
T2296	Trelagliptin succinate 曲格列汀琥珀酸盐,琥珀酸曲格列汀,SYR-472 succinate,SYR472	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Trelagliptin succinate (SYR-472 succinate) 是一种有效的，具有口服活性的DPP-4抑制剂，IC50=4 nM。它可以改善体内血糖控制，能够用于2 型糖尿病(T2DM) 的研究。
T0242L	Sitagliptin phosphate monohydrate MK-0431,MK-0431 phosphate monohydrate,西他列汀磷酸盐一水合物	Proteasome; DPP-4; Autophagy	Autophagy; Proteases/Proteasome; Ubiquitination
	Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) 是一种有效的 DPP-IV 抑制剂，在 Caco-2 细胞提取物中的 IC50 为 19 nM。
T22641	CDPPB	GluR	Neuroscience
	CDPPB 是选择性和脑渗透性的代谢型谷氨酸受体亚型5 (mGluR5) 阳性变构的调节剂，在表达人类 mGluR5 的中国仓鼠卵巢细胞中的 EC50值为 27 nM。它为开发抗精神病药提供了一种可能性。
TF0060	DPPG sodium	Antiviral	Immunology/Inflammation
	DPPG sodium (1,2-Dipalmitoyl-sn-glycero-3-PG sodium) 是一种脂质体，是一种表面活性剂，抑制牛痘病毒感染。
T11093	DPPH 2,2-联苯基-1-苦基肼基,2,2-Diphenyl-1-picrylhydrazyl	Others	Others
	DPPH (2,2-Diphenyl-1-picrylhydrazyl) 是一种稳定的自由基，可用于测量抗氧化剂的自由基清除活性。DPPH 中氮原子的奇数电子通过从抗氧化剂吸收氢原子而还原为相应的肼。通过 DPPH 方法可用于水性和非极性有机溶剂中，检查亲水性和亲脂性抗氧化剂。
TF0112	DPPS 12-Dipalmitoyl-sn-glycero-3-PS sodium salt,DPPS-Na	Others	Others
	DPPS (12-Dipalmitoyl-sn-glycero-3-PS sodium salt) 是一种阴离子二酰基磷脂，是磷脂酰丝氨酸(PS)的一种形式，是一种位于细胞膜内小叶的带负电荷的磷脂。DPPS 被用来制作阳离子囊泡和脂质体。
T22747	DPPI 1c hydrochloride	Others	Others
	DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (IC50 = 104 nM) that shows selectivity over enzymes with DPP-like activity (IC50 > 30 μM).
T84980	DPPE-MPEG(2000) 1,2-Dipalmitoyl-rac-glycero-3-PE-N-Polyethyleneglycol-2000	Others	Others
	DPPE-MPEG(2000) is a polyethylene glycol (PEG) derivative of 1,2-dipalmitoyl-rac-glycero-3-phosphoethanolamine (DPPE), characterized as a PEGylated phospholipid.
T22543	ACDPP hydrochloride	Others	Others
	mGlu5 receptor antagonist
T32617	L-DPPG L-Dipalmitoylphosphatidylglycerol	Others	Others
	L-DPPG is a bioactive chemical.
T74311	DPPE-mPEG	Others	Others
	DPPE-mPEG 是一种 PEG- 修饰的脂类。DPPE-mPEG 可以减少蛋白质的非特异性吸附，延长体内循环时间。
T64008	Thi-DPPY	Others	Others
	Thi-DPPY 是一种有效的、口服具有活力的 JAK3 抑制剂，能够作用于 BTK (IC50: 62.4 nM)、JAK (IC50: 1.38 nM)。Thi-DPPY 能够抗 HBE 细胞的增殖。Thi-DPPY 在体内具有抗炎作用。Thi-DPPY 对特发性肺纤维化（IPF）表现出研究潜力。

化合物

Cat.No: T79608

Target: JAK

Cat.No: T11526

Synonym: H-Lys(4-nitro-Z)-pyrrolidide

Target: DPP-4

Cat.No: T21501

Target: Others

Cat.No: T24016

Synonym: DPP4PIOL

Target: Others

Cat.No: T10082

Target: Others

NVP DPP 728 dihydrochloride

Cat.No: T21691

Target: Others

Isopropyl 5-(Diphenylphosphoryl)pentanoate

Cat.No: T84524

Synonym: DPP isopropyl ester

Target: Others

NVP-DPP728 dihydrochloride

Cat.No: T39481

Synonym: NVP-DPP728 dihydrochloride

Target: Others

Cat.No: T61422

Target: Others

Cat.No: T61018

Target: Others

Cat.No: T79256

Target: Others

DPP-4 inhibitor 3

Cat.No: T61414

Target: Others

DPP-4/GPR119 modulator 1

Cat.No: T74528

Target: Others

Cat.No: T7133

Synonym: SK-0403,阿拉格列汀

Target: Proteasome, DPP-4

DPP-4/GPR119 modulator 2

Cat.No: T63964

Target: Others

Cat.No: T6192

Synonym: SYR-322,阿格列汀,阿洛利停

Target: Ferroptosis, Proteasome, DPP-4

DPP IV/hCA II-IN-1

Cat.No: T74978

Target: Others

Retagliptin Phosphate

Cat.No: T12710

Synonym: SP 2086,瑞格列汀磷酸盐

Target: Proteasome, DPP-4

Cat.No: T15079

Target: Proteasome, DPP-4

Cat.No: T6203

Synonym: BMS-477118,沙克列汀,Onglyza,沙格列汀

Target: Proteasome, DPP-4

Cat.No: T7369

Synonym: 吉格列汀酒石酸盐,LC15-0444

Target: Proteasome, DPP-4

Alogliptin Benzoate

Cat.No: T2401

Synonym: 苯甲酸阿格列汀,SYR 322,Alogliptin(SYR-322)benzoate

Target: Ferroptosis, Proteasome, DPP-4

Cat.No: T1502

Synonym: 维达列汀,NVP-LAF 237,维格列汀,LAF237

Target: Apoptosis, Ferroptosis, Proteasome, DPP-4

Cat.No: T0242

Synonym: 西他列汀,MK0431,西格列汀

Target: Proteasome, DPP-4, Autophagy

Talabostat mesylate

Cat.No: T4042

Synonym: Val-boroPro,PT100

Target: Proteasome, DPP-4

Cat.No: T0191

Synonym: BI 1356,利格列汀,利拉利汀

Target: Ferroptosis, Proteasome, DPP-4, Autophagy

Saxagliptin hydrate

Cat.No: T0178

Synonym: 沙格列汀单水化合物,Onglyza hydrate,BMS-477118 hydrate

Target: Proteasome, DPP-4

Cat.No: T6237

Synonym: SYR-472,曲格列汀

Target: Proteasome, DPP-4

Puromycin aminonucleoside

Cat.No: T16684

Synonym: 维生素E醋酸酯,NSC 3056

Target: Apoptosis, Proteasome, Aminopeptidase, Antibacterial, Antibiotic

Cat.No: T25340

Synonym: Ile-Pro-Ile,抑二肽素A

Target: DPP-4

Cat.No: TQ0038

Synonym: AZD7986,INS 1007

Target: Proteasome

UAMC00039 dihydrochloride

Cat.No: T4467

Synonym: UAMC 00039 dihydrochloride

Target: Proteasome

Teneligliptin hydrobromide

Cat.No: T6999

Synonym: Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)

Target: Others, Proteasome, DPP-4

Cat.No: T2316

Synonym: MK-3102,奥格列汀

Target: Proteasome, DPP-4

Cat.No: T8550

Target: Others, NF-κB, Proteasome

Cat.No: T1674

Synonym: 那格列奈,A4166,Senaglinide

Target: Potassium Channel, Proteasome, PPAR

Sitagliptin phosphate

Cat.No: T23358

Synonym: 磷酸西他列汀,Januvia,MK-0431 phosphate,Sitagliptin (phosphate)

Target: DPP-4, Autophagy

Gemigliptin Tartrate(911637-19-9 free base)

Cat.No: T7369L

Synonym: 吉格列汀酒石酸盐,LC15-0444 tartrate

Target: Proteasome, DPP-4

Trelagliptin succinate

Cat.No: T2296

Synonym: 曲格列汀琥珀酸盐,琥珀酸曲格列汀,SYR-472 succinate,SYR472

Target: Proteasome, DPP-4

Sitagliptin phosphate monohydrate

Cat.No: T0242L

Synonym: MK-0431,MK-0431 phosphate monohydrate,西他列汀磷酸盐一水合物

Target: Proteasome, DPP-4, Autophagy

Cat.No: T22641

Target: GluR

Cat.No: TF0060

Target: Antiviral

Cat.No: T11093

Synonym: 2,2-联苯基-1-苦基肼基,2,2-Diphenyl-1-picrylhydrazyl

Target: Others

Cat.No: TF0112

Synonym: 12-Dipalmitoyl-sn-glycero-3-PS sodium salt,DPPS-Na

Target: Others

DPPI 1c hydrochloride

Cat.No: T22747

Target: Others

DPPE-MPEG(2000)

Cat.No: T84980

Synonym: 1,2-Dipalmitoyl-rac-glycero-3-PE-N-Polyethyleneglycol-2000

Target: Others

ACDPP hydrochloride

Cat.No: T22543

Target: Others

Cat.No: T32617

Synonym: L-Dipalmitoylphosphatidylglycerol

Target: Others

Cat.No: T74311

Target: Others

Cat.No: T64008

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T16838	Saikogenin A	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Saikogenin A 是一种二肽基肽酶 IV 抑制剂，可从中药柴胡中提取。
TN1418	Azaleatin 杜鹃黄素,2-(3,4-二羟基苯基)-3,7-二羟基-5-甲氧基苯并吡喃-4-酮	DPP-4	Proteases/Proteasome
	Azaleatin 是分离自Rhododendron 种中的 O-甲基化黄酮醇。它是二肽基肽酶-IV 的抑制剂。它在 2 型糖尿病和肥胖症中有研究的价值。
T7773	DPPC 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOL,二棕榈酸磷脂酰胆碱,129Y83	Endogenous Metabolite	Metabolism
	DPPC (129Y83) 是一种磷酸甘油酯，能够用于制备脂质体单层。DPPC-脂质体能够用作小鼠中诱导针对 GSL 抗原的免疫应答的递送载体。
T83863	Fluostatin A sodium	Others	Others
	Fluostatin A是一种最初从链霉菌中分离出的荧光酮类化合物。它对二肽基肽酶3（DPP-3）的选择性抑制作用优于对DPP-1、DPP-2和DPP-4的抑制作用（IC50s分别为0.44, >100, >100, 和 >100 µg/ml）。
T39219	Ficusonolide	Others	Others
	Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.
TN7280	Fluostatin B	Others	Others
	Fluostatin B, a fluorenone discovered in Streptomyces, is an inhibitor of dipeptidyl peptidase 3 (DPP-3; IC50= 24 µg/ml).
T81898	Lyciumamide A
	DPP-IV-IN-5，一种从枸杞果实中分离得到的化合物，对过氧化物酶体增殖物激活受体(PPARγ)展示中等拮抗活性，其EC50值介于10.09至44.26 μM，同时对二肽基肽酶-4 (DPPIV)亦有抑制作用，IC50值为47.13 μM。

天然产物

Cat.No: T16838

Target: Proteasome, DPP-4

Cat.No: TN1418

Synonym: 杜鹃黄素,2-(3,4-二羟基苯基)-3,7-二羟基-5-甲氧基苯并吡喃-4-酮

Target: DPP-4

Cat.No: T7773

Synonym: 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOL,二棕榈酸磷脂酰胆碱,129Y83

Target: Endogenous Metabolite

Fluostatin A sodium

Cat.No: T83863

Target: Others

Cat.No: T39219

Target: Others

Cat.No: TN7280

Target: Others

Cat.No: T81898

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00221	DPP4/CD26 Protein, Mouse, Recombinant (hFc) dipeptidylpeptidase 4,Dpp-4,Cd26,THAM	Mouse	HEK293 Cells
	DPP4/CD26 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 112.9 kDa and the accession number is P28843.
TMPY-00074	DPP4/CD26 Protein, Mouse, Recombinant (His) dipeptidylpeptidase 4,Dpp-4,Cd26,THAM	Mouse	HEK293 Cells
	DPP4/CD26 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.9 kDa and the accession number is P28843.
TMPH-03279	DPP4/CD26 Protein, Rat, Recombinant (His & SUMO) Dpp4,Dipeptidyl peptidase IV,DPP IV,CD26,D...	Rat	E. coli
	Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular ...
TMPY-00777	DPP2 Protein, Human, Recombinant (His) DPP2,DPPII,QPP,dipeptidyl-peptidase 7	Human	HEK293 Cells
	DPP2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.6 kDa and the accession number is Q9UHL4.
TMPY-00732	Cathepsin C Protein, Human, Recombinant (His) DPP-I,PLS,JP,cathepsin C,CPPI,DPPI,PDON1,P...	Human	HEK293 Cells
	Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also known as dipeptidyl peptidase I (DPPI/DPP1), activates a number of granule-associated serine proteases with pro-inflammatory and immune functions by removal of their inhibitory N-terminal dipeptides. This lysosomal exo-cysteine protease belonging to the peptidase C1 family. Active c...
TMPY-00779	DPP4/CD26 Protein, Human, Recombinant TP103,CD26,ADCP2,DPPIV,ADABP,dipeptidylpeptidase 4	Human	HEK293 Cells
	DPP4/CD26 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 85.4 kDa and the accession number is P27487.
TMPY-00778	DPP4/CD26 Protein, Human, Recombinant (hFc) DPPIV,TP103,ADABP,CD26,ADCP2,dipeptidylpeptidase 4	Human	HEK293 Cells
	DPP4/CD26 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 112 kDa and the accession number is P27487.
TMPJ-01358	DPP3 Protein, Human, Recombinant (His) Dipeptidyl arylamidase III,Dipeptidyl aminopeptidase III,Dip...	Human	E. coli
	Dipeptidyl peptidase 3(DPP3), is a member of the S9B family in clan SC of the serine proteases. DPP3 has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH). It releases an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity and also acts on dipeptidyl 2-naphthylamides.Increased activity of this protein has a relat...
TMPY-00122	DPP4/CD26 Protein, Human, Recombinant (His) TP103,ADABP,CD26,ADCP2,DPPIV,dipeptidylpeptidase 4	Human	HEK293 Cells
	DPP4/CD26 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.3 kDa and the accession number is P27487.
TMPH-02628	Cathepsin C Protein, Mouse, Recombinant (His & Myc) Dipeptidyl transferase,Dipeptidyl peptidase I,Cathepsin J,	Mouse	E. coli
	Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.
TMPJ-00271	SMAD3 Protein, Human, Recombinant (His & Flag) SMAD 3,Mothers against DPP homolog 3,hMAD-3,MADH3,J...	Human	E. coli
	Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated...
TMPJ-01108	SMAD4 Protein, Human, Recombinant (His) DPC4,SMAD 4,Deletion Target in Pancreatic Carcinoma 4,hSMAD4...	Human	E. coli
	SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumo...
TMPK-00377	DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) DPP4,DPPIV,ADCP2,CD26,ADABP,TP103,EC 3.4.1...	Cynomolgus,Rhesus	HEK293 Cells
	CD26/dipeptidyl peptidase (DPP)IV is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metastases express DPPIV/CD26 to a variable extent.
TMPY-01854	DPP10 Protein, Human, Recombinant (His) DPPY,DPRP3,DPRP-3,DPL2,dipeptidyl-peptidase 10 (non...	Human	HEK293 Cells
	Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein which belongs to thepeptidase S9B family.DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP1 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally p...
TMPY-02737	DPP2 Protein, Mouse, Recombinant (His) dipeptidyl-peptidase 7,DPPII,QPP,Dpp2	Mouse	HEK293 Cells
	DPP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is Q9ET221.
TMPY-04046	DPP4/CD26 Protein, Cynomolgus, Recombinant dipeptidylpeptidase 4	Cynomolgus	HEK293 Cells
	DPP4/CD26 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 84.6 kDa and the accession number is F6VRB0.
TMPJ-01129	SMAD1 Protein, Human, Recombinant (GST) hSMAD1,Transforming Growth Factor-Beta-Signaling Protein 1,T...	Human	E. coli
	SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated ...
TMPY-03952	DPP4/CD26 Protein, Cynomolgus, Recombinant (hFc) dipeptidylpeptidase 4	Cynomolgus	HEK293 Cells
	DPP4/CD26 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 112.9 kDa and the accession number is F6VRB0.
TMPY-04251	DPP4/CD26 Protein, Cynomolgus, Recombinant (His) dipeptidylpeptidase 4	Cynomolgus	HEK293 Cells
	DPP4/CD26 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is XP_005573375.1.

重组蛋白

DPP4/CD26 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-00221

Species: Mouse

Expression System: HEK293 Cells

DPP4/CD26 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00074

Species: Mouse

Expression System: HEK293 Cells

DPP4/CD26 Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03279

Species: Rat

Expression System: E. coli

DPP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00777

Species: Human

Expression System: HEK293 Cells

Cathepsin C Protein, Human, Recombinant (His)

Cat.No: TMPY-00732

Species: Human

Expression System: HEK293 Cells

DPP4/CD26 Protein, Human, Recombinant

Cat.No: TMPY-00779

Species: Human

Expression System: HEK293 Cells

DPP4/CD26 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00778

Species: Human

Expression System: HEK293 Cells

DPP3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01358

Species: Human

Expression System: E. coli

DPP4/CD26 Protein, Human, Recombinant (His)

Cat.No: TMPY-00122

Species: Human

Expression System: HEK293 Cells

Cathepsin C Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02628

Species: Mouse

Expression System: E. coli

SMAD3 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-00271

Species: Human

Expression System: E. coli

SMAD4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01108

Species: Human

Expression System: E. coli

DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00377

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

DPP10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01854

Species: Human

Expression System: HEK293 Cells

DPP2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02737

Species: Mouse

Expression System: HEK293 Cells

DPP4/CD26 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-04046

Species: Cynomolgus

Expression System: HEK293 Cells

SMAD1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01129

Species: Human

Expression System: E. coli

DPP4/CD26 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-03952

Species: Cynomolgus

Expression System: HEK293 Cells

DPP4/CD26 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-04251

Species: Cynomolgus

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T13121	Teneligliptin D8 MP-513 D8	Others	Others
	Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.
TMIH-0583	Trelagliptin-13C-d3
	Trelagliptin-13C-d3 是 Trelagliptin 的 13C 和氘代化合物。Trelagliptin 的 CAS 号为 865759-25-7。Trelagliptin 是一种有效的，具有口服活性的DPP-4抑制剂，IC50=4 nM。它可以改善体内血糖控制，能够用于2 型糖尿病 (T2DM) 的研究。
T10288	Alogliptin (13CD3) SYR-322 (13CD3)	Others	Others
	Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.
TMIJ-0142	Vildagliptin-d7
	Vildagliptin-d7 是 Vildagliptin 的氘代化合物。Vildagliptin 的 CAS 号为 274901-16-5。Vildagliptin 是一种选择性二肽基肽酶IV (DPP-IV) 抑制剂，在人 Caco-2 细胞中抑制 DPP-IV 的IC50为 3.5 nM。它具有出色的口服生物利用度和降血糖活性。
TMIJ-0143	Linagliptin-13C-d3
	Linagliptin-13C-d3 是 Linagliptin 的 13C 和氘代化合物。Linagliptin 的 CAS 号为 668270-12-0。Linagliptin 是一种有效的、可口服的、基于二氢嘌呤二酮的二肽基肽酶 4 抑制剂，具有降血糖活性。
TMIH-0302	Linagliptin-d4
	Linagliptin-d4 是 Linagliptin 的氘代化合物。Linagliptin 的 CAS 号为 668270-12-0。Linagliptin 是一种有效的、可口服的、基于二氢嘌呤二酮的二肽基肽酶 4 抑制剂，具有降血糖活性。

同位素标记化合物

Teneligliptin D8

Cat.No: T13121

Synonym: MP-513 D8

Target: Others

Trelagliptin-13C-d3

Cat.No: TMIH-0583

Alogliptin (13CD3)

Cat.No: T10288

Synonym: SYR-322 (13CD3)

Target: Others

Vildagliptin-d7

Cat.No: TMIJ-0142

Linagliptin-13C-d3

Cat.No: TMIJ-0143

Cat.No: TMIH-0302

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